1.Human Infection of Salmonella Matadi in Korea.
Yonsei Medical Journal 2013;54(5):1297-1298
2.A Case of Acute Phlegmonous Gastritis Causing Gastroparesis and Cured with Medical Treatment Alone.
Nha Young KIM ; Ju Sang PARK ; Ki Jong LEE ; Han Kyeol YUN ; Ja Seon KIM
The Korean Journal of Gastroenterology 2011;57(5):309-314
Acute phlegmonous gastritis is an uncommon disease, often fatal condition characterized by suppurative bacterial infection of the gastric wall. It has a high mortality rate mainly because the diagnosis is usually made late. Until recently, gastrectomy in combination with antibiotics was recommended. We had experienced a case of 66-year-old man presented with epigastric pain, nausea, vomiting, and hematemesis, followed by aspiration pneumonia. At upper gastrointestinal endoscopy, the gastric lumen was narrow, and the mucosa was severely inflamed, which was erythematous, swelled, and showed necrotic areas covered with purulent exudate. Klebsiella oxytoca and Acinetobacter lwoffii were isolated in the gastric tissue culture. Contrast-enhanced computerized tomography scan of abdomen demonstrated diffuse gastric wall thickening and an intramural abscess in the gastric antral wall. Although delayed gastric emptying by gastroparesis prolonged the in-hospital period, the only medical treatment with antibiotics alone successfully cured the patient without gastrectomy.
Acinetobacter/isolation & purification
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Acute Disease
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Aged
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Anti-Bacterial Agents/*therapeutic use
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Anti-Infective Agents/therapeutic use
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Cefotaxime/therapeutic use
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Ceftriaxone/therapeutic use
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Ciprofloxacin/therapeutic use
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Drug Resistance, Multiple, Bacterial
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Drug Therapy, Combination
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Gastritis/*diagnosis/drug therapy/microbiology
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Gastroparesis/*diagnosis/microbiology
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Gastroscopy
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Humans
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Imipenem/therapeutic use
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Klebsiella oxytoca/isolation & purification
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Male
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Ofloxacin/therapeutic use
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Pneumonia/diagnosis/drug therapy
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Tomography, X-Ray Computed
3.Antibiotics-resistance pattern and genetic type of Streptococcus pneumoniae isolated from children in Hangzhou.
Chun-zhen HUA ; Shi-qiang SHANG ; Xiao-feng SUN ; Jian-ping LI ; Zhi-min CHEN ; Xi-lin YU
Chinese Journal of Pediatrics 2004;42(1):16-19
OBJECTIVETo investigate the antibiotics-resistance type and molecular epidemiology of Streptococcus pneumoniae isolated from children in Hangzhou.
METHODSThe sensitivities of 323 strains of Streptococcus pneumoniae to 9 antibiotics were determined in vitro by Kirby-Bauer diffuse methods, and MICs of penicillin and cefotaxime were determined by E-test methods.
RESULTSAmong all 323 strains isolated from children during the period from August 2001 to July 2002, 136 strains (42.1%) were sensitive to penicillin, while 57 strains (17.7%) were penicillin-resistant. Penicillin MICs ranged from 0.012 microg/ml to 4.0 microg/ml. All the strains were sensitive to cefotaxime and its MICs ranged from 0.012 microg/ml to 4.0 microg/ml. The most resistant antibiotic was erythromycin and it's resistant-rate was as high as 90.7%, followed by tetracycline (87.6%), trimethoprim-sulfamethoxazole (48.6%) and chloromycetin (14.9%). Totally 197 strains (61.0%) were multi-drug-resistant pneumococci and most of them were resistant to trimethoprim-sulfamethoxazole, erythromycin and tetracycline at the same time. Two strains (0.6%) were resistant to rifampin and none was resistant to vancomycin and ofloxacin. BOX PCR typing was carried out and no overwhelming fingerprinting pattern was found among penicillin resistant Streptococcus pneumoniae strains which were isolated from patients, while the banding patterns were always similar or identical among the strains isolated from the same specimen or from the same patient at different time, respectively.
CONCLUSIONThe antibiotics-resistant rate of pneumococci was high in Hangzhou, but the third-generation cephalosporins were still the best antibiotics against Streptococcus pneumoniae. One child could be infected or colonized by more than one pneumococci clone at the same or different time.
