One hundred and sixty seven cases of tumors of genito-urinary tract admitted during the period from Sept l959 to Aug. 1969 were studied statistically in the Department of Urology, Yonsei medical college hospital and following results were obtained. 1. During the period, 1,405 cases, (1,O49 males, 356 females) hospitalized, 167 cases (143 males and 24 females) had tumors of the genito-urinary tracts, giving a rate of 11.88% (male 10.17%, female 1.7l%), 2. In l67 cases of the genito-urinary tracts, 58 cases or 34.73% were benign tumors and 109 cases .or 65.27% were malignant tumors. 3. A gradual tendency of annual increase of the tumor is observed. 4. Of 167 cases 135 cases or 80.8% were seen by us at the age of 40 or more, and 32 cases or 19.2% at the age of 39 years or below. 5. Of the tumors, 56 cases or 33.53% were vasical, 54 cases or 32.82% prostatic, 23 cases or 13.75% renal, 10 cases or 5.88% penile, urethral and testicular, and 2 cases or 1.I3% ureteral and epididymal, the lowest 6, Transitional cell carcinoma of bladder is observed in 29.34% of all tumors, Squamous cell carcinoma of penis in 5.88%, Papilloma of urethra in 5. 39%, Adenoma of prostate in 4.17% and Seminoma of testis in 3.59%.
Adenoma ; Carcinoma, Squamous Cell ; Carcinoma, Transitional Cell ; Female ; Humans ; Male ; Papilloma ; Penis ; Prostate ; Seminoma ; Testis ; Ureter ; Urethra ; Urinary Bladder ; Urology

A case of seminoma of the cryptorchism, found in 34 years old Korean male is reported. In Campbell's series, the incidence of malignancy in cryptorchism is claimed to be 35 times greater than in the normally descended testicle. A case of seminoma of the cryptorchism is added to literature.
Adult ; Cryptorchidism* ; Humans ; Incidence ; Male ; Seminoma* ; Testis

The urodynamic studies of patients with benign prostatic hyperplasia has been useful in evaluating the degree of obstruction, the results of therapy and postprostatectomy syndromes. The urodynamic studies were performed in 30 patients with benign prostatic hyperplasia admitted to the Department of Urology, Kyung Hee University Hospital during the period from January, 1983 to July, 1984 The following results were obtained: 1. In 14 cases performed uroflowmetry, the maximal flow rate (7.1 (4.5 ml /sec) and the mean flow rate (2.6 ( 1.5 ml/sec) were very lower than normal 2. The cystometry and the anal sphincter electromyography were done in 29 cases. The results we- re as follows: The detrusor hyperreflexia in 12 cases, the detrusor-sphincter dyssynergia in 7 cases and normal in 10 cases were found. 3. In 29 cases performed the urethral pressure profilometry, the functional urethral length 15.4 ( 1.18 cm) and the prostatic length (4.38 (1.07 cm) were longer than normal but the maximal urethral closure pressure (62.3 (23.9 cm H2O) was similar to normal. 4. There was correlation statically between the prostatic length and the weight of removed adenoma in the group performed transurethral prostatectomy (r=0.49, p<0.05).
Adenoma ; Anal Canal ; Ataxia ; Electromyography ; Humans ; Prostatic Hyperplasia* ; Reflex, Abnormal ; Transurethral Resection of Prostate ; Urodynamics* ; Urology

