4.Changes of cardiac pathology in patients with cor pulmonale and coal workers' pneumoconiosis.
Hong-Mei HOU ; Jun-Hua PENG ; Jing SUN ; Wei-Ping JIANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(6):472-472
Aged
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Anthracosis
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complications
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pathology
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Cardiomyopathy, Hypertrophic
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pathology
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Edema
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Humans
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Male
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Middle Aged
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Myocardium
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pathology
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Pulmonary Heart Disease
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etiology
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pathology
5.Pathological characteristics of dilated hearts with sole myocardial wall damage in recipients.
Hong ZHAO ; Feng-ying LÜ ; Lai-feng SONG ; Hong-yue WANG ; Li LI ; Lei LIU ; Guo-fen CHEN ; Jie HUANG ; Sheng-shou HU
Chinese Journal of Cardiology 2007;35(10):923-926
OBJECTIVEIt is difficult to differentiate the causes of dilated cardiomyopathy only by clinical evaluation and image analysis. Pathomorphologic examinations on diseased hearts may help to improve the diagnosis accuracy.
METHODSFifty-six extransplanted hearts from June, 2004 to June, 2006 were examined. Gross and histopathological findings were recorded, photographed and final pathological diagnosis was compared to clinical diagnosis.
RESULTSDilations were caused by sole myocardial wall damage in 38 (67.9%) of the 56 patients, including 19 primary dilated cardiomyopathy, 9 arrhythmogenic right ventricular cardiomyopathy, 1 non-compaction cardiomyopathy, 6 ischemic cardiomyopathy, 1 alcoholic cardiomyopathy, 1 hypertensive cardiomyopathy and 1 giant cell myocarditis. The clinical and pathological diagnoses were different in 15 cases (39.5%). The most discrepancies were arrhythmogenic right ventricular cardiomyopathy (77.8%), ischemic cardiomyopathy (83.3%), and giant cell myocarditis (100%).
CONCLUSIONSThis pathological study of recipient hearts showed a high portion of patients with arrhythmogenic right ventricular cardiomyopathy and ischemic cardiomyopathy were misdiagnosed as primary cardiomyopathy. Correct diagnosis of primary cardiomyopathy needs to rule out possible secondary causes of myocardial dilation.
Adolescent ; Adult ; Cardiomyopathy, Dilated ; diagnosis ; pathology ; Cardiomyopathy, Hypertrophic ; diagnosis ; pathology ; Female ; Heart Transplantation ; Humans ; Male ; Middle Aged ; Myocardial Ischemia ; pathology ; Myocardium ; pathology ; Young Adult
8.Importance of endomyocardial biopsy in unexplained cardiomyopathy in China: a report of 53 consecutive patients.
Zhuang TIAN ; Yong ZENG ; Kang-An CHENG ; Peng GAO ; Da-Chun ZHAO ; Quan-Cai CUI ; Xiu-Chun JIANG ; Lian-Feng CHEN ; Quan FANG
Chinese Medical Journal 2010;123(7):864-870
BACKGROUNDAlthough endomyocardial biopsy (EMB) plays a crucial role in the final diagnosis in patients with heart failure of unknown etiology, the invasive nature of this technique limits its clinical application in China. The purpose of this study was to evaluate the clinical application of EMB in diagnosing cardiomyopathy with unexplained etiologies in China.
METHODSFifty-three consecutive patients (38 males, age 14 - 67 years, median 43 years) were included in the study who were initially diagnosed as unexplained cardiomyopathy and under EMB biopsy in Peking Union Medical College Hospital from 2006 to 2009. The patients were clinically divided into four groups: dilated, hypertrophic, restrictive and unclassified cardiomyopathy. Biopsies were performed via right internal jugular vein with the use of the bioptome under fluoroscopic guidance. Three to five endomyocardial samples were taken from each patient for light microscopy examination and one sample for electron microscopy was taken if necessary. For each patient, an initial clinical diagnosis, an EMB diagnosis and a final diagnosis prior to discharge were established. All the data were compared and analyzed for the evaluation of clinical utility of EMB in China.
