2.Advances in the study on endogenous sulfur dioxide in the cardiovascular system.
Chinese Medical Journal 2014;127(21):3803-3807
OBJECTIVEThis review summarized the current advances in understanding the role of the novel gasotransmitter, sulfur dioxide (SO2), in the cardiovascular system.
DATA SOURCESArticles on the advances in the study of the role of endogenous sulfur dioxide in the cardiovascular system were accessed from PubMed and CNKI from 2003 to 2013, using keywords such as "endogenous sulfur dioxide" and "cardiovascular system".
STUDY SELECTIONArticles with regard to the role of SO2 in the regulation of cardiovascular system were selected.
RESULTSRecently, scientists discovered that an endogenous SO2 pathway is present in the cardiovascular system and exerts physiologically significant effects, such as regulation of the cardiac function and the pathogenesis of various cardiopulmonary diseases such as hypoxic pulmonary hypertension, hypertension, coronary atherosclerosis, and cardiac ischemia-reperfusion (I/R) injury, in the cardiovascular system.
CONCLUSIONSEndogenous SO2 is a novel member of the gasotransmitter family in addition to the nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Studies indicated that it has a role in regulating the cardiovascular disease.
Animals ; Cardiovascular Diseases ; metabolism ; pathology ; Cardiovascular System ; metabolism ; pathology ; Humans ; Hydrogen Sulfide ; metabolism ; Nitric Oxide ; metabolism ; Sulfur Dioxide ; metabolism
3.Multiple effects of vitamin D.
Chinese Medical Journal 2013;126(15):2978-2983
4.Potential implications of ketone body metabolism changes and ketogenic therapy in the treatment of heart failure.
Qiong WANG ; Siyu YAN ; Shuyu KUANG ; Mengmeng ZHOU ; Chunling JIANG
Chinese Critical Care Medicine 2023;35(7):769-772
Heart failure (HF) has become a major challenge in the treatment of global cardiovascular diseases. Great progress has been made in the drug treatment of HF, however, rehospitalization rate and mortality of patients with HF are still high. Hence, there is an urgent need to explore new treatment strategy and new underlying pathogenic mechanisms. In recent years, some researchers have suggested that regulation of ketone body metabolism may become a potentially promising therapeutic approach for HF. Some studies showed that the oxidative utilization of fatty acids and glucose was decreased in the failing heart, accompanied by the increase of ketone body oxidative metabolism. The enhancement of ketone body metabolism in HF is a compensatory change during HF. The failing heart preferentially uses ketone body oxidation to provide energy, which helps to improve the body's cardiac function. This review will discuss the potential significance of ketone body metabolism in the treatment of HF from three aspects: normal myocardial ketone body metabolism, the change of ketone body metabolism in HF, the effect of ketogenic therapy on HF and its treatment.
Humans
;
Heart Failure/metabolism*
;
Myocardium/metabolism*
;
Ketone Bodies/metabolism*
;
Cardiovascular Diseases
;
Fatty Acids/metabolism*
;
Energy Metabolism
6.Gut microbiota derived metabolites in cardiovascular health and disease.
Protein & Cell 2018;9(5):416-431
Trillions of microbes inhabit the human gut, not only providing nutrients and energy to the host from the ingested food, but also producing metabolic bioactive signaling molecules to maintain health and elicit disease, such as cardiovascular disease (CVD). CVD is the leading cause of mortality worldwide. In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide. These gut microbiota derived metabolites play critical roles in maintaining a healthy cardiovascular function, and if dysregulated, potentially causally linked to CVD. A better understanding of the function and dynamics of gut microbiota derived metabolites holds great promise toward mechanistic predicative CVD biomarker discoveries and precise interventions.
Cardiovascular Diseases
;
metabolism
;
microbiology
;
pathology
;
Gastrointestinal Microbiome
;
Humans
;
Metabolome
7.Association of Adiponectin 45T/G Polymorphism with Diabetic Cardiovascular Complications in Korean Type 2 Diabetes.
Myeong Jin JI ; Eu Jeong KU ; Tae Keun OH ; Hyun Jeong JEON
Journal of Korean Medical Science 2018;33(17):e124-
BACKGROUND: Adiponectin is an adipokine that regulates lipid and glucose metabolism and has been shown to have anti-inflammatory and anti-atherogenic effects. It also plays an important role in the development of cardiovascular disease (CVD). METHODS: This study evaluated the association between adiponectin 45T/G polymorphism and cardiovascular complication in type 2 diabetes in Koreans. RESULTS: The present study included 758 patients with type 2 diabetes. The distribution of the adiponectin 45T/G polymorphism was 3.56% (n = 27) for GG, 42.35% (n = 321) for TG, and 54.09% (n = 410) for TT in patients with type 2 diabetes. The prevalence of CVD was significantly higher in subjects with the GG + TG genotype compared to those with the TT genotype (17.5% vs. 9.8%, P = 0.002). The G allele was associated with a higher risk of CVD (P = 0.002). CONCLUSION: Our findings suggest that the adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes.
Adipokines
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Adiponectin*
;
Alleles
;
Cardiovascular Diseases
;
Genotype
;
Glucose
;
Humans
;
Metabolism
;
Prevalence
Result Analysis
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