1.The Effects of Succinylcholine on Serum Potassium in Patients with Spinal Cord Lesion.
Chae Ryung LIM ; Kyung Yeon YOO ; In Ho HA
Korean Journal of Anesthesiology 1990;23(3):443-449
Succinylcholine (Sch) has long been used to facilitate laryngoscopy and endotracheal intubation for general anesthesia, because of a rapid onset of intense but brief paralysis. However, exaggerated potassium (K+) release following Sch, sufficient to cause ventricular dysrhythmias and cardiac arrest, has sporadically been reported in susceptible conditions, including spinal cord injury, severe burn, massive trauma and neuromuscular disorder. And diazepam has been shown to attenuate the increase in serum K+ following Sch administration. The purpose of this study was to assess the effect of Sch on serum K+ in patients with spinal cord lesions, and to assess the effect of pretreatment with diazepam (0.05 mg/kg IV) on potassium flux. The results were as follows: 1) Baseline K+ values were not significantly different among the groups. 2) The time to peak increases in K+ was 3 minutes following Sch in all groups. 3) The magnitude of maximum increases in K' following Sch were 0.32 Eq/l, 0.63 mEq/l, 0.06 mEq/I and 1,10 mEq/I in group 1, group 2A, group 2B, and group 3, respectively. 4) Diazepam pretreatment attenuated the increases in K+ following Sch. From the above results, it can be concluded that Sch may safely be used to facilitate intubation in paraplegic patients, provided that they are normokalemic and pretreated with diazepam.
Anesthesia, General
;
Burns
;
Diazepam
;
Heart Arrest
;
Humans
;
Hypnotics and Sedatives
;
Intubation
;
Intubation, Intratracheal
;
Laryngoscopy
;
Paralysis
;
Potassium*
;
Spinal Cord Injuries
;
Spinal Cord*
;
Succinylcholine*
2.Central Venous Catheter-related Cardiac Tamponade in Premature Infants: A Report of Two Cases and a Literature Review.
Se Ryung YANG ; Hoon Bum SHIN ; Na Mi LEE ; Dae Yong YI ; Hyery KIM ; Sin Weon YUN ; Soo Ahn CHAE ; In Seok LIM ; Eung Sang CHOI
Korean Journal of Perinatology 2015;26(3):250-254
Although central catheter-related complications are frequently reported and are inevitable in the neonatal care unit, the incidence of pericardiac tamponade is low but may be fatal. Index of suspicion, prompt diagnosis, and urgent pericardiocentesis are crucial for lifesaving. We encountered two premature cases of central venous catheter-related pericardial tamponade. The first case was a 4-day-old male premature infant (gestational age [GA], 33(+5) weeks; birth weight [BW], 1,864 g), and the second case was a 4-day-old female premature infant (GA, 28(+6) week; BW, 1,050 g). Each infant had an indwelling central venous catheter since birth and at the third day of hospitalization. The conditions of the babies suddenly deteriorated, but both babies were successfully resuscitated with urgent echocardiography and prompt pericardiocentesis.
Birth Weight
;
Cardiac Tamponade*
;
Central Venous Catheters
;
Diagnosis
;
Echocardiography
;
Female
;
Hospitalization
;
Humans
;
Incidence
;
Infant
;
Infant, Newborn
;
Infant, Premature*
;
Male
;
Parturition
;
Pericardiocentesis
3.A Case of Hemophagocytic Lymphohistiocytosis with Clonal Karyotype Abnormalities.
Gae Ryung CHOI ; Ha Nui KIM ; Chi Hyun CHO ; Byoung Joon YOO ; Myung Han KIM ; Jang Su KIM ; Chae Seung LIM ; Kap No LEE
Laboratory Medicine Online 2011;1(2):110-114
There have been a few reports of hemophagocytic lymphohistiocytosis (HLH) with chromosomal abnormalities. Clonal chromosomal abnormalities in HLH patients are usually found in association with hematologic malignancies and rarely with epstein-barr virus (EBV) infection. Here, we report a fatal case of HLH with clonal karyotype abnormalities. A 75-yr-old man was admitted with persistent anorexia and high fever. Laboratory data revealed pancytopenia, hypofibrinogenemia, hyperferritinemia, prolonged prothrombin time and activated partial thromboplastin time, and marked elevated level of serum transaminases. In real time-PCR using whole blood, EBV DNA was not detected but cytomegalovirus (CMV) DNA was detected. The bone marrow aspiration smear showed hyperplasia of mature histiocytes with prominent hemophagocytosis. In chromosomal analysis of bone marrow aspirates, complex chromosomal abnormalities were found. In spite of steroid pulse therapy and antibiotic treatment, he died of disseminated intravascular coagulopathy.