Capasicin, a neurotoxin extracted from red peppers, has selective effects on peptide-containing C-fiber and induces the release of neuropeptides from sensory nerve endings. Mast cells and neuropeptide-containing nerve fibers occur in close proximity throughout in the airway mucosa, around blood vessls in the smooth muscle, and beneath the epithelium. Capsaicin stimuli trigger these sensory nerve fibers to release neuropeptides, which may then initiate the process of neurogenic inflammation. Neurogenic inflammation denotes the vasodilatation and vascular permeability changes that follow neuropeptide-induced mast cell antivation. The purpose of this study was to determine whether capsaincin could induce mast cell activation in vivo. For this, effects of capsaincin on the ear swelling of mouse, degranulation of skin and mesenteric mast cells, and vascular permeability of rat in vivo were measured. We found that in vivo capsaicin induced the ear swelling of mouse, degranulation of skin and mesenteric mast cells in a dose-dependent fashion. Additionally capsaicin caused to increase of vascular permeability. These results suggest that capsaicin induces inflammation through activations of mast cell.
Animals ; Capillary Permeability ; Capsaicin ; Capsicum ; Ear ; Epithelium ; Inflammation ; Mast Cells* ; Mice ; Mucous Membrane ; Muscle, Smooth ; Nerve Fibers ; Neurogenic Inflammation ; Neuropeptides ; Rats ; Sensory Receptor Cells ; Skin ; Vasodilation

No abstract available.
Apoptosis* ; Prostate* ; Prostatic Hyperplasia*

The causes of asymptomatic microscopic hematuria in adult male are variable. In spite of various urologic investigations, the causes of asymptomatic microscopic hematuria is not identified in most cases, and most of identified causes are benign nature. So, it is very hard to decide to what extent should the evaluation of these causes be carried. 2l,157 cases was visited to the Department of Health Service, Kyung Hee University Hospital from January, 1983 to December, 1984 for evaluation prior to occupy at foreign countries. Among 21,157 cases, 131 cases was checked IVP for asymptomatic microscopic hematuria. The results as follows: l. Among 21,157 cases, 131 cases were checked IVP for asymptomatic hematuria and male all. 2. The range of age in 131 cases of checked IVP was 22 to 52 year, average of age was 32.5 years. 3. IVP was revealed abnormal in l8 cases (13.7%), that 12 cases of urinary stone, 3 cases of wandering kidney, 2 cases of caliceal diverticulum and 1 case of old pyelonephritic scar. 4. Endoscopy was done in 12 cases of 113 cases that was revealed normal on IVP, but there was no abnormal findings. 5. 1 case that revealed normal IVP and proteinuria was diagnosed mesangial proliferative glomerulonephritis on renal biopsy. As above results, IVP is necessary for evaluation of asymptomatic microscopic hematuria in adult male. If IVP is normal no more studies are necessary.
Adult* ; Biopsy ; Cicatrix ; Diverticulum ; Endoscopy ; Glomerulonephritis ; Health Services ; Hematuria* ; Humans ; Kidney ; Male* ; Proteinuria ; Urinary Calculi ; Urolithiasis

Plasmodium vivax malaria re-emerged in South Korea in 1993, and epidemics continue since then. We examined genetic variation in the region encompassing the apical membrane antigen-1 (PvAMA-1) of the parasites by DNA sequencing of the 22 re-emerging P. vivax isolates. The genotype of the PvAMA-1, which was based on sequence data previously reported for the polymorphic regions, showed that two haplotypes were present at one polymorphic site. Compared with reported data, the two types, SKOR type I and type II, were similar to Chinese CH-10A and CH-05A isolates, respectively. Thus, the present study showed that two genotypes of AMA-1 genes coexist in the re-emerging Korean P. vivax.
Adult ; Aged ; Amino Acid Sequence ; Animals ; *Antigens, Protozoan ; Base Sequence ; Child ; Female ; Genotype ; Human ; Korea ; Malaria, Vivax/*genetics ; Male ; Membrane Proteins/chemistry/*genetics ; Middle Aged ; Molecular Sequence Data ; Polymorphism (Genetics) ; Protozoan Proteins/chemistry/*genetics ; Support, Non-U.S. Gov't

