A case of hepatic fascioliasis misdiagnosed as metastatic carcinoma was reported. The patient was a 22-year-old woman who had had rectal adenocarcinoma (Duke stage C2), and had been treated by Mile'operation 8 months ago. A computed tomogram(CT) demonstrated multiple low density nodules in the liver suggesting a metastatic tumor. A partial liver lobectomy was performed. The resected liver showed multiple necrotic nodules, which appeared to be abscesses containing eggs of the Fasciola species. Parasitic infection should be considered as one of the possible etiologies of hepatic nodules which mimic metastatic carcinoma either clinically or radiologically.
Female ; Humans ; Adenocarcinoma ; Neoplasm Metastasis

Apocrine carcinoma is a rare type of mammary cancer, which shows partial or total apocrine differentiation in either ductal or lobular carcinoma. The malignant transformation of apocrine epithelium of the breast was first described by Krompecher in 1916. It is well known that their relationship to true apocrine glands of the skin is only a morphological similarity, and this histological difference does not affect the prognosis. The authors experienced two cases of apocrine carcinoma of the breast which involved infiltrating ductal carcinoma of a 64-year old woman and intraductal carcinoma of a 69-year old woman respectively. Electron microscopic examination and brief review of literature was done.
Female ; Humans

The transverse sacral fracture is rare; however, if it accompanies neurological injury or instability, difficult surgical treatment may be necessary. We performed surgical decompression and laminoplasty in a patient with neurological deficits and anterior displacement of S2 on S1. The patient showed a successful clinical outcome by neurological improvement.
Decompression ; Decompression, Surgical ; Humans ; Sacrum

No abstract available.
Thymus Hyperplasia*

Local cutaneous reactions have been reported at injection sites of interferon therapy, but these are usually erythema or rarely induration. Skin necrosis at the injection site is rare. We describe here a patient with multiple sclerosis who presented with cutaneous necrosis at the injection sites of interferon-β. Biopsy of the necrotic lesion showed dermal vessel thrombosis and complete ischemic coagulative necrosis of epidermis and dermis.
Biopsy ; Dermis ; Epidermis ; Erythema ; Humans ; Interferon-beta* ; Interferons ; Multiple Sclerosis ; Necrosis* ; Skin* ; Thrombosis

BACKGROUND: Parent's alcohol drinking not only influences their health but also their children. This research was designed to assess the family function of children who were affected by parent's alcohol drinking. METHODS: Questionnaire survey was performed on 208 high school students (129 males and 79 females) in Daejeon from March to April, 2005. We defined the students whose CAST (Children of Alcoholics Screening Test) score was 6 or more as children of alcoholics (COA) group. Then, we evaluated the family function by family APGAR score between the COA group and the control group. RESULTS: Among the total, 36 (27.9%) male and 27 (34.1%) female students were in COA group. There was a significant (P<0.01) negative correlation between the CAST score and the family APGAR score in all students. In boys, there was no significant correlation between the CAST score and the family APGAR score, but in girls, there was significant negative correlation (P<0.01). Mean family APGAR score of the COA group was significantly (P<0.05) lower than that of the control group in all students. In boys, there was no significant difference, but in girls, the COA group's family APGAR score was significantly lower than the control group's score (P<0.05). CONCLUSION: The high school students, especially girl students, who were affected by parent's alcohol drinking showed a lower family APGAR score. Therefore, family physicians need to evaluate the family function when encountering students similar to COA group.
Alcohol Drinking ; Alcoholics* ; Apgar Score ; Child* ; Female ; Humans ; Male ; Mass Screening* ; Physicians, Family ; Surveys and Questionnaires

Isolate fracture of lunate is very rare. The authors reported a neglected fracture of lunate which was founded incidentally after the dorsal wall fracture of triquetrum. Pain reduction and improvement of range of motion was achieved after excising the dorsal fragment of lunate.
Range of Motion, Articular