Anti-Bacterial Agents ; pharmacology ; therapeutic use ; Cefotaxime ; pharmacology ; therapeutic use ; Child, Preschool ; China ; Chloramphenicol ; pharmacology ; therapeutic use ; Drug Resistance, Bacterial ; drug effects ; Erythromycin ; pharmacology ; therapeutic use ; Female ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Ofloxacin ; pharmacology ; therapeutic use ; Penicillins ; pharmacology ; therapeutic use ; Pneumococcal Infections ; drug therapy ; microbiology ; Respiratory Tract Infections ; drug therapy ; microbiology ; Rifampin ; pharmacology ; therapeutic use ; Streptococcus pneumoniae ; classification ; drug effects ; isolation & purification ; Tetracycline ; pharmacology ; therapeutic use ; Trimethoprim ; pharmacology ; therapeutic use
4.A Case of Pneumatosis Cystoids Intestinalis with Polymyositis.
Soon Jae LEE ; Ji Young PARK ; Se Ah KWON ; Dong Hee KOH ; Min Ho CHOI ; Hyun Ju JANG ; Sea Hyub KAE ; Jin LEE
The Korean Journal of Gastroenterology 2011;57(4):249-252
Pneumatosis cystoides intestinalis (PCI), characterized by presence of intramural gas cyst in the intestinal wall is associated with various medical condition. Polymyosistis, however, is rarely associated with PCI. Few cases are reported in the world, and none has not been reported previously in Korea. A 67-year-old woman with polymyositis developed mild abdominal pain and abdominal distension during treatment with steroid and azathioprine. Radiographic findings including CT scan showed intraperitoneal free gas and intramural air, compatible with PCI. The patient's symptom and clinical findings improved after the treatment with antibiotics and high-dose oxygen therapy.
Aged
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Anti-Bacterial Agents/therapeutic use
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Anti-Inflammatory Agents/therapeutic use
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Azathioprine/therapeutic use
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Cefotaxime/therapeutic use
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Female
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Humans
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Oxygen Inhalation Therapy
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Pneumatosis Cystoides Intestinalis/complications/*diagnosis/drug therapy
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Polymyositis/complications/*diagnosis/drug therapy
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Prednisolone/therapeutic use
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Radiography, Abdominal
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Tomography, X-Ray Computed
5.A Case of Pneumatosis Cystoids Intestinalis with Polymyositis.
Soon Jae LEE ; Ji Young PARK ; Se Ah KWON ; Dong Hee KOH ; Min Ho CHOI ; Hyun Ju JANG ; Sea Hyub KAE ; Jin LEE
The Korean Journal of Gastroenterology 2011;57(4):249-252
Pneumatosis cystoides intestinalis (PCI), characterized by presence of intramural gas cyst in the intestinal wall is associated with various medical condition. Polymyosistis, however, is rarely associated with PCI. Few cases are reported in the world, and none has not been reported previously in Korea. A 67-year-old woman with polymyositis developed mild abdominal pain and abdominal distension during treatment with steroid and azathioprine. Radiographic findings including CT scan showed intraperitoneal free gas and intramural air, compatible with PCI. The patient's symptom and clinical findings improved after the treatment with antibiotics and high-dose oxygen therapy.
Aged
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Anti-Bacterial Agents/therapeutic use
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Anti-Inflammatory Agents/therapeutic use
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Azathioprine/therapeutic use
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Cefotaxime/therapeutic use
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Female
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Humans
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Oxygen Inhalation Therapy
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Pneumatosis Cystoides Intestinalis/complications/*diagnosis/drug therapy
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Polymyositis/complications/*diagnosis/drug therapy
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Prednisolone/therapeutic use
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Radiography, Abdominal
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Tomography, X-Ray Computed
6.Drug rash with eosinophilia and systemic symptoms syndrome following cholestatic hepatitis A: a case report.
Jihyun AN ; Joo Ho LEE ; Hyojeong LEE ; Eunsil YU ; Dan Bi LEE ; Ju Hyun SHIM ; Sunyoung YOON ; Yumi LEE ; Soeun PARK ; Han Chu LEE
The Korean Journal of Hepatology 2012;18(1):84-88
Hepatitis A virus (HAV) infections occur predominantly in children, and are usually self-limiting. However, 75-95% of the infections in adults are symptomatic (mostly with jaundice), with the illness symptoms usually persisting for a few weeks. Atypical manifestations include relapsing hepatitis, prolonged cholestasis, and complications involving renal injury. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, drug-induced hypersensitivity reaction characterized by skin rash, fever, lymph-node enlargement, and internal organ involvement. We describe a 22-year-old male who presented with acute kidney injury and was diagnosed with prolonged cholestatic hepatitis A. The patient also developed DRESS syndrome due to antibiotic and/or antiviral treatment. To our knowledge, this is the first report of histopathologically confirmed DRESS syndrome due to antibiotic and/or antiviral treatment following HAV infection with cholestatic features and renal injury.
