No abstract available.
Empathy* ; Psychotherapy*

The International Forum on Taopsychotherapy and Western Psychotherapy was held on August 21 and 22, 2004 at Hotel Lotte, Seoul in commemoration of the 30th anniversary of the Korean Academy of Psychotherapists. The author described the background and significance of the meeting, in relation to the current situation within the field of psychotherapy in Korea. He also reported on the general outline of the scientific programs at the International Forum and major issues which emerged from discussions among presenters and discussants, together with the participants from the floor. In addition, the author briefly introduced the subject of Taopsychotherapy, compared with western psychotherapy.
Anniversaries and Special Events ; Korea ; Psychotherapy* ; Seoul

Current anatomy education in Korea has been dependent upon foreign textbooks and atlas. Various models and medical devices commonly used in Korea were imported from overseas. Now, it is necessary to design, produce and supply medical education, operative tools and treatment supportive devices customized to Korean human body and constitution. Accordingly, this is the time to assemble and deliver medical data to Korean population. Indivicess from the measurement for various types of bones were calculated, and the results were compared with data from foreign atlas and pictures. Individual drawings of bones from sacrum, hip bone and lower limb were made by using parameters we calculated, thus the atlas of Korean skeleton was constructed from artistic anatomical point of view. As a result, there were significant differences between Korean skeletons and the medical drawings from the oversea edition, and also we found numerous exaggerated and false dimensions without actual measurement. In the present study, we primarily focused on building musculoskeletal system of Korea population and set our goal as utilizing its graphic data for medical education in Korea. The present study would be the first study preparing theoretical foundations of Korean skeletal graphic system based on Korean body shape by comparison with other ethnic groups and foreign graphical models. Simultaneously, we conducted practical construction of the skeletal atlas by employing Korean standard measure data.
Constitution and Bylaws ; Education ; Education, Medical ; Ethnic Groups ; Foundations ; Hip* ; Human Body ; Humans ; Korea ; Lower Extremity* ; Musculoskeletal System ; Sacrum ; Skeleton*

Current anatomy education in Korea has been dependent upon foreign textbooks and atlas. Various models and medical devices from overseas were imported and commonly used in Korea, Now, we need to provide our own literatures and graphic data based on Korean population for student education. It is necessary to design, produce and supply medical education, operative tools and treatment supportive devices customized to Korean human body and constitution. Accordingly, this is the time to assemble and deliver medical data to Korean population. In this study, we primarily focused on building musculoskeletal system of Korea population and set our goal as utilizing its graphic data for medical education in Korea. It is first study preparing theoretical foundations of Korean skeletal graphic system based on Korean body shape by comparison with other ethnic groups and foreign graphical models. Simultaneously, we conducted practical construction of the skeletal atlas by employing Korean standard measures. Parameters from the measurement for various types of bones were calculated, and the results were compared with data from foreign atlas and pictures. Individual drawings of bones from skull, upper extremity was made by using parameters we calculated, thus the atlas of Korean skeleton was constructed from artistic anatomical point of view. As a result, there were significant differences between Korean skeletons and the medical drawings from the oversea edition. Because many foreign drawings used data from Caucasians only and there were numerous exaggerated and false dimensions without actual measurement. In conclusion, the result of the study is expected to provide fundamental data for building anatomical atlas about Korean human body structure.
Constitution and Bylaws ; Education ; Education, Medical ; Ethnic Groups ; Foundations ; Human Body ; Humans ; Korea ; Musculoskeletal System ; Skeleton* ; Skull ; Upper Extremity*

Nitric oxide has been considered to be an important modulator of the epileptic seizure response. Previous studies have mainly focused on the nitric oxide synthase (NOS) expressed in glial cells and vascular endothelial cells in the brain following seizures, while less data have been available reading the change of neuronal NOS (nNOS) produced in neurons. Polypeptide growth factors play a central role in a variety of environmentally induce structural changes in the cortex and hippocampus of adult brain. neuregulin is widely expressed in the central and peripheral nerve cells and Schwann cells, glia, oligodendrocytes and muscle cells, to control cellular proliferation, differentiation and migration. erbB family are the receptors of the neuregulin and consist of erbB2, erbB3 and erbB4. We have, therefore, investigated the change in the expression of nNOS and erbB4 in the rat hippocampus, one of the brain structures most vulnerable to seizures. Rats were injected with kainic acid (KA) and sacrificed 6 h, 1 d, 3 d and 6 d after KA administration. The expression pattern of nNOS and erbB4 was studied using reverse transcription-polymerase chain reaction analysis, NADPH-diaphorase (NADPH-d) histochemistry and immunohistochemistry. The increase in the level of nNOS reached maximal values in samples obtained 1 d after KA treatment. The optical densities of NADPH-d-positive neurons in the CA1 and dentate gyrus (DG) regions of the hippocampus were shown to have increased in samples obtained 1 d and 3 d after injection of KA. The number of NADPH-d-positive neurons in the CA1 regions of the hippocampus was shown to have decreased in samples obtained 3 d and 6 d after injection of KA. However, the number of NADPH-d-positive neurons in the DG region did not change significantly. We show that erbB4 immunoreactivity is increased in hippocampus, reaching maximal levels 3 d after KA treatment, some NOS neurons contain erbB4 protein. We propose that the survival of NOS neuron in the hippocampus after injection of KA is associated with expression of erbB4, neuregulin receptor.
Adult ; Animals ; Brain ; Cell Proliferation ; Dentate Gyrus ; Endothelial Cells ; Epilepsy ; Hippocampus* ; Humans ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins ; Kainic Acid ; Muscle Cells ; Neuroglia ; Neurons ; Nitric Oxide Synthase* ; Nitric Oxide* ; Oligodendroglia ; Peripheral Nerves ; Rats* ; Schwann Cells ; Seizures*

