Nonhealing wounds which significantly impair the quality of life for millions of people and impart an enormous burden on society are a challenge to clinical medicine. Therefore, the study of healing chronic wounds is vitally important. In the last two decades, extensive study on stem cells and the potential clinical applications have provided new perspectives in the management of chronic wounds. Increased reports state the notable effectiveness of stem cells transplantation. In this review, we summarize the main mechanisms of the long lasting restoration of the nonhealing wounds and address tremendous increase in the understanding of stem cell transplantation applied in the nonhealing chronic wounds.
Humans ; Stem Cell Transplantation ; trends ; Wound Healing

It is no doubt that the gene therapy using recombinant engineering cells provides a novel approach to many refractory diseases. However, the transplant rejection from the host's immune system against heterogeneous cells has been the main handicap of its clinical application. The modern cell micro-encapsulation technique with good immune isolation makes it possible to overcome this problem and has shown potential application foreground in clinical therapies for a lot of diseases such as Parkinson's disease and Hemophiliac disease. This article reviews mainly the relative materials and techniques in processing micro-encapsulation, the host cells used to construct the recombinant genetic engineering cells and application of cell micro-encapsulation technique in the field of gene therapy.
Biomedical Engineering ; methods ; trends ; Cell Transplantation ; methods ; trends ; Genetic Therapy ; trends ; Humans ; Miniaturization ; Tissue Engineering ; methods ; trends

A lot of advances have been made in testis autotransplantation, testis homotransplantation, testicular tissue transplantation, Leydig cell transplantation and spermatogonial stem cell transplantation in the past decades. And recent years, have witnessed remarkable progress in Leydig cell transplantation and spermatogonial stem cell transplantation, which promise to be new means for the treatment of male infertility and hypogonadism. The development and present state of testis transplantation are summarized in this paper based on the related literature of recent years.
Cell Transplantation ; history ; trends ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Organ Transplantation ; history ; trends ; Testis ; transplantation ; Tissue Transplantation ; history ; trends

Humans ; Stem Cell Transplantation ; Tissue Engineering ; trends ; Wound Healing

No abstract available.
Animals ; Cell Transplantation/trends ; Confucianism ; Graft Rejection ; Humans ; Korea ; Organ Transplantation/trends ; Research Support, Non-U.S. Gov't ; Transplantation, Heterologous/adverse effects/*trends

Congestive heart failure (CHF) has emerged as a major worldwide epidemic and its main causes seem to be the aging of the population and the survival of patients with post-myocardial infarction. Cardiomyocyte dropout (necrosis and apoptosis) plays a critical role in the progress of CHF; thus treatment of CHF by exogenous cell implantation will be a promising medical approach. In the acute phase of cardiac damage cardiac stem cells (CSCs) within the heart divide symmetrically and/or asymmetrically in response to the change of heart homeostasis, and at the same time homing of bone marrow stem cells (BMCs) to injured area is thought to occur, which not only reconstitutes CSC population to normal levels but also repairs the heart by differentiation into cardiac tissue. So far, basic studies by using potential sources such as BMCs and CSCs to treat animal CHF have shown improved ventricular remodelling and heart function. Recently, however, a few of randomized, double-blind, placebo-controlled clinical trials demonstrated mixed results in heart failure with BMC therapy during acute myocardial infarction.
Animals ; Clinical Trials as Topic ; trends ; Heart Failure ; pathology ; surgery ; Humans ; Mesenchymal Stem Cell Transplantation ; methods ; trends ; Myocytes, Cardiac ; transplantation ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; trends

Stem cell can both self-renew and have the ability to differentiate into one or more cell types that perform normal tissue/organ function throughout life, including embryonic stem cell and adult stem cell. The treatment with stem cells will be widely used in the future. This article reviews recent advances in studies of the use of embryonic stem cells and spermatogonial stem cells in male reproduction.
Embryonic Stem Cells ; transplantation ; Humans ; Male ; Spermatogonia ; cytology ; Stem Cell Transplantation ; trends ; Stem Cells ; cytology

Cell Proliferation ; Child ; Humans ; Nervous System Diseases ; surgery ; Neurons ; transplantation ; Stem Cell Transplantation ; adverse effects ; methods ; trends

Adipose-derived stem cells (ADSCs) are pluripotent stem cells isolated from the adipose tissue and have the potential for self-renewal and multi-directional differentiation into neurogenic cells, smooth muscle cells, endothelial cells, and so on. Erectile dysfunction (ED) is a common male sexual dysfunction that has a negative impact on the lives of the patients and their partners. Current treatments of ED include surgery and medication, with oral 5-phosphodiesterase inhibitors as the first-line drugs. However, a small number of the patients are not sensitive to these therapies and cannot be improved or cured pathologically. So far, animal experiments and preclinical trials have confirmed the safety and efficacy of ADSCs, which act on ED though paracrine mechanisms. This review summarizes the advances in the recent 5 years in the studies of ADSCs for the treatment of ED.
Adipocytes ; transplantation ; Adipose Tissue ; cytology ; Animals ; Cell Differentiation ; Erectile Dysfunction ; surgery ; Humans ; Male ; Stem Cell Transplantation ; methods ; trends

No abstract available.
Animals ; Erectile Dysfunction/therapy ; Humans ; Male ; Stem Cell Transplantation/*methods ; Urologic Diseases/*therapy ; Urology/methods/trends