No abstract available.
Chungcheongnam-do* ; Family Planning Services* ; Humans

bcl-2 and c-myc protein expression were studied in 44 epidermal (8 seborrheic keratoses, 21 squamous cell carcinomas, and 15 basal cell carcinomas), and 26 melanocytic tumors(8 nevi, and malignant melanomas) by immunohistochemistry using the specific anti-bcl-2 and anti-c-myc monoclonal antibodies. 14 out of 15 basal cell carcinomas(BCC) (93.3%) showed expression of bcl-2 protein, 12 of which (85.7%) showed coexpression of c-myc protein. In the melanocytic tumors, 7 out of 8 nevi showed bcl-2 expression (87.5%). Five of these 7 cases (62.5%) also showed c-myc protein expression. Eight of 18 malignant melanomas(MM) (44.4%) showed expression of bcl-2 protein and 7 of these 8 cases (38.9%) also showed c-myc protein expression. All seborrheic keratoses and squamous cell carcinoma(SCC) were negative for bcl-2 proteins. 12 of 15 SCCs(80%) were positive for c-myc protein. In conclusion, bcl-2 and c-myc proteins were coexpressed in BCCs, nevi, and MMs. Coexpression of bcl-2 and c-myc proteins in these tumors was statistically significant(p<0.01), while no considerable differences of bcl-2 and c-myc expression were found between nevi and MMs. These results suggests that bcl-2 may cooperate with c-myc to promote tumorigenesis of BCCs, nevi, and MMs(p<0.01).
Cell Transformation, Neoplastic

Gastric glomus tumor is an uncommon benign, submucosal neoplasm and does not require radical surgical procedure. Because there are no specific clinical or radiologic features associated with the glomus tumor, it can be recognized only by its histologic characteristics. We report a 30-year-old woman who had 10 years history of epigastric hunger pain. Radiologically, a gastric submucosal tumor was discovered, which was suggestive of leiomyoma. Gastric antrectomy was performed. The tumor cells showed immunohistochemical and ultrastructural evidence of smooth muscle differentiation.
Female ; Humans

We performed the intravitreal injection of air and pure perfluoropropane(C3F8) gas in the pigmented rabbits and observed the changes of gas levels by the ultrasonography. We also observed the changes of the intra-ocular gas levels by the ultrasonography and measured the intraocular pressures(IOPs) in 9 patients who had undergone vitrectomy and fluid-gas exchange with 20% sulfur hexafluoride(SF6) and 14% perfluoropropane(C3F8) gases. In the pigmented rabbits, the air was not expanded and completely absorbed within 2 days, and the C3F8 gas was expanded maximally at 3 to 7 days and completely absorbed after 3 weeks. Among nine human eyes treated with vitrectomy and fluid-gas exchange, the intraocular pressures were elevated above 25mmHg at 1 day after operation in 2 eyes, which were controlled with medical therapy. The lOPs were significantly correlated with the amount of the intraocular gases(r=0.3476, p<0.05). The assessment of intraocular gas level by ultrasonography seems to be easier and more objective method than others previously reported.
Absorption* ; Gases ; Humans ; Intraocular Pressure ; Intravitreal Injections ; Rabbits ; Sulfur ; Ultrasonography ; Vitrectomy

We performed the intravitreal injection of air and pure perfluoropropane (C3F8) gas in the pigmented rabbits and observed the changes of gas levels by the ultrasonography. We also observed the changes of the intra-ocular gas levels by the ultrasonography and measured the intraocular pressures (lOPs) in 9 patients who had undergone vitrectomy and fluid-gas exchange with 20% sulfur hexafluoride (SF6) and 14% perfluoropropane (C3F8) gases. In the pigmented rabbits, the air was not expanded and completely absorbed within 2 days, and the C3F8 gas was expanded maximally at 3 to 7 days and completely absorbed after 3 weeks. Among nine human eyes treated with vitrectomy and fluid-gas exchange, the intraocular pressures were elevated above 25mmHg at 1 day after operation in 2 eyes, which were controlled with medical therapy. The lOPs were significantly correlated with the amount of the intraocular gases (r=0.3476, p<0.05). The assessment of intraocular gas level by ultrasonography seems to be easier and more objective method than others previously reported.
Absorption* ; Gases ; Humans ; Intraocular Pressure ; Intravitreal Injections ; Rabbits ; Sulfur Hexafluoride ; Ultrasonography ; Vitrectomy