Kainic acid (KA) is a frequently used excitotoxin in experimental epilepsy research. The excitatory effect of KA leads to generalized convulsions when KA is administered systematically at convulsant doses. Nitric oxide (NO) is a gaseous messenger that plays a role in neurotransmission. NO is formed by NO synthase (NOS) from arginine. Purification and molecular cloning led to identification of at least three NOS isoforms designated as neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (iNOS). In the central nervous system, NO seems to be involved in plasticity and cytotoxicity. Therefore, the present study has investigated the congruence of mRNA induction and protein expression of nNOS, eNOS, iNOS and neuropeptide Y (NPY) following KA-induced seizure activity. The patterns of NOS and NPY were studied by NADPH-diaphorase histochemistry, immunohistochemistry and RT-PCR in the rat brain. NADPH-d displayed a region-specific induction pattern. Regions of NADPH-d induction were the motor cortex and perirhinal cortex of KA treated group. Whereas NADPH-d neurons were not induced in auditory cortex, visual cortex, cingulate cortex, insular cortex, retrosplenial cortex and ectorhinal cortex of KA treated group. NPY neurons were not induced in all cortical areas of KA treated group. Subsequent to cortical neuronal induction, NADPH-d activity was increased in constitutive NADPH-d neurons of 1 and 3 days group of KA treatment. 1 and 3 days following KA administration, increased levels of nNOS, eNOS and iNOS mRNA were seen in the cerebral cortex. However, the level of NPY mRNA was decreased in 6 and 12 days after seizure. These findings demonstrate that mRNAs encoding for NOS isoforms are translated into the respective proteins following excitotoxic seizure.
Animals ; Arginine ; Auditory Cortex ; Brain ; Central Nervous System ; Cerebral Cortex* ; Cloning, Molecular ; Epilepsy* ; Gyrus Cinguli ; Immunohistochemistry ; Kainic Acid ; Motor Cortex ; Neurons* ; Neuropeptide Y* ; Neuropeptides* ; Neurotoxins ; Nitric Oxide Synthase* ; Nitric Oxide* ; Plastics ; Protein Isoforms ; Rats* ; RNA, Messenger ; Seizures ; Synaptic Transmission ; Visual Cortex

Background: Melasma shows characteristic histological features of photoaged skin. Objective: We evaluated the effect of dermal rejuvenation using a temperature-controlled continuous non-invasive radiofrequency (RF) device on melasma. Methods: Continuous skin heating at the temperature of 43°C for 20 minutes was performed in ten subjects with melasma who underwent 3 tri-weekly RF sessions. Pigmentation was evaluated with Mexameter® and investigator’s global assessment (IGA). Immunohistochemical staining and image analysis was performed to evaluate biopsies from melasma skin before and after the treatment. Results: The lesional melanin index was decreased by 13.7% at week 9. IGA score was improved from 3.50 at baseline to 2.95 at week 9. No significant adverse event was reported. Histologic analysis revealed reduced melanin and increased collagen density and thickness.The expression of procollagen-1 and type IV collagen was increased after the treatment. The number of p16 INK4A -positive senescent fibroblasts was reduced after the treatment, while the expression of heat shock protein 70 and 90 was increased. Stromal derived factor-1, a senescence-associated anti-melanogenic factor secreted from the fibroblasts, was up-regulated after the treatment, while the level of c-kit was not changed. Conclusion Thermal skin stimulation by the temperature-controlled continuous RF device improved melasma through dermal rejuvenation.