Acute Kidney Injury/diagnosis
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Anti-Bacterial Agents/*adverse effects/therapeutic use
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Cefotaxime/adverse effects/therapeutic use
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Cholestasis/complications/*diagnosis
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Cytomegalovirus/genetics
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Cytomegalovirus Infections/drug therapy/virology
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DNA, Viral/analysis
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Eosinophilia/etiology
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Exanthema/*chemically induced/pathology
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Ganciclovir/therapeutic use
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Hepatitis A/complications/*diagnosis/drug therapy
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Humans
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Hydrocortisone/therapeutic use
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Immunoglobulins/therapeutic use
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Male
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Syndrome
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Young Adult
7.Changes of Ascites Nitric Oxide According to the Treatment Course in Cirrhotic Patients with Spontaneous Bacterial Peritonitis.
Young Soo PARK ; Chae Yoon CHON ; Hyeyoung KIM ; Yong Han PAIK ; Si Young SONG ; Sang Hoon AHN ; Sinae HONG ; Kwang Hyub HAN ; Young Myoung MOON
The Korean Journal of Hepatology 2004;10(3):207-215
BACKGROUND/AIMS: Nitric oxide (NO) is a molecule involved in vascular dilatation and pathogen suppression. It also has immunologic and regulatory functions. Liver cirrhosis is characterized by an increased risk for bacterial infections, including spontaneous bacterial peritonitis (SBP). The role of NO in SBP which develops in cirrhosis has not been clearly established. The aim of this study was to investigate the role of NO in the pathogenesis of SBP and its clinical usefulness for prediction of disease prognosis. METHODS: This study was designed to investigate the changes of ascites NO in the course of treatment. Nitric oxide metabolite (nitrites+nitrates [NOx]) was measured by chemiluminescence in 84 ascites samples obtained from 84 cirrhotic patients. Among them, the 38 patients with SBP were treated with cefotaxime 2.0 g, q 12hr for 7 days. In 24 of SBP patients, ascites was obtained consecutively before treatment (day 0), during treatment (day 2), and after treatment (day 7). RESULTS: Ascites NO levels in the patients with SBP (n=38; 82.3 +/- 14.4 micro M) were not different from those in patients with sterile ascites (n=46; 54.6 +/- 13.0 micro M). There was no significant change of NO levels in sequential ascites samples during antibiotic treatment. Ascites NO level before treatment was significantly higher in SBP patients who responded to antibiotics (n=26; 101.86 micro M/L) than that in SBP patients who did not respond to antibiotics (n=12; 40.03 micro M/L, P=0.044). A significant direct correlation was found between ascites and serum NO levels before treatment (Pearson correlation, r2=0.86, P=0.001). Among the SBP patients, treatment response rate to antibiotics were significantly higher in those patients with pretreatment NO level>or=80 micro M/L in multivariate analysis. CONCLUSIONS: Ascites NO level was not different between ascites from SBP patients and ascites from cirrhotic patients with sterile ascites. There were no changes of ascites NO in SBP patients during treatment. Therefore ascites NO was not useful to predict the progress of SBP. Ascites NO levels reflect serum NO levels, and the patients with higher NO level may have better response to antibiotics.
Adult
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Anti-Bacterial Agents/therapeutic use
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Ascitic Fluid/*chemistry
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Bacterial Infections/complications/*drug therapy
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Cefotaxime/therapeutic use
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English Abstract
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Female
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Humans
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Liver Cirrhosis/*complications
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Male
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Middle Aged
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Nitric Oxide/*analysis
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Peritonitis/complications/*drug therapy
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Prognosis
8.Megalocytic Interstitial Nephritis Following Acute Pyelonephritis with Escherichia coli Bacteremia: A Case Report.
