1.Immunohistochemical Study of p53 Protein Expression in Colorectal Tumors.
Mi Sook LEE ; Chae Hong SUH ; Sung Chul LIM
Korean Journal of Pathology 1996;30(7):595-603
The aims of this study were to assess the role of p53 overexpression in colorectal tumorigenesis and the association with clinicopathological features. The immunohistochemical results were semiquantitatively assessed. Expression of aberrant p53, tumor-suppressor gene product, was studied immunohistochemically using a monoclonal antibody in 11 nonneoplastic polyps, 19 tubular adenomas, 9 villous adenomas, and 48 colorectal carcinomas. Five out of 11 nonneoplastic polyps, 14 out of 19 tubular adenomas and one out of 9 villous adenomas expressed p53 protein. Seven out of 24 colorectal carcinomas without lymph node metastasis and 14 out of 24 colorectal carcinomas with lymph node metastsis expressed p53 protein. The case of more than 75% positivity of p53 in colorectal carcinoma with lymph node metastasis was seven out of 24, but that in lymph node negative group was two out of 24. In the colorectal carcinoma with lymph node metastasis group; metastatic intranodal neoplastic cells were expressed positively for p53 in 10 out of 14 cases and zero out of 10 cases in group of positive and negative expression of primary lesions, respectively. p53 protein expression was not significantly correlated with variable clinicopathologic features such as age, sex, tumor location, tumor size, differentiation and Dukes' stage. It is suggested that p53 protein overexpression could be a early event in pathogenesis of colon cancer but is not involved in progression of villous adenoma to adenocarcinoma. p53 overexpression seems to be involved in metastatic ability of colorectal carcinomas.
Adenoma
;
Neoplasm Metastasis
;
Cell Transformation, Neoplastic
2.Clinical Efficacy of Individual Cognitive Behavioral Therapy for Patients with Primary or Secondary Insomnia.
Youn Mi SHIN ; Boseok CHA ; Chae Mi LIM ; Hong Beom SHIN
Sleep Medicine and Psychophysiology 2010;17(1):34-40
OBJECTIVES: This study aimed to evaluate the clinical efficacy of individual cognitive behavioral therapy (CBT) for Patients with Primary or Secondary Insomnia. METHODS: Participants were recruited from a primary care sleep clinic from January 2008 to June 2009. The study sample included 64 outpatients with primary insomnia (n=30) and secondary insomnia (n=34) according to the criteria of DSM-IV. Participants completed sleep diaries, Dysfunctional Beliefs and Attitudes about Sleep Scale-16 (DBAS), State-Trait Anxiety Inventory (STAI) before CBT and shortly after completion of CBT. CBT was provided in 7 weekly, 40-50-minute individual therapy sessions. RESULTS: Both groups of patients with primary and secondary insomnia showed significant improvement in the DBAS and sleep parameters including sleep onset latency, total sleep time, and sleep efficiency. Repeated-measures ANOVA of the DBAS and sleep parameters showed no significant group-by-time interactions between patients with primary and secondary insomnia, suggesting the efficacy of CBT for patients with secondary insomnia was equivalent to that of CBT for patients with primary insomnia. CONCLUSION: This study suggests that CBT is effective for the management of primary and secondary insomnia in a primary care setting.
Anxiety
;
Cognitive Therapy
;
Diagnostic and Statistical Manual of Mental Disorders
;
Humans
;
Outpatients
;
Primary Health Care
;
Sleep Initiation and Maintenance Disorders
3.Overexpression of p53 Protein in Endometrial Hyperplasia and Adenocarcinoma.
Yun Sin KIM ; Mi Sook LEE ; Sung Chul LIM ; Jang Shin SOHN ; Chae Hong SUH
Korean Journal of Pathology 1997;31(7):655-661
Proliferations of the endometrial glands form a continuum from focal glandular crowding through simple hyperplasia, complex hyperplasia and atypical hyperplasia to frank adenocarcinoma. But objective criteria to distinguish these proliferative endometrial lesions are not clear-cut and terminology is confusing. The p53 protein is a nuclear phosphoprotein that can regulate cell proliferation and suppress tumor growth. Mutation in the p53 gene have been reported in a variety of human tumors, and in selected malignancies overexpression of p53 has been associated with poor prognosis. In this study we examined a series of endometrial proliferative lesion, including hyperplasia, adenocarcinoma, and adenomyosis to determine whether or not p53 is overexpressed in these lesions. In the result, p53 immunoreactivity was observed in 3 of 17 (17.6%) simple hyperplasia, one of 6 (16.6%) complex hyperplasia, none of 3 (O%) atypical hyperplasia, 6 of 13 (46.1%) adenocarcinoma and none of 10 (O%) adenomyosis. In conclusion, p53 mutation seems to play a role in oncogenesis of endometrial adenocarcinoma in early phase but there was no significant relationship between p53 overexpression and histologic grade of adenocarcinoma.
