1.Managing Thyroid Microcarcinomas.
Yonsei Medical Journal 2012;53(1):1-14
Papillary thyroid microcarcinomas (PTMCs) are the most common form of classic papillary thyroid carcinoma (PTC). PTMCs are typically discovered by fine-needle-aspiration biopsy (FNAB), usually with sensitive imaging studies, or are found during thyroid surgery in a patient without a previously known history of thyroid carcinoma. However, the definition of PTMC has not always been universally accepted, thus creating controversy concerning the diagnosis and treatment of PTMC. The aim of this review is to summarize the clinical features of PTMC and identify the widely differing opinions concerning the diagnosis and management of these small ubiquitous thyroid tumors.
Biopsy, Fine-Needle
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Carcinoma, Papillary/mortality/*pathology/*surgery
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Humans
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*Neoplasm Staging
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Thyroid Neoplasms/mortality/*pathology/*surgery
2.Coexistence of Chronic Lymphocytic Thyroiditis with Papillary Thyroid Carcinoma: Clinical Manifestation and Prognostic Outcome.
Jun Soo JEONG ; Hyun Ki KIM ; Cho Rok LEE ; Seulkee PARK ; Jae Hyun PARK ; Sang Wook KANG ; Jong Ju JEONG ; Kee Hyun NAM ; Woong Youn CHUNG ; Cheong Soo PARK
Journal of Korean Medical Science 2012;27(8):883-889
The study aimed to identify the clinical characteristics of coexisting chronic lymphocytic thyroiditis (CLT) in papillary thyroid carcinoma (PTC) and to evaluate the influence on prognosis. A total of 1,357 patients who underwent thyroid surgery for PTC were included. The clinicopathological characteristics were identified. Patients who underwent total thyroidectomy (n = 597) were studied to evaluate the influence of coexistent CLT on prognosis. Among the total 1,357 patients, 359 (26.5%) had coexistent CLT. In the CLT group, the prevalence of females was higher than in the control group without CLT (P < 0.001). Mean tumor size and mean age in the patients with CLT were smaller than without CLT (P = 0.040, P = 0.047, respectively). Extrathyroidal extension in the patients with CLT was significantly lower than without CLT (P = 0.016). Among the subset of 597 patients, disease-free survival rate in the patients with CLT was significantly higher than without CLT (P = 0.042). However, the multivariate analysis did not reveal a negative association between CLT coexistence and recurrence. Patients with CLT display a greater female preponderance, smaller size, younger and lower extrathyroidal extension. CLT is not a significant independent negative predictive factor for recurrence, although presence of CLT indicates a reduced risk of recurrence.
Adult
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Carcinoma/complications/*diagnosis/surgery
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Carcinoma, Papillary/complications/*diagnosis/surgery
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Disease-Free Survival
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Female
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Follow-Up Studies
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Hashimoto Disease/complications/mortality/*pathology
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Humans
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Lymphatic Metastasis
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Male
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Middle Aged
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Neoplasm Staging
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Odds Ratio
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Predictive Value of Tests
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Prognosis
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Recurrence
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Sex Factors
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Survival Rate
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Thyroid Neoplasms/complications/*diagnosis/surgery
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Thyroidectomy