Hee Jin KWON ; Kwai Han YOO ; In Young KIM ; Seulkee LEE ; Hye Ryoun JANG ; Ghee Young KWON
Journal of Korean Medical Science 2015;30(1):110-114
Megalocytic interstitial nephritis is a rare form of kidney disease caused by chronic inflammation. We report a case of megalocytic interstitial nephritis occurring in a 45-yrold woman who presented with oliguric acute kidney injury and acute pyelonephritis accompanied by Escherichia coli bacteremia. Her renal function was not recovered despite adequate duration of susceptible antibiotic treatment, accompanied by negative conversion of bacteremia and bacteriuria. Kidney biopsy revealed an infiltration of numerous histiocytes without Michaelis-Gutmann bodies. The patient's renal function was markedly improved after short-term treatment with high-dose steroid.
Acute Disease
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Acute Kidney Injury/complications/*drug therapy/pathology
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Anti-Bacterial Agents/therapeutic use
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Azithromycin/therapeutic use
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Bacteremia/*drug therapy/microbiology/pathology
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Cefotaxime/therapeutic use
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Creatinine/blood
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Escherichia coli
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Escherichia coli Infections/*drug therapy/microbiology/pathology
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Female
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Humans
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Kidney/pathology
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Methylprednisolone/therapeutic use
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Middle Aged
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Nephritis, Interstitial/*drug therapy/immunology/pathology
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Pyelonephritis/complications/*drug therapy/pathology
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Renal Dialysis
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Shock, Septic/drug therapy/microbiology
9.First Detection of VIM-4 Metallo-beta-Lactamase-Producing Citrobacter freundii in China.
Annals of Laboratory Medicine 2013;33(1):84-85
No abstract available.
Aged
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Anti-Bacterial Agents/pharmacology/therapeutic use
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Cefotaxime/therapeutic use
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China
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Ciprofloxacin/therapeutic use
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Citrobacter freundii/drug effects/*enzymology/isolation & purification
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Drug Resistance, Multiple, Bacterial
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Humans
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Imipenem/pharmacology
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Male
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Microbial Sensitivity Tests
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Respiratory Tract Infections/*diagnosis/drug therapy/microbiology
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Thienamycins/pharmacology
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beta-Lactamases/*metabolism
10.Comparison of Second- and Third-Generation Cephalosporin as Initial Therapy for Women with Community-Onset Uncomplicated Acute Pyelonephritis.
U Im CHANG ; Hyung Wook KIM ; Seong Heon WIE
Yonsei Medical Journal 2015;56(5):1266-1273
PURPOSE: This study examined the clinical effectiveness of parenteral cefuroxime and cefotaxime as empirical antibiotics for treating hospitalized women with uncomplicated acute pyelonephritis (APN). MATERIALS AND METHODS: This study was based on the clinical and microbiologic data of 255 hospitalized women with APN. Of these 255 women, 144 patients received cefuroxime and 111 received cefotaxime. RESULTS: There were no marked differences in the demographic features, clinical characteristics, and treatment duration between the populations of the cefuroxime and cefotaxime groups. The rates of defervescence showed no significant differences in the two groups at 48, 72, 96, and 120 hours. The clinical cure rates observed at the follow-up visit 4 to 14 days after the completion of antimicrobial therapy were not statistically different between the cefuroxime and cefotaxime groups [94.9% (129 of 136) versus 98.0% (100 of 102), respectively; p=0.307], and the microbiological cure rates were also not significantly different [88.3% (91 of 103) versus 95.0% (76 of 80), respectively; p=0.186]. The median hospitalization periods in the cefuroxime and cefotaxime groups were 7 (6-8) and 7 (6-8) days (p=0.157), respectively. Microbiological success rates after 72-96 hours of initial antimicrobial therapy were also not statistically different in the cefuroxime and cefotaxime groups, 89.4% (110 of 123) versus 94.9% (93 of 98; p=0.140). CONCLUSION: Cefuroxime, a second-generation cephalosporin, is an appropriate antibiotic option for the initial treatment of uncomplicated APN and its efficacy does not differ from cefotaxime, a third-generation cephalosporin, in the initial parenteral therapy for community-onset APN.
Administration, Intravenous
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Adult
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Aged
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Anti-Bacterial Agents/administration & dosage/*therapeutic use
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Cefotaxime/administration & dosage/*therapeutic use
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Cefuroxime/administration & dosage/*therapeutic use
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Community-Acquired Infections/*drug therapy
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Escherichia coli/drug effects
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Female
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Humans
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Infusions, Parenteral
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Length of Stay
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Male
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Middle Aged
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Pyelonephritis/*drug therapy/microbiology
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Retrospective Studies
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Treatment Outcome