1.Immunocytochemical study on the changes of the T lymphocytes and subsets in the peripheral blood of stomach cancer patients.
Woo Song HA ; Sang Kyung CHOI ; Ho Seong HAN ; Soon Chan HONG ; Soon Tae PARK ; Young Chai KIM ; Sun Young KIM ; Wan Sung CHOI
Journal of the Korean Surgical Society 1991;40(3):290-297
No abstract available.
Humans
;
Stomach Neoplasms*
;
Stomach*
;
T-Lymphocytes*
2.A Case of Concurrent Esophageal and Doudenal Double Primary Cancer.
Chai Ho LIM ; Hai Ju YANG ; Young Wan KIM ; Wan Jae HEO ; Jae Sun KIM ; Nag Hyun SEONG ; Koung Sik PARK ; Jong Beom CHOI ; Seok In JEONG
Korean Journal of Gastrointestinal Endoscopy 1997;17(4):533-538
The occurrence of double primary cancer of the esopbagus and duodenum is considered very rare. Moreover, it is difficult to manage this type of double cancer because esophageal cancer has a biologic tendency to early metastasis. We report a case of double primary cancer, which we have synchronously confirmed esophageal squamous cell carcinoma and duodenal adenocarcinoma with gastrofiberscopic biopsy, and then treated them by gastrojejunostomy and systemic chemotherapy.
Adenocarcinoma
;
Biopsy
;
Carcinoma, Squamous Cell
;
Drug Therapy
;
Duodenum
;
Esophageal Neoplasms
;
Gastric Bypass
;
Neoplasm Metastasis
3.A Case of Acute Hemolytic Anemia and Methemoglobinemia Induced by Massive Dapsone Intoxication.
Nag Hyun SEONG ; Young Wan KIM ; Wan Jae HEO ; Chai Ho LIM ; Jae Sam KIM ; Seok Kie PAEK ; Kyung Sik PARK ; Chun Il LEE
Korean Journal of Hematology 1997;32(1):106-111
Dapsone toxicity is evidenced by varying clinical pictures ranging from deep cyanosis in an otherwise alert normal appearing individual to restlessness, dyspnea, extensive hemolytic anemia, methemoglobinemia, sulfhemoglobinemia and serious central nervous system dysfunction. We experienced a case of acute massive dapsone intoxication in 34 years old man due to voluntary ingestion of 25g of this drug as a suicide attempt. A severe methemoglobinemia developed, accompanied by nausea, vomiting, intense cyanosis, headache, and dyspnea. Subsequently moderate hemolytic anemia observed. The patient recovered completely after intensive treatment with methylene blue, activated charcoal hemoperfusion, oral charcoal ingestion, steroid, and conservative treatment. Methylene blue was given by continuous intravenous infusion in order to avoid overdosage. We herein report a case of the acute hemolytic anemia and severe methemoglobinemia induced by massive dapsone intoxication with a review of the literature.
Adult
;
Anemia, Hemolytic*
;
Central Nervous System
;
Charcoal
;
Cyanosis
;
Dapsone*
;
Dyspnea
;
Eating
;
Headache
;
Hemoperfusion
;
Humans
;
Infusions, Intravenous
;
Methemoglobinemia*
;
Methylene Blue
;
Nausea
;
Psychomotor Agitation
;
Suicide
;
Sulfhemoglobinemia
;
Vomiting
4.Observation of the Free-living Adults of Strongyloides stercoralis from a Human Stool in Korea.
Young Hee HONG ; Jong Wan KIM ; In Soo RHEEM ; Jae Soo KIM ; Suk Bae KIM ; Jong Yil CHAI ; Sang Mee GUK ; Seung Ha LEE ; Min SEO
Infection and Chemotherapy 2009;41(2):105-108
A 76-year-old Korean man living in Cheonan, Chungcheongnam-do, visited one University Hospital with dyspnea and abdominal pain. He has been undergoing transcatheter arterial chemoembolization (TACE) for the past three years for the treatment of hepatocellular carcinoma. Abdominal pain developed 10 days ago, and became worse several days prior to coming to the emergency room. Physical examination revealed tenderness over the umbilicus. Eosinophil count was 22% without increase in the number of white blood cells. Stool examination showed adult and larval nematodes, which were subsequently identified as free-living adult worms and rhabditiform larvae of Strongyloides stercoralis. Follow-up stool examination performed six days later demonstrated only rhabditiform larvae of S. stercoralis. This is the first report on the recovery of free- living adult worms from human stool in the world.
Abdominal Pain
;
Adult
;
Aged
;
Carcinoma, Hepatocellular
;
Dyspnea
;
Emergencies
;
Eosinophils
;
Follow-Up Studies
;
Humans
;
Korea
;
Larva
;
Leukocytes
;
Physical Examination
;
Strongyloides
;
Strongyloides stercoralis
;
Umbilicus
5.Observation of the Free-living Adults of Strongyloides stercoralis from a Human Stool in Korea.
