1.A Case of Malignant Histiocytosis Showing Papulosquamous Skin Lesions and Fever as Initial Manifestations.
Ji Hwan HWANG ; Kyu Han KIM ; Byoung Kook KIM ; Hyeong Don BANG ; Kyoung Chan PARK
Annals of Dermatology 1996;8(2):117-120
We report a case of malignant histiocytosis which began with intermittent fever and scaly skin lesions. A 3-year-old girl presented with erythematous scaly papules on the face and the trunk, and high fever for 3 months. The cutaneous lesions consisted of widespread coin-sized erythematous scaly papules with marginal brownish pigmentation. She was anemic and thrombocytopenic and had impairment of the liver function. Histopathologic study of the skin lesions showed non-specfic findings except for hyperkeratosis. However, bone marrow examination revealed an increased number of histiocytes, mostly immature with active phagocytosis of erythroid cells, myeloid cells, and platelets. She was diagnosed as having malignant histiocytosis and treated with cyclophosphamide and vincristine. She died the next day after the treatment had begun.
Bone Marrow Examination
;
Child, Preschool
;
Cyclophosphamide
;
Erythroid Cells
;
Female
;
Fever*
;
Histiocytes
;
Histiocytic Sarcoma*
;
Humans
;
Liver
;
Myeloid Cells
;
Phagocytosis
;
Pigmentation
;
Skin*
;
Vincristine
2.A Case of Juvenile Chronic Myelogenous Leukemia Presented as Recurrent Erythema Nodosum-Like Lesions.
Ji Hwan HWANG ; Kyu Han KIM ; Byoung Kook KIM ; Hyeong Don BANG ; Kyoung Chan PARK
Annals of Dermatology 1996;8(2):125-128
No abstract available.
Erythema*
;
Leukemia, Myelomonocytic, Juvenile*
3.Low-Grade Endometrial Stromal Sarcoma with Inferior Vena Cava Extension: First Report in Korea.
Mi Hyeong KIM ; Chan Kwon JUNG ; Jeong Kye HWANG ; In Sung MOON ; Ji Il KIM
Vascular Specialist International 2014;30(3):98-101
Low-grade endometrial stromal sarcoma (LGESS) with intravascular extension is very rare, with only 26 cases having been reported. We experienced a case of LGESS with inferior vena cava (IVC) extension. A 60-year-old female presented with left leg edema. She had a history of total hysterectomy, and was diagnosed of leiomyoma at that time. On imaging study, tumor masses were located around both common iliac veins (CIV), and within the CIV and IVC. The pelvic masses on both side and IVC mass were resected, and then the patient received adjuvant hormonal therapy and radiotherapy over the remnant pelvic masses. LGESS with IVC extension is difficult to distinguish from intravascular leiomyomatosis. LGESS is a malignant disease and commonly recurs, even in early stages. Accurate diagnosis, complete resection, proper adjuvant therapy and close follow-up are very important.
Diagnosis
;
Edema
;
Female
;
Follow-Up Studies
;
Humans
;
Hysterectomy
;
Iliac Vein
;
Korea
;
Leg
;
Leiomyoma
;
Leiomyomatosis
;
Middle Aged
;
Radiotherapy
;
Sarcoma, Endometrial Stromal*
;
Vena Cava, Inferior*
4.The Correlation between Responses of Peripheral Blood Mononuclear Cells and Immediate Hypersensitivity of Skin to Mite Antigen in Atopic Dermatitis.
