1.Two Cases of Slipped Capital Femoral Epiphysis in Children Receiving Growth Hormone Therapy.
Hwan Seok LEE ; Eun Ae YANG ; Eun Hui HONG ; Min Hyun CHO ; Cheol Woo KO
Journal of Korean Society of Pediatric Endocrinology 2009;14(2):163-167
Slipped capital femoral epiphysis is a rare hip disorder that mainly occurs in pubertal children. Although the exact cause of this disorder is unknown, it is known to be associated with obesity, trauma, delayed sexual development, delayed bone maturation, chronic renal failure, genetic diseases, endocrine disorders (growth hormone deficiency, hypothyroidism, hypogonadism), growth hormone therapy, and gonadotropin releasing hormone agonist (GnRH agonist) therapy. We report 2 cases of slipped capital femoral epiphysis in adolescent females who were receiving growth hormone therapy. The first case is of a 16 year-old-girl with chronic renal failure and renal osteodystrophy. The second case is of an 11 year-old-girl with idiopathic precocious puberty who had received GnRH agonist and growth hormone therapy. Unilateral or bilateral slipped capital femoral epiphysis developed at 1 year 3 months after treatment in both the cases. The chief complaints were pain in the hip joint and lower extremities. Growth hormone and/or GnRH agonist therapy was stopped, and in situ screw fixations of the involved hip epiphyses were performed.
Adolescent
;
Child
;
Endocrine System Diseases
;
Epiphyses
;
Female
;
Gonadotropin-Releasing Hormone
;
Growth Hormone
;
Hip
;
Hip Joint
;
Humans
;
Hypothyroidism
;
Kidney Failure, Chronic
;
Lower Extremity
;
Obesity
;
Puberty, Precocious
;
Renal Osteodystrophy
;
Sexual Development
;
Slipped Capital Femoral Epiphyses
2.A Case of Sarcoidosis Associated with Non-tuberculous Mycobacteria
Seung Hui SEOK ; Jung U SHIN ; Hyun Jung KIM ; Hee Jung LEE ; Moon Soo YOON ; Dong Hyun KIM
Korean Journal of Dermatology 2020;58(7):483-486
Sarcoidosis is a multisystem granulomatous disease of unknown etiology. A range of factors including tuberculous infection, beryllium exposure, and cold climate have been implicated in the pathogenesis of the condition. A 45-year-old woman presented with a 4-month history of an asymptomatic eyelid swelling and multiple erythematous papules on the neck. Histological examination of the neck, orbital soft tissue, and lacrimal gland was consistent with sarcoidosis. Ziehl−Neelsen stains and polymerase chain reactions (PCRs) for tuberculosis on the skin biopsy specimens were negative. However, the orbital soft tissue specimen was positive for non-tuberculous mycobacteria (NTM) PCR. The patient was finally diagnosed with sarcoidosis associated with NTM. Treatment with systemic steroid and hydroxychloroquine was started, resulting in an improvement of skin lesions. We herein report a case of sarcoidosis associated with NTM infection with review of the literature, as only little is known regarding the role of mycobacteria in sarcoidosis.
3.Analysis of Vulvar Dermatoses Presenting as Vulvar Pruritus: A Single-Center Retrospective Study
Seung Hui SEOK ; Jung U SHIN ; Dong Hyun KIM ; Moon Soo YOON ; Hee Jung LEE
Korean Journal of Dermatology 2021;59(7):527-533
Background:
Vulvar pruritus is a common complaint among women presenting to dermatologists. However, few studies have analyzed the dermatologic conditions that cause it.
Objective:
This retrospective study aims to evaluate the clinical features and causes of pruritic skin lesions of the female external genitalia.
Methods:
This study included 161 female patients with vulvar pruritus between 2008 and 2018 at CHA Bundang Medical Center. Data were collected by reviewing the electronic medical records retrospectively. The age, diagnosis, and histopathologic findings of the patients were reviewed.
