No abstract available.
Extracellular Matrix Proteins* ; Extracellular Matrix* ; Peptides* ; Titanium*

Recently it is known that Turner's syndrome is frequently associated with hypothyroidism. We report a case of Turner's syndrome associated with subclinical hypothyroidism. A 23-year-old female was admitted to the hospital with complaints of amenorrhea and short stature. She had a mosaicism of 45, X0/46, Xi(X_q) in the cell, cultured from the peripheral blood. The plasma thyroxine and triiodothyronine were normal and there was no clinical symptom of hypothyroidism. But the thyroid-stimulating hormone(TSH) concentration was unusually higher(184 uU/L). She has been treated with the cyclic therapy of conjugated estrogen and medroxyprogesterone, in addition to the thyroxine replacement therapy. After 2 months, the menstruation was restored and TSH was normalized.
Amenorrhea ; Cells, Cultured ; Estrogens ; Female ; Humans ; Hypothyroidism ; Medroxyprogesterone ; Menstruation ; Mosaicism ; Plasma ; Thyroxine ; Triiodothyronine ; Turner Syndrome ; Young Adult

188 consecutive cases with basilar skull fractures(BSF) out of 2676 head injury patients who were treated in Chung-Ang Gil Hospital from July 1993 to June 1995, were analyzed. These fractures are difficult to diagnose by ordinary X-ray examinations, routine head computed tomography(CT) and are frequently inferred by clinical signs. Therefore, it's diagnosis is somtimes delayed or missed in initial assessment of trauma patients. They are different from cranial vault fractures in several aspects other than difficulties in the diagnosis. It involves more commonly the cranial nerves(CN), makes cerebrospinal fluid(CSF) fistulae and leads to central nervous system(CNS) infections if the CSF fistulae are not detected or treated early and properly. The authors reviewed the clinical features, radiological findings, rate of delayed diagnosis, complications and outcomes. The most common feature of BSF was otorrhea(64.4%) and followed by rhinorrhea(39.4%), raccoon eye(32.4%) and hemotympanum(24.5%). In only 6.4% of cases, the fracture lines were detected by ordinary skull radiographs and diagnosed as BSF. In contrast, the high resolution skull base CT confirmed the fractures in 62.2%. Clinical diagnoses were made in 14.9%. Commonly combined craniofacial lesions were cranial vault fractures(51.1%), intracranial hemorrhages(46.3%), and facial bone fractures(34.0%). Most of CSF leakages(89.7%) were noted within 24 hours after injury and most of the leakages (87.7%) had ceased by conservative management within 2 weeks, but 5.1% that did not respond to conservative treatment and lumbar CSF drainage, needed invasive operative repair. The incidence of meningitis was 3.2% and the prophylactic antibiotics had no benificial effect on lowering the infection rate. Facial nerve was the most frequently involved cranial nerve followed by vestibulo-cocchlear, oculomotor, and olfactory nerve in decreasing order of frequency. The onset of facial palsy was immediate in 31.8% and the remainder were delayed more than 24 hours after head injury. Of 188 patients, 21 cases(11.2%) were delayed in the diagnosis of BSF.
Anti-Bacterial Agents ; Cranial Nerves ; Craniocerebral Trauma ; Delayed Diagnosis ; Diagnosis ; Drainage ; Facial Bones ; Facial Nerve ; Facial Paralysis ; Fistula ; Head ; Humans ; Incidence ; Meningitis ; Olfactory Nerve ; Raccoons ; Skull ; Skull Base ; Skull Fracture, Basilar*

No abstract available.
Animals ; Periodontal Ligament* ; Phosphotransferases* ; Rats*

This work describes tamaoxifen, a nonsteroidal antiestrogen compound, which has been used extensively in the treatment of breast cancer on account of its efficacy and relatively low toxicity. It has been reported to inhibit glioma proliferation in all cell line tested, acting by a mechanism independent of estrogen receptor blockade. Tamoxifen causes cytotoxicity at higher concentration(>or=5 micrometer), as compared with control. Our results showed that this compound decreased the rate of cell proliferation in dose-dependent manner. Its treatment against the C6 glioma cells also resulted in enhancement of the antitumor effect. These data suggest that tamoxifen may serve as an useful agent in chemotherapy of glioma.
Breast Neoplasms ; Cell Line ; Cell Proliferation ; Drug Therapy ; Estrogen Receptor Modulators ; Estrogens ; Glioma* ; Tamoxifen*

