1.Carpal Tunnel Syndrome in Behcet's Disease.
Jungsoo LEE ; Suhyun CHO ; Do Young KIM ; Zhenlong ZHENG ; Hoon PARK ; Dongsik BANG
Yonsei Medical Journal 2015;56(4):1015-1020
PURPOSE: Behcet's disease (BD) is a chronic inflammatory disease characterized by orogenital ulcers, skin and ocular lesions, in addition to articular, vascular, and neurologic symptoms. Carpal tunnel syndrome (CTS), can also occur in BD patients secondary to inflammation in the connective tissues, vessels, and tendons, as well as nerve involvement in BD itself. However, reports of patients who have CTS in BD are rare. The aim of this study was to evaluate the clinical characteristics of CTS in BD patients. MATERIALS AND METHODS: Retrospective analysis of the medical records of 1750 BD patients, and 14 (0.8%) BD patients who were diagnosed with CTS was performed at the BD Specialty Clinic of Severance Hospital. Patient demographics, disease activity/severity for both diseases, and the clinical characteristics of CTS in BD were recorded and analyzed. RESULTS: All 14 BD patients with CTS were women. Twelve patients (85.7%) were diagnosed with active BD. The CTS was mild in 8 patients (57.2%), moderate in 3 patients (21.4%), and severe in 3 patients (21.4%). Ten patients (71.4%) had BD prior to the diagnosis of CTS, and these 10 patients all had active BD. CONCLUSION: CTS can occur as a result of the inflammation associated with BD and can also be the presenting symptom of nerve involvement in BD. CTS can also develop as the initial symptom of BD. Therefore, a higher degree of suspicion should be maintained for CTS in patients with BD and vice versa; however, the exact relationship is uncertain.
Adult
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Age Distribution
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Aged
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Behcet Syndrome/complications/diagnosis/*epidemiology
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Carpal Tunnel Syndrome/diagnosis/*epidemiology
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Female
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Humans
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Inflammation
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Male
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Middle Aged
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Retrospective Studies
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Sex Distribution
2.Carpal tunnel syndrome caused by tophaceous gout.
The Korean Journal of Internal Medicine 2014;29(4):544-545
3.Melorheostosis of the hand affecting the c6 sclerotome and presenting with carpal tunnel syndrome.
Shalimar ABDULLAH ; Noreen Fazlina Mat NOR ; Nor Hazla Mohamed HAFLAH
Singapore medical journal 2014;55(4):e54-6
Melorheostosis is a rare, progressive bone disease accompanied by hyperostosis and soft tissue fibrosis. While affected adults present with contracture and pain, children present with limb length discrepancy and deformity. We report the case of a 20-year-old woman with melorheostosis since childhood who presented with right hand deformity and numbness. Radiographs showed not only a combination of dense sclerosis and opacities, but also the classic 'flowing candle wax' appearance. Radiography can be used to identify melorheostosis, thus preventing unnecessary bone biopsies. Carpal tunnel release revealed the presence of a thickened flexor retinaculum and a degenerated median nerve distal to the retinaculum, but did not show hyperostosis. This case highlights the role of nerve decompression in melorheostosis and the importance of early identification of the disease to prevent unnecessary bone biopsies.
Carpal Tunnel Syndrome
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complications
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diagnostic imaging
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surgery
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Diagnosis, Differential
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Female
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Fibrosis
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pathology
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Hand
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pathology
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Hand Deformities
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diagnostic imaging
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surgery
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Humans
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Hypesthesia
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Median Nerve
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surgery
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Melorheostosis
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complications
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diagnostic imaging
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surgery
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Radiography
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Sclerosis
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diagnostic imaging
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Young Adult
4.Carpal tunnel syndrome in pregnancy - you need to ask!
Jamari SAPUAN ; Kai Feng YAM ; Mohamad Faiz NOORMAN ; Prisca Kim De CRUZ ; Wan Nurhalimatun Wan Abdul RAZAB ; Zatel Iman ROZALI ; Mohamed Faizal SIKKANDAR ; Rajesh SINGH
Singapore medical journal 2012;53(10):671-675
INTRODUCTIONCarpal tunnel syndrome (CTS) is a common pregnancy complication. However, it is often overlooked by medical practitioners and patients alike. This study aimed to describe CTS in relation to pregnancy and assess how significant the disease was among pregnant women.
METHODSIn a prospective cross-sectional study, 333 respondents were randomly selected from among pregnant women attending the primary care maternal health clinic in a university hospital. CTS was diagnosed clinically based on patient history and physical examination. The severity of CTS was assessed using the Boston Carpal Tunnel Questionnaire. Symptomatic respondents were asked whether they had mentioned their problems to doctors and received appropriate treatment.
RESULTS82 (24.6%) pregnant women presented with symptoms of CTS, a majority of whom were ethnic Malays (Malay 87.8%; non-Malay 12.2%). The risk for developing CTS during the third trimester of pregnancy was found to be two-fold among Malay women compared to patients of other ethnicities (odds ratio 2.262; 95% confidence interval 1.10-4.46; p = 0.024). The commonest complaint was daytime numbness (76.8%). The severity of CTS among patients was predominantly mild (80.5%), and the symptoms were severe enough to affect hand function in approximately one-third (34.1%) of the group. However, only 25.6% of symptomatic patients mentioned their problems to their doctors, and of these, 9.5% received treatment.