Results:
The patients’ mean age was 49 years. On physical examination, 71.4% of patients (n=115) had definite skin lesions, and 28.6% (n=46) had ‘vulvar pruritus without skin rash’. The most common diagnostic category, confirmed by skin biopsy, was inflammatory dermatoses (53.4%, n=86), including lichen sclerosus et atrophicus, lichen simplex chronicus, nonatopic eczema, atopic eczema, and psoriasis. Moreover, 7.5% of patients (n=12) were diagnosed with infectious diseases, including candidiasis, herpes simplex virus, syphilis, and scabies; 5.6% (n=9) were diagnosed with neoplastic diseases, including vulvar intraepithelial neoplasia, squamous cell carcinoma, extramammary Paget’s disease, and Bowen’s disease.
Conclusion
The causes of vulvar itch are vast, and often, multiple causes coexist simultaneously. Therefore, it requires a systemic approach to establish the correct diagnosis. Dermatologists should actively participate in the diagnosis and treatment.
4.Analysis of Vulvar Dermatoses Presenting as Vulvar Pruritus: A Single-Center Retrospective Study
Seung Hui SEOK ; Jung U SHIN ; Dong Hyun KIM ; Moon Soo YOON ; Hee Jung LEE
Korean Journal of Dermatology 2021;59(7):527-533
Background:
Vulvar pruritus is a common complaint among women presenting to dermatologists. However, few studies have analyzed the dermatologic conditions that cause it.
Objective:
This retrospective study aims to evaluate the clinical features and causes of pruritic skin lesions of the female external genitalia.
Methods:
This study included 161 female patients with vulvar pruritus between 2008 and 2018 at CHA Bundang Medical Center. Data were collected by reviewing the electronic medical records retrospectively. The age, diagnosis, and histopathologic findings of the patients were reviewed.
Results:
The patients’ mean age was 49 years. On physical examination, 71.4% of patients (n=115) had definite skin lesions, and 28.6% (n=46) had ‘vulvar pruritus without skin rash’. The most common diagnostic category, confirmed by skin biopsy, was inflammatory dermatoses (53.4%, n=86), including lichen sclerosus et atrophicus, lichen simplex chronicus, nonatopic eczema, atopic eczema, and psoriasis. Moreover, 7.5% of patients (n=12) were diagnosed with infectious diseases, including candidiasis, herpes simplex virus, syphilis, and scabies; 5.6% (n=9) were diagnosed with neoplastic diseases, including vulvar intraepithelial neoplasia, squamous cell carcinoma, extramammary Paget’s disease, and Bowen’s disease.
Conclusion
The causes of vulvar itch are vast, and often, multiple causes coexist simultaneously. Therefore, it requires a systemic approach to establish the correct diagnosis. Dermatologists should actively participate in the diagnosis and treatment.
5.Physician perceptions of blood pressure control in patients with chronic kidney disease and target blood pressure achievement rate.
Ran hui CHA ; Hajeong LEE ; Jung Pyo LEE ; Young Rim SONG ; Sung Gyun KIM ; Yon Su KIM
Kidney Research and Clinical Practice 2017;36(4):349-357
BACKGROUND: Blood pressure (BP) control is the most-established method for the prevention of chronic kidney disease (CKD) progression. However, the ideal BP target for CKD patients is still under debate. METHODS: We performed a survey of regular registered members of the Korean Society of Nephrology to determine physician perceptions of BP control in patients with CKD. In addition, we evaluated the target BP achievement rate using data from the APrODiTe-2 study. RESULTS: Two-thirds of physicians considered the target BP for CKD to be < 130/85 mmHg. The systolic BP (SBP) thresholds for diabetic CKD, proteinuria ≥ 300 mg/day, 30 ≤ glomerular filtration rate (GFR) < 60 mL/min/1.73 m2, age < 60 years, and the presence of atherosclerotic (ASO) complications were significantly lower than the SBP thresholds of the opposite parameters. The three major hurdles to controlling BP were non-compliance with lifestyle modification and medications, and self-report of well-controlled home BP. Most physicians prescribed home and ambulatory BP monitoring to less than 50% of their patients. The target BP achievement rates using the SBP thresholds in this survey were as follows: non-diabetic (69.3%); diabetic (29.5%); proteinuria < 300 mg/day (72.3%); proteinuria > 300 mg/day (33.7%); GFR ≥ 60 (76.4%); GFR < 30 (47.8%); no evidence of ASO (67.8%); and the presence of ASO (42.9%). CONCLUSION: The target BP was lower in patients with higher cerebro-cardiovascular risks. These patient groups also showed lower target BP achievement rates. We also found a relatively lower application and clinical reflection rate of home or ambulatory BP monitoring.