Young Hee HONG ; Jong Wan KIM ; In Soo RHEEM ; Jae Soo KIM ; Suk Bae KIM ; Jong Yil CHAI ; Sang Mee GUK ; Seung Ha LEE ; Min SEO
Infection and Chemotherapy 2009;41(2):105-108
A 76-year-old Korean man living in Cheonan, Chungcheongnam-do, visited one University Hospital with dyspnea and abdominal pain. He has been undergoing transcatheter arterial chemoembolization (TACE) for the past three years for the treatment of hepatocellular carcinoma. Abdominal pain developed 10 days ago, and became worse several days prior to coming to the emergency room. Physical examination revealed tenderness over the umbilicus. Eosinophil count was 22% without increase in the number of white blood cells. Stool examination showed adult and larval nematodes, which were subsequently identified as free-living adult worms and rhabditiform larvae of Strongyloides stercoralis. Follow-up stool examination performed six days later demonstrated only rhabditiform larvae of S. stercoralis. This is the first report on the recovery of free- living adult worms from human stool in the world.
Abdominal Pain
;
Adult
;
Aged
;
Carcinoma, Hepatocellular
;
Dyspnea
;
Emergencies
;
Eosinophils
;
Follow-Up Studies
;
Humans
;
Korea
;
Larva
;
Leukocytes
;
Physical Examination
;
Strongyloides
;
Strongyloides stercoralis
;
Umbilicus
6.A Case of Undifferenciated Large Cell Carcinoma of Lung Associated with Neurofibromatosis.
Jeong Rye HYUN ; Jae Sam KIM ; Nak Hyun SEOK ; Seok Kie PAEK ; Wan Jae HUH ; Chai Ho IM ; Hai Ju YANG ; Kye Young KIM
Korean Journal of Medicine 1997;52(2):257-262
Neurofibromatosis also referred to as von Recklinghausen`s disease, is an autosomal dominant disease, which is characterized by cutaneous neurofibromas, cafe-au-lait spot, and axillary freckles. Although neruofibromatosis is a congenital disorder, the pulmonary manifestation become evident in adulthood. Approximately 15percent of patients with cutaneous lesions have intrathoracic neurofibromas. In some patients with neurofibromatosis, the lungs are the seat of interstitial fibrosis, leiomyoma, and bullous lesion, meningocele or less commonly lung cancer. The association of neurofibromatosis and lung cancer is rare, A 47-year-old man, who was a heavy smoker, was admitted to our hospital because of hemoptysis. Since cafe-au-lait sopts, diffuse pigmentation and multiple neurofibromatosis were observed on the skin, he was considered to have von Recklinghausen`s disease. Chest X-ray film showd extensive hazy density affecting all of his lung field, and minimal peribronchial infiltratin in his left lower lung field. Chest CT showed that near total consolidative lesions were present of right middle lobe. Also, some patchy infiltration were present in his right lower lobe and some of left lower lobe. Histoathological examination of the percutaneous lung biopsy specimen demonstrated that he had undifferentiated large cell carcinoma. The Authors have experienced a case of neurofibromatosis combined with undifferntiated large cell carcinoma. A brief review of related literature was conducted.
Biopsy
;
Blister
;
Cafe-au-Lait Spots
;
Carcinoma, Large Cell*
;
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
;
Fibrosis
;
Hemoptysis
;
Humans
;
Leiomyoma
;
Lung Neoplasms
;
Lung*
;
Melanosis
;
Meningocele
;
Middle Aged
;
Neurofibroma
;
Neurofibromatoses*
;
Pigmentation
;
Skin
;
Thorax
;
Tomography, X-Ray Computed
;
X-Ray Film
7.Improved immunodetection of human papillomavirus E7.
Ju Hong JEON ; Sung Yup CHO ; Chai Wan KIM ; Dong Myung SHIN ; Joon Cheol KWON ; Kyung Ho CHOI ; In Gyu KIM
Experimental & Molecular Medicine 2002;34(6):496-499
Human papillomavirus E7 (HPV E7) is a viral oncoprotein that plays an important role in cervical carcinogenesis through binding with retinoblastoma protein (Rb). Inactivation of Rb by E7 is necessary but not sufficient for cellular transformation, suggesting other protein-protein interactions are required for E7-mediated cellular transformation aside from the interaction with Rb. However, studies on the oncogenic function of HPV E7 have been limited by its poor immunoreactivity. In this report, we show that the fixation of purified recombinant HPV E7 on blotted nitrocellulose membrane with glutaldehyde markedly enhanced the immunoreactivity of HPV E7 protein. Using HeLa and Caski cell line which are infected with HPV 18 and HPV 16, respectively, we demonstrated that native HPV E7 proteins also could be detected by this method. These results therefore can provide the experimental conditions for detection of HPV E7 proteins with greater sensitivity and may help to analyze E7 functions.