No abstract available.
Fistula* ; Stomach* ; Tuberculosis*

Vascular cell adhesion molecule-1 (VCAM-1) has been implicated in selective eosinophil recruitment characterizing allergic inflammation. To understand the events involved in selective eosinophil migration into allergic inflammatory sites, we performed quantitative analysis of VCAM-1 mRNA expression levels in the nasal mucosa of TDI-induced allergic rats. Expression levels of VCAM-1 mRNA from inferior turbinate were examined using competitive PCR in 35 allergic rats and 5 control rats and compared with infiltrated eosinophil counts. Quantity of VCAM-1 mRNA was more increased in allergy group than in the control group, especially in group sacrificed 3 hours to 4 days after provocation. Infiltrating eosinophils were correlated with the expression levels of VCAM-1 mRNA (p<0.01). These results suggest that VCAM-1 plays a predominant role in controlling antigen-induced eosinophil recruitment into the tissue, and that the induction of VCAM-1 expression on the endothelium at the site of allergic inflammation regulates eosinophil recruitment.
Animals ; Endothelium ; Eosinophils ; Hypersensitivity ; Inflammation ; Nasal Mucosa* ; Polymerase Chain Reaction ; Rats* ; RNA, Messenger* ; Turbinates ; Vascular Cell Adhesion Molecule-1*

A 13-year-old male developed cardiac arrest and pulmonary edema during an elective surgery for chronic mastoiditis following a local injection of 0. 1 ml of 1: 1000 adrenaline under general anesthesia. After several days, 14-year-old male developed same episode during tonsillectomy under local anesthesia at ENT out patient department. They showed an immediate and favorable response to treatment with CPPB, rapid digitalization, fluid therapy, etc. The clinical course and pathophysiology of adrenaline induced pulmonary edema will be discussed.
Adolescent ; Anesthesia, General ; Anesthesia, Local ; Epinephrine* ; Fluid Therapy ; Heart Arrest ; Heart Arrest, Induced* ; Humans ; Male ; Mastoid ; Mastoiditis ; Pulmonary Edema* ; Tonsillectomy

Between March 1994 and March 1995, 10 patients with thoracolumbar burst fractures underwent a one-stage operation consisting of anterior decompression, reduction, bony fusion with iliac bone and stabilization with Kaneda device. The mean follow-up was 6.4 Months. Most patients with incomplete neurologic lesions showed postoperative improvement and were upgraded one or two steps in the Frankel scale. No patient showed neurological deterioration after surgery. Loss of reduction was 5.5 degree during follow-up period. Anterior decompression and strut fusion was used to effectively recover the neurological deficit and reduce the pain in a thoraco-lumbar burst fracture.
Decompression ; Follow-Up Studies ; Humans

We report here on an uncommon case of metastatic choriocarcinoma to the lung, brain and lumbar spine. A 33-year-old woman was admitted to the pulmonary department with headache, dyspnea and hemoptysis. There was a history of cesarean section due to intrauterine fetal death at 37-weeks gestation and this occurred 2 weeks before admission to the pulmonary department. The radiological studies revealed a nodular lung mass with hypervascularity in the left upper lobe and also a brain parenchymal lesion in the parietal lobe with marginal bleeding and surrounding edema. She underwent embolization for the lung lesion, which was suspected to be an arteriovenous malformation according to the pulmonary arteriogram. Approximately 10 days after discharge from the pulmonary department, she was readmitted due to back pain and progressive paraparesis. The neuroradiological studies revealed a hypervascular tumor occupying the entire L3 vertebral body and pedicle, and the tumor extended to the epidural area. She underwent embolization of the hypervascular lesion of the lumbar spine, and after which injection of polymethylmethacrylate in the L3 vertebral body, total laminectomy of L3, subtotal removal of the epidural mass and screw fixation of L2 and L4 were performed. The result of biopsy was a choriocarcinoma.
Adult ; Arteriovenous Malformations ; Back Pain ; Biopsy ; Brain ; Cesarean Section ; Choriocarcinoma ; Dyspnea ; Edema ; Female ; Fetal Death ; Headache ; Hemangioma ; Hemoptysis ; Hemorrhage ; Humans ; Laminectomy ; Lung ; Neoplasm Metastasis ; Paraparesis ; Parietal Lobe ; Polymethyl Methacrylate ; Pregnancy ; Spine