No abstract available.
Breast ; Carcinoma, Lobular ; Collagen

PURPOSE: The purpose of this study is to evaluate mammographic findings of invasive ductal carcinoma(IDC) and invasive lobular carcinoma(ILC)and to find differential points between the two. MATERIALS AND METHODS: 239 patients, who underwent mammography prior to surgery and were proved to have IDC(224 patients) or ILC(15 patients)pathologically, were analized retrospectively. On mammogram, presence of mass and micro calcification were analized. When there was a mass on mammogram, lesion opacity was classified into high, equal, or low opacity andborder of the mass was classified into spiculated, poorly marginated, and well-marginated. When there was nodefinite mass, mammographic findings were classified into asymmetric opacity and no mass. RESULTS: Masses were observed in 168 patients(75%) of IDC and 12 patients(80%) of ILC. Border of the masses were spiculated(n=50,22.3%), poorly marginated(n=112, 50%), or well-marginated(n=6, 2.7%) in patients with IDC. Spiculated and poorly marginated borders were observed in 8 patients(53.3%) and 4 patients(26.7%) respectively, in patients with ILC. Microcalcifications were seen in 88 patients(39.3%) of IDC and 2 patients(13.3%) of ILC. Equal or low opacities ofthe lesions were observed in 29 patients(17.3%) of IDC and 5 patients(33.3%) of ILC. CONCLUSION: Although equalor low opacities were observed more frequently in ILC and microcalcifications were noted more frequently in IDC,it was difficult to differentiate the two diseases based on mammographic findings.
Carcinoma, Ductal* ; Carcinoma, Lobular* ; Humans ; Mammography ; Retrospective Studies

Among breast cancers, the incidence of invasive lobular carcinoma is rather low, varying in the literature 0.7% to 20% and there have been no reports concerning the frequency of cutaneous metastases from invasive lobular carcinoma. Herein, we describe an interesting case of nodular metastatic lesions from invasive lobular carcinoma.
Breast Neoplasms* ; Breast* ; Carcinoma, Lobular ; Incidence ; Neoplasm Metastasis

Minute pulmonary meningothelial-like nodules (MPMNs) are incidentally found lesions in lung resection specimens and autopsies. MPMNs have been associated with neoplastic and non-neoplastic pulmonary conditions and occasionally with extrapulmonary diseases. We report a case of a female patient presenting with invasive lobular carcinoma of the breast and MPMNs, masquerading as metastatic deposits. We describe the morphological, immunohistochemical and ultrastructural features of MPMNs and emphasize the importance of their recognition for proper staging and treatment of patients. To our knowledge, this is the first case in the English literature describing this coexistence.
Autopsy ; Breast ; Breast Neoplasms ; Carcinoma, Lobular ; Female ; Humans ; Lung

PURPOSE: This study was undertaken to investigate X-ray mammographic findings which correlated with histopathologic classification of breast carcinomas. MATERIALS AND METHODS: In 114 cases (113 patients) weeviewed X-ray mammographic findings of breast carcinoma and their histopathologic classification, and the findings were analysed to define mass, calcification, and spiculation. RESULTS: According to histopathologic classifications of breast carcinomas, infiltrating ductal carcinoma was the most common(78.9%). X-rays mammographyrevealed that irregular mass was found in 43.9% of cases, calcification in 47.4 %, and radiating spiculation in75.4%. Mass with spiculation accounted for 41.2%, and mass with calcification and spiculation for 34.2%. A commonfinding of ductal carcinoma in situ was an ill-defined mass with malignant clustered microcalcification. Infiltrating ductal and infiltrating lobular carcinomas showed irregular masses with spiculation and colloid or medullary carcinomas had well-defined masses. CONCLUSION: Mass with spiculation, and mass with calcification and spiculation were common findings of breast carcinoma. The differences in X-ray mammographic findings among each different histopathologic type of breast carcinoma are helpful for differential diagnosis.
Breast Neoplasms* ; Breast* ; Carcinoma, Ductal ; Carcinoma, Intraductal, Noninfiltrating ; Carcinoma, Lobular ; Classification* ; Colloids ; Diagnosis, Differential

