A study carried out on patients with hepatocellular carcinoma in Hue hospital during 2000-2001. The obtained results as following: the average age of patients with hepatocellular carcinoma with positive HBVDNA was lower than this of patients with the hepatocellular carcinoma with positive HCVRNA. While the rate of male/female among group of hepatocellular carcinoma with positive HBVDNA was higher than this among group of hepatocellular carcinoma with the positive HCVRNA. The clinical and biological symptoms and ultrasound related with the cirrhosis in the group of hepatocellular carcinoma with the positive HCVRNA were more frequent than these in the group of hepatocellular carcinoma with positive HBVDNA were. There was difference of survival rate in the end of the sixth month between 2 groups but there was no difference in the end of the ninth month.
Carcinoma, Hepatocellular ; Ultrasonography

No abstract available.
Carcinoma, Hepatocellular* ; Ultrasonography*

Radiofrequency ablation (RFA) takes an important role in management of hepatocellular carcinoma (HCC) as the most popular local therapy in the world. There are many data supporting that RFA is an excellent treatment modality for early-stage HCC with favorable treatment outcomes and minimal invasiveness. Currently, RFA extends treatement indications from unresectable early-stage HCC to intermediate-stage HCC in selected cases. Thus, with technical advances in guidance and ablation as well as devices, RFA widens its territory in the combat field against HCC.
Carcinoma, Hepatocellular* ; Catheter Ablation* ; Ultrasonography

Eastern and Western guidelines for the management of hepatocellular carcinoma (HCC) are known to significantly differ on many points, because they reflect different diagnostic and therapeutic approaches to this cancer. Importantly, these guidelines are primarily consensus-driven when it comes to surveillance, both in term of the tests used and surveillance program design. The main difference between East and West lies in clinical practice, as several Eastern countries implement coordinated and systematic surveillance programs, while most Western countries rely on individual adherence to surveillance recommendations. This review article presents an overview of the evidence supporting surveillance programs for HCC, with a particular focus on the efficacy, cost-effectiveness, and consequences of this approach for patient survival. Western and Eastern guideline recommendations are discussed.
Carcinoma, Hepatocellular ; Fibrosis ; Humans ; Ultrasonography

Contrast-enhanced ultrasonography (CEUS) using microbubble ultrasonography contrast agent can show the vascular structure and unique contrast enhancement patterns of focal liver lesions, including hepatocellular carcinoma (HCC). CEUS shows three phases, similar to a vascular pattern on computer tomography (CT), and typical arterial enhancement and portal or late phase washout in HCC. CEUS can show real-time images without nephrotoxicity or radiation hazard and can be used as guidance for loco-regional treatment and estimation of treatment response of HCC. In addition, some data recently revealed the usefulness of CEUS in the early estimation of response to anti-cancer pharmacological (i.e., sorafenib) therapy in advanced HCC. Although CEUS has limitations in clinical practice and more investigation is needed for its validation, it is recommended as a main diagnostic modality in a few major clinical practice guidelines for HCC. Thus, greater understanding of CEUS is necessary to extend its application in real practice for diagnosis and management of diseases.
Carcinoma, Hepatocellular ; Diagnosis ; Liver ; Microbubbles ; Ultrasonography

Fibrolamellar hepatocelluar carcinoma is a distinct clinicopathologic variant of hepatocellular carcinoma. We describe here the sonographic and CT findings of fibrolamellar hepatocellular carcinoma in a 17-year-old patient that mimicked hepatic malignant lymphoma due to the multiple small hypoattenuating nodules and extensive lymphadenopathy that we observed. We also include a review of the relevant literatures.
Adolescent ; Carcinoma, Hepatocellular* ; Humans ; Liver Neoplasms ; Lymphatic Diseases ; Lymphoma* ; Ultrasonography