Kyu Han KIM ; Hyeong Don BANG ; Jin Ho CHUNG ; Kyoung Chan PARK
Korean Journal of Dermatology 1995;33(2):232-239
BACKGROUND: House dust mites have been reported to play an aportant role in the pathogenesis of atopic dermatitis(AD). In fact a high positive rate for house dust mites in the skin prick test was observed in patients of AD. However, it is quite difficult to determine the clinical relevance of positive immediate hypersensitivity to mite antigen by clarical history alone because AD patients are nearly always exposed to these antigens in their daily lives. OBJECTIVE: The aim of this study was to elucidate the clinical. singficance of a positive immediate hypersensitivity reaction by observing the proliferative respons of peripheral blood mononuclear cells(PBMC) to mite antigen in the AD. METHODS: The proliferative response of PBMC separated from Dermatopkagoides farinae(Df) positive AD patients to Df antigen was compared with that from Df negative normal controls, Df positive normal controls and Df negative AD patients. RESULTS: PBMC from Df positive AD patients showed signinc not proliferation in response to Df antigen evaluated by comparing stimulation indices(SI) among different experiment groups. CONCLUSION: Significant correlation between responses of PBMC and immediate hypersensitivity of skin to Df antigen in AD was found, and it was suggested the Df may be a real aggravating factor in the Df positiv AD patients. SI may be used as ar objective criteria to select patients for hyposensitization therapy after doing a skin test.
Dermatitis, Atopic*
;
Desensitization, Immunologic
;
Humans
;
Hypersensitivity, Immediate*
;
Mites*
;
Pyroglyphidae
;
Skin Tests
;
Skin*
5.Polymorphism in the IL-1 Receptor Antagonist Gene in Vitiligo.
Yong Suk LEE ; Kyong Chan PARK ; Sang Woong YOUN ; Hyeong Don BANG ; Kyu Han KIM
Annals of Dermatology 1995;7(4):299-302
BACKGROUND: The severity of several chronic inflammatory diseases was reported to be associated with polymorphism of the IL-1 receptor antagonist gene(IL-lrn). OBJECTIVE: This study was performed to study the polymorphism of the IL-1rn in vitiligo and in the normal Korean population. METHODS: Thirty one cases of vitiligo and seventy nine normal Koreans as control were studied for the polymorphism of IL-1 rn. RESULTS: The frequency of allele 2 of the IL- I rn in 31 patients with vitiligo was compared with that of the 79 healthy controls. The frequency of allele 2 was 1.6% in vitiligo patients and 3.8% in the normal controls. CONCLUSION: There was no significant difference in the frequency of allele 2 between the vitiligo patients and normal controls.
Alleles
;
Humans
;
Interleukin-1*
;
Vitiligo*
6.Multiple congenital anomalies in infant born to mother with type II overt diabetes mellitus: a case report.
Hyeong Soon KIM ; Jae Sung CHO ; Sei Kwang KIM ; In Kyu KIM ; Yong Seok JEE ; Chan Ho SONG
Korean Journal of Obstetrics and Gynecology 1993;36(9):3492-3500
No abstract available.
Diabetes Mellitus*
;
Humans
;
Infant*
;
Mothers*
7.Ovarian Large Cell Neuroendocrine Carcinoma Associated with Endocervical-like Mucinous Borderline Tumor: A Case Report and Literature Review.
Jun Mo KIM ; Hyeong Chan SHIN ; Mi Jin KIM
Korean Journal of Pathology 2011;45(5):523-528
Ovarian large cell neuroendocrine carcinoma is a rare tumor that is usually associated with surface epithelial tumors. Mucinous tumors are most common surface epithelial component identified in reported cases. Ovarian mucinous tumor associated with large cell neuroendocrine carcinoma is almost always an intestinal type. However, large cell neuroendocrine carcinoma associated with pure mucinous borderline tumor of endocervical-like type has not been described previously. The present case report describes a large cell neuroendocrine carcinoma associated with endocervical-like mucinous borderline tumor of the ovary in a 35-year-old woman. The tumor was confirmed by histopathology and immunohistochemistry. A review of the pertinent literature is included.
Adult
;
Carcinoma, Neuroendocrine
;
Female
;
Humans
;
Immunohistochemistry
;
Mucins
;
Ovary
8.correlation between the concentrations of follicular fluid epidermal growth factor and estradiol in IVF program.
