Although nearly 100 cases of prurigo pigmentosa have been reported in Japan, there has been no report in Korea. Recently, we exporienced two cases of prurigo pigmentosa in Korean women of 27 and 20 years of age. Histopathological findings of reddish papules showed exocytosis, inter and intra-cellular edema in the epidermis, liquefaction degeneration of the basal cell layei and perivascular round cell infiltration in the dermis. The specimens from the pigmented lesions show merely incontinence of pigments and mild perivascular round cell infiltration. We treated two patients with oral antihistamines and topical corticosteroids. One patient showed complete regression after 8 months of treatment but the other patient was lost for follow up.
Adrenal Cortex Hormones ; Dermis ; Edema ; Epidermis ; Exocytosis ; Female ; Follow-Up Studies ; Histamine Antagonists ; Humans ; Japan ; Korea ; Prurigo*

No abstract available.
Candida* ; Granuloma*

During the course of infectious mononucleosis, intake of ampicillin and its analogues such as amoxicillin may cause hypersensitivity skin rashes. We report herein a case of ampicillin induced skin rash in a 41-year-old female patient with infectious mononucleosis. Infectious mononucleosis was confirrned by datetion of IgM antibody against Epstein-Barr(EB) viral capsid antigen(VCA) in her serum. During the icuteillness, she taked ampicillin for 3 days, and 1 week after the intake of ampicillin, a genertliz:d erythernatous and purpuric maculopapualr eruption developed. Physicians should be careful not to use ampicillin and its analogue if batients are suspected to be infected with EB virus as ampicillin induces severe skin rashes in patients with infectious mononucleosis.
Adult ; Amoxicillin ; Ampicillin* ; Capsid ; Exanthema* ; Female ; Humans ; Hypersensitivity ; Immunoglobulin M ; Infectious Mononucleosis* ; Skin*

We report a case of toxic shock syndrome in 17-year-old female patient with skin abscess. She had a skin abscess on left inner thigh about 6th days ago, but no treatment was done. And then she presented with the features of high fever, hypotension, generalized rash, myalgia and diarrhea. After the treatment with anti-shock measures, skin wound dressing and systemic antibiotics adminstration, she was completely recovered with generalized desquamation on 10th hospital day.
Abscess ; Adolescent ; Anti-Bacterial Agents ; Bandages ; Diarrhea ; Exanthema ; Female ; Fever ; Humans ; Hypotension ; Myalgia ; Shock, Septic* ; Skin ; Thigh ; Wounds and Injuries

Povidone-iodine (PVP-I) is a widely used antiseptic for the skin and mucous membrane. It is known that povidone-iodine rarely induce contact sensitization. Recently, we have experienced 2 cases of povidone-iodine contact dermatitis. Standard patch test with PUP-I, PVP and, iodine were performed.
Dermatitis, Allergic Contact* ; Dermatitis, Contact ; Iodine ; Mucous Membrane ; Patch Tests ; Povidone-Iodine* ; Skin

A 21-year-old male suffered from generalized anhidrosis and heat intolerance for about 15 years. Other clinical features included multiple angiokeratoma on the back, scrotum and extremities, together with ocular involvement. The electronmicroscopic studies of the skin demonstrated laminated intracytoplamic inclusions in the endothelial cells, pericytes of dermal vessels, fibroblasts and eccrine glandular cells. a Galactosidase assay of leukocytes from the patient and his uncle showed nearly absence of the activity,
Angiokeratoma ; Endothelial Cells ; Extremities ; Fibroblasts ; Galactosidases ; Hot Temperature ; Humans ; Hypohidrosis* ; Leukocytes ; Male ; Pericytes ; Scrotum ; Skin ; Young Adult

Though many effort,s have been made to develop a safe and effective treatment to control osmidrosis, no such goal has been achieved yet. A subcutaneous shaving method, developed by Inaba, appeared to be a favorable choice because of minimal postoperative scar formation. The authors, with this method operated on 112 cases of osmidrosis and compared the results with those of conventianal surgical therapy performed earlier in our department. The results were as follows : 1. The. average age at the time of the operation was 22.0 years old, and the sex ratio between male and female was 37 to 75. 2. The age onset ranged from 11 to 36 years with average of 15.5 years. 3. Family history for osmidrosis was found in 84.8%. 4. General anesthesia were used in 13 cases, while 99 cases were operated under local anesthesia. 5. The mean duration for operation were 75 minutes. 6. Flematoma were observed in 4.5%, wound disruption in 1.3%, and skin necrosis in 3.1%. 7. The results of analysis in 72 follow up cases for more than 6 months showed: 1). Rate for successful reduction of the malodor was 91.7%. 2) The rate of suppression of sweating was 88.9%. 3) The rate of skin tensian with motion was 2.8%. 4 ) The, pstoperative scars were mild or invisible in 95.1%
Anesthesia, General ; Anesthesia, Local ; Cicatrix ; Female ; Follow-Up Studies ; Humans ; Male ; Necrosis ; Sex Ratio ; Skin ; Sweat ; Sweating ; Wounds and Injuries

63 of 348 patients patch tested with an European standard series, had positive reaction to either a fragrance mix or Balsam of Peru. Twelve showed positiv reaction to bot,h patches. The number of positive patch tests to the fragrance mix was 56, while those to Balsarn of Peru was 19 out, of the 63 patients, manifesting sensitivities of 83% and 30% repectively. The fragrance mix was considered a useful screening patch for fragrance allergies. Twenty-five of the patients showing fragrance allergy were further analysed with 8 individual fragrance ingredients at 2% petrolatum. Cinnamic aldehyde and cinnamic alcohol were considered as she most frequent and important. sensitizers.
Humans ; Hypersensitivity* ; Mass Screening ; Patch Tests* ; Peru ; Petrolatum

The purpose of this study was to investigate the effects of combined exercise on visceral fat, cardiac function, adipocytokine, and NT-pro BNP concentration according to angiotensin-converting enzyme(ACE) genotype in obese middle aged men. Fifty three obese men (II type: 18, ID type: 20, DD type: 15), ratio of visceral and subcutaneous were over 0.4, were enrolled in the study. The combined exercise program included stretching, resistance training, aerobic exercise, and yoga. The exercise was conducted for 60 minutes, 4 times a week for 12 week period. ACE genotype was determined using a polymerase chain reaction (PCR), and the genetic subtype was classified in three patterns e.g. II, ID, DD. As a results, body weight, BMI, and WHR significantly decreased after 12 weeks of combined exercise in ID type and DD type. Body fat(%), visceral fat and V/S significantly decreased after 12 weeks in DD type. HDL-C and LDL-C significantly improved in II, ID and DD type. Cardiac structure decreased in all genotype and cardiac function increased in DD type. IL-6 and NT-pro BNP, the risk factors of cardiovascular disease, were significantly decreased in DD type, after 12 weeks. Therefore, exercises have shown to be most effective in type DD which is also considered as the risk of cardiovascular diseases. Among all the ACE genotype, DD type requires the most exercise.

The "baboon sydrome" is the term used to denote a characteristic distribution pattern of systemic allergic contact dermatitis. Such skin manifestation is described as mercury exanthem in Japan. Until now, mercury, ampicillin, nickel is reported to produce this condition. We report herein 3 cases of the baboon syndrome. Among 3 cases, 2 cases were associated with mercury, but in the other we could not demonstrate the allergen.
Ampicillin ; Dermatitis, Allergic Contact ; Exanthema ; Japan ; Nickel ; Papio* ; Skin Manifestations