No abstract available.
Hepatitis, Chronic*

No abstract available.
Cholestasis, Intrahepatic*

No abstract available.
Acidosis, Renal Tubular* ; Humans ; Infant, Newborn*

No abstract available.

No abstract available.
Osteoblastoma* ; Spine*

OBJECTIVES: MDM-2 is an oncoprotein that inhibits p53 tumor suppressor protein. Amplication and over- expression of its protein have been observed in human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To elucidate the role of p53 and MDM-2 protein in cervical neoplasia we investigated the expression rates of MDM-2 and p53 protein in surgically resected specimens. METHEDS: Immunohistochemical studies using anti-p53 and anti-MDM-2 protein in the paraffin embedded section of 62 cases including cervical intraepithelial neoplasm(CIN) and invasive cervical cancer were performed. RESULTS: Expression rates of p53 protein were 25% in CIN I& CINII, 20% in CINIII, and 44% in invasive carcinoma, respectively. The MDM-2 protein were 33% in CIN I & CIN II, 16% in CIN III, and 48% in invasive carcinoma, respectively. There was no evident correlation between p53 positivity and MDM-2 positivity(p>0.05). However, correlation between MDM-2 negativity and p53 negativity was statistically significant(p=0.002) CONCLUSION: These data suggest that the expression of p53 protein is presumed to be necessarily correlated with MDM-2 protein expression in cervical neoplasia.
Carcinogenesis ; Humans ; Paraffin ; Proto-Oncogene Proteins c-mdm2* ; Tumor Suppressor Protein p53 ; Uterine Cervical Neoplasms

Purpose: The incidence of isolated level III lymph node recurrence in breast cancer was evaluated, and a surgical approach with preoperative tattooing was introduced. When a suspicious infraclavicular lymph node was detected, fine-needle aspiration cytology was performed to confirm the recurrence of breast cancer. In addition, surgical excision was considered to evaluate the biological characteristics of the recurrent lesion. Methods: The treatment strategy was determined through multidisciplinary team discussions, which included breast surgeons, plastic surgeons, oncologists, radiologists, pathologists, and radiation oncologists. Preoperative tattooing was performed, and the lymph nodes were removed after splitting the pectoralis major muscle. Results: Among 85 cases of locoregional recurrence, isolated recurrent lymph nodes were observed in 25 cases. Three patients with an isolated recurrent infraclavicular lymph node received radiotherapy, and six patients underwent excision biopsy due to a history of radiotherapy for primary tumors. There was no failure in identifying the recurrent lymph node and no major complication. Conclusion The removal of isolated level III lymph node is safe, easy and can provide useful information for systemic therapy.

Focal fatty change of the liver is a nodular lesion which is a rarely described and poorly characterized entity. The hepatic nodule measured 1.4cm at its maximum diameter, was subcapsular in location and occurred adjacent to the falciform ligament. Microscopically it was composed of hepatic tissue with a preserved lobular architecture. The central venous structures and portal tracts with their triads were regularly placed. The cytoplasm of almost all of the hepatocytes within the nodule was replaced by macrovesicular fat vacuoles with the nuclei displaced. Several large abnormal vessels were found at the margin of the nodule. The nodule was discovered incidentally on postmortem examination of a female infant who proved, at autopsy, to have multiple cardiac anomalies and bronchopneumonia. The possible inadequate local tissue perfusion due to abnormal intrahepatic vessels at this particular location could be augmented by multiple cardiac anomalies culminating in focal ischemia and focal fatty change. When encountered in surgery or on gross examination, it could be confused with other space occupying lesions such as liver cell adenoma, abscess and metastatic lesions.
Fatty Liver/complications ; Fatty Liver/pathology* ; Female ; Heart Defects, Congenital/complications ; Hepatic Artery/abnormalities ; Human ; Infant

Although crystalloid solutions such as Ringer's lactate have become the standard for initial volume replacement after hemorrhage, it is controversy whether this fluid alone restores and maintains the depressed physiologic function after severe hemorrhage. Six anesthetized dogs were bled(35ml/kg) and resuscitated with Ringers lactate solution (100 ml/kg). Physiologic variables are measured initialy, after hemorrhage, after resucitation. Compared with initial value, after resuscitation data show marked reduction in hemoglobin, oxygen carrying capacity, vascular resistance, and electrolyte. But cardiac output and blood gas analysis data was not changed. Prothrombin time and partial thromboplastin time was prolongated. From this study crystalloid resuscitation in severe hemorrhagic shock restore cardiac output and perfusion, but fail to maintain adequate oxygen carrying capacity.
Animals ; Blood Gas Analysis ; Cardiac Output ; Natural Resources ; Dogs* ; Hemorrhage ; Lactic Acid ; Oxygen ; Partial Thromboplastin Time ; Perfusion ; Prothrombin Time ; Resuscitation* ; Shock, Hemorrhagic* ; Vascular Resistance

OBJECTIVES: Work-family conflict can arise from two opposite directions: the experiences at work interfere with family life and the experiences in the family interfere with work life. This study explored the effects of the presence of two income sources on the association between work-family conflict and job attitude. METHODS: Responses to structured survey questionnaires were received from 236 two-income families living in the Seoul Metropolitan Area. RESULTS: A differential effect was observed between single-income families and two-income families. Higher job satisfaction was related with lower work interference with family (WIF) among single-income families and with lower family interference with work (FIW) among two-income families. CONCLUSIONS: Employee welfare programs need to be expanded to enhance job satisfaction for the increasing number of two-income families.
Humans ; Job Satisfaction ; Questionnaires