1.The effect of temperature of cardioplegic solution on myocardial protection from ischemia.
Yong Han KIM ; Young Jin KIM ; Tae Whan KOH ; Jong Wuk LEE ; Dong Suep SOHN ; Dai Yun CHO ; Ki Min YANG
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(2):131-136
No abstract available.
Cardioplegic Solutions*
;
Ischemia*
2.Effect of oxygenation of cardioplegic solution on postischemic recovery of cardiac function after ischemic arrest in isolated rat heart(II).
Jong Bum CHOI ; Tae Geun RIM ; Jae Do YOON ; Soon Ho CHOI ; Bong Kyu CHOI
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(12):1391-1398
No abstract available.
Animals
;
Cardioplegic Solutions*
;
Oxygen*
;
Rats*
3.Changes of myocardial temperature following infusion of cold cardioplegic solution in open heart surgery.
Sung Woo LIM ; Han Yeung RYU ; Jung Cheul LEE ; Sung Sae HAN
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(4):345-351
No abstract available.
Cardioplegic Solutions*
;
Heart*
;
Thoracic Surgery*
4.Effect of oxygenation of cardioplegic solution on electrical stability and postischemic recovery of cardiac function after ischemic arrest in isolated rat heart(I).
Jae Do YOON ; Jong Bum CHOI ; Soon Ho CHOI ; Bong Kyu CHOI
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(2):125-130
No abstract available.
Animals
;
Cardioplegic Solutions*
;
Oxygen*
;
Rats*
5.The effect of additives in the cardioplegic solution on the recovery of myocardium, comparison among albumin, mannitol, and glucose.
Eun Gi KIM ; Chong Kook LEE ; Sang Hun LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(11):1058-1067
No abstract available.
Cardioplegic Solutions*
;
Glucose*
;
Mannitol*
;
Myocardium*
6.Early postoperative hemodynamic changes in patients of congenital complex heart disease using blood cardioplegic solution.
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(11):1192-1202
No abstract available.
Cardioplegic Solutions*
;
Heart Diseases*
;
Heart*
;
Hemodynamics*
;
Humans
7.A Value of Myocardial Temperature Monitoring for Determining the Amount of Cardioplegic Solution in CABG Patients.
Tae Gook JUN ; Ki Bong KIM ; Hurn CHAE
Korean Circulation Journal 1994;24(3):474-481
This study was designed to determine if topical cardiac hypothermia is a necessary adjunct to intraoperative myocardial protection. In this study, 105 patients ranging in age from 22 to 74 years were included. Myocardial temperature was measured at the ventricular septum. All patients received cold blood cardioplegia without topical cooling. In most of the patients(90%) the myocardial temperature was dropped to 10-15degrees C without topical cooling. In Group A, myocardial temperature was dropped rapidly to 10-15degrees C with, 1,000ml or less cardioplegic solution. In Group B, the amount of cardioplegic solution required for lowering myocardial temperature to 10-15degrees C was 1,000-2,000ml. In Group C, myocardial temperature was not dropped below 18degrees C or cardioplegic solution over 2,000ml was required for lowering myocardial temperatur. Eight patients(8/61, 8%) in group A, 12 patients(12/35, 34%) in group B and 8 patients(8/9. 89%) in group C had Complete obstructive lesions in at least one of major branches of coronary artery(p=0.001). Myocardial perfusion score was different among the groups(8.27+/-2.27 in group A, 9.98+/-2.21 in group B, 10.30+/-2.49 in group C, p<0.002). These data suggest that routine topical hypothermia may be unnecessary if myocardial temperature of less than 15degrees C could be attained with cold blood cardioplegia, especially in case of myocardial perfusion score below 10.
Cardioplegic Solutions*
;
Heart Arrest, Induced
;
Humans
;
Hypothermia
;
Perfusion
;
Ventricular Septum
8.Comparison of the cardioprotection between crystalloid and blood cardioplegia in adult patients undergoing cardiac surgery: a meta-analysis.
Chun-ling CHEN ; Hong ZHENG ; Hai GUO
Chinese Journal of Surgery 2013;51(1):71-76
OBJECTIVESTo compare the cardioprotection effect between blood and crystalloid cardioplegia during cardiac surgery in adult patients, and provide a theoretical basis for optimal myocardial protection strategies.
METHODSA meta-analysis of randomized controlled trials (RCT) studies about comparing blood and crystalloid cardioplegia in adult patients undergoing cardiac surgery were performed. Cochrane library (Issue 3, 2011), MEDLINE, EMBase, PubMed, HighWire, CBM and CNKI were searched from January 1985 to December 2011. Studies were assessed according to the Cochrane Handbook for systematic reviews. Data were extracted from these trials and analyzed by RevMan5.1 software.
