OBJECTIVE: To evaluate the effect of IL-10 on development of collagen-induced arthritis, on humoral and cellular immunity and on the endogenous production of IL-10 in DBA/1J mice. METHODS: DBA/1J mice were immunized with chicken type II collagen in Freund s complete adjuvant. Murine recombinant IL-10 was given intraperitoneally twice a week from the day of second immunization (week 3) in doses of 0.002ug, 0. 02ug and 0. 2ug for 3 different groups, respectively. Dexamethasone was injected in one group to suppress the arthritis development and this group was used as negative control group. Levels of anti-collagen antibodies, serum IL-10 and stimulation indices of splenic monocytes to collagen were measured at the end of study. RESULTS: The 0. 02ug IL-10 and 0. 2ug IL-10 treated groups developed earlier and more severe arthritis (week 6 and 8) compared to that of the control group while the 0. 002ug IL-10 group has shown similar course to the control group in terms of incidence and severity of arthritis, At week 10, all groups with or without IL-10 injections developed arthritis with similar degree of severity while dexamethasone group showed far less incidence and severity of arthritis. The serum levels of anti-collagen antibody, IL-10 and spleen monocyte stimulation indices to collagen antigen showed no difference among control group, IL-10 injected groups and dexamethasone injected group. CONCLUSION: This study shows IL-10 could worsen the arthritis in CIA with the dosage used in this study without significant influence on the level of anti-collagen antibodies or stimulation indices of spenic monocyte to collagen.
Animals ; Antibodies ; Arthritis ; Arthritis, Experimental* ; Chickens ; Collagen ; Collagen Type II ; Dexamethasone ; Immunity, Cellular ; Immunization ; Incidence ; Interleukin-10* ; Mice ; Monocytes ; Spleen

Low-grade endometrial stromal sarcoma (LGESS) with intravascular extension is very rare, with only 26 cases having been reported. We experienced a case of LGESS with inferior vena cava (IVC) extension. A 60-year-old female presented with left leg edema. She had a history of total hysterectomy, and was diagnosed of leiomyoma at that time. On imaging study, tumor masses were located around both common iliac veins (CIV), and within the CIV and IVC. The pelvic masses on both side and IVC mass were resected, and then the patient received adjuvant hormonal therapy and radiotherapy over the remnant pelvic masses. LGESS with IVC extension is difficult to distinguish from intravascular leiomyomatosis. LGESS is a malignant disease and commonly recurs, even in early stages. Accurate diagnosis, complete resection, proper adjuvant therapy and close follow-up are very important.
Diagnosis ; Edema ; Female ; Follow-Up Studies ; Humans ; Hysterectomy ; Iliac Vein ; Korea ; Leg ; Leiomyoma ; Leiomyomatosis ; Middle Aged ; Radiotherapy ; Sarcoma, Endometrial Stromal* ; Vena Cava, Inferior*

Primary hepatic sarcoma is a rare tumor, with fewer than 60 previously reported cases. It is thought to arise from hepatic connective tissue or vascular channels. The tumor is located usually in the intrahepatic area. Pedunculated or bulging lesion is also reported. We report a case of primary leiomyosarcoma of the liver occuring in a 62-year-old Korean woman. A pedunculated, 21 16 cm sized mass is located in the left lateral segment of the liver. Microscopically, the tumor is hypercellular and composed of elongated, partly pleomorphic spindle cells with blunt-ended nuclei, which are focally reactive for muscle specific actin. Mitotic figures are 5/10 high power fields (HPFs). No other primary site is recognized on clinical study.
Actins ; Connective Tissue ; Female ; Humans ; Leiomyosarcoma* ; Liver ; Middle Aged ; Sarcoma

While most dermal melanocytoses are congenital or have an onset in early childhood, there is an acquired group with a late onset. We describe a case of aldolescent onset, unilateral, macular dermal melanocytosis on the hand. A 16-year-old girl presented with a 10-month history of gray-bluish pigmentation on the right palm and the volar side of the right fourth finger. The light microscopic studies showed spindle-shaped dermal melanocytes. The S-100 protein staining of these cells was positive and CD68 staining was negative. Dermal melanocytosis of the macular type, as observed in our case, is very rare.
Adolescent ; Female ; Fingers ; Hand* ; Humans ; Melanocytes ; Pigmentation ; S100 Proteins

