No abstract available.
Arthroplasty, Replacement, Hip*

No abstract available.
Child* ; Humans ; Lung Diseases, Interstitial*

PURPOSE: The reliability and validity of a Korean version of the Obsessive-Compulsive-Inventory-Revised (OCI-R) was examined in non-clinical student samples. MATERIALS AND METHODS: The Korean version of OCI-R was administered to a total of 228 Korean college students. The Maudsley Obsessive Compulsive Inventory (MOCI), Beck's Depression Inventory (BDI), and Beck's Anxiety Inventory (BAI) were administered to 228 students. RESULTS: The total and each of subscale of the Korean OCI-R demonstrated excellent internal consistency, good test-retest reliability, moderate convergent validity and good divergent validity. CONCLUSION: It was concluded that the Korean version of the OCI-R has strong psychometric properties as the original version.
Female ; Humans ; Korea ; Male ; Obsessive-Compulsive Disorder/*diagnosis ; *Psychological Tests/statistics & numerical data ; Psychometrics ; Questionnaires ; Reproducibility of Results ; Young Adult

PURPOSE: To measure the amount of type II collagen with western blotting method and to verify its relations with the clinical, radiological and second look arthroscopic findings in patients who were treated with microfracture surgery. MATERIALS AND METHODS: From October 1997 to December 2000, second look arthroscopies and biopsies were performed in 21 knees of 20 patients at 1 year after surgery. Their mean age at the time of operation was 62.7 years(range, 44-77years) and mean follow-up period were 1 year 3months(range, 10-30 months). 21 cases were classified into 3 groups (Group I >70%, Group II 20-70%, Group III < 20% of normal control) according to the result of western blotting of type II collagen. We analyzed the relationship of western blotting of type II collagen with clinical, radiological, extent of regenerated articular cartilage, patient's age, weight and preoperative varus deformity. RESULTS: Average amounts of type II collagen were 44% of those in control group. The amounts of type II collagen formation had positive correlation with extent of regenerated cartilage and preoperative varus deformity but no correlation with clinical score, joint space widening, patient's weight and age. CONCLUSION: The results of this study provide the rationale to select the osteoarthritic patients indicated for microfracture surgery.
Arthroscopy ; Biopsy ; Blotting, Western* ; Cartilage ; Cartilage, Articular ; Collagen Type II* ; Congenital Abnormalities ; Follow-Up Studies ; Humans ; Joints ; Knee ; Osteoarthritis

BACKGROUND: The hindlimb unweighting (HLU) rat model mimics cardiovascular deconditioning following microgravity or human bed rest, particularly for the development of orthostatic intolerance. We have examined vascular responses to alpha1 adrenergic and non-alpha1 adrenergic agonists in vitro. We have also explored the reversibility of the contractile abnormalities observed. METHODS: Dose-response curves were generated to phenylephrine (PE) and norepinephrine (NE) (10(-9) to 10(-4) M), U46619 (U4) (10(-10) to 10(-6) M) at one-half log order intervals in controls (n = 6), HLU (n = 6), or recovered rats (n = 6). EC(50)s and maximal responses (E(max)) were calculated by nonlinear logistic regression analysis with PRIZM software (Graphpad, Mountain View, CA). RESULTS: Simulated microgravity results in attenuated contractile responses to both alpha1 adrenergic and non-alpha1 adrenergic agonists, but the impaired contractile phenomenon reverses with time. CONCLUSIONS: The decreased vascular reactivity after microgravity and prolonged bed rest could cause attenuated baroreflex function and produce orthostatic intolerance, but that problem resolved with time.
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid ; Adrenergic Agonists ; Animals ; Baroreflex ; Bed Rest ; Cardiovascular Deconditioning ; Hindlimb ; Humans ; Logistic Models ; Norepinephrine ; Orthostatic Intolerance ; Phenylephrine ; Rats ; Weightlessness

