OBJECTIVETo explore the anti-aging effect of artemisia burning products (ie. smoke of moxibustion) and its proper intervention parameters.

METHODSAccording to factorial experiment design, 70 SAMP8 mice were randomly divided into one model group (group M) and 6 intervention groups: low concentration with 15 min group (group A1), low concentration with 30 min group (group A2), middle concentration with 15 min group (group B1), middle concentration with 30 min group (group B2), high concentration with 15 min group (group C1), high concentration with 30 min group (group C1). There were 10 cases in each group. Ten age-matched SAMR1 mice were used as normal group (group Z). All the mice in the 6 intervention groups were fumed with artemisia burning products of different concentration and time. The content of serum malondialdehyde (MDA), the activity of superoxide dismutase (SOD) and glutathione reductase (GSH-Px) were tested.

RESULTSMDA content in group M was significantly higher than that in group Z (both P < 0.05), while SOD and GSH-Px activity were significantly lower in group M than that in group Z (both P < 0.05). Results of MDA, SOD and GSH-Px in 6 intervention groups were either of no statistically significant differences, or better than that in group M. Among 6 intervention groups, results of MDA and GSH-Px were better in group B1, while the result of SOD was better in group B2. Time factor didn't make any difference, while concentration of artemisia burning products is meaningful. As to SOD and GSH-Px, there's a strong interaction between the two factors.

CONCLUSIONWith certain concentration and time period, the intervention of artemisia burning products can exert anti-aging effect by increasing antioxydative capability and reducing metabolites of free radicals. Middle concentration and 30 minutes are recommended when intervened with artemisia burning products.

Aging ; blood ; metabolism ; Animals ; Antioxidants ; metabolism ; Artemisia ; chemistry ; Disease Models, Animal ; Glutathione Peroxidase ; blood ; Glutathione Reductase ; blood ; Humans ; Male ; Malondialdehyde ; blood ; Mice ; Moxibustion ; Superoxide Dismutase ; blood

Objective To investigate the clinical efficacy of alanyl glu-tamine injection on the prevention and treatment of chemotherapy -in-duced oral mucositis in patients with malignant lymphoma.Methods A total of 130 cases suffering from chemotherapy of malignant lymphoma were divided into treatment group(n=65) and control group(n=65).Both groups were given sodium bicarbonate solution gargled.Patients in control group were given 12.5% sodium bicarbonate solution gargle, 3 times a day.And patients in treatment group were given alanine gluta-mine injection 20 g· d -1 for 1 week on the basis of control group.After the chemotherapy cycle, the incidence of oral mucositis and stomatitis cure time were compared between the two groups.Results The chemo-therapy-induced oral mucositis rate were 35.38%and 46.15%in treat-ment group and control group, with statistical difference( P<0.05).The cure time for grade Ⅲ chemotherapy -induced oral mucositis were (8.25 ±0.96), ( 11.17 ± 1.47 ) d, with statistical difference ( P<0.05).There was no drug related adverse reaction during the treat-ment.Conclusion Alanyl glutamine injection combined with sodium bi-carbonate gargled has a significantly preventive and therapeutic effect on chemotherapy-induced oral mucositis in patients with malignant lymphoma.