No abstract available.

No abstract available.
Appendicitis* ; Dichlorodiphenyl Dichloroethylene*

The intradermal studies with the fraction of Ascaris lumbricoides and Toxocara canis were performed to human and dog, and the following results were observed. Wheal and erythema were appeared in the cases of ascaris infection or who had past history, but not in the ascaris free before. The size of wheal reached to peak 30 minutes after the injection. The crude antigen had specificity and showed no cross reaction. The crude antigen cause the strongest and largest reaction than the other substances; protein, polysaccharide and the mixed antigen. No cutaneous reaction was observed with the fraction of polysaccharides. The size of wheal did not parallel with the worm burden. The skin reaction was appeared four weeks after the infection.
parasitology-nematode-Ascaris lumbricoides ; Toxocara canis ; immunology-crude antigen-skin test ; dog ; protein ; polysaccharide ; antigen

No Abstract available.
Dermatomyositis* ; Erythema*

BACKGROUND: Bullous pemphigoid is a rare autoimmune bullous disease characterized by subepidermal bulla. The serum of these patients contains detectable autoantibodies which bind to the hemidesmosome of the basement membrane zone. It is well known that there are two bullous pemphigoid antigen molecules, 230KD and 170KD protein. Serum studies in Caucasian patients show that 70-80% of the patients recognize 230KD antigen while 10-30% recognize 170KD antigen, In contrast, in herpes gestationis, which is an autommune-mediated bullous disease of pregnancy, 90% of the patients recognize 170KD and 10% recognize 230KD antigen, The autoantibody of herpes gestationis(HG factor) has a strong complement binding capacity and it may share the same epitope as the antibody of bullous pemphigoid patients which recognize 170KD antigen. OBJECTIVE: The purpose of this study was to characterize the clinical and histological manifestations of Korean patients with bullous pemphigoid and to characterize the autoantibodies of Korean bullous pemphigoid patients by immunoblotting. We also wished to compare the characteristics of the antibodies with that of American bullous pemphigoid patients, and to elucidate the hypothesis that the bullous pemphigoid autoantibody against 170KD protein has the same strong complement binding capacity as the herpes gestationis autoantibody. MEHTODS: We investigated the clinical and histological characteristics of 9 Korean patients and also performed a complement binding capacity and immunoblotting study on the sera of 9 Korean patients and 16 American patients. RESULTS: 1. Korean bullous pemphigoid patients clinically showed polymorphic skin eruption in addition to tense bullae. They frequently showed pruritic erythematous patches and urticarial plaques. Histologically, infiltration of subepidermal bullae with eosinophils, neutrophils and lymphocytes were observed in all patient's specimen, in which eosinophils were the most predominant cells, Uncommonly, eosinophilic spongiosis, vaculoar degeneration of basal cells were observed. These observations did not have any particular characteristics or racial differences compared to those patients reported in Western literature. 2. In the immunoblotting study of Korean bullous pemphigoid patients, 7 of 9 sera(785) recognized 230KD antigen and, also, 7 of 9 sera(78%)recognized 170KD antigen, In contrast, 15 of 16 American patients sera (94%) recognized 230KD antigen and 6 of 16 patients sera(38%) recognized 170KD antigen. The high incidence of the autoantibody against 170KD in Korean patients shows possible racial differences in autoantibody formation. 3. There was no relationship between the types of autoantibodies typed by immunoblotting and the complement binding capacity. In other words, autoantibodies against 170KD antigen do not carry the same potential as autoantibodies of herpes gestationis for the complement biding capacity, CONCLUSION: The above results suggest tha there may be racial difference in bullous pemphigoid autoantibodies between Korean bullous pemphigoid patients and American patients. In conclusion, We conclude that 170KD bullous pemphigoid antibodies do not always have the same strong complement binding as herpes gestationis antibody.
Antibodies ; Autoantibodies ; Basement Membrane ; Complement System Proteins* ; Eosinophils ; Female ; Hemidesmosomes ; Humans ; Immunoblotting* ; Incidence ; Lymphocytes ; Neutrophils ; Pemphigoid Gestationis ; Pemphigoid, Bullous ; Pregnancy ; Skin ; Transcutaneous Electric Nerve Stimulation

No abstract available.
Child* ; Humans ; Nephrotic Syndrome*

The objective of my article is to investigate how the West had strong interest in tropical diseases and developed tropical medicine and hygiene from the 1870s through the 1910s. Its focus is to identify the geopolitical conditions in which the West constructed 'tropical diseases'to extend its imperial interests into non-Western tropical regions. The article has several specific research tasks: first, I attempt to explore the way in which European people transformed their attitudes toward tropical diseases from the sixteenth century to the 1860s. A variety of writings by European physicians are discussed; the second part shows European change in its domestic sanitary situation in relation to its imperial interests in tropical regions. Sanitary hygiene in metropole and colonies are not separate, but interconnected; third, the paper illuminates how the West responded to the spread of 'Asiatic cholera' in the nineteenth century. Cholera provides a typical example for the West to perceive Asian origin of tropical diseases; finally, the article demonstrates that hygienic governance of tropical diseases is the key to imperial dominion over colonies by taking the Panama Canal as an example. Although several European countries such as Spain, Britain, Germany, and France had strong imperial interests in the Panama Canal that might facilitate trade between the Atlantic and the Pacific, they failed to occupy the canal because of their inability to control high prevalence of malaria and yellow fever. Taking advantage of 'tropical medicine, ' the United States succeeded in taking up the canal by eradicating tropical diseases in the canal. It was owing to the scientific development of tropical hygiene and medicine that the West transformed its pessimistic into optimistic position about the colonization of tropical regions. Tropical diseases became the geopolitical reference for Western conceptualization of Asia, Africa, Latin America, and the Pacific.
Tropical Medicine/*history ; Sanitation/history ; Hygiene/*history ; Humans ; History, 20th Century ; History, 19th Century ; Europe ; Colonialism/history ; Cholera/epidemiology/*history ; Attitude of Health Personnel

No abstract available.
Femur* ; Osteomyelitis*

Epidermolysis bullosa simplex (EBS) is a group of autosomal dominantly inherited genetic disorders characterized by blistering due to mechanical- stress-induced degeneration of basal epiderrnal cells. Recently, it was discovered that EBS is induced by keratin 5 and 14 gene mutations. Weber Cockayne (W-C) EBS is the mildest type, with blistering concentrates primarily on palar and plantar regions, and basal cell cytolysis by keratin filament perturbations is present. Herein we report a case of W-C EBS with its ultrastructural findings. Electron microscopy showed cytolysis and separation of the basal epidermal cells, mainly at the subnuclear cytoplasm. The cyto- plasm of basal cells showed edema, loosening and intact rnitochondria. Besides the cytoplasmic changes, the nucleus also showed lytic degeneration. Characteristically, dense condensation of tonofilarnent was observed, which suggests that W-C EBS is. also a disorder of keratin.
Blister ; Cytoplasm ; Edema ; Epidermolysis Bullosa Simplex* ; Epidermolysis Bullosa* ; Keratin-5 ; Microscopy, Electron

No abstract available.
Fractures, Compression* ; Osteoporosis* ; Vertebroplasty*