1.Duodenal medullary carcinoma: report of a case.
Jing WANG ; Yuchun MIAO ; Xuanqin YANG ; Enwei XU ; Fang CHANG ; Ning ZHANG
Chinese Journal of Pathology 2015;44(12):916-917
3.Cytopathologic Analysis on Fine Needle Aspiration Cytologic Misdiagnoses of the Thyroid.
Chan Pil PARK ; Joo Seob KEUM ; Won Mi LEE ; Moon Hyang PARK ; Jung Dal LEE
Korean Journal of Cytopathology 1998;9(2):169-180
Fine needle aspiration cytology(FNAC) has been used effectively as the initial modality in evaluating various thyroid lesions. We correlated cytologic and histopathologic features to investigate the diagnostic pitfalls of FNAC of the thyroid. A total of 1,593 FNACs of the thyroid were diagnosed at the Department of Pathology, Hanyang University Hospital, from January 1993 to December 1997. There were 963 cytologically benign cases(60.5%), 97 suspicious cases(6.1%), and 75 malignant cases(4.71%). The remaining 458 cases(28.8%) were unsatisfactory. Subsequent surgical resection was done in 192 cases. Seventy-two cases(37.5%) were cytologi cally diagnosed as benign, 45 cases(23.4%) suspicious, 56 cases(29.2%) malignant, and 19 cases(9.9%) unsatisfactory. Histopathologically, 101 cases were benign(11 thyroidites, 52 adenomatous hyperplasias, 34 follicular adenomas, and four Hurthle cell adenomas), and 91 cases malignant(72 papillary carcinomas, 16 follicular carcinomas, one medullary carcinoma, one anaplastic carcinoma, and one granular cell tumor). After excluding 19 unsatisfactory cases, 63 were misdiagnosed. They included 17 benign(three thyroidites and 14 adenomatous hyperplasias), 27 suspi cious(16 follicular adenomas, four Hurthle cell adenomas, and seven follicular carcinomas), and 19 malignant(16 papillary carcinoma, one medullary carcinoma, one anaplastic carcinoma, and one granular cell tumor) lesions. The accuracy rates in the benign, suspicious, and malignant categories were 54.9%, 49.8%, & 92.8%, respectively. The cytological pitfalls were as follows: (1) bloody background, (2) crowded follicular cell clusters indistinguishable between follicular neoplasia and adenomatous hyperplasia, (3) papillary structure, irregular nuclear membrane and pleomorphism mimicking those of papillary carcinoma, (4) indistinct eosinophilia in follicular epithelial cells, (5) unusual cellular components not commonly seen in FNACs of the thyroid.
Adenoma
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Biopsy, Fine-Needle*
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Carcinoma
;
Carcinoma, Medullary
;
Carcinoma, Papillary
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Diagnostic Errors*
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Eosinophilia
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Epithelial Cells
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Hyperplasia
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Nuclear Envelope
;
Pathology
;
Thyroid Gland*
4.Simultaneous medullary carcinoma, papillary carcinoma and granulomatous inflammation of the thyroid.
Kamal KATARIA ; Rajni YADAV ; Chitra SARKAR ; Asis Kumar KARAK
Singapore medical journal 2013;54(7):e146-8
Thyroid tumours with both papillary and medullary carcinoma features are rare and represent less than 1% of all thyroid malignancies. These tumours have a different clinical presentation and biological behaviour from tumours that have only papillary or medullary carcinoma features. The phenomenon of mixed thyroid tumours can be observed in two settings--a mixed tumour showing dual differentiation, or a collision tumour. For a precise diagnosis of this rare mixed thyroid carcinoma, fine needle aspiration cytology results should be correlated with serum calcitonin and thyroglobulin levels. The diagnosis should also be confirmed using immunocytochemistry. Surgery is the treatment of choice, and the role of postoperative radioiodine is controversial. We herein report the case of a 35-year-old man with a mixed medullary-papillary carcinoma of the thyroid, which presented with C-cell hyperplasia, granulomatous inflammation and metastasis to the cervical lymph nodes. The patient was treated with total thyroidectomy and nodal clearance. This case highlights the need for awareness of coexistent entities as they warrant separate treatments.
