The relationships between medical doctors and pharmacist play an important role. Because clinical information will not be discussed and exchanged if there is no cooperation between them. The clinical pharmacists relate with inpatients and outpatients. Otherwise, they have relations with nurse, sister, laboratories and other technician
Pharmacists ; Pharmacology, Clinical

In order to manage and safely and rationally use the drug, the Ministry of Health promulgates the regulations for management of toxic drug, stupefacients and psychotrope such as the toxic drug regulation accopanying the Dicision No 278BYT-QD; The addictive drug regulation and the list of addictive drug; the psychotic drug regulation and list of psychotropes. Concurrently, there have many texts of government, criminal law, inter-ministry circular letter, decree of president, the programs of ministry of health.
Pharmaceutical Preparations ; Drug Toxicity

Among adverse drug reactions, the anaphylactic shock is most severe and easily causes death. The cause of anaphylactic shock can be drugs (especially antibiotics), intravenous solution, and allergy, poison and microbial, the data of the anaphylactic shock in hospitals throughout the country has been reported. In order to limit the adverse drug reactions, it should know the medical history as well as have ready the drugs and equipment for timely management.
adverse effects ; hospitals

Phosphatidylinositol-3-kinase (PI3K) pathway signaling is an established oncogenic signal transduction pathway implicated in multiple malignancies. Therapeutic targeting of PI3K pathway components has improved outcomes in chronic lymphocytic leukemia, kidney cancer, breast cancer, and neuroendocrine tumors. Gastric cancers harbor some of the highest rates of oncogenic alterations in PI3K but attempts to translate this genomic observation have met with limited clinical success and novel approaches are needed. In the following review we discuss PI3K signaling, previous preclinical and clinical investigations in gastric cancer, and discuss future strategies aimed at overcoming resistance and improving efficacy. Identification and refinement of molecular tumor subtypes, development of predictive biomarkers along, and rational drug combination strategies are key to capitalizing on the therapeutic potential of PI3K pathway directed therapies in gastric cancers.
Biomarkers ; Breast Neoplasms ; Kidney Neoplasms ; Leukemia, Lymphocytic, Chronic, B-Cell ; Molecular Targeted Therapy ; Neuroendocrine Tumors ; Oncogene Protein v-akt ; Signal Transduction ; Stomach Neoplasms* ; TOR Serine-Threonine Kinases

Phosphatidylinositol-3-kinase (PI3K) pathway signaling is an established oncogenic signal transduction pathway implicated in multiple malignancies. Therapeutic targeting of PI3K pathway components has improved outcomes in chronic lymphocytic leukemia, kidney cancer, breast cancer, and neuroendocrine tumors. Gastric cancers harbor some of the highest rates of oncogenic alterations in PI3K but attempts to translate this genomic observation have met with limited clinical success and novel approaches are needed. In the following review we discuss PI3K signaling, previous preclinical and clinical investigations in gastric cancer, and discuss future strategies aimed at overcoming resistance and improving efficacy. Identification and refinement of molecular tumor subtypes, development of predictive biomarkers along, and rational drug combination strategies are key to capitalizing on the therapeutic potential of PI3K pathway directed therapies in gastric cancers.
Biomarkers ; Breast Neoplasms ; Kidney Neoplasms ; Leukemia, Lymphocytic, Chronic, B-Cell ; Molecular Targeted Therapy ; Neuroendocrine Tumors ; Oncogene Protein v-akt ; Signal Transduction ; Stomach Neoplasms* ; TOR Serine-Threonine Kinases