1.Clinical Significance of Lymph Node Dissection in Patients with Muscle-Invasive Upper Urinary Tract Transitional Cell Carcinoma Treated with Nephroureterectomy.
Kang Su CHO ; Hyun Min CHOI ; Kyochul KOO ; Sung Jin PARK ; Koon Ho RHA ; Young Deuk CHOI ; Byung Ha CHUNG ; Nam Hoon CHO ; Seung Choul YANG ; Sung Joon HONG
Journal of Korean Medical Science 2009;24(4):674-678
We investigated the value of lymph node dissection in patients with cN0 muscle-invasive transitional cell carcinoma of the upper urinary tract (UUT-TCC). Medical records of 152 patients with cN0 muscle-invasive UUT-TCC, who underwent nephroureterectomy between 1986 and 2005, were reviewed. Sixty-three patients (41.4%) underwent lymph node dissection. The median number of lymph nodes harvested was 6 (range, 1 to 35), and from these, lymph node involvement was confirmed in 9 patients (14.3%). Locoregional recurrence (LR) and disease-recurrence (DR) occurred in 29 patients and 63 patients, respectively. Fifty-five patients (36.2%) had died of cancer at the last follow-up. The number of lymph nodes harvested was associated with the reduction of LR (chi-square(trend)=6.755, P=0.009), but was not associated with DR (chi-square(trend)=1.558, P=0.212). In the survival analysis, N stage (P=0.0251) and lymph node dissection (P=0.0073) had significant influence on LR, but not on DR or disease-specific survival. However, the number of lymph nodes harvested did not affect LR-free, DR-free, or disease-specific survival. We conclude that lymph node dissection may improve the control of locoregional cancer, as well as staging accuracy, in cN0 muscle-invasive UUT-TCC, but that it does not clearly influence survival.
Aged
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Aged, 80 and over
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Carcinoma, Transitional Cell/mortality/*surgery/therapy
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Female
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Humans
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Kidney Neoplasms/mortality/*surgery/therapy
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*Lymph Node Excision
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Male
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Middle Aged
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Neoplasm Staging
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Nephrectomy
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Recurrence
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Retrospective Studies
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Survival Analysis
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Ureteral Neoplasms/mortality/*surgery/therapy
2.Impact of adjuvant chemotherapy in patients with upper tract urothelial carcinoma and lymphovascular invasion after radical nephroureterectomy.
Kwang Suk LEE ; Kwang Hyun KIM ; Young Eun YOON ; Kyung Hwa CHOI ; Seung Choul YANG ; Woong Kyu HAN
Korean Journal of Urology 2015;56(1):41-47
PURPOSE: To evaluate the impact of adjuvant chemotherapy (AC) in patients with upper tract urothelial carcinoma and lymphovascular invasion (LVI) after radical nephroureterectomy (RNU). MATERIALS AND METHODS: We retrospectively analyzed the clinical records and clinicopatholgic outcomes of patients (n=552) treated with RNU between 1986 and 2013. Patients treated with neoadjuvant chemotherapy and those for whom LVI status was not recorded were excluded. Patients were divided into two groups according to LVI (n=86) or no LVI (n=256). RESULTS: The study included 344 patients (240 men and 104 women) with a median of 53.9 months of follow-up (range, 1-297 months) after RNU. Tumors were organ confined (T2/N0) in 211 (61.3%) and tumor grade high in 291 (84.6%). AC was administered in 64 patients (18.6%). A total of 280 patients (81.4%) were treated with surgery alone. Patients with LVI tended to be older (p=0.049), have a higher pT stage (pT3/T4, p<0.001), be pN+ (p<0.001), have a high tumor grade (p<0.001), and experience recurrence (p<0.001). In the multivariate analysis, LVI was an independent prognostic factor for cancer-specific survival and overall survival (p=0.002 and p<0.001, respectively). The multivariate analysis demonstrated that in the subgroup of patients with LVI, AC was a significant prognostic factor for cancer-specific survival and overall survival (hazard ratio, 0.51; p=0.027 and hazard ratio, 0.50; p=0.025, respectively). CONCLUSIONS: AC does not seem to reduce mortality in patients with advanced upper tract urothelial carcinoma after RNU. In the subgroup of patients with LVI, AC had a positive impact on cancer-specific survival and overall survival. LVI would be helpful for selecting patients who are appropriate for AC.
Aged
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Carcinoma, Transitional Cell/drug therapy/*mortality/surgery
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*Chemotherapy, Adjuvant
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Female
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Follow-Up Studies
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Humans
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Kidney Neoplasms/drug therapy/*mortality/surgery
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Lymphatic Metastasis
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Male
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Middle Aged
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Multivariate Analysis
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Neoplasm Grading
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Neoplasm Recurrence, Local
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Neoplasm Staging
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Nephrectomy
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Prognosis
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Retrospective Studies
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Survival Rate
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Ureter/pathology
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Ureteral Neoplasms/drug therapy/*mortality/surgery
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Urinary Tract/pathology