No Abstract Available.
Mucinoses*

No Abstract Available.
Lupus Erythematosus, Systemic*

Purpose: This study conducted a concept analysis to clarify the meaning of anxiety in hospitalized patients with infectious diseases who have been placed in isolation. Methods: This study used Walker and Avant’s process of concept analysis. Results: Anxiety in hospitalized patients with infectious diseases who have been placed in isolation can be defined by the following attributes: 1) fear, 2) guilt, 3) isolation, 4) discrimination, 5) frustration, 6) shame, and 7) uncertainty. The antecedents of anxiety were as follows: 1) a lack of information about infectious diseases, 2) restrictions of movement, 3) blockage of the social support system, 4) helplessness, and 5) negative biases. The consequences of anxiety were 1) internalized stigma, 2) loss of confidence, 3) lack of social activities and avoidance, 4) insomnia, 5) poor quality of life. Conclusion The definition and attributes of anxiety identified in this study can be applied to enhance the understanding of anxiety in hospitalized patients with infectious diseases who have been placed in isolation. Systematic suppose should also be provided to reduce anxiety in these patients.

Purpose: This study investigated the effects of infection control fatigue, job stress, and resilience on burnout in nurses responding to coronavirus disease 2019 (COVID-19). Methods: This correlational study was conducted among 151 nurses working at three hospitals designated for treating COVID-19 patients in Jeonbuk Province, South Korea. Data were collected with self-report questionnaires between February 10 and 28, 2022 and analyzed using the IBM SPSS Statistics 28.0 program with descriptive statistics, Pearson product-moment correlations, and hierarchical multiple regressions. Results: The participants' scores were 3.56±0.48 out of 5 for infection control fatigue, 2.49±0.25 out of 4 for job stress, 3.49±0.45 out of 5 for resilience, and 3.02±0.34 out of 5 for burnout. Burnout was significantly associated with working experience, average working hours, working department, and desire to stay in the current department. Burnout showed statistically significant moderate positive correlations with infection control fatigue and job stress, and a statistically significant moderate negative correlation with resilience. Hierarchical regression analysis showed that infection control fatigue, job stress, and resilience were factors affecting burnout in COVID-19 response nurses, with an explanatory power of 36.6%. Conclusion Based on the above results, it is clear that job stress, infection control fatigue, and resilience are factors to consider when designing an intervention to reduce burnout in COVID-19 response nurses.

Purpose: This study investigated the effects of infection control fatigue, job stress, and resilience on burnout in nurses responding to coronavirus disease 2019 (COVID-19). Methods: This correlational study was conducted among 151 nurses working at three hospitals designated for treating COVID-19 patients in Jeonbuk Province, South Korea. Data were collected with self-report questionnaires between February 10 and 28, 2022 and analyzed using the IBM SPSS Statistics 28.0 program with descriptive statistics, Pearson product-moment correlations, and hierarchical multiple regressions. Results: The participants' scores were 3.56±0.48 out of 5 for infection control fatigue, 2.49±0.25 out of 4 for job stress, 3.49±0.45 out of 5 for resilience, and 3.02±0.34 out of 5 for burnout. Burnout was significantly associated with working experience, average working hours, working department, and desire to stay in the current department. Burnout showed statistically significant moderate positive correlations with infection control fatigue and job stress, and a statistically significant moderate negative correlation with resilience. Hierarchical regression analysis showed that infection control fatigue, job stress, and resilience were factors affecting burnout in COVID-19 response nurses, with an explanatory power of 36.6%. Conclusion Based on the above results, it is clear that job stress, infection control fatigue, and resilience are factors to consider when designing an intervention to reduce burnout in COVID-19 response nurses.

Purpose: This study investigated the effects of infection control fatigue, job stress, and resilience on burnout in nurses responding to coronavirus disease 2019 (COVID-19). Methods: This correlational study was conducted among 151 nurses working at three hospitals designated for treating COVID-19 patients in Jeonbuk Province, South Korea. Data were collected with self-report questionnaires between February 10 and 28, 2022 and analyzed using the IBM SPSS Statistics 28.0 program with descriptive statistics, Pearson product-moment correlations, and hierarchical multiple regressions. Results: The participants' scores were 3.56±0.48 out of 5 for infection control fatigue, 2.49±0.25 out of 4 for job stress, 3.49±0.45 out of 5 for resilience, and 3.02±0.34 out of 5 for burnout. Burnout was significantly associated with working experience, average working hours, working department, and desire to stay in the current department. Burnout showed statistically significant moderate positive correlations with infection control fatigue and job stress, and a statistically significant moderate negative correlation with resilience. Hierarchical regression analysis showed that infection control fatigue, job stress, and resilience were factors affecting burnout in COVID-19 response nurses, with an explanatory power of 36.6%. Conclusion Based on the above results, it is clear that job stress, infection control fatigue, and resilience are factors to consider when designing an intervention to reduce burnout in COVID-19 response nurses.