Anorexia
;
Bone Marrow
;
Chromosome Aberrations
;
Cytomegalovirus
;
DNA
;
Fever
;
Hematologic Neoplasms
;
Herpesvirus 4, Human
;
Histiocytes
;
Humans
;
Hyperplasia
;
Karyotype
;
Lymphohistiocytosis, Hemophagocytic
;
Pancytopenia
;
Partial Thromboplastin Time
;
Prothrombin Time
;
Transaminases
4.Evaluation of ABO Antibody Titration Using Tube and Column Agglutination Techniques.
Chi Hyun CHO ; Ha Nui KIM ; Seung Gyu YUN ; Gye Ryung CHOI ; Jae Yeoul CHOI ; Jang Su KIM ; Chae Seung LIM ; Young kee KIM ; Kap No LEE
Laboratory Medicine Online 2011;1(1):57-63
BACKGROUND: ABO antibody titration is useful for the evaluation of ABO-incompatible bone marrow or solid organ transplantations, yet the results quite vary between different test methods used. We compared the results of microcolumn agglutination and tube methods. METHODS: Anti-A and anti-B isoagglutionin titers were determined in 63 healthy individuals (23 O, 20 A, and 20 B blood groups) using 4 different methods: immediate spin tube (tube), microcolumn agglutination without anti-human globulin (AHG) (CAT), tube with AHG (tube-AHG) and microcolumn agglutination with AHG (CAT-AHG). RESULTS: The median (range) titers of anti-A and anti-B in group O individuals by tube, CAT, tube-AHG, and CAT-AHG methods were 64 (8-512), 64 (8-512), 128 (8-2,048), and 128 (16-2,048); 64 (16-128), 128 (16-256), 128 (16-512), and 256 (16-512), respectively. The median (range) titers of anti-A in group B and anti-B in group A individuals by the four methods were 64 (16-128), 128 (8-128), 128 (8-256), and 256 (8-256); 64 (8-128), 64 (8-128), 32 (8-128), and 64 (8-256), respectively. The isoagglutinin titer measured by CAT-AHGmethod was the highest. The titers measured by CAT and CAT-AHG methods were 0-1 titer higher than those by tube and tube-AHG methods, respectively. Whatever method was used, the isoagglutinin titers were higher in women than in men. CONCLUSIONS: CAT-AHG was the most sensitive method among the four methods tested. Since AHG titer values are critical for the clinical management and CAT has less manual procedures than tube method, CAT-AHG method could be used for the standardization of ABO antibody titration in different institutions.
Agglutination
;
Animals
;
Bone Marrow
;
Cats
;
Female
;
Humans
;
Organ Transplantation
;
Transplants
5.The effects of a newsletter on bedding control on house dust mite allergen concentrations in childcare centers in Korea.
Jeonghoon KIM ; Kyoung Yong JEONG ; Ho Jang KWON ; Heasuk YANG ; Hye Yung YUM ; Seon Ah LEE ; Chae Bong KIM ; Hyunjung KIM ; Wan Ryung LIM ; Soyoung HONG ; Kyoosang KIM
Environmental Health and Toxicology 2015;30(1):e2015008-
OBJECTIVES: Bedding in childcare centers (CCCs) can hold house dust mite (HDM) allergens. This study examined whether HDM allergen levels can be reduced through the distribution of an educational newsletter on bedding control to parents of CCC children in Korea. METHODS: All 38 CCCs were measured for Der 1 (sum of Der f 1 and Der p 1) concentrations on classroom floors and bedding before the intervention. Educational newsletters on children’s bedding control were sent to 21 CCCs by mail, and teachers were asked to distribute the newsletters to the parents of the children (intervention group). The remaining 17 CCCs were not sent newsletters (control group). The measurement of Der 1 concentrations in 38 CCCs was repeated after the intervention. Dust samples were collected with a vacuum cleaner and analyzed using enzyme-linked immunosorbent assay methods. RESULTS: The Der 1 concentrations on the bedding were significantly higher than those on the floors in 38 CCCs at baseline (p<0.05). Although changes of the Der 1 concentrations for the control group (n=17) were not significant, Der 1 concentrations for the intervention group (n=21) decreased significantly from 2077.9 ng/g dust to 963.5 ng/g dust on the floors and from 3683.9 ng/g dust to 610.4 ng/g dust on bedding (p<0.05). CONCLUSIONS: The distribution of educational newsletters on bedding control to parents may be an effective means of controlling HDMs in CCCs.