CONCLUSIONCTS is prevalent in the third trimester of pregnancy, especially among Malay women, in whom the risk of developing the syndrome is two-fold. Yet, this troublesome complication of pregnancy appears to be under-recognised, with most patients not being treated appropriately.
Adolescent ; Adult ; Carpal Tunnel Syndrome ; diagnosis ; epidemiology ; etiology ; pathology ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Pregnancy ; Pregnancy Complications ; diagnosis ; epidemiology ; pathology ; Pregnancy Trimesters ; Risk Factors ; Severity of Illness Index ; Young Adult
5.Carpal Tunnel Syndrome and Peripheral Polyneuropathy in Patients with End Stage Kidney Disease.
Hee Kyu KWON ; Sung Bom PYUN ; Won Yong CHO ; Chang Su BOO
Journal of Korean Medical Science 2011;26(9):1227-1230
This study was designed to identify the causes of the development of carpal tunnel syndrome (CTS) associated with end stage kidney disease (ESKD). A total of 112 patients with ESKD, 64 on hemodialysis (HD) and 48 on peritoneal dialysis (PD), were enrolled. The duration of ESKD and dialysis, the site of the arteriovenous (A-V) fistula for HD, laboratory data such as blood urea nitrogen, creatinine, and beta-2-microglobulin were determined. Clinical evaluation of CTS and electrophysiological studies for the diagnosis of CTS and peripheral neuropathy were performed. The electrophysiological studies showed that the frequency of CTS was not different in the HD and PD groups (P = 0.823) and the frequency of CTS was not different in the limb with the A-V fistula compared to the contralateral limb (P = 0.816). The frequency of HD and PD were not related to beta-2-microglobulin levels, an indicator of amyloidosis. The frequency of CTS did not increase as the severity of the peripheral neuropathy and the duration of ESKD and dialysis increased (P = 0.307). The results of this study do not support that microglobulin induced amyloidosis or placement of an A-V fistula are associated with an increase in CTS.
Adult
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Aged
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Amyloidosis/complications
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Arteriovenous Fistula/complications
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Blood Urea Nitrogen
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Carpal Tunnel Syndrome/*complications/*diagnosis
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Creatinine/blood
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Electrophysiological Phenomena
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Female
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Humans
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Kidney Failure, Chronic/*complications/*therapy
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Male
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Middle Aged
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Peritoneal Dialysis/adverse effects
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Polyneuropathies/*complications/*diagnosis
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Renal Dialysis/adverse effects
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beta 2-Microglobulin/blood
6.Lipomatosis of nerve: a clinicopathologic analysis of 15 cases.
Rong-jun MAO ; Ke-fei YANG ; Jian WANG
Chinese Journal of Pathology 2011;40(3):165-168
OBJECTIVETo study the clinicopathologic features of lipomatosis of nerve (NLS).
METHODSThe clinical, radiologic and pathologic features were analyzed in 15 cases of NLS.
RESULTSThere were a total of 10 males and 5 females. The age of patients ranged from 4 to 42 years (mean age = 22.4 years). Eleven cases were located in the upper limbs and 4 cases in the lower limbs. The median nerve was the most common involved nerve. The patients typically presented before 30 years of age (often at birth or in early childhood) with a soft and slowly enlarging mass in the limb, with or without accompanying motor and sensory deficits. Some cases also had macrodactyly and carpal tunnel syndrome. MRI showed the presence of fatty tissue between nerve fascicles, resembling coaxial cable in axial plane and assuming a spaghetti-like appearance in coronal plane. On gross examination, the affected nerve was markedly increased in length and diameter. It consisted of a diffusely enlarged greyish-yellow lobulated fusiform beaded mass within the epineural sheath. Histologically, the epineurium was infiltrated by fibrofatty tissue which separated, surrounded and compressed the usually normal-appearing nerve fascicles, resulting in perineural septation of nerve fascicles and microfascicle formation. The infiltration sometimes resulted in concentric arrangement of perineural cells and pseudo-onion bulb-like hypertrophic changes. The perineurial cells might proliferate, with thickening of collagen fibers, degeneration and atrophic changes of nerve bundles. Immunohistochemical study showed that the nerve fibers expressed S-100 protein, neurofilament and CD56 (weak). The endothelial cells and dendritic fibers were highlighted by CD34. The intravascular smooth muscle cells were positive for muscle-specific actin.
CONCLUSIONSNLS is a rare benign soft tissue tumor of peripheral nerve. The MRI findings are characteristic. A definitive diagnosis can be made with histologic examination of tissue biopsy.
Adolescent ; Adult ; Antigens, CD34 ; metabolism ; CD56 Antigen ; metabolism ; Carpal Tunnel Syndrome ; complications ; pathology ; Child ; Child, Preschool ; Diagnosis, Differential ; Extremities ; innervation ; Female ; Hand Deformities, Congenital ; complications ; pathology ; Humans ; Lipoma ; pathology ; Lipomatosis ; complications ; diagnosis ; metabolism ; pathology ; surgery ; Magnetic Resonance Imaging ; Male ; Median Nerve ; metabolism ; pathology ; Nerve Sheath Neoplasms ; pathology ; Neurofibroma ; pathology ; Neurofilament Proteins ; metabolism ; Neuroma ; pathology ; Peripheral Nervous System Diseases ; complications ; diagnosis ; metabolism ; pathology ; surgery ; Peripheral Nervous System Neoplasms ; pathology ; Retrospective Studies ; S100 Proteins ; metabolism ; Vimentin ; metabolism ; Young Adult