BACKGROUND/AIMS: To suggest a lexicon for liver ultrasonography and to identify radiologic features indicative of benign or malignant lesions on surveillance ultrasonography. METHODS: This retrospective study included 188 nodules (benign, 101; malignant, 87) from 175 at-risk patients identified during surveillance ultrasonography for hepatocellular carcinoma. We created a lexicon for liver ultrasonography by reviewing relevant literature regarding the ultrasonographic features of hepatic lesions. Using this lexicon, two abdominal radiologists determined the presence or absence of each ultrasonographic feature for the included hepatic lesions. Independent factors associated with malignancy and interobserver agreement were determined by logistic regression analysis and kappa statistics, respectively. RESULTS: Larger tumor size (odds ratio [OR], 1.12; 95% confidence interval [CI], 1.06-1.183; P<0.001), multinodular confluent morphology (OR, 7.712; 95% CI, 1.053-56.465; P=0.044), thick hypoechoic rim (OR, 5.878; 95% CI, 2.681-12.888; P<0.001), and posterior acoustic enhancement (OR, 3.077; 95% CI, 1.237-7.655; P=0.016) were independently associated with malignant lesions. In a subgroup analysis of lesions <2 cm, none of the ultrasonographic features were significantly associated with malignancy or benignity. Interobserver agreement for morphology was fair (κ=0.36), while those for rim (κ=0.427), echogenicity (κ=0.549), and posterior acoustic enhancement (κ=0.543) were moderate. CONCLUSIONS: For hepatic lesions larger than 2 cm, some ultrasonography (US) features might be suggestive of malignancy. We propose a lexicon that may be useful for surveillance US.
Acoustics ; Carcinoma, Hepatocellular* ; Humans ; Liver ; Logistic Models ; Retrospective Studies ; Ultrasonography*

The encapsulated hepatocellular (HCC) is a pathologic subtype of HCC. It is a well defined tumor that tends to grow slowly, and has a better prognosis than any other gross forms of HCC. Twenty surgically resected HCC were evaluated retropectively to correlate the thickness of pseudocapsules in pathology with those in computed tomography and ultrasound. At a histologic examination, pseudocapsules of seven cases were composed of two layers, an inner compact fibrous zone and outer loose fibrous zone interlaced with compressed liver parenchyma containing small vessels and newly formed bile ducts. Sonographic thickness and pathologic measurements of pseudocapsule relatively well correlated, but the former slightly overestimated the thickness of pathologic pseudocapsule (r=0.825, y=2.56x-1.23, P<0.05). On the other hand, thickness in CT and pathologic measurement did not correlate well. Thirteen cases showed one layer of pseudocapsule in which two cases were composed of thin layer of compact fibrosis and eleven cases composed of loose fibrosis. There were poor correlations in this group between thickness of pseudocapsules in pathology and those in images. Image overtly overestimated the thickness of the pseudocapsules in pathology. In conclusion, radiologic pseudocapsule of HCC may represent the compressed liver parenchyma as well as the fibrous pseudocapsule.
Bile Ducts ; Carcinoma, Hepatocellular* ; Fibrosis ; Hand ; Liver ; Pathology ; Prognosis ; Ultrasonography

The encapsulated hepatocellular (HCC) is a pathologic subtype of HCC. It is a well defined tumor that tends to grow slowly, and has a better prognosis than any other gross forms of HCC. Twenty surgically resected HCC were evaluated retropectively to correlate the thickness of pseudocapsules in pathology with those in computed tomography and ultrasound. At a histologic examination, pseudocapsules of seven cases were composed of two layers, an inner compact fibrous zone and outer loose fibrous zone interlaced with compressed liver parenchyma containing small vessels and newly formed bile ducts. Sonographic thickness and pathologic measurements of pseudocapsule relatively well correlated, but the former slightly overestimated the thickness of pathologic pseudocapsule (r=0.825, y=2.56x-1.23, P<0.05). On the other hand, thickness in CT and pathologic measurement did not correlate well. Thirteen cases showed one layer of pseudocapsule in which two cases were composed of thin layer of compact fibrosis and eleven cases composed of loose fibrosis. There were poor correlations in this group between thickness of pseudocapsules in pathology and those in images. Image overtly overestimated the thickness of the pseudocapsules in pathology. In conclusion, radiologic pseudocapsule of HCC may represent the compressed liver parenchyma as well as the fibrous pseudocapsule.
Bile Ducts ; Carcinoma, Hepatocellular* ; Fibrosis ; Hand ; Liver ; Pathology ; Prognosis ; Ultrasonography

We describe a case of spontaneous total necrosis of hepatocellular carcinoma (HCC). Contrast-enhanced CT scanning revealed a hypoattenuating mass during both the hepatic arterial and portal venous phase. During the latter, subtle capsular enhancement was noted. Ultrasonography demonstrated the presence of a hypoechoic mass with a peripheral hyperechoic rim. The patient underwent tumorectomy, and a totally necrotic mass was found. Microscopic examination revealed necrotic tissue with HCC ghost cells, suggesting spontaneous total necrosis of HCC.
Carcinoma, Hepatocellular* ; Humans ; Liver ; Necrosis* ; Tomography, X-Ray Computed ; Ultrasonography