PURPOSE: We studied the effectiveness and toxicities of 5-fluorouracil+leucovorin, combination chemotherapy in advanced or recurred colo-rectal cancer patients, who didn't have previous chemotherapy and enrolled from August 1993 to July 1998. MATERIALS AND METHODS: All patients were treated with leucovorin followed by 5-fluorouracil for 5 consecutive days every 4 weeks. Among 43 patients who were enrolled, 40 patients received treatment at least 2 courses, and they were evaluable. Male to female ratio was 21 to 19. In serum CEA level, 27 patients were greater than 5 ng/ml and 13 were less than 5 ng/ml. And primary site was colon in 21 patients and rectum in 19 patients. RESULTS: The complete response rate was 7,5% and the partial response rate was 25%. The median survival duration was 14.7 months, the median response duration was 16.0 months, and median time to progression was 7.3 months. In the analysis of response, survival duration, time to progression according to various characteristics of patients, serum CEA level and liver involvement were revealed significant difference in survival duration, time to progression (p=0.0122, 00350 & 0.0202, 0.0123) on univariate analysis, but no significant difference on multivariates. Hematologic and non-hematologic toxicities were mild and tolerable. CONCLUSION: This study indicates that the combination of 5-fluorouracil (370 mg/m) and leucovorin (20 mg/m) is effective and tolerable regimen in advanced or recurred colo-rectal cancer patients without previous chemotherapy.
Colon ; Drug Therapy ; Drug Therapy, Combination* ; Female ; Fluorouracil* ; Humans ; Leucovorin* ; Liver ; Male ; Rectal Neoplasms* ; Rectum

Low-grade endometrial stromal sarcoma (LGESS) with intravascular extension is very rare, with only 26 cases having been reported. We experienced a case of LGESS with inferior vena cava (IVC) extension. A 60-year-old female presented with left leg edema. She had a history of total hysterectomy, and was diagnosed of leiomyoma at that time. On imaging study, tumor masses were located around both common iliac veins (CIV), and within the CIV and IVC. The pelvic masses on both side and IVC mass were resected, and then the patient received adjuvant hormonal therapy and radiotherapy over the remnant pelvic masses. LGESS with IVC extension is difficult to distinguish from intravascular leiomyomatosis. LGESS is a malignant disease and commonly recurs, even in early stages. Accurate diagnosis, complete resection, proper adjuvant therapy and close follow-up are very important.
Diagnosis ; Edema ; Female ; Follow-Up Studies ; Humans ; Hysterectomy ; Iliac Vein ; Korea ; Leg ; Leiomyoma ; Leiomyomatosis ; Middle Aged ; Radiotherapy ; Sarcoma, Endometrial Stromal* ; Vena Cava, Inferior*

A Statistical observations were done on 587 pediatric patients who were diagnosed as having congenital heart disease by cardiac catheterization angiography and operation at Dong San Hospital Keimyung University, during the period of January 1982 to june 1987. The results were as follows 1) Out of 587 patients, 317 cases were male and 276 cases were female. There were female preponderance in atrial septal defect and patent ductus arteriosus, whille in male tetralogy of Fallot, pulmonary stenosis, and ventricular septal defect. 2) The incidence of congenital heart disease were as folliws;ventricular septal defect 35.7% tetralogy of Fallot 17.5%, patient ductus arteriousus 13.9%, arterial septal defect 7.5% and pulmonary stenosis 2.9%. 3) Most of the patients were visited hospital for the first time between the age of 2 and 10 years. 4) Assosiated anomalies of major congenital heart disease were as follows:the most commonly associated anomaly in ventricular septal defect were pulmonary stenosis and patent ductus arteriosus. Pulmonary stenosis was frequently associated with atrial septal defect. Right sided aortic arch and pentalogy were assosiated with tetralogy of Fallot. The mitral regurgitation was associated with patent ductus arteriosus mostly. 5) The overall surgical mortality was 6.8%. The mortality was high in tetralogy of Fallot(16.1%), transposition of great vessels(28.5%).
Angiography ; Aorta, Thoracic ; Cardiac Catheterization ; Cardiac Catheters ; Ductus Arteriosus, Patent ; Female ; Heart Defects, Congenital* ; Heart Septal Defects, Atrial ; Heart Septal Defects, Ventricular ; Humans ; Incidence ; Male ; Mitral Valve Insufficiency ; Mortality ; Pulmonary Valve Stenosis ; Statistics as Topic* ; Tetralogy of Fallot

The clinicolaboratory findings, cardiac catheterization, and outcome of operation were analyzed in 78 patients with tetralogy of Fallot, which were diagnosed by echocardiography, cardiac catheterization, and a cardiac angiography and confirmed by operation at Dong San Hospital, Keimyung University, during a 4(1/2)-year period from January 1984 to June 1988. The following results were obtained : 1) Out of the 78 cases, 45 were male and 64 were female. 2) The electrocardiogram showed right axis deviation in 71 cases(91%) and right ventricular hypertrophy in 66 cases(84.6%). 3) Chest X-ray revealed that, the cardiothoracic ratio was normal or decreased in 68 cases(87.3%), and cardiac apex elevation was noticed in 57 cases(73%). 4) Pulmonary stenosis were chiefly valvular and infundibular type(53.8%). 5) The associated heart diseases with TOF were patent foramen ovale(64.1%), right sided aortic arch(19.2%), and secundum ASD(10.3%), in that order. 6) There was an intimate correlation between secondary polycythemia and thrombocytopenia. 7) Among the 78 Cases, 73 cases had total correction, 1 case had shunt operation, and 4cases had total correction after shunt operation. The highest mortality rate occurred in the cases of total correction after shunt operation(25%). The cases with a main pulmonary artery size of 1/3 to 2/3 against, the aorta had a higher mortality than the other group, and no cases expired in the group with a ratio of more than 2/3. The overall surgical mortality was 8.9%.
Angiography ; Aorta ; Axis, Cervical Vertebra ; Cardiac Catheterization ; Cardiac Catheters ; Echocardiography ; Electrocardiography ; Female ; Heart Diseases ; Humans ; Hypertrophy, Right Ventricular ; Male ; Mortality ; Polycythemia ; Pulmonary Artery ; Pulmonary Valve Stenosis ; Tetralogy of Fallot* ; Thorax ; Thrombocytopenia

