OBJECTIVES: This study was designed to verify neuro-developmental hypothesis of schizophrenia and mood disorder. METHOD: We performed Brain Magnetic Resonance Imaging study in 34 schizophrenic patients, 18 mood disorder patients and 22 controls and compared the incidence and the size of carum septi pellucidi (CSP). RESULTS: The incidences of CSP in schizophrenia, mood disorder and controls were 61%, 61%, and 41%, respectively. The incidences of large CSP, defined as largest diameter larger than 3mm in T1-weighted image, were 24% in schizophrenic patients, 11% in mood disorder patients, and 5% in controls. But they didn't show statistically significant differences. CONCLUSION: We could find the tendency that the incidence of CSP was high as following order; schizophrenia, mood disorder, controls. But it was not statistically significant difference. To verify neuro-developmental hypothesis, we need larger pool of patients and better study design.
Brain ; Carum ; Humans ; Incidence ; Magnetic Resonance Imaging* ; Mood Disorders* ; Schizophrenia*