1.A comparative study on the accuracy of axial length and anterior chamber depth in cataract patients with A-scan and IOL Master
Chan-Chan, WANG ; Guo-Fu, WU ; Xue-Qing, YU
International Eye Science 2017;17(9):1697-1699
AIM:To compare the accuracy of conventional contact A-scan and IOL Master in measuring axial length and anterior chamber depth, and to evaluate the characteristics of these two different methods.METHODS:Totally 145 cases (189 eyes) who underwent phacoemulsification and intraocular lens implantation in our hospital from January 2015 to December 2016 were observed prospectively.They were divided into five groups according to ocular axial length measured by IOL Master(Group A:AL≤22mm, Group B:22mm
2.Implemeuting Health Impact Assessment Learning from the Theories and Experiences of Environmental Impact Assessment
Chan WANG ; Kenan BI ; Xiaojing MA
Chinese Health Economics 2017;36(2):5-7
Objective:To learn from the experiences of environmental impact assessment,and explore the theories and practices of health impact assessment.Methods:With suitability analysis of reference to environmental impact assessment and literature research,the current situation,practices and problems of environmental impact assessment were summarized.Results and Conclusion:Drawing on experiences in environmental impact assessment,it needed to start the establishment and implementation of health impact assessment system with healthy cities,healthy towns and villages,improve relevant laws and regulations,strengthen supervision and management of health impact assessment.
3.International experiences on social capital running hospitals and the implications for China
Chinese Journal of Hospital Administration 2016;32(2):89-91
This article introduced the experiences of nongovernmental capital running hospitals in US,Germany,India and Israel and put forward some suggestions that need to be considered in China, such as innovating supply model of health care service,treating social capital running hospitals equally and strengthening supervision.
4.Treatment effects of traditional Chinese medicines Suoquan Pill and Wuling Powder on clozapine-induced hypersalivation in patients with schizophrenia: study protocol of a randomized, placebo-controlled trial.
Chiachun HUNG ; Pinkuei FU ; Hsynyi WANG ; Chinhong CHAN ; Tsuohung LAN
Journal of Integrative Medicine 2011;9(5):495-502
Background: It is reported that 30% to 80% schizophrenia patients suffered from hypersalivation when taking clozapine. Some investigations of the use of formulas of traditional Chinese medicine (TCM) to treat clozapine-induced hypersalivation suggested their potential treatment effects. In these formulas, Suoquan Pill (SQP) and Wuling Powder (WLP) were suggested to have therapeutic effects in improving clozapine-induced hypersalivation. Methods and design: A prospective, double-blind, randomized, placebo-controlled study will be conducted to test the therapeutic effects of SQP and WLP in relieving hypersalivation in patients taking clozapine. A total of 45 patients will be enrolled into this study with 15 in each treatment group. Patients will receive medication according to their assigned group. Either SQP 10 g per oral dose twice daily, WLP 10 g per oral dose twice daily or placebo powder 10 g per oral dose twice daily will be prescribed to the patients for 8 weeks. The Drooling Severity Scale, Nocturnal Hypersalivation Rating Scale and sialoscintigraphy will be used as the primary outcome measures; the Clinical Global Impressions Severity, the Positive and Negative Syndrome Scale, the Abnormal Involuntary Movement Scale, the Simpson-Angus Scale and the TCM constitutional scale will be used as the secondary outcome measures Discussion: It is hypothesized that SQP and WLP will have a beneficial effect in controlling clozapine-induced hypersalivation symptoms. It may also improve the life quality of psychotic patients by improving their mental status. Trial registration: ClinicalTrials.gov (Identifier: NCT01045720).
5.Effects of extracts of Radix Scrophulariae on blood pressure in spontaneously hypertensive rats and the underlying mechanisms.
Chan CHEN ; Changxun CHEN ; Ximin WU ; Rui WANG ; Yiming LI
Journal of Integrative Medicine 2012;10(9):1009-17
To explore the effects of extracts of Radix Scrophulariae (ERS) on blood pressure, vasoconstrictors and morphology of artery in spontaneously hypertensive rats (SHRs).
6.Suppressive effect of IL-10 and TGF-β1 derived from regulatory T cells on osteoclast differentiation and bone resorption
Chengyan LUO ; Ling WANG ; Chan SUN ; Dajin LI
Chinese Journal of Endocrinology and Metabolism 2009;25(4):434-437
ner. Furthermore, IL-10 and TGF-β1 showed a synergic effect. Conclusion IL-10 and TGF-β1, the cytokines of regulatory T cells, suppress the formation and bone resorption function of the osteoclasts.