No abstract available.
Endometriosis* ; Female ; Omentum*

Screening test of Human Immunodeficiency Virus(HIV) infection was introduced on Korean Blood Donor Test Program in July 1987, and the test results between July 1987 and December 1990 were reported on the Korean Journal of Blood Transfusion on May 1992. Moreover, we assessed anti-HIV ELISA screening test result of 3,905,986 blood donors donated at Korean Red Cross Blood Centers between January 1991 and December 1993. The seropositivity of anti-HIV ELISA screening test was 0.26% in 1991, 0.30% in 1992 and 0.18% in 1993.0.15% of all donors in 1991 was reactive repeatedly, and 0.15% in 1992 and 0.08% in 1993. The prevalence of HIV infected donors confirmed by Western Blot Assay was 0.0003% in 1991, 0.0015% in 1992, and 0.0009% in 1993. The sero-positivities of anti-HIV screening tests with AIDSDIA reagent and HIVIRO reagent were 0.32% and 0.17% and the difference was significantly(p<0.05). The sero-positivities of ELISA screening and Western Blot. Assay detecting anti-HIV were lower in soldier group than in non-soldier donor group (p< 0.05).
Blood Donors* ; Blood Transfusion ; Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; HIV* ; Humans ; Korea* ; Mass Screening ; Military Personnel ; Prevalence* ; Red Cross ; Tissue Donors

p63 is a recently described p53 homologue. It is involved in survival and differentiation of reserve/stem cells in epithelia. To obtain new insights into the role of p63 in malignant lymphomas (MLs), immunohistochemical staining for p63 and p53 was performed in 126 cases of MLs. p63 was expressed in 38 cases of MLs (30.2%) including 32/61 cases (52.5%) of diffuse large B-cell lymphoma (DLBCL), 1/8 cases (12.5%) of precursor T-lymphoblastic lymphoma (T-LBL), 4/14 cases (28.6%) of follicular lymphoma, 1/6 cases (16.7%) of T/NK cell lymphoma. Among p63 positive cases, p63 was strongly expressed in 15/32 cases of DLBCL and 1/1 case of T-LBL. p63 was not expressed in mantle cell lymphomas, peripheral T-cell lymphomas, marginal zone B-cell lymphomas, plasma cell myelomas and Hodgkin's lymphomas. p63 was coexpressed with p53 in 18/38 p63 positive cases in which only 4 cases were strongly coexpressed. All p63+/p53+ cases were DLBCL. p63 overexpression (above 30%) cases showed significant poor survival (p=0.0228) in DLBCL. However, there was no statistically significant correlation between p63 expression and IPI score on Multivariate analysis. We could speculate that p63 could act indirectly as an oncogene by inhibiting p53 functions. Stage of differentiation of neoplastic lymphocytes appears to have a correlation with p63 expression in MLs.
Gene Expression Profiling ; Humans ; Incidence ; Korea/epidemiology ; Lymphoma/*metabolism/*mortality ; Membrane Proteins/*metabolism ; Pseudolymphoma/*metabolism/*mortality ; Research Support, Non-U.S. Gov't ; Risk Assessment/*methods ; Risk Factors ; Survival Analysis ; Survival Rate ; Tumor Markers, Biological/*metabolism

No abstract available.
Epidermolysis Bullosa Dystrophica* ; Epidermolysis Bullosa*

Patients with signs of benign prostatic hyperplasia undergo excretory urography as a part of the diagnostic measures. The investigation is expected to yield information on the upper urinary tract and pathology of the bladder. But the necessity of excretory urography as a routine study before prostatectomy has been questioned. Herein we analyzed 154 patients who underwent excretory urography before prostatectomy at department of Urology, Masan Koryo General Hospital from January 1990 to December 1992. Of 154 patients, 117(76.0% ) showed normal upper tract with cystogram compatible with benign prostatic hyperplasia, 19(12.3% ) dilated upper tract. 1 (0.6% ) nonvisualized kidney, 9(5. 8%) incidental upper tract anomalies, 12(7.8% ) urolithiasis. Most of these anomalies could not alter the planned therapeutical procedures. We concluded that excretory urography is not always necessary in diagnosis of benign prostatic hyperplasia, but only in selected cases.
Diagnosis ; Hospitals, General ; Humans ; Kidney ; Pathology ; Prostatectomy ; Prostatic Hyperplasia* ; Urinary Bladder ; Urinary Tract ; Urography* ; Urolithiasis ; Urology