3.Ceftriaxone Induced Immune Hemolytic Anemia: Detection of Drug-dependent Antibody by Ex-vivo Antigen in Urine.
Sin Young KIM ; Kyung Soon SONG ; Hyun Ok KIM ; Hwan Mo LEE
Yonsei Medical Journal 2002;43(3):391-394
There have been a few reported cases of immune hemolytic anemia induced by ceftriaxone. We encountered a patient with immune hemolytic anemia that seemed to be stimulated by a degradation product of ceftriaxone. The patient's direct antiglobulin test was positive only for C3d, and no ceftriaxone-dependent antibodies were detectable in the patient's serum. To demonstrate the presence of the ceftriaxone-induced antibodies, an ex-vivo antigen in urine was obtained from the patient. In addition, we prepared a 1 mg/mL suspension solution of ceftriaxone, and group AB serum as a complement source. Using several combinations of the above reactants, the indirect antiglobulin test was performed. Only the indirect antiglobulin test using the patient's serum with the ex-vivo urine antigen was found to be positive. Other combinations were not reactive. To our knowledge, this is the first reported case in Korea, in which the causative antibody appeared to be stimulated solely by a degradation product of ceftriaxone.
Anemia, Hemolytic, Autoimmune/*chemically induced/*diagnosis/immunology/urine
;
Antigens/urine
;
Case Report
;
Ceftriaxone/*adverse effects
;
Cephalosporins/*adverse effects
;
Coombs' Test
;
Human
;
Male
;
Middle Age
4.Ceftriaxone Induced Immune Hemolytic Anemia: Detection of Drug-dependent Antibody by Ex-vivo Antigen in Urine.
Sin Young KIM ; Kyung Soon SONG ; Hyun Ok KIM ; Hwan Mo LEE
Yonsei Medical Journal 2002;43(3):391-394
There have been a few reported cases of immune hemolytic anemia induced by ceftriaxone. We encountered a patient with immune hemolytic anemia that seemed to be stimulated by a degradation product of ceftriaxone. The patient's direct antiglobulin test was positive only for C3d, and no ceftriaxone-dependent antibodies were detectable in the patient's serum. To demonstrate the presence of the ceftriaxone-induced antibodies, an ex-vivo antigen in urine was obtained from the patient. In addition, we prepared a 1 mg/mL suspension solution of ceftriaxone, and group AB serum as a complement source. Using several combinations of the above reactants, the indirect antiglobulin test was performed. Only the indirect antiglobulin test using the patient's serum with the ex-vivo urine antigen was found to be positive. Other combinations were not reactive. To our knowledge, this is the first reported case in Korea, in which the causative antibody appeared to be stimulated solely by a degradation product of ceftriaxone.
Anemia, Hemolytic, Autoimmune/*chemically induced/*diagnosis/immunology/urine
;
Antigens/urine
;
Case Report
;
Ceftriaxone/*adverse effects
;
Cephalosporins/*adverse effects
;
Coombs' Test
;
Human
;
Male
;
Middle Age
5.Research and clinical value of antibacterial-application software.
Yong-jie LIANG ; Xiao-bo ZHAI ; Li-xian HE ; Zhong-liang GUO ; Tao REN ; Zhi-gao HE ; Lu ZHANG ; Yong-hua ZHENG
Chinese Medical Journal 2008;121(1):86-89
Adult
;
Aged
;
Aged, 80 and over
;
Anti-Bacterial Agents
;
therapeutic use
;
Cephalosporins
;
administration & dosage
;
Enterobacter cloacae
;
Enterobacteriaceae Infections
;
drug therapy
;
Female
;
Gentamicins
;
adverse effects
;
Humans
;
Imipenem
;
adverse effects
;
Isosorbide Dinitrate
;
adverse effects
;
analogs & derivatives
;
Male
;
Ofloxacin
;
adverse effects
;
Software
6.Effects of cefdinir in pediatric infectious diseases.
Chinese Journal of Pediatrics 2005;43(3):233-235
7.Cefepime-induced encephalopathy with triphasic waves in three Asian patients.
Deidre Anne De SILVA ; Andrew B S PAN ; Shih-Hui LIM
Annals of the Academy of Medicine, Singapore 2007;36(6):450-451
Aged
;
Anti-Bacterial Agents
;
adverse effects
;
therapeutic use
;
Asian Continental Ancestry Group
;
Cephalosporins
;
adverse effects
;
therapeutic use
;
Electroencephalography
;
Female
;
Humans
;
Kidney Failure, Chronic
;
Liver Cirrhosis
;
Male
;
Middle Aged
;
Neurotoxicity Syndromes
;
diagnosis
;
etiology
;
Singapore
8.Clinical evaluation of multi-function "rapid" allergic skin test instrument for application in drug allergy testing.
Yu-Bin ZHAO ; Zhe HAO ; Yan-Ming XIE ; Li-Ru CHI
China Journal of Chinese Materia Medica 2013;38(18):3028-3030
OBJECTIVETo evaluate the multi-function rapid allergic skin test instrument for application in drug allergy testing.
METHODThree hundred patients were planned to be treated with cephalosporins Injection were divided randomly into 3 groups, the new allergic skin test instrument group, normal allergic skin test instrument group, and traditional skin test group, the true positive rate and false positive rate were calculated. Using multifunctional rapid allergy skin test was carried out on 210 cases of volunteers preliminary clinical evaluation of traditional Chinese medicine injections skin test.
RESULTThere were no significance difference between the new allergic skin test instrument group and control group in the true positive rate. As compared with the control group, a significance difference was found between the new allergic skin test instrument group and control group in false positive rate respectively (P < 0.05).
CONCLUSIONThe multi-function rapid allergic skin test instrument is safe and easy to use, with a higher rate of accuracy and lower false positive rate.