Blood Pressure*
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Glomerular Filtration Rate
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Humans
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Life Style
;
Methods
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Nephrology
;
Proteinuria
;
Renal Insufficiency, Chronic*
6.Pseudomyxoma Peritonei: A Rare Cause of Oliguric Acute Kidney Injury
Hye Sook MIN ; Jeung Hui PYO ; Eul Sun MOON ; Jonghyun CHOI ; Young Sun KANG ; Mi Jin LEE ; Jin Joo CHA ; Dae Ryong CHA
Chonnam Medical Journal 2013;49(2):87-90
Pseudomyxoma peritonei is a rare clinical condition that causes the accumulation of mucinous ascites, which gradually results in the compression of intra-abdominal organs. Most published reports of pseudomyxoma peritonei concern the mass effect of the resulting ascites, which presents as abdominal pain or intestinal ileus in severe cases. However, few reports of renal complications of the disease have been published. Here, we present a case of oliguric acute kidney injury caused by external compression by pseudomyxoma peritonei. After decompression with external drainage, the patient's renal function rapidly improved.
Abdominal Pain
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Acute Kidney Injury
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Ascites
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Decompression
;
Drainage
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Ileus
;
Mucins
;
Oliguria
;
Pseudomyxoma Peritonei
7.Scar Sarcoidosis after Blepharoplasty: A Case Report
Ji Hae AN ; Seung Hui SEOK ; Jung U SHIN ; Hyun Jung KIM ; Dong Hyun KIM ; Moon Soo YOON ; Hee Jung LEE
Korean Journal of Dermatology 2021;59(1):64-66
Sarcoidosis is a chronic multi-organ disorder of unknown etiology, characterized by the development of non-caseating granulomas. Scar sarcoidosis is a cutaneous manifestation of sarcoidosis that originates in old cutaneous scars. Sarcoidosis may develop in scars that occur after surgery, vaccination, cosmetic tattoos, and herpes zoster infection. Upper eyelid blepharoplasty is the most popular aesthetic facial surgery performed in the Asian population. Despite the large number of blepharoplasty procedures performed over the last century, relatively few reports have described scar sarcoidosis involving a blepharoplasty scar. We report a rare case of sarcoidosis that originated in a post-blepharoplasty scar, together with a literature review. Scar sarcoidosis should be considered in the differential diagnosis in patients who present with post-blepharoplasty changes in an old scar.
8.Debridement Arthroplasty using Posteromedial Approach in Elbow Joint with Pain and Bony Limitation of Motion.
Sang Jin CHEON ; Dong Ho LEE ; Seung Han CHA ; Hui Taek KIM ; Jeung Tak SUH
Journal of the Korean Shoulder and Elbow Society 2009;12(1):67-75
PURPOSE: This study evaluated the clinical outcomes of debridement arthroplasty using the posteromedial approach in elbow joints with pain and bony limitation of motion. MATERIALS AND METHODS: This study involved 16 elbows in 16 patients with pain and bony limitation of motion, which were treated by debridement arthroplasty using the posteromedial approach from March 2005 to March 2008. The mean follow up period was 27.6 (13~52) months. The clinical outcomes were analyzed using the Visual Analogue Scale(VAS) for pain scale, the preoperative and postoperative range of motion and the Mayo Elbow Performance Scores(MEPS). RESULTS: The VAS was decreased significantly from a preoperative mean of 4.5 to a postoperative mean 1.1 (p<0.001). The average arc of motion improved significantly from 61.6 (0~90)degrees preoperatively to 109.4 (80-120)degrees postoperatively (p<0.001). The MEPS also improved significantly from 59.4 to 85.6 postoperatively (p<0.001). There were no complications, such as hematoma and elbow instability. CONCLUSION: Debridement arthroplasty using the posteromedial approach is a useful surgical procedure in the elbow joint with pain and bony limitation of motion, where all compartments can be debrided, the ulnar nerve can be manipulated easily and damage to the medial collateral ligament can be minimized.