BACKGROUND: Most breast carcinomas are easily categorized as ductal or lobular. However, in some cases the distinction can be difficult since some tumors may have intermediate features of these two. Prior studies suggest that E-cadherin is useful to classify tumors as ductal or lobular, as it is lost in lobular but not in ductal carcinomas. METHODS: We studied the histologic features and E-cadherin expression by immunohistochemistry in 57 cases of breast carcinomas, which were divided into three groups based on histology. Group 1 included 4 cases of infiltrating lobular carcinoma (IFL) and 1 case of lobular carcinoma in situ (LCIS) (n=5). Group 2 included infiltrating ductal carcinoma (IFD) with some features of IFL (n=48). Group 3 included a solid type of intraductal carcinoma (DCIS) (n=4). E-cadherin staining was scored as negative or positive. RESULTS: All 5 cases from group 1 were E-cadherin negative, and all 4 DCIS cases were positive. Only 2 (0.04%) of the 48 cases from group 2 were E-cadherin negative. CONCLUSIONS: Our findings suggest that the majority of cases with morphologically IFD with some IFL features are ductal. E-cadherin immunostaining is of value in helping to characterize breast carcinomas with indeterminate morphologic features.
Breast Neoplasms ; Breast* ; Cadherins* ; Carcinoma, Ductal ; Carcinoma, Intraductal, Noninfiltrating ; Carcinoma, Lobular* ; Immunohistochemistry

Mixed lobular and ductal carcinoma in situ is very rare. We recently experienced a case of invasive lobular carcinoma associated with mixed lobular and ductal carcinoma in situ in a 50-year-old female. The infiltrating portions of lobular carcinoma revealed thread-like strands of tumor cells. Lobular carcinoma in situ with pagetoid spread into the ducts and ductal carcinoma in situ of the predominantly papillary type were also noted in the same mass.
Breast* ; Carcinoma, Ductal* ; Carcinoma, Intraductal, Noninfiltrating* ; Carcinoma, Lobular* ; Female ; Humans ; Middle Aged

PURPOSE: Architectural distortion is a suspicious abnormality for the diagnosis of breast cancer. The aim of this study was to investigate the clinical significance of sonographically detected architectural distortion. MATERIALS AND METHODS: From January 2006 to June 2008, 20 patients were identified who had sonographically detected architectural distortions without a history of trauma or surgery and abnormal mammographic findings related to an architectural distortion. All of the lesions were pathologically verified. We evaluated the clinical and pathological findings and then assessed the clinical significance of the sonographically detected architectural distortions. RESULTS: Based on the clinical findings, one (5%) of the 20 patients had a palpable lump and the remaining 19 patients had no symptoms. No patient had a family history of breast cancer. Based on the pathological findings, three (15%) patients had malignancies. The malignant lesions included invasive ductal carcinomas (n = 2) and ductal carcinoma in situ (n = 1). Four (20%) patients had high-risk lesions; atypical ductal hyperplasia (n = 3) and lobular carcinoma in situ (n = 1). The remaining 13 (65%) patients had benign lesions, however, seven (35%) out of 13 patients had mild-risk lesions (three intraductal papillomas, three moderate or florid epithelial hyperplasia and one sclerosing adenosis). CONCLUSION: Of the sonographically detected architectural distortions, 35% were breast cancers or high-risk lesions and 35% were mild-risk lesions. Thus, a biopsy might be needed for an architectural distortion without an associated mass as depicted on breast ultrasound, even though the mammographic findings are normal.
Biopsy ; Breast ; Breast Neoplasms ; Carcinoma, Ductal ; Carcinoma, Intraductal, Noninfiltrating ; Carcinoma, Lobular ; Humans ; Hyperplasia ; Mammography ; Papilloma, Intraductal

