1.Histological studies of surgically resected hepatocellular carcinoma following combined radiotherapy and hyperthermia.
Jin Sil SEONG ; Eun Kyung HAN ; Kwang Hyub HAN ; Sung Hoon NOH ; Chan Il PARK ; John J K LOH ; Heung Jai CHOI
Yonsei Medical Journal 1991;32(2):147-156
Four cases of hepatocellular carcinoma (HCC) were surgically resected following combined radiotherapy (RT) and hyperthermia (HT). Complete necrosis of the tumor without viable tumor cell was found in one case and extensive tumor necrosis was observed in the other three cases; the percentage of necrosis in the specimens were 40%, 70%, and 80%, respectively. Histologic assessment showed mainly coagulative necrosis in the tumor with focal liquefactive necrosis. Cystic dilatation of sinusoids was observed in both tumor and nontumorous normal liver tissue. Other changes in normal liver tissue were unremarkable except for infiltration of inflammatory cells, fatty change, and proliferation of the bile ducts which can usually be seen beyond the area where any space occupying lesions are present. It is concluded that combined radiotherapy and hyperthermia can significantly induce coagulative necrosis of hepatocellular carcinoma with nonsignificant minimal histologic changes in adjacent nontumorous liver tissue.
Carcinoma, Hepatocellular/*pathology/radiotherapy/surgery/*therapy
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Combined Modality Therapy
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Female
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Human
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*Hyperthermia, Induced
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*Liver Neoplasms/*pathology/radiotherapy/surgery/*therapy
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Male
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Middle Aged
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Necrosis
2.Pay close attention to standardization of the treatment of primary liver cancer.
Chinese Journal of Hepatology 2009;17(6):401-402
Antineoplastic Agents
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therapeutic use
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Carcinoma, Hepatocellular
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pathology
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surgery
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therapy
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Catheter Ablation
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methods
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Chemoembolization, Therapeutic
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Combined Modality Therapy
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Hepatectomy
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methods
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Hepatic Artery
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Humans
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Lung Neoplasms
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pathology
;
surgery
;
therapy
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Neoplasm Staging
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Radiotherapy, Conformal