No abstract available.
Cervical Intraepithelial Neoplasia

No abstract available.
Cervical Intraepithelial Neoplasia* ; Statistics as Topic*

No abstract available.
Cervical Intraepithelial Neoplasia* ; Colposcopy* ; Conization*

No abstract available.
Cervical Intraepithelial Neoplasia* ; Cervix Uteri* ; Diagnosis* ; Female

The carcinoma of uterine cervix is the most common malignant neoplasm in Korean women. Nearly all invasive cervical carcinomas are preceded by a intraepithelial stage. The cervical intraepithelial lesion(CIN) is subdivided into I, II, and III, depending on the severity of the changes. To evaluate the histologic characteristics of the CIN, we studied the CIN III by mapping of the uterine cervix. The results were as follows. 1. The CIN III without I or II was 54.8%(17/31 cases). 2. The multifocal CIN III was 12.9%(4/31 cases). 3. The horizontal growth of CIN III was 38.7%(12/31 cases). These results indicate that the CIN III is unifocal and CIN III without I or II is more common.
Cervical Intraepithelial Neoplasia* ; Cervix Uteri* ; Female ; Humans

OBJECTIVE: The aim of this study was to identify human papillomavirus (HPV) in cervical intraepithelial neoplasia (CIN) and to evaluate the persistence of HPV after loop electrosurgical excision precedure (LEEP). METHODS: Records of 138 patients with LEEP performed due to cervicitis, CIN I, CIN II and CIN III were reviewed and persistence of HPV were followed up at 3, 6, 9 and 12 month after LEEP treatment from January 1996 to December 1999. RESULTS: Among 202 patients, 138 cases (68.3%) were showed HPV positive before LEEP and histologic findings were showed as cervicitis 20 cases (14.5%), CIN I 23 cases (16.7%), CIN II 31 cases (22.5%) and CIN III 64 cases (46.3%). Persistence of HPV after LEEP treatment were 10.9% (15/138) at 3 month and 2.9% (4/138) at 6 month. However, among 15 cases of persistent HPV, only 5 cases (33.3%) were showed an abnormal Pap smear at 3 month after LEEP. CONCLUSION: Human papillomavirus (HPV) was eliminated over 90% at 3 month after LEEP treatment in CIN. Detection of HPV was helpful to estimate therapeutic effect and to predict the recurrence or persistence of CIN after LEEP treatment.
Cervical Intraepithelial Neoplasia* ; Humans ; Recurrence ; Uterine Cervicitis

OBJECTIVE: To examine the correlation between cervical cytology and final histological results in patients who have undergone loop electrosurgical excision procedure (LEEP) with or without colposcopy-directed biopsy. METHODS: A retrospective review was performed of 829 patients who underwent LEEP for abnormal cervical cytology at Gangnam Severance Hospital between January 2004 and December 2008. Patients were classified to three groups according to cervical cytology and also divided into two groups based on the treatment they received: see-and-treat group and the standard three-step group. Final histological results were compared for the each study group. RESULTS: There were no differences in the final histological results between see-and-treat and three-step group in patients with high-grade squamous intraepithelial lesions (HSIL) cytology (N=523) (p=0.71). However, in patients with low-grade squamous intraepithelial lesions (LSIL)/atypical squamous cells of undetermined significance (ASCUS) (N=257) or normal cytology (N=49), the final histological results were significantly different between see-and-treat and three-step group (p<0.001) and the rate of overtreatment was significantly higher in the see-and-treat group (p<0.001). CONCLUSION: A see-and-treat protocol may be a viable alternative only in patients with HSIL cytology if colposcopic impression is suggestive of cervical intraepithelial neoplasia (CIN) 2 or 3 lesions.
Biopsy ; Cervical Intraepithelial Neoplasia ; Humans ; Retrospective Studies

