Chorioamnionitis is associated with high maternal and neonatal morbidity and serious complication. In developed countries, due to timely diagnosis and appropriate treatment, it is getting a great progress in the treatment of chorioamnionitis. In the developing countries, where lack the healthcare facilities and effect diagnosis, women are frequently overlooked and not properly treated. In addition to its impact on maternal health, a significant morbidity and mortality will happen in neonate. We discuss chorioamnionitis from pathogenesis to therapeutic environment.