No abstract available.
Follow-Up Studies* ; Lung Neoplasms* ; Lung*

Infections of the face, especially of the medial third or "the danger triangle", are the most frequent primary foci associated with thrombosis of cavernous sinus. Microorganisms entering the facial vein and pterygoid plexus from these sites are easily carried to the sinus through the ophthalmic vein. When the septic thrombosis involves various structures in the sinus, multiple clinical manifestations develop and if appropriate anti-infective therapy is not instituted timely, grave consequences with high mortality is possible. Recently, we experienced such a case. A five-year-old boy had high fever, proptosis, periorbital edema, chemosis and limitation of eye movements. Three days before admission, he had suffered from erythematous swelling spreading over the periorbital area, where simple steroid ointment containing no antibiotics had been applied after a furuncle on the nose had been squeezed. On admission, brain MRI revealed meningeal enhancement, high-signal densities in enlarged right cavernous sinus and narrowing of internal carotid artery. Analysis of cerebrospinal fluid showed bacterial meningitis and the cultures of blood and eye discharge proved to be Staphylococcus aureus. On massive antibiotic therapy, he recovered swiftly without any adverse sequelae. The authors report this case with a warning against wide-spread misuse of steroids and inadequate treatment of the mostly neglected, but once-dreaded minor infections on the face.
Anti-Bacterial Agents ; Brain ; Carotid Artery, Internal ; Cavernous Sinus Thrombosis* ; Cavernous Sinus* ; Cerebrospinal Fluid ; Edema ; Exophthalmos ; Eye Movements ; Fever ; Furunculosis* ; Humans ; Magnetic Resonance Imaging ; Male ; Meningitis, Bacterial ; Mortality ; Nose ; Staphylococcus aureus ; Steroids ; Thrombosis ; Veins

From 1989 to 1996, push back palatoplasty, 2-flap palatoplasty and Furlow's palatoplasty were the main procedures of cleft palate repair in our institute. To compare the maxillary growth state of patients in each palatoplasty group, evaluation of dental occlusion and cephalometric analysis were performed in total 50 patients. The results were as follows: 1. Normal control group was composed of 17 children who didn't have cleft lip or cleft palate. Mean values of cephalometric data in the normal control group were 6.19 cm in SN length, 1.17cm in ONA length, 7.29cm in effective maxillary length 53.88degree in SNO angle, and 82.41 degree in SNA angle. 2. Fourteen patients who underwent push-back palatoplasty showed anterior crossbite in all cases. SNO angle and SNA angle were significantly decreased compared to the normal control group, which indicated significant impairment of maxillary growth. 3. In seventeen patients who underwent 2-flap palatoplasty, 7 patients showed anterior crossbite. Cephalometric parameters showed no significant difference compared to the normal control group. 4. Nineteen patients underwent Furlow's palatoplasty. In this group, 3 patients had anterior crossbite. Cephalometric parameters showed no significant difference compared to the normal control group. Although this report was based on data acquired from patients before the age of complete maxillary growth, our results suggested that each palatoplasty would have a different influence on maxillary growth.
Child ; Cleft Lip ; Cleft Palate ; Dental Occlusion ; Facial Bones* ; Humans ; Malocclusion

Malignant transformation develops in a little less than 2% of mature cystic teratomas. A wide variety of malignant tumors may arise within benign mature cystic teratomas, and the most common of these is squamous cell carcinoma, which account for 75~85%. In general, the tumors are in an advanced stage and the prognosis is poor as most patients die within a year. However, when the tumor is confined to the ovary, they have a good prognosis and the 5-year survival rate is 63~83%. We experienced three cases of squamous cell carcinoma arising in mature cystic teratoma. Two of the carcinomas occurred in postmenopausal women: 58-(case 1) and 66-(case 2) year-old, and were confined to the ovaries. They were alive 37 months and 18 months after the operation, respectively. The third case was a 45-year-old premenopausal woman who had an extraovarian extension of the tumor and early recurrence within two months. Histologically, cases 1 and 3 were conventional well to moderately differentiated squamous cell carcinomas and case 2 showed a well-differentiated squamous cell carcinoma with exuberant proliferating trichilemmal tumor-like areas.
Carcinoma, Squamous Cell* ; Female ; Humans ; Middle Aged ; Ovary* ; Prognosis ; Recurrence ; Survival Rate ; Teratoma*