OBJECTIVE: To evaluate Fragile histidine triad (Fhit) and p53 expression pattern in cervical intraepithelial neoplasm (CIN) and invasive cervical cancer, and to verify the correlation between the loss of Fhit and clinicopathological parameters of invasive cervical carcinoma and the relationship between Fhit and p53 expression. METHODS: 10 low-grade squamous intraepithelial lesions (LSIL), 16 high-grade squamous intraepithelial lesions (HSIL), and 21 invasive cervical carcinomas were evaluated by immunohistochemical staining for Fhit and p53 primary antibody. Their expression patterns in CIN and invasive cervical cancer were analysed semiquantitatively as positive and negative by the staining area and intensity. Clinicopathological data were obtained by review of patients' hospital records. RESULTS: Compared with CIN (LSIL and HSIL), invasive cervical carcinoma showed significantly loss of Fhit expression (p<0.05). P53 expression did not show the significant difference between CIN and invasive cervical cancer. There was no relationship between loss of Fhit and p53 expression in CIN and invasive cervical cancer. But loss of Fhit expression in invasive cervical cancer was also significantly associated with FIGO stage (p<0.05). CONCLUSION: Our results suggest that loss of Fhit expression may play an important role in the malignant transformation of CIN to invasive cancer. However, further molecular studies are needed to elucidate the role of Fhit gene in the carcinogenesis of cervical cancer.
Carcinogenesis ; Cervical Intraepithelial Neoplasia* ; Histidine ; Hospital Records ; Uterine Cervical Neoplasms*

OBJECTIVE: The aim of this study is to compare the clinician's attitude to the large loop excision of transformation zone (LLETZ) according to the subspecialty; gynecologic oncology or not. METHODS: Eighty-one patients who had LLETZ at Seoul National University Bundang Hospital from June 2003 to September 2004 were reviewed. The pathologic reports for LLETZ were compared with the results of punch biopsy according to the operator's subspecialty. RESULTS: Gynecologic oncologist had 38 patients (GO group) and non-gynecologic oncologist had 43 patients (NGO group). The age distribution was not different between two groups (40.3 +/- 8.3 in GO group, 42.4 +/- 9.4 in NGO group; p=0.301). The histopathology of punch biopsy and LLETZ correlated well each other in both groups (p=0.01 in both groups). In NGO group, 11 patients (25.6%) had chronic cervicitis or mild dysplasia on punch biopsy while only a patient (2.6%) had mild dysplasia on punch biopsy in GO group. CONCLUSION: This study shows that the non-gynecologic oncologist used LLETZ more frequently in the management of low-grade cervical intraepithelial neoplasia than gynecologic oncologist.
Age Distribution ; Biopsy ; Cervical Intraepithelial Neoplasia ; Humans ; Seoul ; Uterine Cervicitis

OBJECTIVE: To clarify the possible role of CD44, p53 and p21 in the development or progression of uterine cervical tumors, an immunohistochemical investigation was carried out on 99 cases of cervical intraepithelial neoplasia (CIN) III and stage Ib squamous cell carcinoma. Abnormal expression of CD44, p53 and p21 has been observed in a variety of human tumor, but little is known about its expression during cervical carcinogenesis. METHODS: The author examined the expression pattern of CD44, p53, and p21 in CIN III and invasive carcinoma groups with respect to high risk HPV positivity and tumor invasion. RESULTS: CD44s was expressed in CIN III and invasive carcinoma groups, and the positivities of expression were 75.0% and 52.7%, respectively. The positivities of CD44-v5 and CD44-v6 expression were 81.8%, 63.6% and 43.2%, 36.4%, respectively. The positivities of p53 and p21 expression in CIN III and invasive carcinoma groups were 18.2, 40.0% and 54.5%, 36.4%, respectively. This study revealed that neither CD44s nor CD44v appears to have independent prognostic relevance. No association between p53 immunostaining and p21 expression was found. Expression of CD44 and p21 was independent of the high risk HPV status, but expression of p53 is higher in the high risk HPV negative cases. CONCLUSION: The author demonstrated reduced expression of CD44 and increased expression of p53 with progression from CIN III to invasive squamous cell carcinoma. CD44 may have an important role in early tumorigenesis. Immunohistochemically detected CD44, p53 and p21 appeared to be of no predictive value with regard to clinical outcome.
Carcinogenesis ; Carcinoma, Squamous Cell* ; Cervical Intraepithelial Neoplasia* ; Humans