Primary cutaneous apocrine carcinoma is a rare adnexal tumor of the skin that occurs mainly in the axilla, anogenital area while the scalp and the lower extremities, especially the thigh, are very unusual sites. However, clinical or pathologic characteristics have not been well established due to a paucity of this tumor. Herein, we report very unusual case of apocrine carcinoma present as a huge mass in the lateral thigh of 77-year-old woman, which was aggravated abruptly after an irritation by moxa treatment, with a brief review of the literature.
Aged ; Apocrine Glands ; Axilla ; Carcinoma, Skin Appendage ; Female ; Humans ; Lower Extremity ; Moxibustion ; Scalp ; Skin ; Thigh*

Malignant transformation of mature cystic teratoma of the ovary can develop with an incidence of 1-2%. Squamous cell carcinoma is the most common malignant tumor arising in benign cystic teratoma. The authors have recently experienced a case of combined microcystic adnexal carcinoma and squamous cell carcinoma arising in a benign cystic teratoma of the ovary in a 72-year-old Korean woman. The right ovarian cystic mass had been ruptured and firmly adhered with salpinx and omental fat tissue on operation. Thickened cystic wall with yellowish white solid infiltrative lesion was noted grossly, and two different malignant tumors of microcystic adnexal carcinoma exhibiting both eccrine and hair follicular differentiation and squamous cell carcinoma were observed microscopically. PAS and CEA positivities suggested eccrine differentiation in areas of microcystic adnexal carcinoma.
Aged ; Carcinoma, Skin Appendage/*pathology ; Carcinoma, Squamous Cell/*pathology ; Case Report ; Female ; Human ; Neoplasms, Multiple Primary/*pathology ; Ovarian Neoplasms/*pathology ; Skin Diseases/*pathology ; Skin Neoplasms/*pathology ; Teratoma/*pathology

We report a very rare case of trichilemmal carcinoma (TLC) involving the upper eyelid. To the best of our knowledge, this is the first report of trichilemmal carcinoma of the upper eyelid in Korea. A 51-year-old man presented to our hospital complaining of a bloody discharge from his left upper eyelid. He had a soft and lobulated mass on the palpebral conjunctiva. An incisional biopsy revealed trabecular growth of tumor cells with clear cytoplasm, prominent nucleoli, frequent mitoses, and foci of trichilemmal keratinization. Immunohistochemically, the lesion was positive for p53 and negative for CD 34. A diagnosis of TLC was made, and total excision of the mass and reconstruction of the eyelid were performed. Trichilemmal carcinoma is a rare malignant tumor, though it appears to be an indolent neoplasm with no metastatic potential. The treatment of choice for trichilemmal carcinoma of the eyelid is complete excision with tumor-free margins due to the locally invasive nature of the lesion.
Carcinoma, Skin Appendage/*pathology/surgery ; Diagnosis, Differential ; Eyelid Neoplasms/*pathology/surgery ; Follow-Up Studies ; *Hair ; Humans ; Male ; Middle Aged ; Mohs Surgery ; Skin Neoplasms/*pathology/surgery

INTRODUCTION: Eccrine  carcinoma  is  an  extremely  rare  skin tumor where only 1/13000 specimens have been submitted to dermatopathological  laboratories  in  the  United  States.There  is  no  data  yet  to compare the Philippines with the international  incidence  of  eccrine  carcinoma.  This is a case of a 69-year-old Filipino female who presented with a recurring invasive indolent tumor at the right fronto-parietal area who presented with left sided hemiparesis and seizure.
CASE: The patient was presented with a recurrent invasive indolent  mass  on  her  right  front-parietal  area,  grossly measuring five by four centimeters, nodular flesh colored,which  extended  intracranially.This was associated with left sided hemiparesis and due to the extent of the tumor encroaching through the brain parenchyma, patient was noted  to  have  seizure  episodes.  The  patient  was  given surgical and radiologic options however, she did not comply and died last December 2015.
RESULTS: A cranial MRI with MRA showed a  heterogenous enhancing intracranial mass with extracranial component with compressed entrapped and depressed superior sagittal sinus  by  the  axial  mass  witin  calvarial  penetration  and scalp involvement compressing on the right parietal lobe with parenchyma edema. Biopsy was eventually done and findings were consistent with an eccrine carcinoma.
CONCLUSION: This is the first case of eccrine carcinoma in our institution. Due to the paucity of data, there are no guidelines to the management of an eccrine carcinoma. Hence the imperative need to raise awareness regarding this rare tumor because,  without  a  high  index  of  suspicion  this  rare  entity may be overlooked or misdiagnosed. When presented with an indolent invasive recurrent tumor a high index of suspicion that  an  eccrine  Carcinoma  may  be  suspected.Excision biopsy may be done for correct identification of the tumor.

Human ; Female ; Aged ; Scalp ; Superior Sagittal Sinus ; Seizures ; Sweat Gland Neoplasms ; Biopsy ; Skin Neoplasms ; Carcinoma, Skin Appendage ; Brain ; Edema ; Paresis ; Parietal Lobe

Adult ; Arm ; Carcinoembryonic Antigen ; metabolism ; Carcinoma, Basal Cell ; pathology ; Carcinoma, Skin Appendage ; metabolism ; pathology ; surgery ; Diagnosis, Differential ; Head and Neck Neoplasms ; metabolism ; pathology ; surgery ; Humans ; Male ; Middle Aged ; Mucin-1 ; metabolism ; Skin Neoplasms ; metabolism ; pathology ; surgery