Toxoplasma gondii tachyzoites were isolated from the blood of an ocular patient, and have been successfully passaged in the laboratory, for over a year, by peritoneal inoculation in mice. The isolated parasite was designated the Korean Isolate-1 (KI-1) and its characteristics were compared with those of the RH strain, a wellknown virulent strain originating from a child who suffered from encephalitis. The morphology, pathogenicity, infectivity and cell culture characteristics of the KI-1 were similar to those of the RH strain. Both RH and KI-1 antigens were detected by an anti-T. gondii monoclonal antibody (mAb), Tg563, against the major surface protein SAG1 (30 kDa), whereas no reaction was observed against an anti-Neospora caninum mAb, 12B4. The KI-1 was confirmed as an isolate of T. gondii. A long-term laboratory maintenance and characterization of a local T. gondii isolate is reported for the first time in the Republic of Korea.
Animals ; Antigens, Protozoan/analysis ; Female ; Humans ; Korea ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron ; Middle Aged ; Parasitemia/parasitology ; Sarcoma 180 ; Serial Passage ; Specific Pathogen-Free Organisms ; *Toxoplasma/classification/growth & development/isolation & purification/pathogenicity ; Toxoplasmosis, Ocular/*diagnosis/parasitology ; Tumor Cells, Cultured ; Virulence

To determine the status of Enterobius vermicularis infection among children living on western and southern coastal islands of the Republic of Korea, children (3-10 years) in 39 kindergartens and primary schools were examined using the cello-tape anal swab method, during July and August 2000. Of 1, 661 children examined, 307 (18.5%) were found to be positive for E. vermicularis eggs. The highest infection rate (59.3%) was found in a kindergarten and a branch school of Shinyang primary school on Chujado, Jeju-do (Province). Remarkable differences in egg positive rates were observed in different localities. The egg positive rate for boys (21.3%) was significantly higher than that of girls (15.4%) (P = 0.02). However, positive rates were not significantly dependent on age. The results of the present study show that E. vermicularis infection is highly prevalent among pre-school and primary school children living on the western and southern coastal islands of the Republic of Korea, and indicate the need for efforts to control this infection.
Prevalence ; Parasite Egg Count ; Male ; Korea/epidemiology ; Humans ; Geography ; Female ; Feces/parasitology ; Enterobius/*isolation & purification ; Enterobiasis/*epidemiology/parasitology ; Child, Preschool ; Child ; Animals

A nationwide survey was performed to know the distribution and prevalence of human Gymnophalloides seoi infection on western and southern coastal islands in the Republic of Korea. A total of 4,178 fecal specimens were collected from residents on 45 (24 western and 21 southern) islands, and examined by Kato-Katz and formalin-ether sedimentation techniques. Eggs of G. seoi were detected from 160 (3.8%) people living on 22 (13 western and 9 southern) islands. The prevalence varied by the location of islands; higher on western islands than on southern islands. The highest prevalence was found on Amtaedo (25.3%), followed by Cheungdo (25.0%), and Anchwado (20.9%) (Shinan-gun). A little lower prevalence was observed on Munyodo (13.3%), Shinshido (12.9%), and Sonyudo (10.3%) (Kunsan-shi). Of the remaining islands, the regions showing the prevalence greater than 5% included Kohado, Dallido (Mokpo-shi), Pyeongildo, Kogumdo (Wando-gun), and Keogumdo (Kohung-gun). A strong age predilection was noted (P < 0.05); 95% of the infected people were over 40 years old. Females showed a little higher prevalence than males. The results indicate that human G. seoi infection is more widely distributed than previously considered. Nine of 11 islands (excluding the 2 known areas Munyodo and Sunyudo) that showed greater prevalence than 5% are regarded as new endemic foci of G. seoi.
Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Animals ; Child ; Child, Preschool ; Female ; Human ; Infant ; Intestinal Diseases, Parasitic/*epidemiology ; Korea/epidemiology ; Male ; Middle Aged ; Prevalence ; Sex Factors ; Support, Non-U.S. Gov't ; Trematode Infections/*epidemiology