Adult
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Carcinoma, Medullary
;
pathology
;
surgery
;
Carcinoma, Papillary
;
pathology
;
surgery
;
Humans
;
Inflammation
;
pathology
;
Lymphatic Metastasis
;
Male
;
Neoplasms, Multiple Primary
;
pathology
;
surgery
;
Photomicrography
;
Thyroid Neoplasms
;
pathology
;
surgery
;
Thyroidectomy
5.Synchronous Occurrence of Papillary, Follicular, and Medullary Carcinoma in the Same Thyroid Gland.
Kuk Jin KIM ; Soon Won HONG ; Seok Mo KIM ; Yong Sang LEE ; Hang Seok CHANG ; Cheong Soo PARK
Korean Journal of Endocrine Surgery 2014;14(3):167-170
Incidence of thyroid carcinoma has increased dramatically; however, simultaneous occurrence of different tumors in a single thyroid gland is rare and the embryologic or molecular explanations for such cases lack a solid basis. We report on a 67-year-old woman who underwent surgery for cytologically undetermined nodules in the bilateral thyroid glands. Postoperative pathology findings indicated synchronous occurrence of discrete papillary, follicular, and medullary thyroid carcinoma. She has remained disease-free after postoperative radioactive iodine therapy (130 mCi). This is the fifth report on the synchronous occurrence of different tumors in a single thyroid gland worldwide, and the first ever in Asia.
Adenocarcinoma, Follicular
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Aged
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Asia
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Carcinoma, Medullary*
;
Female
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Humans
;
Incidence
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Iodine
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Neoplasms, Multiple Primary
;
Pathology
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Thyroid Gland*
;
Thyroid Neoplasms
6.Analysis of variation trends of thyroid cancer treated in Tianjin Cancer Hospital form 1954 to 2009.
Song-Feng WEI ; Ming GAO ; Bi-Yun QIAN ; Yi-Gong LI ; Yan ZHANG ; Wen-Yuan CHEN ; Xiang-Qian ZHENG ; Xiao-Long LI ; Yang YU ; Yong CUI
Chinese Journal of Oncology 2011;33(8):613-615
OBJECTIVETo investigate and analyze the variation trends in the pathological composition of thyroid cancer patients treated in Tianjin Cancer Hospital from 1954 to 2009.
METHODSTo retrospectively analyze the incidence and clinical features of different pathological types of thyroid cancers in 4342 patients between different time periods from 1954 to 2009.
RESULTSIn the four main pathological types of thyroid cancers, the component ratio of papillary thyroid cancer in every period was 68.1%, 78.3%, 81.3%, 82.1%, 85.8%, respectively, while the morbidity of patients with papillary thyroid carcinoma concurrent with Hashimoto's thyroiditis was increased, so was the proportion of tumors in diameter < or = 2 cm. The proportion of follicular thyroid carcinoma and anaplastic thyroid carcinoma was decreasing accordingly; however, the proportion of medullary thyroid carcinoma did not change significantly.
CONCLUSIONSThe pathological classification of the thyroid carcinoma patients has significant changes in the 4342 cases treated in our Hospital from 1954 to 2009. The proportion of papillary carcinoma is increased, while that of follicular carcinoma and anaplastic carcinoma is decreased. The reasons might attribute to the improved level of consultations and iodized diet or other factors.
Adenocarcinoma, Follicular ; epidemiology ; pathology ; Carcinoma ; epidemiology ; pathology ; Carcinoma, Medullary ; epidemiology ; pathology ; Carcinoma, Papillary ; epidemiology ; pathology ; China ; epidemiology ; Female ; Hashimoto Disease ; complications ; epidemiology ; pathology ; Humans ; Incidence ; Male ; Retrospective Studies ; Thyroid Neoplasms ; complications ; epidemiology ; pathology ; Tumor Burden
8.Hyalinizing trabecular carcinoma of thyroid: report of a case.