Hyeong Soon KIM ; Sung Sik HAN ; Kyung Hwan CHANG ; In Cheol CHOI ; Won Il PARK ; Dong Jae CHO ; Chan Ho SONG
Korean Journal of Fertility and Sterility 1993;20(3):209-216
No abstract available.
Epidermal Growth Factor*
;
Estradiol*
;
Female
;
Follicular Fluid*
9.Clinical and Radiological Comparison of Femur and Fibular Allografts for the Treatment of Cervical Degenerative Disc Diseases.
Hyeong Seok OH ; Chan Shik SHIM ; Jin Sung KIM ; Sang Ho LEE
Journal of Korean Neurosurgical Society 2013;53(1):6-12
OBJECTIVE: This consecutive retrospective study was designed to analyze and to compare the efficacy and outcomes of anterior cervical discectomy and fusion (ACDF) using a fibular and femur allograft with anterior cervical plating. METHODS: A total of 88 consecutive patients suffering from cervical degenerative disc disease (DDD) who were treated with ACDF from September 2007 to August 2010 were enrolled in this study. Thirty-seven patients (58 segments) underwent anterior interbody fusion with a femur allograft, and 51 patients (64 segments) were treated with a fibular allograft. The mean follow-up period was 16.0 (range, 12-25) months in the femur group and 19.5 (range, 14-39) months in the fibular group. Cage fracture and breakage, subsidence rate, fusion rate, segmental angle and height and disc height were assessed by using radiography. Clinical outcomes were assessed using a visual analog scale and neck disability index. RESULTS: At 12 months postoperatively, cage fracture and breakage had occurred in 3.4% (2/58) and 7.4% (4/58) of the patients in the femur group, respectively, and 21.9% (14/64) and 31.3% (20/64) of the patients in the fibular group, respectively (p<0.05). Subsidence was noted in 43.1% (25/58) of the femur group and in 50.5% (32/64) of the fibular group. No difference in improvements in the clinical outcome between the two groups was observed. CONCLUSION: The femur allograft showed good results in subsidence and radiologic parameters, and sustained the original cage shape more effectively than the fibular allograft. The present study suggests that the femur allograft may be a good choice as a fusion substitute for the treatment of cervical DDD.
Dichlorodiphenyldichloroethane
;
Diskectomy
;
Femur
;
Follow-Up Studies
;
Humans
;
Neck
;
Retrospective Studies
;
Stress, Psychological
;
Transplantation, Homologous
10.The efficacy of thymopentin in the treatment of atopic dermatitis.
Hyeong Don BANG ; Hyun Seung LEE ; Phil Soo AHN ; Dae Hun SUH ; Kyung Chan PARK ; Kyu Han KIM
Journal of Asthma, Allergy and Clinical Immunology 1998;18(4):640-646
BACKGROUND: Thymopentin(TP-5) is an immunomodulatory agent which may be a promising new drug in the treatment of patients with severe atopic dermatitis. OBJECTIVE: The aim of this study was to evaluate the efficacy of thymopentin for treatment of severe atopic dermatitis. MATERIAL AND METHOD: Fifteen patients with severe atopic dermatitis received subcutaneous injections of 50mg thymopentin three times per week for 6 weeks. Clinical extent and severity parameters were assessed at baseline, at regular intervals during therapy and 4 weeks posttherapy. Use of antihistamine and topical steroid were permitted. RESULT: Significant reduction in severity scores and body surface area involvement was observed and no significant side effects were noted(p<0.05). CONCLUSION: Thymopentin may be considered to be an effective adjunctive therapeutic agent in the treatment of severe atopic dermatitis. Further studies will be needed to determine the action mechanism of thymopentin.
Body Surface Area
;
Dermatitis, Atopic*
;
Humans
;
Injections, Subcutaneous
;
Thymopentin*