This study reviews a case of sacral fracture with delayed onset neurological deficit that showed good results after decompressive surgery. The delayed neurological deficit appeared at 4 weeks after injury and it was treated with anterior decompression through transperitoneal approach. A 23-year-old woman was injured in a car accident and had bilateral pubic rami fractures and fractures of the sacral ala on the right side. She was treated with external fixation devices for approximately four weeks, but complained of pain and numbness. The dorsiflexion and plantalflexion of the right ankle was weakened and graded as grade 2. Preoperative pelvic and sacral radiographs, computed tomography, magnetic resonance imaging and electromyelography, and nerve conduction study were performed to identify the region of neurological deficit, and we decided to implement neurological decompression. By transperitoneal approach, we performed bone curratage and decompression around the region of sacral alar slope and S1 foramen. The pain and numbness of the right foot cleared up. Dorsiflexion and plantalflexion of the right ankle improved to grade 5. Anterior decompression by transperitoneal approach proved to bring satisfactory results in a patient, who presented delayed neurological deficit after sacral fracture.
Animals ; Ankle ; Decompression ; External Fixators ; Female ; Foot ; Humans ; Hypesthesia ; Magnetic Resonance Imaging ; Neural Conduction ; Succinates

We describe a case of insulin-dependent diabetes mellitus(lDDM) with a mutation at nucleotide 3243 of mitochondrial DNA. A 24-years-old female presented with recurrent episodes of generalised tonic clonic seizures, cognitive decline, short stature, bilateral sensory neural hearing loss, bilateral optic neuropathy, lactic acidosis, and basal ganglia calcifications in addition to IDDM. Maternal transmission of the disease was suggested, by the fact that her mother have died of diabetic complications of the age of 50. Heteroplasmy of wild type and mutant mitochondrial DNA derived from peripheral leucocytes was detected by Apa I digestion of the polymerase chain reaction products amplified with a set of primer for tBNALUR(UUR) Adenosin-to guanidine substitution, occurring at nucleotide position 3243 in tRNALUR(UUR) gene in comparison with reference sequences was confirmed.
Acidosis, Lactic ; Basal Ganglia ; Diabetes Complications ; Diabetes Mellitus* ; Diabetes Mellitus, Type 1 ; Digestion ; DNA, Mitochondrial* ; Female ; Guanidine ; Hearing Loss, Bilateral ; Humans ; Insulin* ; MELAS Syndrome ; Mothers ; Optic Nerve Diseases ; Point Mutation* ; Polymerase Chain Reaction ; Seizures

BACKGROUND: There are few literatures which show the role of tidal volume on the excretion of nitrous oxide(N2O). The purpose of this study is to pharmacokinetically evaluate the effect of varying oxygen inflow rates and tidal volumes on the excretion of N2O. METHODS: Ten patients undergoing general anesthesia on supine position were selected. Administering N2O 3 L/min and oxygen 2 L/min with enflurane, ventilatory pattern was tidal volume 10 mL/kg and respiratory rate 11/min. Administration of N2O was stopped after 30 minutes, when end-tidal N2O concentration(ETN2O) were near 60% at steady state. Oxygen was given at 4 L/min with tidal volume(VT) 8 mL/kg(treatment 1), 4 L/min with VT 16 mL/kg (treatment 2), 8 L/min with VT 8 mL/kg(treatment 3) and 8 L/min with VT 16 mL/kg(treatment 4). ETN2O was measured every 15 seconds for first 3 minutes and every 1 minute thereafter. The order of 4 treatments were determined with bloc randomization. The time interval between treatments was 30 minutes. Pharmacokinetic parameters were obtained using PKCALC data program. RESULTS: Area under curve and clearance in treatments 1 and 2 were significantly larger than those in treatments 3 and 4. Mean residence time and half-life in treatment 4 were significantly shorter than those in other treatments. CONCLUSIONS: The oxygen inflow rate enhances the excretion of N2O more than the tidal volume does, and the tidal volume does so when the oxygen inflow rate is 8 L/min.
Anesthesia, General ; Anesthetics ; Area Under Curve ; Enflurane ; Half-Life ; Humans ; Nitrous Oxide* ; Oxygen* ; Random Allocation ; Respiratory Rate ; Supine Position ; Tidal Volume*