Allergens
;
Child
;
Dust*
;
Enzyme-Linked Immunosorbent Assay
;
Humans
;
Korea*
;
Parents
;
Periodicals as Topic*
;
Postal Service
;
Pyroglyphidae*
;
Vacuum
6.The effects of a newsletter on bedding control on house dust mite allergen concentrations in childcare centers in Korea.
Jeonghoon KIM ; Kyoung Yong JEONG ; Ho Jang KWON ; Heasuk YANG ; Hye Yung YUM ; Seon Ah LEE ; Chae Bong KIM ; Hyunjung KIM ; Wan Ryung LIM ; Soyoung HONG ; Kyoosang KIM
Environmental Health and Toxicology 2015;30(1):e2015008-
OBJECTIVES: Bedding in childcare centers (CCCs) can hold house dust mite (HDM) allergens. This study examined whether HDM allergen levels can be reduced through the distribution of an educational newsletter on bedding control to parents of CCC children in Korea. METHODS: All 38 CCCs were measured for Der 1 (sum of Der f 1 and Der p 1) concentrations on classroom floors and bedding before the intervention. Educational newsletters on children’s bedding control were sent to 21 CCCs by mail, and teachers were asked to distribute the newsletters to the parents of the children (intervention group). The remaining 17 CCCs were not sent newsletters (control group). The measurement of Der 1 concentrations in 38 CCCs was repeated after the intervention. Dust samples were collected with a vacuum cleaner and analyzed using enzyme-linked immunosorbent assay methods. RESULTS: The Der 1 concentrations on the bedding were significantly higher than those on the floors in 38 CCCs at baseline (p<0.05). Although changes of the Der 1 concentrations for the control group (n=17) were not significant, Der 1 concentrations for the intervention group (n=21) decreased significantly from 2077.9 ng/g dust to 963.5 ng/g dust on the floors and from 3683.9 ng/g dust to 610.4 ng/g dust on bedding (p<0.05). CONCLUSIONS: The distribution of educational newsletters on bedding control to parents may be an effective means of controlling HDMs in CCCs.
Allergens
;
Child
;
Dust*
;
Enzyme-Linked Immunosorbent Assay
;
Humans
;
Korea*
;
Parents
;
Periodicals as Topic*
;
Postal Service
;
Pyroglyphidae*
;
Vacuum
7.Using Genotyping to Identify an A1B(weak) Blood Group.
Chi Hyun CHO ; Byong Joon YOO ; Seung Gyu YUN ; Gye Ryung CHOI ; Jae Yeoul CHOI ; Jang Su KIM ; Chae Seung LIM ; Young Kee KIM ; Kap No LEE
Korean Journal of Blood Transfusion 2010;21(2):158-164
Since an exact ABO blood type match is essential for transfusion therapy, any ABO discrepancies should be resolved prior to the issuing of blood. The authors confirmed the ABO blood group of a 50-year-old male using genotyping. On a routine blood group test, the cell type was A+; however, anti-B was undetected in his serum. To determine the cause of this ABO discrepancy, an adsorption elution test and saliva test were performed. The presence of a weak B substance was suspected despite no evidence of the B antigen on red blood cells. Polymerase-chain-reaction restriction-fragment-length-polymorphism (PCR-RFLP) and sequencing analysis of exons 6 and 7 demonstrated that his blood type was A1Bweak (the A allele tested as the A105 subtype, while the B allele was most similar to the B302 subtype). Again, using genotyping, we subsequently confirmed the A1Bweak blood type in a leukemic patient who was in complete remission.
Adsorption
;
Alleles
;
Erythrocytes
;
Exons
;
Humans
;
Leukemia
;
Male
;
Middle Aged
;
Saliva
8.Characteristics of Intron 6 Nucleotide Sequences of cis-AB in Koreans.
Ha Nui KIM ; Hye Jin LEE ; Gye Ryung CHOI ; Myung Han KIM ; Jang Su KIM ; Chae Seung LIM ; Young Kee KIM ; Kap No LEE
Korean Journal of Blood Transfusion 2010;21(3):230-235
BACKGROUND: The cis-AB is a very rare phenotype in the ABO blood group system. It corresponds to a special ABO allele that encodes glycosyltransferase that is capable of synthesizing both A and B antigens. Until now, the exon 6 and 7 gene sequences of cis-AB alleles are well known. In this study, we report on the intron 6 sequence structure of the cis-AB allele. METHODS: Standard serologic tests for the ABO blood group phenotypes were performed in four cis-AB samples. Allele-separation by cloning and subsequent sequencing was carried out. RESULTS: The results showed that intron 6 of cis-AB is almost identical to the A101 allele except for three single nucleotide polymorphisms at nucleotide positions 163, 179 and 662, where the nucleotides of the A101 replace those of B101. CONCLUSION: The intron 6 sequences of cis-AB in Koreans have both A101 and B101 blood group sequences.
