Study in 195 oropharyngeal carcinoma patients, results showed that this cancer mainly occurred in the group of 40-70 years old (70%), male was more often than female (2.8 times), duration of onset: <3 months: 40%, 3-6 months: 30.2%, 6-12 months: 18.4%, >12 months: 10.7%. Symptoms are: sore throat 59.7%, dysphagia 73.3%, changes of voice 43%, bleeding phlegm 15.8%, difficult swallow 7.8%, and lock-jaw 20.7%. Primary tumors on the right/left were 49.7% and 50.3%. 87.6% of lymph nodes were on the same side of tumors, 12.3% on the opposite side. Most patients have been diagnosed in late stages. 74.8% tumors were squamous cell carcinoma, 25.2% were undifferentiated carcinoma.
Carcinoma/pathology ; Diagnosis ; Oropharyngeal Neoplasms

Carcinoma ; diagnosis ; pathology ; Humans ; Laryngeal Neoplasms ; diagnosis ; pathology ; Larynx ; pathology

Carcinoma, Squamous Cell ; diagnosis ; Carcinoma, Verrucous ; diagnosis ; Epidermis ; pathology ; Humans

Small cell neuroendocrine carcinoma is a type of undifferentiated, malignant neuroendocrine tumor. Most of neuroendocrine tumors exhibit well-differentiated features and are classified as carcinoid tumors. However, carcinomas of the liver with anaplastic characters, which are classified as small-cell carcinomas are extremely rare and only few cases have been reported in the literature. We report an unusual case of primary small cell neuroendocrine carcinoma of the liver in a 67-year-old man. The patient was found to have a palpable mass on right upper quadrant of abdomen on physical examination. The diagnosis was made by immunohistochemical stains of biopsied specimen from the liver. Other possible primary site was excluded by radiologic and endoscopic evaluations. The tumor was composed of small monotonous and hyperchromatic poorly differentiated cells with higher nuclear to cytoplasmic ratio, and were positive for neuroendocrine tissue markers such as synaptophysin, c-kit, and CD56.
Aged ; Carcinoma, Neuroendocrine/*diagnosis/pathology ; Carcinoma, Small Cell/*diagnosis/pathology ; Humans ; Liver Neoplasms/*diagnosis/pathology ; Male

Carcinoma ; diagnosis ; pathology ; Humans ; Salivary Gland Neoplasms ; diagnosis ; pathology

Carcinoma, Verrucous ; diagnosis ; Humans ; Skull Base ; pathology

Angiomyolipoma/diagnosis ; Angiomyolipoma/*pathology ; Biopsy, Needle ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/*pathology ; Diagnosis, Differential ; Liver Neoplasms/diagnosis ; Liver Neoplasms/*pathology

A previously healthy 22-year-old woman was admitted with a complaint of right upper quadrant abdominal pain for 2 weeks. Her past history was not remarkable. On admission, HBsAg and anti-HCV were negative and alpha-FP was within normal range. Abdominal sonography and CT showed a mass in liver measuring 10 11 cm with features of central necrosis and hemorrhage. On 6th hospital day, hemoperitoneum developed suddenly. She underwent emergency laparotomy and trisegmentectomy. Intraoperative finding revealed a hemoperitoneum with a tumor filled with liquefied necrotic tissues. Microscopically, the tumor was mostly composed of pleomorphic spindle cells with abundant anastomosing vascular channels and partly composed of tumor cells with trabecular arrangement. On immunohistochemical staining, tumor cells reacted with cytokeratin and vimentin, while CD34 and hepatocyte staining revealed negative. She died 2 months after the operation. We report a case of rapidly deteriorated primary sarcomatoid hepatocellular carcinoma in a young female without any risk factor.
Adult ; Carcinoma, Hepatocellular/diagnosis/*pathology ; Female ; Humans ; Liver Neoplasms/diagnosis/*pathology ; Sarcoma/diagnosis/*pathology

Hepatoid carcinoma is a primary extrahepatic neoplasm exhibiting features of hepatocellular carcinoma (HCC) in terms of morphology, immunohistochemistry, and behavior. In many cases, tumor cytoplasm is positive for alpha- fetoprotein (alpha-FP) with elevated serum alpha-FP level. Because not all hepatoid carcinomas are associated with alpha- FP overproduction, diagnosis should be made essentially by histological features of the tumor. We present a case of hepatoid carcinoma of the pancreas in a 21-year-old male patient. Abdominal computed tomography and magnetic resonance imaging revealed an inhomogeneously enhanced pancreatic head mass. Serum alpha-FP level was markedly elevated. He underwent pylorus-preserving Whipple's operation. The tumor showed hepatoid and neuroendocrine components simultaneously. The histopathological diagnosis was hepatoid carcinoma associated with neuroendocrine tumor of the pancreas. Seven months after the surgery, the patient is healthy without evidence of recurrence. To date, only 7 cases of hepatoid carcinoma of the pancreas have been reported in the literature, and this is the first case report in Korea.
Adult ; Carcinoma, Hepatocellular/pathology ; Humans ; Male ; Pancreatic Neoplasms/*diagnosis/pathology

Adenocarcinoma ; diagnosis ; pathology ; Aged ; Carcinoma, Neuroendocrine ; diagnosis ; Diagnosis, Differential ; Humans ; Male ; Pancreatic Neoplasms ; diagnosis ; pathology