No abstract available.
Plasmacytoma

No abstract available.
Facies*

Some intracranial masses are usually treated following a presumptive diagnosis based on the clinical picture and neurological studies but in some instances a proven histological diagnosis might alter the method of treatment as well as affect the prognosis. Open surgical biopsy however might cause serious neurological deficit in many of these patients however a stereotaxic approach might avoid such problems. For the correct three dimensional target localization on CT scan we developed nearly artifact free simplified CT interface frame that accurately interface between the CT scanner and the stereotasic instrument makes it possible to take biopsies at exact and with low risk. In 10 patients CT interfaced stereotaxic biopsy of brain lesions were performed. 100% accurate histological diagnosis was obtained and helped considerably in planning further therapy. The localization error was less than 0.04mm and no significant complications occured in these patients.
Artifacts ; Biopsy* ; Brain* ; Diagnosis ; Diagnosis, Differential* ; Humans ; Prognosis ; Tomography, X-Ray Computed

The tethered cord syndrome is a clinical entity manifested by progressive motor and sensory changes in the legs, incontinence, back or leg pain, and scoliosis in young children. Based on remarkable neurological improvement after release of cord tension by sectioning the filum, it might be concluded that the neurological deficit was effected by cord tethering. The main objective of this experiments was to elucidate the pathophysiology involved in the tethered cord by observing the effect of tethered cord on regional spinal cord blood flow(rSCBF) and somatosensory evoked potentials(SEPs) and define a threshold relationship between SEP and rSCBF. Thirty adult cats, weighing 2.7 to 4.2kg were used in this study. The cats were divided into three groups as follows: Control group=non-tethered(10 cats), 5g-traction group=cord traction with 5g weight(10 cats). 10g-traction group=cord traction with 10g weight(10 cats). The rSCBF and SEP measurements were performed immediately after cord traction in each animal, at 30, 60, 90, 120 minutes and the final rSCBF at 3 hours by the hydrogen clearance technique. The results obtained were as follows: 1. Traction and resulted in a reduction of flow to 30%(6.0+/-1.4ml/100g/min) of normal control spinal cord flow(18.2+/-1.6ml/100g/min) at adjacent area of traction(L1) in 5g-traction group and 18%(3.5+/-0.7ml/100g/min) of normal control flow in 10g-traction group during the cord traction for 3 hours. 2. From 30 minutes to 3 hours following the cord traction, there was a tendency toward marked reduction of the blood flow at the adjacent area(L1, T10) in 10-traction group. 3. The rostral area of spinal cord away from traction was less influenced in a reduction of blood flow following the cord traction. 4. A close correlation was found between spinal evoked potentials and flow suggesting a threshold relationship. 1) The SEP was present shortly after traction though marked by altered in shape and suppressed. 2) The SEP responses progressively decreased in latency at the adjacent distal area of the cord during traction, however less changed in shape at the rostral area of the cord. 3) The SEP suppressed in shape if the blood flow in spinal cord was below 14ml/100g/min. 4) The neuronal dysfunction caused by tethered cord could be due to impairment of blood flow. It is assumed that prolonged neuronal dysfunction may lead to structural damage of the neuron.
Adult ; Animals ; Cats* ; Child ; Evoked Potentials ; Humans ; Hydrogen ; Leg ; Neural Tube Defects ; Neurons ; Scoliosis ; Spinal Cord* ; Traction

