2.PIVKA-II as a Serological Marker of Hepatocellular Carcinoma.
The Korean Journal of Hepatology 2006;12(3):315-317
No abstract available.
Biological Markers/*blood
;
Carcinoma, Hepatocellular/*diagnosis
;
Humans
;
Liver Neoplasms/*diagnosis
;
Protein Precursors/*blood
;
Prothrombin
;
Tumor Markers, Biological/*blood
3.Clinical significance of AFP-L3 variants determined by micro centrifugal column.
Yong-zhong WANG ; Li-bo LUO ; Guo-xiang WU ; Min CHEN ; Li-hua RUAN ; Xiang-ke PU ; Shuang-rong HANG
Chinese Journal of Experimental and Clinical Virology 2007;21(2):135-137
OBJECTIVETo evaluate the clinical significance of AFP-L3 in patients with hepatocellular carcinoma.
METHODSSerum AFP-L3 variants were separated by micro centrifugal column, and detected by chemiluminescence.
RESULTSAFP and AFP-L3 levels were higher in patients with hepatocellular carcinoma than those in patients with chronic hepatitis (P<0.001); as a diagnostic target, the sensitivity and specificity of AFP-L3 were 72.3 percent and 97.2 percent, respectively. Eight patients with hepatitis have higher AFP-L3, but none of them were found with carcinoma by CT three months later.
CONCLUSIONAFP-L3 is very useful in the diagnosis of patients with hepatocellular carcinoma.
Adult ; Carcinoma, Hepatocellular ; blood ; diagnosis ; Centrifugation ; Female ; Humans ; Liver Neoplasms ; blood ; diagnosis ; Male ; Middle Aged ; alpha-Fetoproteins ; analysis ; isolation & purification
4.Clinical Efficacy of Serum PIVKA-II in the Diagnosis and Follow up after Treatment of Hepatocellular Carcinoma.
Young Joon YOON ; Kwang Hyub HAN ; Chul KIM ; Chae Yoon CHON ; Young Myoung MOON ; Chang Hoon HAN ; Hye Jin CHOI ; Yong Soo KIM ; Jae Yong HAN ; Hyon Suk KIM
The Korean Journal of Hepatology 2002;8(4):465-471
BACKGROUND/AIMS: Protein induced by vitamin K absence or antagonist II (PIVKA-II) appears to be a useful tumor marker for the evaluation of patients with hepatocellular carcinoma (HCC). But the usefulness of PIVKA-II was not yet clear in Korea where hepatitis B-virus is endemic. We investigated the usefulness of PIVKA-II in the diagnosis and follow-up after treatment of HCC. METHODS: We studied patients with HCC which was pathologically confirmed. PIVKA-II was measured by enzyme immunoassay. PIVKA-II levels before and after treatment, in correlation with imaging studies, were analyzed for the comparison of treatment responses. Kappa index was obtained. RESULTS: A total of 129 patients were included. 93 patients (72%) were HBsAg positive. 86 patients (67%) were PIVKA-II >40 mAU/mL. 52 patients (40%) were AFP >20 ng/mL and 77 patients (60%) were AFP
Carcinoma, Hepatocellular/*diagnosis/therapy
;
English Abstract
;
Human
;
Liver Neoplasms/*diagnosis/therapy
;
Protein Precursors/*blood
;
Prothrombin
;
Tumor Markers, Biological/*blood
5.Amplification of peripheral blood insulin-like growth factor II-mRNA and its clinical significance in the diagnosis of hepatocellular carcinoma.
Deng-fu YAO ; Zhi-zhen DONG ; Yan-hua LIU ; Lin ZHAO ; Jie-fei HUANG ; Xian-yong MENG
Chinese Journal of Hepatology 2003;11(11):695-696
Biomarkers, Tumor
;
blood
;
Carcinoma, Hepatocellular
;
blood
;
diagnosis
;
Female
;
Gene Amplification
;
Humans
;
Insulin-Like Growth Factor II
;
analysis
;
genetics
;
Liver Neoplasms
;
blood
;
diagnosis
;
Male
;
Prognosis
;
RNA, Messenger
;
blood
7.A Case of Nodular Hepatic Involvement of Multiple Myeloma Mimicking Hypervascular Hepatocellular Carcinoma.