RESULTSSixteen trials involved 3934 patients were included, 2004 cases were in blood group, and 1930 were in crystalloid group. There was no statistical heterogeneity between studies using a fixed effects model. Meta-analysis indicated that, there were no significant differences between blood and crystalloid group in the incidence of postoperative 30 days mortality (OR = 1.11, 95%CI: 0.59 - 2.08, P = 0.74), the incidence of postoperative low cardiac output (OR = 0.98, 95%CI: 0.41 - 2.33, P = 0.85), the incidence of perioperative myocardial infarctions (OR = 0.85, 95%CI: 0.55 - 1.29, P = 0.44), and inotropic support requirement (OR = 1.05, 95%CI: 0.81 - 1.38, P = 0.70).
CONCLUSIONThe blood cardioplegia is no difference with crystalloid cardioplegia in adult patients undergoing cardiac surgery.
Adult ; Cardiac Surgical Procedures ; Cardioplegic Solutions ; Humans ; Isotonic Solutions ; Postoperative Complications ; epidemiology ; Randomized Controlled Trials as Topic
9.Effects of Na+ and Ca2+ concentration in cardioplegic and reperfusion solutions on the intracellular Ca2+ of cardiac muscle cells.
Myung Jin KIM ; So Ra PARK ; Chang Kook SUH
Yonsei Medical Journal 1993;34(2):133-144
The removal of Ca2+ from the cardioplegic solutions could cause the danger of inducing a "calcium paradox" during reperfusion. Since intracellular Ca2+ activities are coupled to Na+ activities via Na(+)-Ca2+ exchange, an increase in intracellular Na+ activities during the cardioplegia could cause an abrupt Ca2+ influx when reperfused. To study the effects of Na+ and Ca2+ concentrations in cardioplegic solutions on intracellular Ca2+ activities during the cardioplegia and subsequent recovery period, the membrane potential and intracellular Na+ and Ca2+ activities of guinea pig ventricular papillary were measured. 1) A cardioplegia with low Ca2+ cardioplegic solution significantly decreased the overshoot and duration of the first action potential after cardioplegia, but the changes in action potential configuration were minimized after a cardioplegia with Ca2+ concentration adjusted according to the Na(+)-Ca2+ exchange mechanism. 2) Intracellular Na+ activity was continuously decreased during the cardioplegia, and the intracellular Na+ activity 20 minutes after cardioplegia was the highest with low Ca2+ cardioplegic solution. 3) Intracellular Na+ and Ca2+ activities were continuously decreased during the cardioplegia with Ca2+ concentration adjusted according to the Na(+)-Ca2+ exchange mechanism. 4) During a reperfusion of Tyrode solution after cardioplegia intracellular Na+ and Ca2+ activities were increased. Intracellular Ca2+ activity was increased more rapidly than intracellular Na+ activity. 5) The rate of increase in intracellular Ca2+ activity with reperfusion of Tyrode solution was dependent upon intracellular Na+ activity during cardioplegia, in such a way that the higher the intracellular Na+ activity was, the faster the intracellular Ca2+ activity increased. These data suggest that Na(+)-Ca2+ exchange mechanism may play an important role in the regulation of intracellular Ca2+ activity during recovery after cardioplegia.
Animal
;
Calcium/*pharmacology
;
Cardioplegic Solutions/*pharmacology
;
Ions
;
*Myocardial Reperfusion
;
Osmolar Concentration
;
Papillary Muscles/cytology/*drug effects
;
Sodium/*pharmacology
;
Solutions/pharmacology
10.Evaluation of Cardioprotective Effects of DelNido Cardioplegia.
Seok Jeoung WOO ; Bong Hyun CHANG ; Kyu Tae KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 2000;33(8):613-622
BACKGROUND: The aim of this study is to define the cardioprotective effects (functional and metabolic) of newly developed DelNido cardioplegic solution (containing plasma solution, mannitol, magnesium and lidocaine). MATERIAL AND METHOD: This study assessed the function of rat hearts after itermittent infusion of DelNido cardioplegia with different preserving methods(Air or Icebox) for 2hours and perfusing the hearts on a Langendorff apparatus. Heart rate, left ventricular developed pressure (LVDP) and coronary flow, were measured at pre-ischemic, post-reperfusion 15min, 30min and 45min. Coronary flow was standardized to dry heart weight. Each weight was weighted to calculate water content. Creatine kinase-MB isoenzyme release was measured and ultrastructural assessment was done with electron microscopes. DelNido group was better than St, Thomas group and Icebox group was better than Room-air group. CONCLUSION: DelNido cardioplegia have better myocardial protective effects than St. Thomas cardioplegia when they were preserved in the Room-air. But we can not tell the difference between Delnido cardiplegia with Air preserving method and St. Thomas cardioplegia with Icebox.
Animals
;
Cardioplegic Solutions
;
Creatine
;
Heart
;
Heart Arrest, Induced*
;
Heart Rate
;
Magnesium
;
Mannitol
;
Plasma
;
Rats
;
Water