Xiuzhen LI ; Yanbiao FU ; Baizhou LI
Chinese Journal of Pathology 2014;43(2):130-131
Adult
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CD56 Antigen
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metabolism
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Carcinoma
;
metabolism
;
pathology
;
surgery
;
Carcinoma, Medullary
;
pathology
;
Carcinoma, Papillary
;
metabolism
;
pathology
;
DNA-Binding Proteins
;
metabolism
;
Diagnosis, Differential
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Female
;
Humans
;
Paraganglioma
;
metabolism
;
pathology
;
Thyroid Neoplasms
;
metabolism
;
pathology
;
surgery
;
Thyroidectomy
;
methods
;
Transcription Factors
;
Triglycerides
;
metabolism
9.Postoperative Findings and Risk for Malignancy in Thyroid Nodules with Cytological Diagnosis of the so-called "Follicular Neoplasm".
Eun Sook KIM ; Il Seong NAM-GOONG ; Gyung Yub GONG ; Suck Joon HONG ; Won Bae KIM ; Young Kee SHONG
The Korean Journal of Internal Medicine 2003;18(2):94-97
BACKGROUND: Malignant follicular lesion is not differentiated from benign lesions cytologically. The objective of this study was to assess the rate and the risk of malignancy in thyroid nodules which were cytologically diagnosed as follicular neoplasm by fine-needle aspiration (FNA) cytology. METHODS: All the patients who had undergone surgery with cytological diagnosis of follicular neoplasm from January 1996 through December 2001 in Asan Medical Center were studied retrospectively. Patients' and nodule characteristics were analyzed for factors associated with the presence of cancer. Two hundred and fifteen patients (196 females, 19 males) were included and their mean age was 39.4 years (range: 12~76). RESULTS: About half of the patients (102 out of 215, 47.4%) had malignancy with 29 papillary carcinomas, 57 follicular carcinomas, 15 H rthle cell carcinomas and 1 medullary carcinoma. Previously suggested factors associated with risk for malignancy, such as male gender, large tumor size (> 4 cm) or age of patients (> 45 years), were not associated with increased risk. Diagnosis of H rthle cell neoplasia on FNA was also not associated with increased risk. Only the extremes in age of the patients (below 20 or above 60 years) were associated with increased risk for malignancy. CONCLUSION: In our findings, prevalence of carcinoma in thyroid nodule patients with cytological diagnosis of follicular neoplasm was much higher than those reported. Clinical characteristics, such as male gender, age and nodule size, are not useful predictors for the presence of malignancy. Thyroid nodules with cytological diagnosis of follicular neoplasm warrant immediate surgery.
Adenocarcinoma, Follicular/pathology
;
Adenoma, Oxyphilic/pathology
;
Adolescent
;
Adult
;
Age Factors
;
Aged
;
Biopsy, Needle
;
Carcinoma, Medullary/pathology
;
Carcinoma, Papillary, Follicular/pathology
;
Child
;
Female
;
Human
;
Male
;
Middle Aged
;
Retrospective Studies
;
Risk Factors
;
Thyroid Neoplasms/*pathology
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Thyroid Nodule/*pathology
;
Thyroidectomy
;
Thyroiditis, Autoimmune/pathology
10.Clinicopathologic features of lymphoepithelioma-like gastric carcinoma and literature review.
Chinese Journal of Pathology 2013;42(11):758-759
Aged
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Carcinoma, Medullary
;
metabolism
;
pathology
;
surgery
;
Carcinoma, Squamous Cell
;
metabolism
;
pathology
;
surgery
;
Diagnosis, Differential
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Gastrectomy
;
Humans
;
Keratins
;
metabolism
;
Lymphoma
;
metabolism
;
pathology
;
Melanoma
;
metabolism
;
pathology
;
Middle Aged
;
Neoplasm Staging
;
RNA, Viral
;
metabolism
;
Retrospective Studies
;
Stomach Neoplasms
;
metabolism
;
pathology
;
surgery