BACKGROUND: The hindlimb unweighting (HLU) rat model mimics cardiovascular deconditioning following microgravity or human bed rest, particularly for the development of orthostatic intolerance. We have examined vascular responses to alpha1 adrenergic and non-alpha1 adrenergic agonists in vitro. We have also explored the reversibility of the contractile abnormalities observed. METHODS: Dose-response curves were generated to phenylephrine (PE) and norepinephrine (NE) (10(-9) to 10(-4) M), U46619 (U4) (10(-10) to 10(-6) M) at one-half log order intervals in controls (n = 6), HLU (n = 6), or recovered rats (n = 6). EC(50)s and maximal responses (E(max)) were calculated by nonlinear logistic regression analysis with PRIZM software (Graphpad, Mountain View, CA). RESULTS: Simulated microgravity results in attenuated contractile responses to both alpha1 adrenergic and non-alpha1 adrenergic agonists, but the impaired contractile phenomenon reverses with time. CONCLUSIONS: The decreased vascular reactivity after microgravity and prolonged bed rest could cause attenuated baroreflex function and produce orthostatic intolerance, but that problem resolved with time.
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid ; Adrenergic Agonists ; Animals ; Baroreflex ; Bed Rest ; Cardiovascular Deconditioning ; Hindlimb ; Humans ; Logistic Models ; Norepinephrine ; Orthostatic Intolerance ; Phenylephrine ; Rats ; Weightlessness

PURPOSE: To establish the incidence, type and significance of knee instability in patients with ipsilateral femoral and tibial shaft fracture, comparing with the patients with femoral shaft or tibial shaft fracture alone. MATERIALS AND METHODS: Two hundreds and seventy-nine consecutive patients were retrospectively reviewed from February 2000 to April 2004. They were composed of 80 patients with femoral shaft fracture alone, 176 patients with tibial shaft fracture alone and 23 patient with ipsilateral femoral and tibial shaft fracture. We evaluate the instability of knee based on physical examinations, plain stress films and MRI. We analyze incidence and period to diagnosis of instability, period to complete bony union and Hospital for Special Surgery (HSS) knee score respectively. RESULTS: There were 6.3% of knee instability in femoral shaft fracture alone, 9.7% in tibial shaft fracture alone and 30.4% in ipsilateral femoral and tibial shaft fracture. The average period to diagnosis of instability, average period to complete bony union and average HSS knee score were 9.2 months, 4.7 months and 65 points in femoral shaft fracture alone, 9.1 months, 4.2 months and 69 points in tibial shaft fracture alone, 8.7 months, 5.3 months (femur), 4.7 months (tibia) and 57 points in ipsilateral femoral and tibial shaft fracture respectively. CONCLUSION: We should consider MRI to evaluate the knee instability in patient with ipsilateral femoral and tibial shaft fracture at the time of injury and make a plan early about the treatment of knee instability.
Diagnosis ; Humans ; Incidence ; Knee* ; Magnetic Resonance Imaging ; Physical Examination ; Retrospective Studies

We examined whether pretreatment with a small dose of thiopental was effective in reducing pain induced by the intravenous injection of rocuronium. Withdrawal movement was used to assess pain reduction. Ninety patients were randomly assigned to one of two groups: patients in the control group were pretreated with 2 mL saline, and those in the thiopental group were pretreated with 2 mL (50 mg) thiopental. Thiopental 5 mg/kg was injected intravenously. After a loss of consciousness, the upper arm was compressed with a rubber tourniquet, and the pretreatment drugs were administered. Thirty seconds later the tourniquet was removed and 0.6 mg/kg rocuronium was administered. Withdrawal movement was assessed using a four-grade scale: no movement, movement limited to the wrist, to the elbow or to the shoulder. The frequency of withdrawal movement in the group pretreated with thiopental was lower than in the control group (34 vs. 13, p 0.05). We concluded that pretreatment with 2 mL (50 mg) thiopental is effective in reducing pain caused by the intravenous injection of rocuronium.
Thiopental/*therapeutic use ; Pain Measurement ; Pain/chemically induced/*prevention & control ; Neuromuscular Nondepolarizing Agents/*adverse effects ; Middle Aged ; Male ; Injections, Intravenous ; Humans ; Female ; *Anesthetics, Intravenous ; Androstanols/*adverse effects ; Adult

