Clinical analysis of fracture of femral shaft in 73 cases treated at the 17 Army Hospital during the period from May 1965 to July 1968 is presented. 1) All the patient were males and in the 3rd decade of life. 2) Sites of fracture were 28 in midshaft, 23 in lower one-third, 22 in upper one-third, and 29 cases: had open fracture. 3) 32 cses(43.8%) were injured by traffic accident which is the most common cause in this series. 4) Conservative treatmet was given in 30 cases, plate fixation in 15 cases, and Kuentscher type of I.M. nailing in 28 cases. 5) Criteria evaluating the results were; knee joint motion, length & alignment of the femur, and pain during weight bearing. 6) Severely comminuted fracture tends to deserve conservative measure only and sites of fracture contraindicated for I.M. nailing were best treated by plate or screw fixation. 7) A comparison has been made between the functional results treated by conservative method and open reduction (plate & screw fixation and I.M. Kuentscher nailing). Excellent or good results were obtained, by conservative (30 cases), plate and screw fixation. (15 cases), and I.M. Kuentscher nailing(28cases), in 46.7%, 60%, and 60.7% respectively. Functional results were slightly better in I.M. nailing than the other two methods. 8) Time of complete healing by solid bone union was; 6.5 months in (30 cases of) conservative treatment, 6 months in (10 cases of) plate and screw fixation, and 5.5 months in (22 cases of) I.M. Kuentscher nailing. 9) Postoperative infection rate,severe enough to interfere healing) was 6.6% (only one case) of plate group and 3.6%(only one case) of I.M. nailing group.
Accidents, Traffic ; Adult ; Femur ; Fractures, Comminuted ; Fractures, Open ; Hospitals, Military ; Humans ; Knee Joint ; Male ; Methods ; Weight-Bearing

We studied three patients in whom otorrhea occurred without bacterial infection following ventilation tube (VT) insertion. These patients took oral steroids since the conventional therapy was not effective; however, the oral steroids produced temporal effect since sticky otorrhea occurred when the oral steroids were stopped. We collected ear discharge from each patient and consulted the pathologist about histopathologic findings of it. We identified the predominant eosinophilic infiltration at specimen. We tried to relate this type of otitis media with eosinophilic otitis media (EOM) and treated the patients with intratympanic steroid injection.
Bacterial Infections ; Dexamethasone ; Ear ; Eosinophils ; Humans ; Middle Ear Ventilation ; Otitis ; Otitis Media ; Polymethacrylic Acids ; Steroids ; Ventilation

BACKGROUND: To grasp the status and future directions, an analysis was done on the articles published in the Journal of Korean Society for Clinical Pharmacology and Therapeutics during recent 19 years. METHODS: All the articles published from 1993 through 2011 were retrospectively analyzed. The number of articles and their language distribution were assessed. The articles were classified according to research types. Authors' affiliations and research fields of articles were also analyzed. RESULTS: The Journal of Korean Society for Clinical Pharmacology and Therapeutics as a semi-annual journal published 353 articles (3,659 pages in total) since its first issue in May 1993. A total of 37 issues were published with the average of 10.1 articles per issue. Most articles were written in the Korean language (94.9 %). In publication type of articles, 13.2 % were review articles, 66.7 % original articles, 18.0 % symposium articles, and the rest other types. In affiliation analysis, most authors were from the academia (91.0 %), next from the industry (5.8 %), and thirdly from the authority (2.3 %). The research field dealt with the highest (28.0 %) was Pharmockinetics/Pharmacodynamics/Pharmacometrics (PPP), core of clinical pharmacology. Many articles in PPP field contained the randomized controlled prospective clinical trials, which are the highest level of evidence, indicating high quality of articles. CONCLUSION: These results suggest that the Journal of Korean Society for Clinical Pharmacology and Therapeutics reflects typically the specialized journal for clinical pharmacology. The internationalization efforts for our journal is also required.
Hand Strength ; Pharmacology, Clinical ; Prospective Studies ; Publications ; Retrospective Studies