7.ERCC1-shRNA inhibits the proliferation and promotes the apoptosis of lung cancer A549/DDP cells
Yifeng JIN ; Cuicui CHAN ; Lei FANG ; Ying WANG ; Xingwu CHEN
Journal of Medical Postgraduates 2017;30(6):591-595
Objective Studies show that the ERCC1 gene may be involved in secondary cisplatin resistance.This article aims to investigate the effects of shRNA targeting silencing excision repair cross-complementation group 1 (ERCC1-shRNA) on the proliferation and apoptosis of lung cancer A549/DDP cells treated with different concentrations of cisplatin.Methods Lung cancer A549/DDP cells were divided into a negative control, a blank control, an ERCC1-shRNA1, and an ERCC1-shRNA2 group.Human interfering RNA (RNAi) targeting the human ERCC1 gene was constructed and transfected into the A549/DDP cells using Lipofectamine 2000.The mRNA and protein expressions of ERCC1 in the A549/DDP cells were detected by real-time PCR and Western blot respectively, the proliferation-inhibition rate was assessed by MTT, and their cell cycle and apoptosis were determined by flow cytometry.Results ERCC1-shRNA was successfully constructed and transfected into the A549/DDP cells.Both the mRNA and protein expressions of ERCC1 were significantly lower in the ERCC1-shRNA1 (0.20±0.04 and 0.24±0.10) and ERCC1-shRNA2 (0.47±0.28 and 0.37±0.11) than in the negative control (0.96±0.12 and 1.32±0.13) and blank control groups (0.84±0.07 and 1.45±0.23) (P<0.01).Compared with the negative and blank control groups, the ERCC1-shRNA1 group showed a significantly decreased IC50 value (16.71±2.33 and 16.69±1.69 vs 7.78±0.54, P<0.01) and an increased proportion of G0/G1 phase cells ([72.87±3.23] and [71.75±4.56] vs [82.99±4.23]%, P<0.05), with the cell cycle arrested in the G0/G1 phase.The apoptosis rate of the cells in the ERCC1-shRNA1 group was remarkably lower after treated with cisplatin at the concentrations of 6.25 and 12.5 μg/mL than at 0 μg/mL ([8.17±0.65] and [11.91±1.41] vs [29.97±3.14]%, P<0.05).Conclusion ERCC1-shRNA can inhibit the proliferation and enhance the apoptosis of A549/DDP cells by silencing the expression of the ERCC1 gene.
8.Development of nursing needs scale for school-age children with acute leukemia during lumbar puncture
Anwei XIE ; Yuying CHAN ; Meie NIU ; Yi CHEN ; Qianya WANG
Chinese Journal of Practical Nursing 2016;32(7):497-501
Objective To construct nursing needs scale for school-age children with acute leukemia (AL) during lumbar puncture by using Delphi technique.Methods A certain number of experts were chosen for consulting to form a consulting scale.Two-round consultations were conducted and the results were analyzed.Results The effective response rate of the experts' questionnaire for 2 rounds was 100% (17/17).The specialist group authority coefficient was 0.85.The coordination coefficients for 2 rounds were 0.437 and 0.516 respectively (P < 0.01).The nursing needs scale for school-age children with AL during lumbar puncture comprised of 5 first-level indicators and 30 second-level indicators.Conclusions This scale can scientifically and quickly evaluate the nursing needs of school-age children with AL during lumbar puncture,it provides a research tool to develop individualized interventions with demand as the direction.
9.True experience of parents of children with acute leukemia during lumbar puncture: a qualitative research
Anwei XIE ; Yuying CHAN ; Mei'e NIU ; Yi CHEN ; Xiya WANG ;
Chinese Journal of Practical Nursing 2015;31(4):251-254
Objective We aimed to explore the real experience of parents of children with acute leukemia during lumbar puncture,so as to provide the theoretical and practice evidence for development of individualized nursing measures.Methods Twenty parents of children with acute leukemia participated in semi-structured interviews regarding their experience of lumbar puncture.The data were colected and analyzed by the Colaizzi phenomenological methodology.Results Three themes were extracted including heavy psychological burden,lack of related knowledge of lumbar puncture and demand of multipolarity.Conclusions Attention should be paid closely to parents of children with acute leukemia during lumbar puncture.The individualized nursing measures should be taken by medical workers in order to truly meet their needs,make them stay in a good state and cooper-ate with medical workers to complete the treatment of children.
10.Giant Sacral Chondrosarcoma in an Elderly Male : A Case Report
HZ Chan ; CS Wang ; Azuhairy A ; A Hau ; Zulkiflee O
Malaysian Orthopaedic Journal 2014;8(1):79-81
Primary sacral tumours are rare, therefore experience of
managing their associated complications are very limited.
Effective surgical treatment of pelvic chondrosarcoma
remains a major challenge for orthopaedic surgeons, due to
the complex anatomic structure of the pelvis, the lack of
defined compartment borders, the close vicinity to vital
structures, and the risk of jeopardizing pelvic structural
stability. We report a rare case of a giant sacral
chondrosarcoma (100cm x 80cm) in an elderly male who
successfully underwent tumour resection with good
functional outcome and recovery. Long term follow up is
essential in vie
Chondrosarcoma