Adenocarcinoma*
;
Adenomyosis
;
Carcinogenesis
;
Cell Proliferation
;
Crowding
;
Endometrial Hyperplasia*
;
Female
;
Genes, p53
;
Humans
;
Hyperplasia
;
Prognosis
4.The evaluation of functional status and quality of life of end stage renal failure patients undergoing hemodialysis in SNHA lifetimehealth monitoring program.
Hyun Sook KIM ; Yoon Mi WON ; Kyung Mi PARK ; Chae Gab LIM ; Ho Cheol SHIN ; Eun Sook PARK
Journal of the Korean Academy of Family Medicine 1992;13(5):450-459
No abstract available.
Humans
;
Quality of Life*
;
Renal Dialysis*
;
Renal Insufficiency*
5.A case of bone cryptococcosis in a patient with SLE.
Sang Won SHIN ; Sae Yong KANG ; Heung Jeong WOO ; Yoon Sang CHOI ; Woo Joo KIM ; Seung Chull PARK ; Chae Seung LIM ; Jun Mi KIM ; Yang Seuk CHAE
Korean Journal of Infectious Diseases 1991;23(3):201-206
No abstract available.
Cryptococcosis*
;
Humans
6.A Case of Neonatal Alloimmune Thrombodytopenia Due to Anti - HLA Antibody.
Mi Kyung KIM ; Young Kyoo SHIN ; Baik Lin EUN ; Kwang Chul LEE ; Chae Seung LIM ; Hong Bum OH
Journal of the Korean Society of Neonatology 1998;5(1):113-116
Anti-HLA antibody related neonatal thrombocytopenia is an uncommon disorder caused by platelet antigen incompatibility between mother and fetus in Korea. Mothers who lack the specific platelet antigen produce the IgG against the platelet antigen which the fetus inherits from the father. These IgG antibodies are then transported across the placenta into the fetal circulation where they lead to the destruction of fetal platelets. We report a case of neonatal alloimmune thrombocytopenia related with anti-HLA antibody in second baby of dizygotic twin who had petechia on trunk and platelet count 43,000/mm. Initially, mother and twin showed the positives in antiplatelet antibodies. In microlym- phocytotoxic test at 6 months of age, anti-HLA antibodies was negative in twins but anti-HLA A2, A24 was positive in their mother. The patient was treated with intravenous immunoglobulin and clinically improved and her platelet count was norrnalized.
Antibodies
;
Blood Platelets
;
Fathers
;
Fetus
;
Humans
;
Immunoglobulin G
;
Immunoglobulins
;
Infant, Newborn
;
Korea
;
Mothers
;
Placenta
;
Platelet Count
;
Thrombocytopenia, Neonatal Alloimmune
;
Twins
;
Twins, Dizygotic
7.Etiology of Pediatric Healthcare-associated Infections in a Single Center (2007-2011).
Ki Wook YUN ; Mi Kyung LEE ; Sin Weon YUN ; Soo Ahn CHAE ; In Seok LIM ; Eung Sang CHOI ; Byoung Hoon YOO
Korean Journal of Nosocomial Infection Control 2012;17(1):13-20
BACKGROUND: Healthcare-associated infections (HAIs) are among the most important threats to patient safety. When hospitalized children face these threats, there is morbidity, mortality, prolonged hospitalization, and increased healthcare costs. Research on local healthcare epidemiology is necessary to enhance collective knowledge and evidence formanaging this problem. METHODS: We performed a retrospective analysis of databases of patients who were diagnosed with HAIs at Chung-Ang University Hospital (CAUH) from 2007 through 2011. Cases were selected from the microbiology registry databases. The data on prevalence of HAIs in various wards and its annual trends were compared to previously reported nationwide data. Moreover, we analyzed the patterns of antibiotic susceptibility results for HAI pathogens. RESULTS: A total of 181 HAIs were identified in 122 patients. The HAI rate among pediatric patients at CAUH was 2.4/1,000 person-hospital days. Urinary tract infections (UTIs) (53 episodes, 29.3%) were the most common, followed by pneumonia (33 episodes, 18.2%). Staphylococcus aureus was found to be the most common gram-positive organism, whereas Escherichia coli was the most common gram-negative organism. Methicillin-resistant S. aureus (MRSA) comprised 84% of the S. aureus infections. Imipenem resistance was detected in 58.8% and 55.0% of Acinetobacter baumannii and Pseudomonas aeruginosa isolates, respectively. CONCLUSION: Between 2007 and 2011, UTIs were the most common type of HAIs, and MRSA was the most common pediatric HAI pathogen, both in the general ward and intensive care unit at the CAUH. Further research on the epidemiology and pathogenesis of HAIs is necessary and prevention measures should be implemented to prevent HAIs in children.