Won Kyu PARK ; Jay Chun CHANG ; Heon Zu LEE ; Hong Jin KIM ; Joon Hyuk CHOI ; Mi Jin GU
The Korean Journal of Hepatology 2002;8(4):490-494
Nodular hepatic involvement of multiple myeloma is very rare. We report a case of nodular hepatic involvement of multiple myeloma, mimicking hypervascular hepatocellular carcinoma.
Carcinoma, Hepatocellular/blood supply/*diagnosis
;
Diagnosis, Differential
;
English Abstract
;
Human
;
Liver Neoplasms/blood supply/*diagnosis
;
Male
;
Middle Aged
;
Multiple Myeloma/*diagnosis
8.The clinical significance of cystatin B in hepatocellular carcinoma.
Juan HE ; Zhen-bo FENG ; Mei-hua WU
Chinese Journal of Hepatology 2010;18(12):936-937
Adult
;
Aged
;
Carcinoma, Hepatocellular
;
blood
;
diagnosis
;
Case-Control Studies
;
Cystatin B
;
blood
;
Female
;
Humans
;
Liver Neoplasms
;
blood
;
diagnosis
;
Male
;
Middle Aged
10.The prognostic significance of preoperative plasma level of osteopontin in combination with intercellular adhesion molecule-1 for patients with hepatocellular carcinoma.
Hui ZHANG ; Ning REN ; Qing-hai YE ; Hui-chuan SUN ; Lu WANG ; Yin-kun LIU ; Zhao-you TANG ; Lun-xiu QIN
Chinese Journal of Surgery 2005;43(15):985-988
OBJECTIVETo investigate the enhanced predictive activity of preoperative plasma osteopontin (OPN) level in combination with intercellular adhesion molecule-1 (ICAM-1) for recurrence and prognosis of patients after resection of hepatocellular carcinoma (HCC).
METHODSA total of 75 patients received liver resection for HCC from August 2001 to December 2001 in authors' institute were enrolled in this study. The preoperative plasma levels of OPN and ICAM-1 were detected by ELISA, and the association of them combination with the recurrence and prognosis of HCC patients was analyzed.
RESULTSOPN and ICAM-1 could be detected in all of the plasma samples of the tested patients. A significantly higher OPN level and ICAM-1 level were found in plasma of patients who were found to have HCC recurrence during the follow-up time compared with those without recurrence (210.40 vs. 154.86 ng/ml, P = 0.001; 1011.23 vs. 747.49 ng/ml, P = 0.027). A significant difference of OS and DFS were found in different subgroups with higher or lower level of OPN (625 vs. 808 days, P = 0.0006; 433 vs. 674 days, P = 0.0003); and a similar situation was found in patients of high- and low- ICAM-1 levels (651 vs. 794 days, P = 0.0269; 489 vs. 642 days, P = 0.0248). The 2-year recurrence rates of the patients with higher and lower plasma levels of both OPN and ICAM-1 were 87.50% and 28.00% (P < 0.001), respectively; and the 2-year OS rates were 37.50% and 88.00% (P = 0.001), and the 2-year DFS rates were 12.50%, and 76.00 (P = 0.001), respectively.
CONCLUSIONSThe evaluation of preoperative plasma level of OPN or ICAM-1 may be helpful to predict the recurrence and prognosis of HCC patients in advance. The assessment of OPN level in combination with ICAM-1 could stratify patients into groups with different potentials of HCC recurrence and different outcomes more accurately than OPN or ICAM-1 individually.
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor ; blood ; Carcinoma, Hepatocellular ; diagnosis ; Female ; Humans ; Intercellular Adhesion Molecule-1 ; blood ; Liver Neoplasms ; diagnosis ; Male ; Middle Aged ; Osteopontin ; blood ; Prognosis