PURPOSE: To review the sonographic findings of various diseases showing architectural distortion depicted under mammography. MATERIALS AND METHODS: We collected and reviewed architectural distortions observed under mammography at our health institution between 1 March 2004, and 28 February 2007. We collected 23 cases of sonographically-detected mammographic architectural distortions that confirmed lesions after surgical resection. The sonographic findings of mammographic architectural distortion were analyzed by use of the BI-RADS lexicon for shape, margin, lesion boundary, echo pattern, posterior acoustic feature and orientation. RESULTS: There were variable diseases that showed architectural distortion depicted under mammography. Fibrocystic disease was the most common presentation (n = 6), followed by adenosis (n = 2), stromal fibrosis (n = 2), radial scar (n = 3), usual ductal hyperplasia (n = 1), atypical ductal hyperplasia (n = 1) and mild fibrosis with microcalcification (n = 1). Malignant lesions such as ductal carcinoma in situ (DCIS) (n = 2), lobular carcinoma in situ (LCIS) (n = 2), invasive ductal carcinoma (n = 2) and invasive lobular carcinoma (n = 1) were observed. As ovserved by sonography, shape was divided as irregular (n = 22) and round (n = 1). Margin was divided as circumscribed (n = 1), indistinct (n = 7), angular (n = 1), microlobulated (n = 1) and sipculated (n = 13). Lesion boundary was divided as abrupt interface (n = 11) and echogenic halo (n = 12). Echo pattern was divided as hypoechoic (n = 20), anechoic (n = 1), hyperechoic (n = 1) and isoechoic (n = 1). Posterior acoustic feature was divided as posterior acoustic feature (n = 7), posterior acoustic shadow (n = 15) and complex posterior acoustic feature (n = 1). Orientation was divided as parallel (n = 12) and not parallel (n = 11). There were no differential sonographic findings between benign and malignant lesions. CONCLUSION: This study presented various sonographic findings of mammographic architectural distortion and that it is difficult to differentiate between benign and malignant lesions depicted under sonography. Pathological confirmation is needed for mammographic architectural distortion.
Acoustics ; Breast ; Carcinoma, Ductal ; Carcinoma, Intraductal, Noninfiltrating ; Carcinoma, Lobular ; Cicatrix ; Fibrosis ; Hyperplasia ; Mammography ; Orientation

BACKGROUND: The frequency of invasive lobular carcinomas is about 3% to 15% of all breast carcinomas. It is known that an invasive lobular carcinoma is different from other forms of breast cancer in the aspect of clinical characteristics and metastatic pattern. METHOD: To search of clinical characteristics of invasive lobular carcinomas, we restrospectively investigated 31 cases of invasive lobular carcinomas that had been treated from 1985 to 1996 at the Department of Surgery, Severance Hospital. RESULTS: The peak incidence was in the 40's (12 cases, 38.7%), and the average age was 45.8. The main clinical manifestation was a palpable mass on the breast at the time of visit to the hospital (30 cases, 96.8%), and the most frequent site was the upper outer quadrant (18 cases, 58.1%), followed by the upper inner quadrant (6 cases, 19.4%), of the breast. The most prevalent tumor size was 2-4 cm (14 cases, 45.2%), and the mean size was 3.27 cm. The negativity of the axillary nodes for invasive lobular carcinoma was 67.7%. According to the TNM system, there was 5 casess (16.1%) in stage I, 17 cases (54.8%) in stage IIa, 7 cases (22.6%) in stage IIb, and 2 cases (6.5%) in stage IIIb. The positivity of the estrogen receptor (ER) was 35.7%, and the positivity of the progesterone receptor (PR) was 54.5%. The overall 5-year survival rate was 82%, the overall 5-year disease-free survival was 70%, and the mean survival was 108 months. CONCLUSION: The clinical characteristics of an invasive lobular carcinoma seem to be similar to those of an invasive ductal carcinoma. Further studies are required to search for the clinical characteristics and for an adequate treatment.
Breast Neoplasms ; Breast* ; Carcinoma, Ductal ; Carcinoma, Lobular* ; Disease-Free Survival ; Estrogens ; Incidence ; Receptors, Progesterone ; Survival Rate