Objective To investigate the effect and safety of patients with diclofenac sodium lidocaine analgesia after endoscopic opera-tion. Methods One hundred patients with the implementation of nasal endoscopic treatment in our hospital from August 2012 to June 2014 were randomly divided into observation group and control group with 50 cases in each group. The observation group were injected the diclofe-nac sodium lidocaine,which compared with the control group given fentanyl through a vein for postoperative analgesia with analgesia effect and safety. Results The differences of HR,SBP,DBP,MAP indicators were not significant between and within groups (P>0. 05) with immedi-ately after operation, postoperative 24 h,48 h after surgery. There was no significant difference on the VAS score between the inmmediately after the operation process and compared to the control group (P>0. 05). The observation group with the immediate postoperative VAS score decreased significantly compared with that of the control group after 1 h,4 h,8 h,16 h,24 h,48 h of the surgery,while the observation group VAS scores were significantly lower than that of the control group (P<0. 05). The observation group in analgesia occurred in 6 cases of ad-verse reactions ( 12%) was significantly lower than that of 16 cases of the control group ( 32%) , and the difference was significant (P<0. 05). Conclusion Better effect and low incidence rate of adverse reaction is showed that diclofenac sodium lidocaine analgesia of patients with nasal endoscopic operation.

Objective To explore the application of Propensity Score Matching Methods in medical scientific research,and demonstrate the operation process of SPSS.Methods This article summarized and discussed the principle and application of PSM through the literature,a real example was adopted to introduce the operation procedures of SPSS.Results We can use PSM process to control confounding factors between the retrospective study groups effectively through SPSS.Conclusions PSM is an efficient tool to conduct retrospective study.It can provide necessary help for clinical data mining.

Background The measurement of retinal nerve fiber layer (RNFL) by Cirrus optical coherence tomography (OCT) has been applied widely in ophthalmology.However,previous assessment of RNFL is based on spatial measurement,while the evaluation based on optical characteristics of OCT can offset the shortcomings of spatial measurement in some eye diseases.Objective This study was to analyze the optical characters of RNFL measured by OCT and its correlation with age in healthy Chinese individuals.Methods Four hundred and six normal healthy subjects were collected in Shanghai Shibei Hospital from June 2011 to June 2012,with the age of 40-83 years old.Macular RNFL was unilateral imaged using a Cirrus OCT device with 5 line raster macular scan mode under the approval of Ethic Committee of Shanghai Shibei Hospital and informed consent of subjects.A customized software was used to measure RNFL optical characters,including absorbance (A value) and attenuate coefficient.The difference of the measured parameters in different genders was compared.The correlations between RNFL optical characters and age were analyzed by linear regression analysis.Results The data of 353 eyes were included in the final outcomes.The RNFL thickness,A value and attenuate coefficient were (35.1 ±4.4) μm,121.6 ±5.3 and 2.06 ±0.25,respectively.RNFL thickness and A value showed significantly negative correlations with age (r=-0.487,-0.571,both at P＜0.01) with the regression equation Y=-0.17 X+45.23 and Y=-0.24 X+ 135.82,while a positive correlation was found between the attenuate coefficient and age (r=0.368,P＜0.01) with the regression equation Y=0.01 X+1.63.RNFL thickness and A value showed weaker positive correlations with OCT signal intensity (rs =0.128,P =0.016;rs =0.284,P＜0.01),but no remarked correlation was seen between the attenuate coefficient and OCT signal intensity (rs =-0.053,P=0.319).Conclusions Age of subjects affects the parameters of OCT optical characteristics in normal populaition.Age-related RNFL change in optical characters of OCT should be considered before concluding optical parameters.

BACKGROUND:Preliminary studies of our research group have confirmed that bone morphogenetic protein-4 can stimulate the development of mandible in the growth period, but whether bone morphogenetic protein-4 can interact with bone morphogenetic protein-2 to promote the growth of mandible has not been reported. OBJECTIVE:To detect the expression of bone morphogenetic protein-2 and bone morphogenetic protein-4 in skeletal class II malocclusion during growth peak, and to explore the relationship of the expression of bone morphogenetic protein-2 and bone morphogenetic protein-4 with mandibular growth. METHODS: Patients with skeletal class I malocclusion in growth peak served as group I, and those with skeletal class II malocclusion in growth peak characterized as mandibular retrognathia acted as group II. There were 18 cases in each group. Expression of bone morphogenetic protein-2 and bone morphogenetic protein-4 in serum was detected by real-time fluorescent quantitative PCR. RESULTS AND CONCLUSION:The mRNA expression of bone morphogenetic protein-2 and bone morphogenetic protein-4 in the group II was significantly lower than that in the group I (P < 0.05). In the group II, there was a significant correlation between the expression of bone morphogenetic protein-2 and bone morphogenetic protein-4. These experimental findings confirm that the reduced expression of bone morphogenetic protein-2 and bone morphogenetic protein-4 in skeletal class II malocclusion during growth peak has a certain relationship with mandibular deficiency, and moreover, bone morphogenetic protein-2 interacts with bone morphogenetic protein-4 to promote the growth of mandible.