Arthroplasty
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Collateral Ligaments
;
Debridement
;
Elbow
;
Elbow Joint
;
Follow-Up Studies
;
Hematoma
;
Humans
;
Range of Motion, Articular
;
Ulnar Nerve
9.Effect of Three Dimensional Culture Using Alginate-Fibrin Beads on the Chondrogenic Differentiation of Rabbit's Perichondrial Cells.
Won Joon YOO ; In Ho CHOI ; Chin Youb CHUNG ; Tae Joon CHO ; Cha Hui LEE
Journal of Korean Orthopaedic Research Society 2003;6(1):1-6
PURPOSE: To evaluate the usefulness of three dimensional culture using alginate-fibrin beads on the chondrogenic differentiation of rabbit's perichondrial cells. MATERIALS AND METHODS: Rib perichondrial cells from rabbit expanded by monolayer culture were cultured in monolayer, in alginate bead, and in alginate-fibrin beads. Reverse transcription polymerase chain reaction (RT-PCR) for type I, II, X collagen, and aggrecan was performed at 3 weeks after culture. At that time, we removed the alginate component from the alginate-fibrin bead. Then, the cell-fibrin beads were transplanted into the partial physeal defect of proximal tibia, and some beads were cultured on for additional 3 weeks for RT-PCR. Histologic examination was performed at 2, 4, 8, 12, and 16 weeks after operation. RESULTS: At 3 weeks, type II collagen gene expression was maintained regardless of the culture system used. However, at 6 weeks it was maintained only in three-dimensional culture system using alginate beads and fibrin beads. Histologic examination showed that the implanted perichondrial cell-fibrin beads formed small nest composed of chondrocyte-like cells and matrix. CONCLUSION: These results suggest that alginate-fibrin beads may be used as a biodegradable scaffold for cartilage engineering using perichondrial cells.
Aggrecans
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Cartilage
;
Collagen
;
Collagen Type II
;
Fibrin
;
Gene Expression
;
Polymerase Chain Reaction
;
Reverse Transcription
;
Ribs
;
Tibia
10.Hand Grip and Leg Muscle Strength in Hemodialysis Patients and Its Determinants
Ran-hui CHA ; Geum Sil LEE ; Ju Yeon YOO ; Oe Bog RHEE ; Yong Duk JEON
Journal of Korean Medical Science 2021;36(11):e76-
Background:
Chronic kidney disease is associated with chronic inflammation and progressive loss of peripheral muscle strength and the ability to exercise, and these changes are highly pronounced in patients receiving hemodialysis (HD). We evaluated hand grip strength (HGS) and leg muscle strength (LMS) in patients receiving HD and attempted to identify factors associated with muscle strength.
Methods:
We screened HGS (opposite the fistula side) and LMS (both sides) in HD patients at a single center (n = 112) by using digital hand and leg dynamometers (T.K.K. 5401 and 5710e/5715, Takei Scientific Instruments Co. Ltd., Niigata, Japan).
Results:
The mean age of patients was 62.6 years, and 73.2% of the patients were male.Diabetes was the cause of kidney failure in 50% of the patients, and the median HD vintage was 34 months. A total of 77.7% of patients reported that they participated in regular home-based exercise, and 29.5% of patients regularly participated in hospital-based resistance exercise.HGS and LMS showed good correlation (r = 0.715, P < 0.001). HGS (25.1 vs. 17.0 kg) and LMS (30.1 vs. 20.4 kg) were greater in males (P < 0.001 and P < 0.001, respectively) than in females.Older patients (≥ 60 years) showed less LMS than younger patients in both males and females (P = 0.012 and P = 0.037, respectively), but HGS did not differ according to age. Patients performing regular home- or hospital-based exercise showed higher HGS than those who did not exercise (24.2 vs. 18.6 kg, P = 0.011), but LMS was not significantly different (29.3 vs. 23.6 kg, P = 0.185). Multiple linear regression analysis proved that male sex, younger age, and any type of exercise were factors associated with improved HGS and LMS. Groups of older age (≥ 60 years), male sex, and shorter duration of HD (< median) benefitted more from exercise.
Conclusion
Sex, age, and exercise were the most important determinants of muscle strength in HD patients. We need to encourage patients to engage in regular home or group exercise from the beginning of dialysis and introduce new feasible forms of exercise for HD patients.