PURPOSE: Tracheal transplantation is necessary in patients with extensive tracheal stenosis caused by trauma, congenital disease, benign or malignant tumor. Results with the cryopreserved vascular homograft have prompted us to evaluate cryopreserved trachea. When trachea is cryopreserved, it maintains viability of the cartilage and allogenicity decreased because epithelium of trachea whitch has major allogenicity (MHC class II Antigen) is exfoliated after some periods of cryopreservation. We assessed the proper duration of cryopreservation and probability of trachea allotransplantation. METHODS: The trachea were harvested from Mongrel dogs and frozen to 80degrees C for different length preservation (group 1: 1~10 week, group 2: 1 month, 2 months, 3 months, 6 months, 2 months). Ggoup 1 was thawed and tested epithelial viability, Group 2 was perfomed trachea transplantation with cryopreserved trachea allograft, after one months We checked gross appearance, viability of cartilage and grade of monocyte infiltration (rejection). RESULTS: In group 1, Exfoliation of epithelium was begun after four weeks cryopreservation, in group 2, when allograft was extracted, trachea of 4 dogs was stenosed, and six months preserved trachea was not seen due to total necrosis. Cartilage viability of 4 case of transplantation, three of 4 case were mild infiltration of monocyte. CONCLUSION: We conclude that more than 1 month cryopreservation for prevention of rejection and additional procedure (omentopexy) for graft vascular supply are needed for trachea transplatation. Although cryopreservation was performed, all case of transplantation happened some degree graft rejection. if trachea transplantation will be applied, immune suppress will be needed.
Allografts* ; Animals ; Cartilage ; Cryopreservation ; Dogs* ; Epithelium ; Graft Rejection ; Humans ; Monocytes ; Necrosis ; Trachea* ; Tracheal Stenosis ; Transplants

Changes in microparticles (MP) from red blood cell (RBC) concentrates in the context of irradiation have not been investigated. The aim of this study was to evaluate how irradiation affects the number of MPs within transfusion components. Twenty RBC concentrates, within 14 days after donation, were exposed to gamma rays (dose rate: 25 cGy) from a cesium-137 irradiator. Flow cytometry was used to determine the numbers of MPs derived from RBC concentrates before and 24 hr after irradiation. The mean number of MPs (±standard deviation) in RBC concentrates was 21.9×10(9)/L (±22.7×10(9)/L), and the total number of MPs ranged from 2.6×10(9)/L to 96.9×10(9)/L. The mean number of MPs increased to 22.6×10(9)/L (±31.6×10(9)/L) after irradiation. Before irradiation, the CD41-positive and CD235a-positive MPs constituted 9.5% (1.0×10(9)/L) and 2.2% (263×10(6)/L) of total MPs, respectively. After irradiation, CD41-positive MPs increased to 12.1% (1.5×10(9)/L) (P=0.014), but the CD235a-positive MPs decreased to 2.0% (214×10(6)/L) of the total MPs (P=0.369). Irradiation increases the number of CD41-positive MPs within RBC concentrates, suggesting the irradiation of RBC concentrates could be associated with thrombotic risk of circulating blood through the numerical change.
Cell-Derived Microparticles/chemistry/*metabolism/radiation effects ; Erythrocytes/*cytology/radiation effects ; Flow Cytometry ; Gamma Rays ; Humans ; Membrane Glycoproteins/metabolism ; Metalloendopeptidases/metabolism ; Platelet Membrane Glycoprotein IIb/metabolism

PURPOSE: The Mammotome(R) biopsy is a relatively new surgical technique that is a minimally invasive image-guided procedure, requiring a small incision that produces a barely noticeable scar. The technique is a useful method for the surgical biopsy of properly selected patients. We reviewed the pathology of the biopsies for the proper selection of a mammotome biopsy in patients with re-excised breast tumors. METHODS: During a 24-month period, we performed vacuumassisted breast biopsies for 277 likely benign breast lesions using ultrasound and fine-needle aspiration cytology or a core needle biopsy, in 203 patients. The age of the patients ranged from 15 to 67 yr (average age 36.6 yr), and the average size of the lesions was 2.39+/-1.06 cm (minimum size 0.5 cm, maximum size 5.0 cm). We retrospectively analyzed the pathological findings of the re-excised breast lesions. RESULTS: The pathology of ultrasound-guided vacuum biopsies of the benign-appearing breast lesions were fibroadenomas (69.7%), intraductal papillomas (6.1%), fibrocystic disease (7.9%), phyllodes tumors (2.9%), malignant tumors (1.4%), ductal hyperplasia (2.9%), and other benign diseases (9.1%). Re-excision by a conventional method was performed for nine patients. Reasons for re-excision were the presence of five proven malignancies (a malignant phyllodes tumor in 2 cases, a tubular carcinoma in 1 case, a papillary carcinoma in 1 case and a ductal carcinoma in situ [DCIS] in 1 case), a possible atypical ductal hyperplasia (ADH) malignancy, two marginal involvement in phyllodes tumors and the possible extension of a lesion as an atypical papilloma. In the re-excised specimens, residual tissues were noticed in eight cases. An ADH lesion was proven as a DCIS. CONCLUSION: A case of suggested marginal involvements and/or a possible malignancy should be re-excised because of the high possibility of remnant lesions being present after the mammotome biopsy. The cytological and pathological review must be performed precisely before performing the mammotome procedures with considering of the clinical and radiological findings.
Adenocarcinoma ; Biopsy* ; Biopsy, Fine-Needle ; Biopsy, Large-Core Needle ; Breast Neoplasms ; Breast* ; Carcinoma, Intraductal, Noninfiltrating ; Carcinoma, Papillary ; Cicatrix ; Fibroadenoma ; Humans ; Hyperplasia ; Papilloma ; Papilloma, Intraductal ; Pathology ; Phyllodes Tumor ; Retrospective Studies ; Ultrasonography ; Vacuum