RESULTSIn 26 patients initially diagnosed with restrictive cardiomyopathy (RCM), the etiology of the condition was finally diagnosed using EMB in 15; including 13 amyloidosis and two eosinophilic myocarditis. We employed EMB in 19 patients clinically diagnosed as dilated cardiomyopathy and detected viral myocarditis in one patient, cardiac involvement due to polymyositis in four and doxorubicin-induced cardiomyopathy in one. In five patients with severe left ventricle hypertrophy undergoing EMB, one patient was diagnosed as autophagic vacuolar cardiomyopathy and one as mitochondrial disease. In the remaining three patients with unclassified cardiomyopathy, EMB revealed infiltration of eosinophils as the cause of atrial ventricular block in one patient. Final diagnoses were made in 24 of the total 53 patients (45%) based on the combination of EMB and clinical data. Transient atrial ventricular block in a patient with prior complete left bundle branch block was the only complication occurred during the procedures.
CONCLUSIONThe clinical application of EMB is safe. The combination of EMB and clinical data produced a better understanding of the mechanisms behind the clinically diagnosed cardiomyopathy in China.
Adolescent ; Adult ; Aged ; Biopsy ; methods ; Cardiomyopathies ; classification ; diagnosis ; pathology ; Cardiomyopathy, Dilated ; diagnosis ; pathology ; Cardiomyopathy, Hypertrophic ; diagnosis ; pathology ; Cardiomyopathy, Restrictive ; diagnosis ; pathology ; Female ; Humans ; Male ; Middle Aged ; Myocardium ; pathology ; Young Adult
9.Clinical and morphological features of hypertrophic cardiomyopathy in Korean patients.
Young Bae PARK ; Woo Seung LEE ; Duk Kyung KIM ; Yun Shik CHOI ; Jung Don SEO ; Young Woo LEE
Journal of Korean Medical Science 1989;4(4):163-169
Thirty three cases of hypertrophic cardiomyopathy (HCMP) were reviewed to estimate the relative frequencies of the subtypes of HCMP and to clarify whether there is any racial difference in clinical and morphological features of HCMP. The diagnosis was made by echocardiography, cardiac catheterization and left ventriculography. Twenty four patients underwent coronary angiogram. Numbers of cases by the types of HCMP were 20 (61%) with asymmetrical septal hypertrophy (ASH), 11 (33%) with apical hypertrophy (APH) and 2 (6%) with midventricular hypertrophy (MVH). Mean ages of the patients with APH, ASH and MVH were 54, 46 and 31 years respectively, and the differences were statistically significant (p less than 0.05). The giant negative T wave on electrocardiogram was seen in 4 patients (20%) of ASH and 5 patients (45%) of APH. On echocardiogram mean ratio of interventricular septal to left ventricular posterior wall thickness was 1.9 in ASH, 1.2 in APH and 1.6 in MVH, and the differences were statistically significant (p less than 0.05). All patients with APH showed "spade of ace" deformity in left ventriculography. Coronary angiograms were normal in all patients who had the procedure. Our study showed high frequency of APH of which characteristics were similar to those of the Japanese type APH.
Adult
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Age Factors
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Aged
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Cardiomyopathy, Hypertrophic/diagnosis/*pathology
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Echocardiography
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Electrocardiography
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Female
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Humans
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Korea/epidemiology
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Male
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Middle Aged
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Sex Factors
10.Successful treatment with biventricular pacing in a patient with hypertrophic obstructive cardiomyopathy.
Ji-Qiang HE ; Teng-Yong JIANG ; Yun-Long WANG ; Yan WANG ; Shu-Zheng LÜ
Chinese Medical Journal 2011;124(7):1105-1108
We report the effects of biventricular pacing in a patient with hypertrophic obstructive cardiomyopathy (HOCM) refractory to medical therapy. A 58-year-old man with HOCM had suffered from dyspnea, chest pain and palpitation for 5 years. Cardiac catheterization showed a left ventricular outflow tract (LVOT) gradient of 80 mmHg. He refused septal myomectomy and the septal ablation was not available. Based on intraoperative pressure measurements, he was implanted with biventricular pacing and LVOT gradient decreased to 10 mmHg. During the follow-up period of 6 months, the patient's symptoms were markedly improved. Biventricular pacing may be an alternative therapy for patients with HOCM.
Cardiac Resynchronization Therapy
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methods
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Cardiomyopathy, Hypertrophic
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diagnostic imaging
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pathology
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therapy
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Coronary Angiography
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Electrocardiography
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Humans
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Male
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Middle Aged