No abstract available.
Spinal Fractures*

The Journal of Korean Society for Clinical Pharmacology and Therapeutics (JKSCPT) as a peer-reviewed semi-annual journal has published lots of clinical pharmacology articles of various fields since its first issue in May 1993. Particularly, a number of high-quality articles such as randomized controlled prospective clinical trials have been presented in this journal. The JKSCPT currently has been also indexed in Scopus, one of the famous international bibliographic databases, and the candidate journal accredited by the National Research Foundation of Korea. Although the JKSCPT has accumulated outstanding achievements as the specialized journal for clinical pharmacology in Korea, it is also true that there are many problems to be solved in order to be a more internationally recognized journal. The methods to analyze the status of a journal for the academic society were first suggested in this article. The SWOT analysis on the current status of the JKSCPT was done for establishing future development strategies. Making references to these analyzing methods of a journal and SWOT analysis, numerous problems and the suggestions for the development of the JKSCPT were presented in detail. The future model of the journal for the academic society was also briefly discussed.
Achievement ; Databases, Bibliographic ; Korea ; Pharmacology, Clinical

OBJECTIVES: For the understanding and effective treatment of depressive symptoms in chronic schizophrenia, this study investigated the frequency of depressive symptoms and examined associations between depressive symptoms and positive symptoms, negative symptoms, general psychopathology in chronic schizophrenia. METHOD: The authors assessed the frequency of depressed schizophrenia with 30 or higher scores of HRSD in 135 DSM-IV chronic schizophrenia. We measured PANSS, BPRS in depressed(n=37) and non-depressed schizophrenia(n=37) who were matched in sex, age and dose of antipsychotics to compare positive, negative symptoms and other psychopathology. Also, we evaluated correlation between depressive symptoms and positive symptoms, negative symptoms, other psychopathology in depressed schizophrenic patients. RESULTS: 1) The depressive symptoms were present in 27.4% of chronic schizophrenia. 2) The positive scale of PANSS were significantly higher in depressed than in non-depressed schizophrenia(p<.01), and the negative scale of PANSS were higher in depressed schizophrenia but there were no statisical significance. Thinking disturbance and depressive-anxiety factors of BPRS were significantly higher in depressed than in non-depressed schizophrenia(p<.01, p<.01). 3) The positive and negative scale of PANSS correlated with HRSD in depressed schizophrenia(p<.01, p<.05), and thinking disturbance and depressive-anxiety factors correlated with HRSD in depressed schizophrenia(p<.01, p<.01). CONCLUSION: The depressive symptoms are relatively commom and important part of schizophrenic symptomatology, and they are more related to positive symptoms than negative symptoms of schizophrenia. Thus this study suggest that appropriate assessment and therapeutic intervention for depressive symptoms is especially necessary to the schizophrenic patients with severe positive symptoms.
Antipsychotic Agents ; Depression ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Psychopathology ; Schizophrenia* ; Thinking

Amphotericin B ; therapeutic use ; Antifungal Agents ; therapeutic use ; Fever ; Histoplasma ; Histoplasmosis ; diagnosis ; drug therapy ; microbiology ; pathology ; Humans ; Jaundice ; Male ; Middle Aged

No abstract available.
Catechols ; Cytochrome P-450 Enzyme System ; Cytochromes ; Fatty Alcohols ; Humans ; Liver ; Microsomes, Liver

Adult ; Ascites ; diagnosis ; etiology ; Biopsy ; Diagnosis, Differential ; Duodenal Obstruction ; diagnosis ; etiology ; Endoscopy, Gastrointestinal ; Enteritis ; complications ; drug therapy ; Eosinophilia ; complications ; drug therapy ; Gastritis ; complications ; drug therapy ; Humans ; Intestinal Mucosa ; pathology ; Male ; Tomography, X-Ray Computed

Accidental carbon monoxide poisoning in countries with cold climates is commonly related to indoor heating. This condition appears to be relatively uncommon in tropical Asian countries and therefore the diagnosis may be unsuspected. We report a case of a Malaysian patient who presented with a severe, and ultimately fatal, delayed (biphasic) neuropsychiatric syndrome due to carbon monoxide poisoning. The diagnosis was made only when a history compatible with carbon monoxide poisoning subsequently surfaced, and neuroimaging demonstrated the typical pallidal lesions, associated with marked leukoencephalopathy, seen in this condition. Our case is unique because the poisoning occurred in the setting of indoor operation of a portable electricity generator in a karaoke centre because of power failure. Karaoke is a highly popular form of entertainment in many parts of Asia and we suggest that a high index of suspicion of carbon monoxide poisoning is required in this setting.