1.Esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms.
Myong Ki BAEG ; Myung Gyu CHOI ; Yun Duk JUNG ; Sun Hye KO ; Chul Hyun LIM ; Hyung Hun KIM ; Jin Su KIM ; Yu Kyung CHO ; Jae Myung PARK ; In Seok LEE ; Sang Woo KIM
Gut and Liver 2016;10(1):76-82
BACKGROUND/AIMS: Esophageal squamous cell carcinoma (ESCC) and colorectal neoplasms (CRNs) share risk factors. We aimed to investigate whether the CRN risk is increased in ESCC patients. METHODS: ESCC patients who underwent a colonoscopy within 1 year of diagnosis were retrospectively analyzed. Patients were matched 1:3 by age, gender, and body mass index to asymptomatic controls. CRN was defined as the histological confirmation of adenoma or adenocarcinoma. Advanced CRN was defined as any of the following: > or =3 adenomas, high-grade dysplasia, villous features, tumor > or =1 cm, or adenocarcinoma. The risk factors for both CRN and advanced CRN were evaluated by univariate and multivariate analyses. RESULTS: Sixty ESCC patients were compared with 180 controls. The ESCC group had significantly higher numbers of CRNs (odds ratio [OR], 2.311; 95% confidence interval [CI], 1.265 to 4.220; p=0.006) and advanced CRNs (OR, 2.317; 95% CI, 1.185 to 4.530; p=0.013). Significant risk factors for both CRN and advanced CRN by multivariate analysis included ESCC (OR, 2.157, 95% CI, 1.106 to 4.070, p=0.024; and OR, 2.157, 95% CI, 1.045 to 4.454, p=0.038, respectively) and older age (OR, 1.068, 95% CI, 1.032 to 1.106, p<0.001; and OR, 1.065, 95% CI, 1.024 to 1.109, p=0.002, respectively). CONCLUSIONS: The rates of CRN and advanced CRN are significantly increased in ESCC. Colonos-copy should be considered at ESCC diagnosis.
Adenocarcinoma/diagnosis/*etiology
;
Adenoma/diagnosis/*etiology
;
Aged
;
Carcinoma, Squamous Cell/diagnosis/*etiology
;
Case-Control Studies
;
Colonoscopy
;
Colorectal Neoplasms/diagnosis/*etiology
;
Esophageal Neoplasms/diagnosis/*etiology
;
Female
;
Humans
;
Male
;
Middle Aged
;
Neoplasms, Multiple Primary/diagnosis/*etiology
;
Odds Ratio
;
Retrospective Studies
;
Risk Factors
2.Acute Marjolin's ulcer: a forgotten entity.
Leonard J M SOH ; Hiang Khoon TAN
Annals of the Academy of Medicine, Singapore 2013;42(3):153-154
Aged
;
Carcinoma, Squamous Cell
;
diagnosis
;
etiology
;
Facial Neoplasms
;
diagnosis
;
Female
;
Humans
;
Skin Neoplasms
;
diagnosis
;
etiology
;
Skin Ulcer
;
complications
;
diagnosis
;
Tooth Extraction
4.Case Reports of Lacrimal Sac Tumors Discovered in Patients with Persistent Epiphora Following Dacryocystorhinostomy.
Ka Hyun LEE ; Sun Hyup HAN ; Jin Sook YOON
Korean Journal of Ophthalmology 2015;29(1):66-67
No abstract available.
Aged
;
Biopsy
;
Carcinoma, Squamous Cell/diagnosis/*etiology
;
Dacryocystorhinostomy/*adverse effects
;
Eye Neoplasms/diagnosis/*etiology
;
Female
;
Humans
;
Lacrimal Apparatus/pathology/*surgery
;
Lacrimal Apparatus Diseases/diagnosis/*etiology
;
*Postoperative Complications
;
Tomography, X-Ray Computed
5.The advancement of predictive diagnosis and molecular mechanism in multiple primary lung cancer.