Acinetobacter baumannii
;
Child
;
Child, Hospitalized
;
Delivery of Health Care
;
Escherichia coli
;
Health Care Costs
;
Hospitalization
;
Humans
;
Imipenem
;
Intensive Care Units
;
Methicillin Resistance
;
Methicillin-Resistant Staphylococcus aureus
;
Microbial Sensitivity Tests
;
Patient Safety
;
Patients' Rooms
;
Pneumonia
;
Prevalence
;
Pseudomonas aeruginosa
;
Retrospective Studies
;
Staphylococcus aureus
;
Urinary Tract Infections
8.Paragonimiasis Involving the Female Genital Tract and Cul De Sac: A case report.
Mi Sook LEE ; Yun Sin KIM ; Sung Chul LIM ; Keun Hong KEE ; Ho Jong JEO ; Chae Hong SUH
Korean Journal of Pathology 1996;30(5):457-459
Paragonimiasis caused by Paragonimus westermani is essentially a pulmonary disorder, but it is also known to cause ectopic parasitism at various sites in human host such as the brain, muscle, liver, spinal cord and spleen. Ectopic parasitism of the female genital tract, especially the ovary is relatively rare. We have experienced a case of a 62-year-old Korean woman with asymptomatic ectopic paragonimiasis in the salpinx , ovary, and cul de sac.
Female
;
Humans
9.Evaluation for effectiveness of oriental medicine-based infertility treatment and spontaneous pregnancy rate of infertile patients using systematic review
Jiseun LIM ; Jae Hyun KIM ; Yoo Mi CHAE
Journal of the Korean Medical Association 2019;62(12):645-652
This study is to evaluate the effectiveness of oriental medicine-based infertility treatment and to examine the validity of the oriental medicine-based infertility treatment program through a systematic review. The literature search database included not only PubMed, DBpia, and RISS (Research Information Sharing Service) but also OASIS (Oriental Medicine Advanced Searching Integrated System) and Korean Traditional Knowledge Portal. Among 575 articles that searched, only three papers were randomized controlled trials and could be included for the evaluation of the effects of oriental medicine-based infertility treatment. There was no study showing the effectiveness of oriental medicine-based infertility treatment alone. Among 5,165 articles that searched, only 15 studies could be included for the evaluation of the natural pregnancy rate of infertile patients. These studies reported the natural pregnancy rates from 20.3% to 41.9%. As pregnancy rates ranged from 23.8% to 27.6% after the oriental medicine-based infertility treatment supporting programs, we cannot conclude that pregnancy rates for infertile patients might increase by this project. Therefore, there is a need to reconsider whether the oriental medicine-based infertility treatment program should continue in the future.
10.Analysis and suggestions on medical educators’ roles
Meeran JOO ; Yoo-mi CHAE ; Man-Sup LIM ; Seok-gun PARK
Korean Journal of Medical Education 2021;33(4):411-417
Purpose:
This study aimed to investigate the differences in the perception between professors and students regarding medical educators’ roles and discuss their desirable roles.
Methods:
A survey was administered to 116 professors and 379 students of the medical colleges from Dankook University and Hallym University. The subjects were given a self-created questionnaire designed to measure their perception of medical educators’ roles.
Results:
First, “student performance management” for professors and “teaching skill development” for students were recognized as the most essential medical educators’ role. Second, females students perceived the roles to be more important than males in eight of 10 roles.
Conclusion
First, “student performance management” for professors and “teaching skill development” for students were recognized as the most essential medical educators’ role. Second, females students perceived the roles to be more important than males in eight of 10 roles.