According to the general principle that a surgical procedure should be as atraumatic as possible several authors proposed stereotaxic urokinase treatment in spontaneous intracerebral hematomas. Authors presented 29 cases of spontaneous intracerebral hematomas which were managed with stereotaxic urokinase treatment including 10 cases of preliminary report on Journal of Korean Neurosurgical Society June 1986. 19 cases were basal ganglia hematomas with or without ventricular rupture, 4 cases were thalamic hematomas with ventricular rupture, 3 cases were subcortical hematomas and 3 cases were intraventricular hematomas. The outcome of the treatment was analysed by the location and amount of hematomas, and the degree of disability of patient on admission and discharge. The outcome was worst in thalamic hematomas than putaminal or subcortical hematomas, and poorer as the amount of hematoma increased. The outcome was bad also in the patient who showed poor neurologic condition on admission. Time requiring hematoma dissapperance with urokinase treatment was estimated by the short term follow up CT scanning. All of the patient except moribund cases showed complete disappearance of hematomas within 10 days after treatment, and mean period was 6.7 days. Rebleeding after the urokinase treatment was noted in 4 cases, which was 2 putaminal, one thalamic and one ventricular hematoma. The cause of rebleeding might be mechanical injury of catheter insertion or too strong negative pressure on aspiration. But in 1 case of intraventricular hematoma, the possible causative factor should be anticoagulant effect of urokinase on the injured vessel. With above result, we concluded that this procedure may be better and safer than conventional craniotomy especially in cases of high risky or elderly patient with deep seated intracerebral hematomas. But the efficacy and safety must be studied further with the exact experimental model of spontaneous intracerebral hematomas.
Aged ; Basal Ganglia ; Catheters ; Craniotomy ; Follow-Up Studies ; Hematoma* ; Humans ; Models, Theoretical ; Rupture ; Tomography, X-Ray Computed ; Urokinase-Type Plasminogen Activator*

Functional paraganglioma of the mediastinum is an uncommon tumor of the paraganglion system that causes symptoms and signs of episodic catecholamine release. It has not been reported in Korea. We experienced a case of a 17 years old man with a history of diaphoresis and paroxysmal hypertension refractory to therapy since 14 years old. Urinary execretion of catecholamine and its metabolites were elevated. Computed tomography(CT) scan revealed high density mass located on the posterior mediastinum in the area of the right fifth intercostal space. At thoracotomy, a 3X3X4cm sized lesion was resected and confirmed as a paraganglioma.
Adolescent ; Humans ; Hypertension* ; Korea ; Mediastinum* ; Paraganglioma* ; Pheochromocytoma ; Thoracotomy

Restoring the microbiota via fecal microbiota transplantation (FMT) can be an effective treatment for steroid-refractory acute graft-versus-host disease (GVHD) of the gut. Here, we report two adult patients who underwent FMT to treat steroid-refractory acute GVHD of the gut. The first patient was a 43-year-old man who underwent allogeneic hematopoietic stem cell transplantation (HSCT) with cells from a matched sibling donor. The second patient was a 70-year-old woman who underwent haplo-identical HSCT with cells from her son. Gut GVHD developed at 7 and 4 weeks after HSCT, respectively. After undergoing FMT, the clinical symptoms improved; the first patient had a complete response and the second patient had a partial response. Microbial analyses using RNA gene sequencing showed that a diverse fecal microbiome was recovered by 4 weeks after FMT. FMT should be considered an effective therapeutic option for managing steroid-refractory acute GVHD of the gut.

Restoring the microbiota via fecal microbiota transplantation (FMT) can be an effective treatment for steroid-refractory acute graft-versus-host disease (GVHD) of the gut. Here, we report two adult patients who underwent FMT to treat steroid-refractory acute GVHD of the gut. The first patient was a 43-year-old man who underwent allogeneic hematopoietic stem cell transplantation (HSCT) with cells from a matched sibling donor. The second patient was a 70-year-old woman who underwent haplo-identical HSCT with cells from her son. Gut GVHD developed at 7 and 4 weeks after HSCT, respectively. After undergoing FMT, the clinical symptoms improved; the first patient had a complete response and the second patient had a partial response. Microbial analyses using RNA gene sequencing showed that a diverse fecal microbiome was recovered by 4 weeks after FMT. FMT should be considered an effective therapeutic option for managing steroid-refractory acute GVHD of the gut.

No abstract available.