Lan YUAN ; Lun-Xu LIU ; Guo-Wei CHE
Chinese Journal of Cancer 2010;29(5):575-578
Due to the advanced diagnostic technique and better understanding for multiple primary lung cancers (MPLC), the increasing incidence of MPLC has been reported. Very often, MPLC are misdiagnosed as metastasis because of lacking efficient molecular biomarkers for prediction and diagnosis. Studies on the molecular mechanism for tumorgenesis and progression of MPLC may therefore facilitate the discovery of biomarkers for disease diagnosis and prognosis, so that an individual and rational treatment can be achieved. We tried to further our understanding and improve the diagnostic skill for MPLC by reviewing the current status and the latest advancement of molecular markers related to MPLC.
Adenocarcinoma
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pathology
;
Biomarkers, Tumor
;
analysis
;
Carcinoma, Non-Small-Cell Lung
;
drug therapy
;
radiotherapy
;
Carcinoma, Small Cell
;
pathology
;
Carcinoma, Squamous Cell
;
pathology
;
Chromosome Deletion
;
DNA Damage
;
Genes, Tumor Suppressor
;
Humans
;
Incidence
;
Lung Neoplasms
;
diagnosis
;
epidemiology
;
etiology
;
genetics
;
Neoplasms, Multiple Primary
;
diagnosis
;
epidemiology
;
etiology
;
genetics
;
Smoking
;
adverse effects
6.PET/CT-based classification of delayed radiation encephalopathy following radiotherapy for nasopharyngeal carcinoma.
Xin-lu WANG ; Ji-lin YIN ; Xiang-dong LI ; Xing-yao LI ; Yang-xi OU ; Zheng ZHOU ; Hui ZHENG
Journal of Southern Medical University 2008;28(3):320-323
OBJECTIVETo investigate positron-emission tomography-computed tomography (PET/CT) findings of radiation encephalopathy (RE) following radiotherapy for nasopharyngeal carcinoma (NPC), observe the metabolic changes of the compromised brain tissues, and postulate the clinical classification of RE to provide reference for its diagnosis.
METHODSThis study included 53 pathologically confirmed NPC patients who received previous radical radiotherapy, and the diagnosis of RE was established according to the clinical manifestations and CT/PET findings. All the patients underwent PET/CT whole-body and head scans, and the image data were evaluated along with the clinical data of the patients.
RESULTSRE most frequently involved the lateral or bilateral inferior temporal lobes. PET identified hypometabolic changes in the bilateral temporal lobes of 35 patients (70 lobes) and in the lateral temporal lobe of 18 patients (18 lobes). According to the PET/CT findings, the lesions were classified into 3 types, namely the oedema type (56 temporal lobes), liquefactive necrosis type (10 temporal lobes), and atrophic calcification type (22 temporal lobes). One patient with oedema type lesion received neurotrophic treatment and recovered completely with normal brain tissue density and metabolism, but the oedema type lesions in 2 patients progressed into to atrophic calcification type; the liquefactive necrotic lesions in another 2 patients also progressed into atrophic calcification type.
CONCLUSIONRE patients exhibit significant hypometabolic changes in the inferior temporal lobe on PET. According to the findings by PET/CT, RE can be classified into the oedema type, liquefactive necrosis type, and atrophic calcification type, and lesions of the former two types may progress into the third type.
Adult ; Aged ; Brain ; diagnostic imaging ; radiation effects ; Brain Diseases ; classification ; diagnosis ; etiology ; Carcinoma, Squamous Cell ; radiotherapy ; Female ; Humans ; Male ; Middle Aged ; Nasopharyngeal Neoplasms ; radiotherapy ; Positron-Emission Tomography ; methods ; Radiation Injuries ; classification ; diagnosis ; etiology ; Radiotherapy ; adverse effects ; Tomography, X-Ray Computed ; methods