No abstract available.
Animals ; Hindlimb Suspension* ; Hindlimb*

Gastric glomus tumor is an uncommon benign, submucosal neoplasm and does not require radical surgical procedure. Because there are no specific clinical or radiologic features associated with the glomus tumor, it can be recognized only by its histologic characteristics. We report a 30-year-old woman who had 10 years history of epigastric hunger pain. Radiologically, a gastric submucosal tumor was discovered, which was suggestive of leiomyoma. Gastric antrectomy was performed. The tumor cells showed immunohistochemical and ultrastructural evidence of smooth muscle differentiation.
Female ; Humans

No abstract available.
Electrocardiography* ; Heart Septal Defects, Atrial* ; Hemodynamics*

Primitive neuroectodermal tumors (PNET) of the ovary are rare tumors with an exclusive or almost exclusive malignant neuroectodermal composition, and are generally regarded as a monodermal expression of an ovarian teratoma. The tumors are basically identical with the lesions of the same name occuring typically in the central nervous system of children. These tumors consist chiefly of undifferentiated small cells resembling neuroblasts. There are also mature, well- differentiated neuroectodermal cells, such as astrocytes and ependymal cells. We report a case of ovarian PNET with glial and neuroblastic differentiation and focal teratomatous foci of non-neural tissue in a 17-year-old female.
Adolescent ; Astrocytes ; Central Nervous System ; Child ; Female ; Humans ; Neural Plate ; Neuroectodermal Tumors, Primitive* ; Ovary* ; Teratoma

Core needle biopsy (CNB) was introduced as an alternative diagnostic tool to fine-needle aspiration (FNA), and is increasingly being used in the preoperative assessment of thyroid nodules. CNB provides a definitive diagnosis in most cases, but it sometimes may be inconclusive. CNB has the advantage of enabling a histologic examination in relation to the surrounding thyroid tissue, immunohistochemistry, and molecular testing that can provide a more accurate assessment than FNA in selected cases. Nevertheless, CNB should be performed only by experienced experts in thyroid interventions to prevent complications because CNB needles are larger in caliber than FNA needles. As recent evidence has accumulated, and with improvements in the technique and devices for thyroid CNB, the Korean Society of Thyroid Radiology released its 2016 thyroid CNB guidelines and the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group published a consensus statement on the pathology reporting system for thyroid CNB in 2015. This review presents the current consensus and recommendations regarding thyroid CNB, focusing on indications, complications, and pathologic classification and reporting.
Biopsy, Fine-Needle ; Biopsy, Large-Core Needle* ; Biopsy, Needle ; Classification ; Consensus ; Diagnosis ; Immunohistochemistry ; Needles ; Pathology ; Thyroid Gland* ; Thyroid Nodule*

BACKGROUND: The catalytic subunit of telomerase, hTERT (telomerase reverse transcriptase), is one of the most important components of telomerase, and performs a pivotal role in the mechanism underlying the regulation of telomerase activity in cellular immortalization and carcinogenesis. The principal objective of this study was to investigate hTERT expression in patients with non-small cell lung carcinomas (NSCLCs), and to evaluate its clinical significance and association with the expression of p16 and p53. METHODS: Using tissue microarray, the protein expression profiles of hTERT, p16 and p53 were investigated via immunohistochemistry in 167 samples of NSCLCs. RESULTS: Expression was observed in 54.5% (91/167) of the tumors, which were predominantly squamous cell carcinomas. Patients evidencing hTERT expression in their tumors exhibited significantly poorer survival rates than did patients without hTERT expression in early-stage NSCLCs (p=0.0125). According to the results of our Cox regression analysis, hTERT expression proved to be an independent prognostic factor (p=0.006), particularly for squamous cell carcinomas (p=0.019). hTERT expression was not correlated with p16 expression, but was rather associated with the expression of p53 (p=0.002). CONCLUSIONS: Our results show that hTERT may perform a function in the progression of NSCLC, and that its detection may be useful in predicting the prognosis of NSCLC patients in the early stages of the disease, as well as in the development of a targeted therapy in these tumors.
Carcinogenesis ; Carcinoma, Non-Small-Cell Lung ; Carcinoma, Squamous Cell ; Catalytic Domain ; Humans ; Immunohistochemistry ; Lung* ; Prognosis ; Survival Rate ; Telomerase*

No abstract available.