Cell Extracts/chemistry/immunology
;
Cell Line
;
Human
;
Immunochemistry/*methods
;
Oncogene Proteins, Viral/*analysis/immunology
;
Papillomavirus, Human/chemistry/*immunology
8.Development of the implant surgical technique and assessment rating system.
Jung Chul PARK ; Ji Wan HWANG ; Jung Seok LEE ; Ui Won JUNG ; Seong Ho CHOI ; Kyoo Sung CHO ; Jung Kiu CHAI ; Chang Sung KIM
Journal of Periodontal & Implant Science 2012;42(1):25-29
PURPOSE: There has been no attempt to establish an objective implant surgical evaluation protocol to assess residents' surgical competence and improve their surgical outcomes. The present study presents a newly developed assessment and rating system and simulation model that can assist the teaching staffs to evaluate the surgical events and surgical skills of residents objectively. METHODS: Articles published in peer-reviewed English journals were selected using several scientific databases and subsequently reviewed regarding surgical competence and assessment tools. Particularly, medical journals reporting rating and evaluation protocols for various types of medical surgeries were thoroughly analyzed. Based on these studies, an implant surgical technique assessment and rating system (iSTAR) has been developed. Also, a specialized dental typodont was developed for the valid and reliable assessment of surgery. RESULTS: The iSTAR consists of two parts including surgical information and task-specific checklists. Specialized simulation model was subsequently produced and can be used in combination with iSTAR. CONCLUSIONS: The assessment and rating system provided may serve as a reference guide for teaching staffs to evaluate the residents' implant surgical techniques.
Checklist
;
Dental Implantation
;
Educational Measurement
;
Mental Competency
;
Oral Surgical Procedures
9.Role of collagen membrane in lateral onlay grafting with bovine hydroxyapatite incorporated with collagen matrix in dogs.
Ui Won JUNG ; Jung Seok LEE ; Geun LEE ; In Kyeong LEE ; Ji Wan HWANG ; Min Soo KIM ; Seong Ho CHOI ; Jung Kiu CHAI
Journal of Periodontal & Implant Science 2013;43(2):64-71
PURPOSE: The objective of this study was to elucidate the role of collagen membranes (CMs) when used in conjunction with bovine hydroxyapatite particles incorporated with collagen matrix (BHC) for lateral onlay grafts in dogs. METHODS: The first, second, and third premolars in the right maxilla of mongrel dogs (n=5) were extracted. After 2 months of healing, two BHC blocks (4 mmx4 mmx5 mm) were placed on the buccal ridge, one with and one without the coverage by a CM. The animals were sacrificed after 8 weeks for histometric analysis. RESULTS: The collagen network of the membranes remained and served as a barrier. The quantity and quality of bone regeneration were all significantly greater in the membrane group than in the no-membrane group (P<0.05). CONCLUSIONS: The use of barrier membranes in lateral onlay grafts leads to superior new bone formation and bone quality compared with bone graft alone.
Alveolar Ridge Augmentation
;
Animals
;
Bicuspid
;
Bone Regeneration
;
Bone Substitutes
;
Collagen
;
Dogs
;
Durapatite
;
Guided Tissue Regeneration
;
Inlays
;
Maxilla
;
Membranes
;
Osteogenesis
;
Transplants
10.Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer.
Sung Yup CHO ; Kyungho CHOI ; Ju Hong JEON ; Chai Wan KIM ; Dong Myung SHIN ; Jong Bouk LEE ; Sang Eun LEE ; Choung Soo KIM ; Jeong Soo PARK ; Eui Man JEONG ; Gi Yong JANG ; Kye Yong SONG ; In Gyu KIM
Experimental & Molecular Medicine 2010;42(4):310-318
Transglutaminase 4 is a member of enzyme family that catalyzes calcium-dependent posttranslational modification of proteins. Although transglutaminase 4 has been shown to have prostate-restricted expression pattern, little is known about the biological function of transglutaminase 4 in human. To gain insight into its role in prostate, we analyzed the expression status of human transglutaminase 4 in benign prostate hyperplasia (BPH) and prostate cancer (PCa). Unexpectedly, RT-PCR and nucleotide sequence analysis showed four alternative splicing variants of transglutaminase 4: transglutaminase 4-L, -M (-M1 and -M2) and -S. The difference between transglutaminase 4-M1 and -M2 is attributed to splicing sites, but not nucleotide size. The deduced amino acid sequences showed that transglutaminase 4-L, -M1 and -M2 have correct open reading frames, whereas transglutaminase 4-S has a truncated reading frame. RT-PCR analysis of clinical samples revealed that transglutaminase 4-M and -S were detected in all tested prostate tissue (80 BPH and 48 PCa). Interestingly, transglutaminase 4-L was found in 56% of BPH (45 out of 80) and only in 15% of PCa (7 out of 48). However, transglutaminase 4-L expression did not correlate with serum prostate-specific antigen (PSA) level, prostate volumes or PSA densities. These results will provide a clue to future investigation aiming at delineating physiological and pathological roles of human transglutaminase 4.