Objective To investigate the etiology and treatment of severe infection after ureteroscopic holmium laser lithotripsy. Methods Seven cases (2 men and 5 women) of severe infection after holmium laser lithotripsy under ureteroscope were treated.Their mean age was 44 years (range,37-56 years). The patients were characterized by a temperature over 39 ℃,a heart rate over 110 BPM,and a blood pressure below 80/50 mm Hg (1 mm Hg=0.133 kPa) within 1-12 hours after the operation.The diagnosis of septic shock caused by gram negative bacteria was suggested by the clinical manifestation and the urine culture. Anti-shock therapy was conducted with rapid supplement of colloidal and crystalloid solution of 3000-4000 ml.The vasoactive drugs,dopamine (2-5 ?g/kg per minute) or norepinephrine (4-8 ?g/kg per minute) were used for the establishment of stable circulation,and the third generation cephalosporins for the control of infection empirically.Low dose corticosteroids (dexamethasone,10-20 mg) were administered if the patients had adrenocortical insufficiency or significant intoxication. Results All patients were treated successfully within 8 to 48 hours,then the hypertensors were gradually stopped.Their temperature and blood routine tests returned to normal 3 days later.. Conclusions The causes of severe infection after holmium laser lithotripsy under ureteroscope are preoperative urinary tract infection,high perfusion pressure or postoperative urinary tract obstruction.Peri operative anti infection and appropriate operation skill can effectively prevent the infection.

Objective: To investigate the effect of CpG motif oligodeoxynucleotides (CpG ODN) on the antigen induced allergic airway reaction in mice. Methods: The asthma model was set up in the C57BL/6 mice with OVA, the CpG ODN in the dose of 30 ?g was co administered intraperitoneally with the antigen in sensitization stage to study its effect on the airway allergenic reactions. Results: (1)Compared with the control, coadministration of CpG ODN in sensitization phase significantly inhibited airway eosinophilia after antigen challenge( P

Objective To explore the personality characters of patients with mental disorders and to determine the differences of dimension,trait level and model of personality between patients and normal subjects.Methods The patients with mental disorders(n=376) and normal subjects(n=368) were assessed with revised NEO personality inventory(NEO-PI-R).Results The mean scores of extroversion(E) and conscientiousness(C) of five-factor personality model of NEO-PI-R in patients were significant lower than those in normal group((P

Objective To explore the relationship between job burnout feeling and sleep quality in psychiatric female medical staff.Methods 100 female medical staff were randomly selected from two mental hospitals in Wenzhou,and the Pittsburgh sleep quality index was used to evaluate and Maslach burnout inventory;and the relation-ship between sleep quality and job burnout was analyzed.Results Female psychiatric and medical personnel to the personality dimension score was (10.84 ±4.75)points,which was higher than Maslach norm (7.12 ±5.22)points;emotion exhaustion scores of (14.44 ±6.38)points,low achievement sense score of (15.07 ±6.89)points,below the Maslach often die emotion exhaustion scores of (22.19 ±9.53)points and low achievement sense scores (36.54 ± 7.34)points.The differences were statistically significant (t =-12.15,7.84,-31.15,all P <0.01).Job burnout and there were significant correlations between sleep quality and the emotional exhaustion and personification and PQSI seven dimensions and the total score was a positive correlation,low sense of achievement and PQSI total score and negatively correlated with seven dimensions.Conclusion Wenzhou psychiatric female medical staff burnout is significantly higher than the general population,there is a correlation between staff burnout and sleep quality,and the more serious burnout,poorer quality of sleep.Improving the quality of sleep of medical staff is one of the ways to relieve job burnout.

Bioprocess equipment is of great importance in application of modern industrial biotechnology.With the rapid development of industrial biotechnology,demands for talents capable of understanding the theory,design and manipulation of modern bioprocess equipment increased.The experiences in aspects such as the building of teachers' contingent,construction of teaching materials,innovation of teaching method from the top-quality course construction of Bioprocess Equipment was discussed in this paper.

It is the core of the recent science and technology management to impmve the innovation and competition of scientific research team.The transformation of the psychological contract between the organization and the individuals presents a deep influence on the administration.The idea of psychological contract is introduced into organization management in order to fit the needs of contemporary science and technology development.and help to inspire the team innovation at a deeper level and in a broader scope.This Paper studied the effect of the psychological contract on inspiring the team and individuals with innovation attitude and on impmving the organization and inspiration of 973 projects in order to accelerate the innovation of the organization and management.