ABO Blood-Group System
;
Alleles
;
Base Sequence
;
Blood Grouping and Crossmatching
;
Clone Cells
;
Cloning, Organism
;
Exons
;
Introns
;
Nucleotides
;
Phenotype
;
Polymorphism, Single Nucleotide
;
Serologic Tests
9.Unraveling the diagnostic odyssey: stimulator of interferon gene-associated vasculopathy with onset in infancy in a 30-year-old female
Hae Ryung KIM ; Seon Hee LIM ; Ji Soo PARK ; Dong In SUH ; Seungbok LEE ; Soo Yeon KIM ; Jong Hee CHAE ; Seong Heon KIM
Journal of Rheumatic Diseases 2024;31(3):182-187
Stimulator of interferon gene (STING)-associated vasculopathy with onset in infancy (SAVI) is an extremely rare autoinflammatory disease. We present the case of a female Korean patient with early-onset interstitial lung disease who was initially suspected to have systemic lupus erythematosus (SLE) but was ultimately diagnosed with SAVI. The patient exhibited signs of interstitial lung disease and cutaneous manifestations before the age of 1 year and continued to have recurrent fever accompanied by pulmonary infiltrates. Based on positive findings for antibodies associated with SLE, such as antinuclear antibodies and anti-double-stranded DNA, the pulmonary involvement was considered a manifestation of SLE. Another significant symptom was recurrent skin ulceration, which led to partial spontaneous amputation of most of the toes due to inflammation. Given the early onset of interstitial lung disease, severe skin ulcers, and symptoms resembling SLE, autoinflammatory syndrome, especially SAVI was suspected.Following confirmation by genetic testing at age 29 years, the patient was started on tofacitinib, a Janus kinase inhibitor. Despite the prolonged use of multiple immunosuppressive therapies, the patient’s lung condition continued to worsen, ultimately requiring lung transplantation. This observational report highlights the importance of considering SAVI as a potential diagnosis when manifestations of interstitial lung disease are observed during infancy. Early proactive treatment is crucial for lung involvement, as this can have long-term effects on patient’s prognosis.
10.The Development of the 'Mental Fitness' Scale.
So Hyun CHO ; Jong Min WOO ; Won KIM ; Keum Ryung BYUN ; Eun Ho KANG ; Sam Wook CHOI ; Soo Young BANG ; Seung Hwan LEE ; Young Min PARK ; Jeong Ho CHAE ; Seong Kyeon LIM ; Kyeong Sook CHOI
Journal of Korean Neuropsychiatric Association 2011;50(2):116-124
OBJECTIVES: The purpose of this study was to develop and validate the 'Mental Fitness'Scale, which was designed to measure the characteristics of being mentally fit or positive mental health. METHODS: Interviews using open-ended questions were conducted on 105 healthy adults between 20 and 65 years of age to obtain the 25 candidate items of the 'Mental Fitness' Scale. To evaluate the validity of the new scale, these items and the Beck Depression Inventory (BDI), the Positive and Negative Affect Scale (PANAS), and the Epworth Sleepiness Scale(ESS) were administered to 212 healthy adults. To assess test-retest reliability, the preliminary 'Mental Fitness' Scale items were administered two weeks later to 47 healthy subjects selected by random sampling. A comparison was made between the 212 healthy subjects and 42 psychiatric patients with depressive or anxiety disorders. RESULTS: Factor analysis yielded four subscales (mental energy, empathic communication, flexibility, and self-assurance). Five items were excluded due to their low factor loadings. The test-retest reliability coefficients were significantly high, ranging between 0.57-0.76. Internal consistency was computed, and Cronbach's alpha for four subscales ranged between 0.66-0.88, and was 0.90 for the total score. Concurrent validity was assessed by correlating the four subscales and the total score with total scores on the BDI, PANAS, and ESS. The correlations were all at significant levels. CONCLUSION: These results indicate that the 'Mental Fitness' Scale is a reliable and valid instrument for assessing positive mental health.
Adult
;
Anxiety
;
Depression
;
Humans
;
Mental Health
;
Pliability