The dendriform pulmonary ossification (DPO) is a rare condition of unknown origin in which branching mature bony spicules, usually containing marrow, are found within the alveolar septa. DPO manifests slow progression over many years or may remain unchanged; spontaneous regression has not been recorded. Most patients have no symptoms directly attributed to the ossification, although they may have symptoms due to the underlying fibrotic process. We experienced a case of DPO in 38 year-old-man who presented with cough and sputum for a month. The chest X-ray showed marked coarsened interstitial lung markings in both lungs, especially in the lower lobes. Open lung biopsy was done. Grossly, there were significant dendriform osseous structures. Histologically, branching arrays of mature bone were found in the interstitium and occasionally in alveolar spaces. Some bony trabeculae contained fatty or cellular marrow. The alveolar septa showed fibrous thickening with chronic inflammation. The transition between fibrosis and bone tissue was observed. Our case suggests that dendriform pulmonary ossification may be a rare special manifestation of chronic fibrosing interstitial inflammation of the lung. Osseous structures seem to derive from metaplastic bone formation in the vicinity of undergoing fibrous process.
Biopsy ; Bone and Bones ; Bone Marrow ; Cough ; Fibrosis ; Humans ; Inflammation ; Lung ; Lung Diseases, Interstitial ; Osteogenesis ; Sputum ; Thorax

OBJECTIVE: The aim of this study was to detect the prevalence of hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) in The Republic of Korea Air Force (ROKAF) pilots, and to investigate the factors related to occupational exposure. METHODS: For 720 pilots who visited aeromedical center, ROKAF for general health screening from January, 2001 to August, 2002, HBsAg and anti-HBs were tested using passive hemagglutination and passive hemagglutination, respectively. If HBsAg results had been positive or vague, we performed confirmation test by ASAN Easy Test(R) HBs kit. RESULTS: The overall prevalence of HBsAg and Anti-HBs was 1.8% and 49.4%, respectively. HBsAg positivity was 0.0% in 20-24 years, 0.8% in 25-29 years, 1.1% in 30-34 years, 4.4% in 35-39 years, 1.5% in 40-44 years, 5.4% in 45-49 years, 5.3% in 50-54 years and significantly different below and above thirties (P=0.024). The prevalence of HBsAg in pilots was not different with general adults. Anti-HBs positivity was 100.0% in 20-24 years, 43.9% in 25-29 years, 57.1% in 30-34 years, 50.0% in 35-39 years, 62.1% in 40-44 years, 50.0% in 45-49 years, 73.7% in 50-54 years and significantly increased with age (44.2% in twenties, 53.6% in thirties, 58.9% in more than 40) (P=0.005). The pilots susceptible to HBV infection who were negative in both HBsAg and anti-HBs were found in 49.0% of entire subjects. CONCLUSION: The prevalence of HBsAg and anti-HBs in pilots was lower than in general adults. The pilots tendered to be more susceptible to HBV infection than general adults. Hepatitis B vaccine should be integrated into pilot health programmes.
Adult ; Chungcheongnam-do ; Hemagglutination ; Hepatitis B Surface Antigens* ; Hepatitis B Vaccines ; Hepatitis B virus ; Hepatitis B* ; Hepatitis* ; Humans ; Mass Screening ; Occupational Exposure ; Prevalence ; Republic of Korea

No abstract available.
Child* ; Heart Diseases* ; Heart* ; Humans ; Incidence* ; Tricuspid Valve Insufficiency*