BACKGROUND: This article presents long-term outcomes after correcting secondary bilateral cleft lip nasal deformities using a refined reverse-U incision and V-Y plasty or in combination with a composite graft in order to elongate the short columella. METHODS: A total of forty-six patients underwent surgery between September 1996 and December 2008. The age of the patients ranged from 3 to 19 years of age. A bilateral reverse-U incision and V-Y plasty were used in 24 patients. A composite graft from the helical root was combined with a bilateral reverse-U incision in the 22 patients who possessed a severely shortened columella. The follow-up period ranged between 2 and 10 years. RESULTS: A total of 32 patients out of 46 were evaluated postoperatively. The average columella length was significantly improved from an average of 3.7 mm preoperatively to 8.5 mm postoperatively. The average ratio of the columella height to the alar base width was 0.18 preoperatively and 0.29 postoperatively. The postoperative basal and lateral views revealed a better shape of the nostrils and columella. The elongated columella, combined with a composite graft, presented good maintenance of the corrected position with no growth disturbance. A composite graft showed color mismatching in several patients. Twenty-six patients demonstrated no alar-columella web deformity and satisfactory symmetry of the nostrils. Four patients experienced a drooping and overhanging of the corrected alar-columella web. CONCLUSIONS: A bilateral reverse-U incision with V-Y plasty or in combination with a composite graft was effective in correcting secondary bilateral cleft lip nasal deformity.
Cleft Lip ; Congenital Abnormalities ; Follow-Up Studies ; Humans ; Nose ; Rhinoplasty ; Succinates ; Transplants

For the purpose of obtaining reference materials for the prevention and management of mental health promoting in industrial workers, this survey was investigated the relationship between subjective fatigue symptoms and its related factors such as demographic, job and health related variables. 442 cases of industrial workers which occurred in 7 factories of machine an4 metal manufacturing industrial in Taejon industrial area surveyed by self-recorded questionnaire. The results were as follows : 1. In the complaint raters of fatigue, "eye strain" was the highest (21.9%) and followed by "feel like tying" (12.4%) and "feel a pain in the low back" (12.4%), "feel drowsy" (12.2%), "yawning a lot"(11.8%) and "whole body feels tired" (11.1%) in the descending order. 2. In the average weighted scores of fatigue complaints, dullness and steepness group (I) was the highest, followed by difficulty in concentration group(II) and bodily projection of fatigue group(III) in the descending order. 3. The average weighted scores of fatigue complaints by general characteristics were significantly higher in the lower age group, lower education group and unmarried divorce group. But there was no significant difference in sex. 4. By the working condition, the fatigue scores were significantly higher in manual worker and shift worker than in clerical worker and day worker. 5. By the life style, the fatigue scores were significantly lower in 7-8 sleeping hour group and every day eating breakfast group than in other groups. But fatigue score of everyday alcohol drinking group and the lower health practice indecies group were significantly higher than that of other groups. 6. By the health status and psychological factors, the fatigue scores were higher in unhealthy group, unsatisfaction income level group, unsatisfaction worker contents group and the group of badly self-control in work. 7. In the stepwised multiple regression, factors affecting the fatigue symptoms scores were depression symptom score, health status, marital status, job satisfaction, job repeatedness and body mass index.
Alcohol Drinking ; Body Mass Index ; Breakfast ; Daejeon ; Depression ; Divorce ; Eating ; Education ; Fatigue* ; Humans ; Job Satisfaction ; Life Style* ; Marital Status ; Mental Health ; Psychology ; Questionnaires ; Single Person

The synchondrosis between the sixth and seventh costal cartilage is usually used for the base frame in autogenous ear reconstruction. If the synchondrosis is loose, a variety of modifications can be devised. This report introduces new methods for these problems. In cases of incomplete synchondrosis, only the surface of the base block margin was smoothly tapered without carving for the removal of the conchal deepening. The secure fixation of the two segments (helix and antihelix) to the base block using fine wire sutures gave stability to the unstable basal frame. After confirming that all the segments were assembled in one stable piece, the remaining conchal deepening of the basal framework was removed, and the outer lower portion of the basal cartilage was trimmed along its whole length. A total of 10 consecutive patients with microtia, ranging from 8 to 13 years old, were treated from 2008 to 2009. The follow-up period was 6 months to 2 years. Despite incomplete synchondrosis, the stable frameworks were constructed using the authors' method and aesthetically acceptable results were achieved. The proposed method can provide an easy way to make a stable cartilage framework regardless of the variable conditions of synchondrosis.
Cartilage ; Congenital Abnormalities ; Ear ; Ear Cartilage ; Follow-Up Studies ; Humans ; Sutures