Adolescent ; Adult ; Aged ; Case-Control Studies ; Cephalosporins ; administration & dosage ; adverse effects ; Child ; Child, Preschool ; Drug Hypersensitivity ; diagnosis ; etiology ; Drugs, Chinese Herbal ; administration & dosage ; adverse effects ; Female ; Humans ; Male ; Middle Aged ; Skin Tests ; methods ; Young Adult
9.Analysis of Adverse Cutaneous Drug Reactions using an Electronic Drug Adverse Reaction Reporting System at a Single Secondary Referral Center: A Retrospective Study.
Cheong Ha WOO ; Mira CHOI ; Han Jeong YUN ; Hai Jin PARK
Korean Journal of Dermatology 2018;56(4):251-258
BACKGROUND: Adverse cutaneous drug reactions (ACDRs) are common and are responsible for increased morbidity, mortality, and socioeconomic costs. OBJECTIVE: The purpose of our study was to investigate the common drugs and clinical patterns related to ACDRs using an electronic drug adverse reaction reporting system at a single secondary referral center. METHODS: We conducted a retrospective analysis of the ACDR database between January 2014 and April 2016 at the Ilsan Paik Hospital. RESULTS: The study analyzed 320 patients with ACDRs (male:female ratio=93:227; mean age 50.8±17.8 years). Using a Korean causality evaluation algorithm, the percentage of drugs with a possible relationship with ACDRs was calculated to be 50.6%, while the percentage with a probable relationship was 44.7%. Antibiotics (44.0%), radiocontrast media (15.1%), and non-steroidal anti-inflammatory drugs (NSAIDs) (14.3%) were the most commonly implicated drugs. Antibiotics, including cephalosporins (30.6%) and quinolones (10.2%), were responsible for the majority of the ACDRs. Acetic acid (5.9%) and propionic acid (5.9%) derivatives of NSAIDs were also common causative agents. The most common clinical presentations were maculopapular exanthema (33.4%), pruritus (30.9%), and urticaria (25.7%). Severe ACDRs were significantly associated with older age, eosinophilia, and underlying heart and renal diseases (p<0.05). CONCLUSION: Antibiotics, radiocontrast media, and NSAIDs were identified as common causes of ACDRs. Older age, eosinophilia, heart disease, and renal disease were associated with severe ACDRs.
Acetic Acid
;
Adverse Drug Reaction Reporting Systems
;
Anti-Bacterial Agents
;
Anti-Inflammatory Agents, Non-Steroidal
;
Cephalosporins
;
Contrast Media
;
Diethylpropion
;
Drug-Related Side Effects and Adverse Reactions
;
Eosinophilia
;
Exanthema
;
Heart
;
Heart Diseases
;
Humans
;
Mortality
;
Pruritus
;
Quinolones
;
Retrospective Studies*
;
Secondary Care Centers*
;
Urticaria
10.Pediatric adverse drug reactions collected by an electronic reporting system in a single tertiary university hospital.
Geun Mi PARK ; Joo Hyun PARK ; Joo Won JUNG ; Hye Won HAN ; Jae Youn KIM ; Eun LEE ; Hyun Ju CHO ; Yeongho KIM ; Jisun YOON ; Jinho YU ; Tae Bum KIM ; Soo Jong HONG
Allergy, Asthma & Respiratory Disease 2016;4(5):354-359
PURPOSE: The incidence of adverse drug reactions (ADRs) is increasing. However, studies on the prevalence of ADRs in children are rare. The aim of this study was to investigate the causative drugs and clinical features of ADRs for children in a tertiary university hospital of Korea. METHODS: We retrospectively collected ADRs by a computerized self-reporting system in Asan Medical Center. ADRs of children under the age 18 were collected from January 2005 to August 2015, and we analyzed only ADRs containing current symptoms among total ADR data. RESULTS: A total of 1,408 ADR cases were reported, There were 764 male (54.3%) and 644 female patients (45.7%), and the mean age was 11.5±5.8 years (range, 0–18 years). Antibiotics (n=479, 34.0%) were the most common causative drugs, followed by tramadol (n=173, 12.3%), nonsteroidal anti-inflammatory agents (NSAIDs) and acetylsalicylic acid (n=103, 7.3%), narcotics (n=91, 6.5%), antineoplastics (n=87, 6.2%), and sedatives (n=82, 5.8%). The most common clinical features were skin manifestations (n=500, 34.4%). Gastrointestinal symptoms (n=435, 29.9%) were the second most common clinical features, followed by neuropsychiatric symptoms (n=155, 10.7%) and respiratory symptoms (n=123, 8.5%). Among antibiotics, glycopeptides (n=110, 23.0%), third-generation cephalosporins (n=83, 17.3%), and penicillin/β-lactamase inhibitors (n=60, 12.7%) were the most frequently reported causative drugs. CONCLUSION: Antibiotics were the most reported common causative drugs of ADRs in children, followed by tramadol, NSAID, and narcortics. Compared with adults, the prevalence of contrast medium-induced ADR was lower in children with a higher prevalence of sedative-associated ADR. Greater attention to possible ADRs in children is needed among medical personnel.
Adult
;
Anti-Bacterial Agents
;
Anti-Inflammatory Agents, Non-Steroidal
;
Antineoplastic Agents
;
Aspirin
;
Cephalosporins
;
Child
;
Chungcheongnam-do
;
Drug-Related Side Effects and Adverse Reactions*
;
Female
;
Glycopeptides
;
Humans
;
Hypnotics and Sedatives
;
Incidence
;
Korea
;
Male
;
Narcotics
;
Prevalence
;
Retrospective Studies
;
Skin Manifestations
;
Tramadol