BACKGROUND: The authors have developed a Digital image chart(DIC) and digital Radiotherapy Record System (DRRS). We have evaluated the DIC and DRRS for reliability, usefulness, ease of use, and efficiency. METHOD AND MATERIALS: The basic design o f the DIC and DRRS was to build an digital image database of radiation therapy patient records for a more efficient and timely flow of critical image in formation throughout the department. This system is a subunit of comprehensive radiation oncology managemert system (C-ROMS) and composed of a picture archiving and communication system (PACS), radiotherapy information database, and a radiotherapy imaging database. The DIC and DRRS were programmed using Delphi under a Windows 95 environment and is capable of displaying the digital images of patients identification photos, simulation films, radiotherapy setup, diagnostic radiology image... Gross lesion photos, and radiotherapy planning isodose charts with beam arrangements. Twenty-three clients in the department are connected by Ethernet (10 Mbps) to the central image server (Sun Ultra-sparc 1 workstation). RESULTS: From the introduction of this system in February 1998 through December 1999, we have accumulated a total of 15,732 individual images for 2,556 patients. We can organize radiation therapy in; paperless environment in 120 patients with breast cancer. Using this system, we have succeeded in the prompt, accurate, and simultaneous access to patient care information from multiple locations throughout the department. This coordination has resulted in improved operational efficiency within the department. CONCLUSION: The authors believe that the DIC and DRRS has contributed to the improvement of radiation oncology department efficacy as well as to time and resource savings by providing necessary visual information throughout the department conveniently and simultaneously. As a result, we can also achieve the paperless and filmless practice of radiation oncology with this system.
Breast Neoplasms ; Dacarbazine ; Hospital Information Systems ; Humans ; Income ; Patient Care ; Radiation Oncology* ; Radiotherapy*

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous clinicopathological entity, and its molecular classification into germinal center B cell-like (GCB) and activated B cell-like (ABC) subtypes using gene expression profile analysis has been shown to have prognostic significance. Recent attempts have been made to find an association between immunohistochemical findings and molecular subgroup, although the clinical utility of immunohistochemical classification remains uncertain. METHODS: The clinicopathological features and follow-up data of 68 cases of surgically resected gastrointestinal DLBCL were analyzed. Using the immunohistochemical findings on tissue microarray, the cases were categorized into GCB and non-GCB subtypes according to the algorithms proposed by Hans, Muris, Choi, and Tally. RESULTS: The median patient age was 56 years (range, 26-77 years). Of the 68 cases included, 39.7% (27/68) involved the stomach, and 60.3% (41/68) involved the intestines. The GCB and non-GCB groups sorted according to Hans, Choi, and Tally algorithms, but not the Muris algorithm, were closely concordant (Hans vs. Choi, kappa=0.775, P<0.001; Hans vs. Tally, kappa=0.724, P<0.001; Choi vs. Tally, kappa=0.528, P<0.001). However, there was no prognostic difference between the GCB and non-GCB subtypes, regardless of the algorithm used. On univariate survival analyses, international prognostic index risk group and depth of tumor invasion both had prognostic significance. CONCLUSION: The Hans, Choi, and Tally algorithms might represent identical DLBCL subgroups, but this grouping did not correlate with prognosis. Further studies may delineate the association between immunohistochemical subgroups and prognosis.
B-Lymphocytes* ; Classification ; Follow-Up Studies ; Gastrointestinal Tract ; Germinal Center ; Humans ; Immunohistochemistry ; Intestines ; Lymphoma, B-Cell* ; Prognosis ; Stomach ; Transcriptome

We report a case of perigastric histiocytic sarcoma (HS) involving the lesser omental sac in a 30-year-old man. HS is an exceedingly rare malignancy of mature tissue histiocyte. The tumor was a multi-lobulated, bulging enhancing mass in the lesser omentum with metastasis to lymph nodes and liver. The tumor consisted of diffuse non-cohesive proliferation of pleomorphic large oval to round neoplastic cells with giant cells showing vesicular chromatin and ample eosinophilic cytoplasm. In some areas, the tumor cells showed spindling with elongation of the nuclei and cellular shapes. Many of the tumor cells, especially giant forms contained phagocytosed lymphocytes. Immunohistochemical analysis of the tumor cells showed expression of leukocyte common antigen, CD68, lysozyme, vimentin, CD4, and CD163. Ki-67 index was 50-60%. After the operation, he was treated with chemotherapy, but the response was poor.
Adult ; Antigens, CD45 ; Chromatin ; Cytoplasm ; Eosinophils ; Giant Cells ; Histiocytes ; Histiocytic Sarcoma ; Humans ; Liver ; Lymph Nodes ; Lymphocytes ; Muramidase ; Neoplasm Metastasis ; Omentum ; Sarcoma ; Vimentin