No abstract available.
Breast* ; Female* ; Humans

The study was undertaken to asses the changes in the size and densities of intracranial hematomas by analyzingthe sequential CT examination of 23 patients ar Soon Chun Hyang College Hospital from July '80 to Aug. '81. Theresuls were as follows; 1. The high densities of hematoma were the cause of hematoma, hematoma locaiton, age andsex of patients, and initial hematoma size. 3. The CT findings that indicate complete absorption of hematomas werenormalization of mass effect, not diappearence of hematoma densities. 4. In intracerebral hematoma, the highdensity of hematoma reduced it's density and mass effect about 4-6 weeks duration. 5. In subdural hematoma, about7 weeks after head trauma, the CT findings were normalized.
Absorption ; Craniocerebral Trauma ; Equidae ; Hematoma ; Hematoma, Subdural ; Humans

No abstract available.
DNA* ; Lymphoma, Non-Hodgkin*

Farmers have suffered from a variety of work-related injuries and diseases. They are exposed to a number of hazards related to farming activity. Farm machines like tractors and small cultivators and animal-related injuries are the primary causes of acute injuries and fatalities. Pesticide exposure is another dominant concern among farmers that can result in acute poisoning or some chronic health outcomes such as neurological diseases or some types of cancer. Farm work can also involve toxic chemicals such as gases (methane, ammonia, H2S, etc.), diesel exhaust particulates, miscellaneous chemicals, and heavy metals, any of which may cause respiratory disease, systemic poisoning, and other health effects in farmers. Some ingredients of pesticides, several plants (poison ivy and poison sumac), and sun and heat exposure can be causes of skin disease. The most frequent cause of respiratory disease is organic dust from livestock production and handling grain or hay. Furthermore, low back pain and osteoarthritis of the hip and knee are common problems among farmers. These are caused by poor ergonomic working conditions like heavy weight lifting, repetitive movement, and awkward postures which involve squatting for long periods of time while working near the ground, long working hours, and a heavy workload. Farmers are also vulnerable to a number of infectious diseases (avian influenza, scrub typhus, leptospirosis, etc.) that may be transmitted from animals or the farm environment. Noise and vibration from powered farm machinery, heat and cold, and a stressful environment due to diminished profit margins can affect farmers' health. Even though farmers are working under very poor working conditions, social and institutional support is insufficient. Greater interest and effort is required to improve farmers' working conditions.
Ammonia ; Animals ; Cold Temperature ; Communicable Diseases ; Dust ; Edible Grain ; Gases ; Handling (Psychology) ; Hip ; Hot Temperature ; Influenza, Human ; Knee ; Leptospirosis ; Livestock ; Low Back Pain ; Metals, Heavy ; Noise ; Osteoarthritis ; Pesticides ; Posture ; Scrub Typhus ; Skin Diseases ; Social Conditions ; Solar System ; Vehicle Emissions ; Vibration ; Weight Lifting

No abstract available.
Genetic Therapy* ; Molecular Imaging*

Catheterization of the subarachnoid space provides a useful tool to deliver drugs to spinal cord in rat. However, the passage of a long intrathecal catheter inserted via the cisterna magnum to lumbar spinal levels increases the risk of spinal cord trauma and the mislocation of catether into other places. Thus, present study was aimed to introduce direct subarachnoid catheterization of the rat lumbar spinal cord with novel shape of catheter. An intrathecal PE-10 catheter was fabricated with coil (four-time helix with 2 mm diameter) on either end and attached small silicon beads on both end of the coil. Using the silicon bead at insertion part as an anchorage, the catheter was advanced into the subarachnoid space until the silicon bead was embedded on a drilled hole over interspinous space between L4 and L5 vertebra. And then, silicon bead was tightly attached by surgical glue and dental resin with vertebra. Using the other side of silicon bead, catheter was tightly suturing with muscle layer. Finally, external portion of the catheter was placed into stainless steel protector on neck to reduce the damage by rat. Following this catheterization, it is not significantly affect the general physiology (i.e. motor function, weight gain and mechanical allodynia) of the rat without catheter loss over 2 weeks. Moreover, intrathecal injection either fluorescent dye or lidocaine further confirmed that drug diffusion site was appropriated for intended target.
Adhesives ; Animals ; Catheterization ; Catheters ; Diffusion ; Injections, Spinal ; Lidocaine ; Mandrillus ; Muscles ; Neck ; Rats ; Resins, Synthetic ; Silicones ; Spinal Cord ; Spinal Cord Injuries ; Spine ; Stainless Steel ; Subarachnoid Space ; Weight Gain