PURPOSE: In our previous study, the authors developed high heat-treated mineralized porcine cancellous bone(TS-GBB, TaeSan Green Bone Block) as bone-substitute. So we projected that this experiments about TSGBB would prove its safety about problems after transplants, and its stability in mechanical strength as the human bone-substitute. MATERIALS AND METHODS: Highly heat-treated mineralized porcine cancellous bone was made. The chemical, mechanical, and morphological properties were evaluated through various tests. Animal study Total 31 New Zealand White rabbits were randomly selected. Bony defect on medial side of the proximal tibia was made. TS-GBB was implanted into the defect area in experimental group, while it was not inserted in control group. For stable fixation self-designed plate of stainless steel was used in both groups. At 2, 8, and 24 weeks, radiological evaluation was performed to measure new bone formation. At 4 and 16 weeks, clinical laboratory tests were performed. Mechanical shear tests were performed for control and experimental groups at 2, 8, and 16 weeks after operation. Also, histological observations were performed by H & E staining at 2 and 16 weeks after operation. Clinical experiments With the approval of IRB in Pusan Paik Hospital of Inje University and Hwasoon Hospital of Chunnam National University, the clinical trials were processed. After harvesting iliac bone for auto grafts from the 40 patients, 20 for each hospital, the TS-GBB were inserted to the donor site. ESR, CRP, WBC count were performed at postoperative time immediately, 1 week, 4 weeks, and 12 weeks to examine possible infection. At 12 weeks after operation, additional X-ray and CT observation were performed. RESULTS: Animal study At all laboratory finding, two group did not indicate a significant difference. At radiologic evaluation, we could comfirm that bone defect size was small gradually by new bone formation in the control group but new bone formation degree was more smaller and slower compared to the TS-GBB group. And at result of biological dynamic stiffness experiments, at postoperative 16 weeks, maximum load at breakage of control group showed to approximately 70% in normal tibia's that. But, maximum load at breakage or yield of TS-GBB group showed to more than 95% in normal tibia's that. In histologic examination, at postoperative 16 weeks, we comfirmed that in control group atypical bony tissue existed in defect site. On the other side, in TS-GBB group new bone formation formed in uniform. Clinical experiments In 20 cases of Inje University, absorption rate was slow a little at 1 case, but the others absorbed normally. In 17 cases of Hwasun Hospital of Chunnam National University, we comfirmed in grade 3 about TS-GBB's absorption and new bone formation at 16 case. At only 1 case, degree of TS-GBB's absorption and new bone formation was poor. In clinical chemistry tests to evaluate the safety, 19 of 20 patients who participated in the experiment in Pusan Paik hospital showed no specific abnormality and showed similar result to preoperative laboratory. In 1 case at postoperative 12 weeks, CRP was elevated, at 16 weeks this patient showed in normal value in ESR, CRP, and WBC count. In 20 patients of Hwasun Hospital all showed similar results to preoperative laboratory in clinical chemistry tests. CONCLUSION: We think that TS-GBB is the suitable material for regeneration of bone defect site as xenograft of clinical bone substitute.
Absorption ; Animals ; Bone Substitutes ; Chemistry, Clinical ; Clinical Chemistry Tests ; Ethics Committees, Research ; Humans ; Osteogenesis ; Rabbits ; Reference Values ; Regeneration ; Stainless Steel ; Tibia ; Tissue Donors ; Transplantation, Heterologous ; Transplants

Sweet's syndrome is an uncommon reactive dermatosis characterized by fever, polymorphonuclear leukocytosis, painful erythematous cutaneous plaques and dense dermal infiltrate of neutrophils at the skin lesions. Unlike Sweet's syndrome associated with patients with malignancies, autoimmune diseases, antecedent infectons-most commonly the upper respiratory infections, it is reported to be rarely associated with systemic lupus erythematosus (SLE). Here we report a rare case of young female with Sweet's syndrome and SLE presenting with high fever.
Autoimmune Diseases ; Female ; Fever ; Humans ; Leukocytosis ; Lupus Erythematosus, Systemic* ; Neutrophils ; Respiratory Tract Infections ; Skin ; Skin Diseases ; Sweet Syndrome*