No abstract available.
Craniosynostoses* ; Humans ; Infant, Newborn*

Balloon dilatation angioplasty was performed in a 15 months old child with isolated discrete unoperated coarctation of the aorta. The peak systolic pressure gradient across the coarctation before balloon angioplasty was 80 mmHg, and immediately after balloon angioplasty it decreased to 19 mmHg. No significant complications were encountered during the procedure. No evidence of aneurysm formation and restenosis was seen on 6 months follow-up examination. Balloon dilatation angioplasty seems to be a safe and effective nonsurgical alternative for relieving the obstruction associated with discrete coarctation of the aorta.
Aneurysm ; Angioplasty ; Angioplasty, Balloon* ; Aortic Coarctation* ; Blood Pressure ; Child ; Dilatation ; Follow-Up Studies ; Humans ; Infant

BACKGROUND: Constriction or banding of the pulmonary artery to create pulmonary artery stenosis is a palliative procedure designed to limit pulmonary blood flow in congenital cardiac malformation with unrestricted left to right shunt. Activation of sensory endings such as the arterial baroreceptors results in an inhibitory endings in the heart. The purpose of this study is to test the hypothesis that acute pulmonary artery constriction(PAC) results in an enhanced cardiopulmonary inhibition of the arterial baroreflex. METHODS: Baroreflex control of renal sympathetic nerve activity(RSNA) were examined in rabbits before and during reversible PAC. New Zealand white rabbits were instrumented with an occluder around the main pulmonary artery, a right ventricular catheter, femoral artery and venous catheters, and recording electrodes around renal sympathetic nerves. Baroreflex mediated changes in RSNA were monitored during decreases and increases in mean arterial pressure. RESULTS: Acute PAC produced significant([<0.05) changes in mean arterial pressure(76.3+/-1.9 vs. 59.8+/-3.0mmHg), right ventricular systolic pressure(23.1+/-4.2 vs. 42.3+/-7.4mmHg), and resting RSNA(100 vs. 71+/-6.3%). The effect of acute PAC on the arterial baroreflex was characterized by decreases in RSNA range(103.0+/-1.3 vs. 83.8+/-3.8%) and gain (-3.5+/-0.2 vs. -2.6+/-0.2). CONCLUSION: Acute PAC significantly attenuates arterial baroreflex control of RSNA in rabbits. The attenuated arterial baroreflex regulation of RSNA may be result of an enhanced inhibitory influence from activated cardiac receptors.
Arterial Pressure ; Baroreflex* ; Catheters ; Constriction ; Constriction, Pathologic ; Electrodes ; Femoral Artery ; Heart ; Pressoreceptors ; Pulmonary Artery* ; Rabbits*

No abstract available.
Doxorubicin* ; Membrane Potentials* ; Membranes* ; Purkinje Fibers* ; Sodium*

No abstract available.
Constriction* ; Heart Ventricles* ; Pulmonary Artery* ; Rabbits*

Congenital tricuspid stenosis is an uncommon congenital heart anomaly. Tricuspid stenosis is usually associated with other anomalies, most commonly severe pulmonary stenosis or atresia with secondary hypoplasia of the right ventricle. Clinically it may be difficult to distinguish from tricuspid atresia. A case of congenital tricuspid stenosis in a 32 day-old-girl is presented. The patient had cyanosis and dyspnea. Echocardiographic study revealed tricuspid stenosis with right ventricular hypoplasia, atrial septal defect and pulmonary stenosis.
Constriction, Pathologic* ; Cyanosis ; Dyspnea ; Echocardiography ; Heart ; Heart Defects, Congenital ; Heart Septal Defects, Atrial ; Heart Ventricles ; Humans ; Pulmonary Valve Stenosis ; Tricuspid Atresia

No abstract available.
Balloon Valvuloplasty* ; Child* ; Constriction, Pathologic* ; Humans

No abstract available.
Baroreflex* ; Cyclosporine* ; Rabbits*

Graded infusion and bolus injection methods of vasoactive drugs have both been used to measure baroreflex sensitivity. To determine whether the two methods produce the same values of baroreceptor sensitivity, phenylephrine and nitroglycerin was administered intravenously by both graded infusion and bolus injection methods to 11 rabbits. To evaluate the baroreflex control of heart rate(HR), a logistic sigmoid function model was used. The range of HR and baroreflex gain by the bolus method(100.53+/-0.62, 0.113+/-0.011) were significantly(p<0.05) larger than those measured by the graded infusion method(108.49+/-1.66, 0.126+/-0.013). However, there were no significant changes in the pressure at the midrange of the baroreflex curve. Thus my results indicate that baroreflex control of HR by the graded infusion and bolus injection methods is not equivalent and that baroreflex-induced HR response to a gradual change in pressure is less than that seen with a repid change.
Baroreflex* ; Colon, Sigmoid ; Heart ; Heart Rate ; Nitroglycerin ; Phenylephrine ; Pressoreceptors ; Rabbits*

No abstract available.
Adolescent* ; Adult* ; Child* ; Heart Defects, Congenital* ; Humans ; Rehabilitation*