No abstract available.
Blood Glucose* ; Carcinoma, Hepatocellular* ; Humans

A hepatic angiomyolipoma is a rare benign tumor mainly composed of blood vessels, smooth muscle cells and fat cells in varying proportion. Hepatic angiomyolipoma is often misdiagnosed as a hepatocellular carcinoma in preoperative imaging work-up. To date, there has been little published data describing PET findings of hepatic angiomyolipoma. We report one case of hepatic angiomyolipoma that showed a high acetate and relatively low FDG uptake on PET images.
Adipocytes ; Angiomyolipoma ; Blood Vessels ; Carcinoma, Hepatocellular ; Liver ; Myocytes, Smooth Muscle

During the most recent decade, remarkable progress has taken place in intra-arterial therapy for hepatocellular carcinoma. Advances in knowledge of hepatic vascular anatomy and tumor blood supply have contributed to the safety and efficacy of intra-arterial therapies. Technological advances in C-arm computed tomography and microcatheter systems have improved the technical success rates for superselective or ultraselective catheterization of tumor-feeding arteries. Drug-eluting bead technology has provided the option of performing chemoembolization with less systemic exposure to anticancer drugs and a more standardized delivery. Radio-embolization with yttrium-90 microspheres has emerged as a promising option offering increased quality of life. In addition, chemoembolization plays a central role in recently developed combination therapy strategies. In this era of advanced technologies and new treatment options, efforts should be made to understand the advantages and disadvantages of new technologies and treatment strategies and to apply them properly, which may lead to better local control of tumors, better quality of life, and longer patient survival.
Arteries ; Blood ; Carcinoma, Hepatocellular* ; Catheterization ; Catheters ; Humans ; Microspheres ; Quality of Life

OBJECTIVETo observe the dynamic levels of serum Golgi protein 73(GP73) in patients prior to and after the onset of liver cancer, and to explore the related factors.

METHODSFrom 2007 to 2012, a periodical screening program was carried out in a group of high risk population with positive Hepatitis B surface antigens (HBsAg) , twice a year. Their serum specimens from every screening time point were kept in Qidong Biobank until liver cancer was diagnosed. Thirty-nine patients with liver cancer were recruited for the study, each of them at least had three times of specimens collected as well as B ultrasound scan (BUS) exam results at onset of disease and within 30 months before diagnosed, amongst 6 time points. In total, there were 162 specimens collected to test GP73 by double-antibody sandwich enzyme-linked immuno-sorbent assay (ELISA). Statistical analyses of time series and differences among groups were performed by stata software 10.

RESULTSThe average value of 39 patient's GP73 at the time point of liver cancer onset was (126.77 ± 73.73) µg/L, while the values at the other five time points prior to the onset were (128.32 ± 81.18) , (129.97 ± 83.62) , (127.38 ± 80.10) , (135.52 ± 97.88) and (138.24 ± 93.58) µg/L, respectively, with no significant difference (F = 0.07, P = 0.997). No obvious changing trends of GP73 were observed among the 39 liver cancer cases at the 6 time points. All 162 samples were divided into two groups: without hepatic cirrhosis (63 samples) and with cirrhosis (99 samples) according to findings of B-ultrasonic wave; whose average GP73 values were separately (97.16 ± 51.39) and (151.20 ± 91.68) µg/L. The difference showed statistical significance (F = 18.22, P < 0.01). Furthermore, if we grouped the samples by the average value of GP73 at 130.19 µg/L, then there were only 1/14 of the subjects without hepatic cirrhosis having higher GP73 values, but 12 of the 25 subjects with hepatic cirrhosis having higher GP73 values. The difference showed statistical significance (P = 0.013). The results of Linear regression model also showed that there was no correlation between GP73 and time series (t = 0.75, P = 0.455), but significant correlation between GP73 and hepatic cirrhosis (t = 4.30, P < 0.01).

CONCLUSIONNo significant changes of the dynamic levels of GP73 could be found among the liver cancer patients within 30 months prior to the onset of disease. GP73 values of the patients with liver cancer may depend on their background of hepatic diseases; and hepatic cirrhosis might be one of the main influencing factors or confounding factors.

Biomarkers, Tumor ; blood ; Carcinoma, Hepatocellular ; blood ; Humans ; Liver Neoplasms ; blood ; Membrane Proteins ; blood ; Retrospective Studies

Biomarkers, Tumor ; blood ; Carcinoma, Hepatocellular ; diagnosis ; Humans ; Liver Neoplasms ; diagnosis ; RNA, Messenger ; blood ; alpha-Fetoproteins ; analysis

Carcinoma, Hepatocellular ; blood ; Female ; Humans ; Liver Neoplasms ; blood ; Male ; alpha-Fetoproteins ; biosynthesis

Carcinoma, Hepatocellular ; blood ; blood supply ; Endothelin-1 ; blood ; Female ; Humans ; Liver Neoplasms ; blood ; blood supply ; Male ; Neovascularization, Pathologic ; metabolism ; Nitric Oxide ; blood ; Vascular Endothelial Growth Factors ; blood

No abstract available.
Biological Markers/*blood ; Carcinoma, Hepatocellular/*diagnosis ; Humans ; Liver Neoplasms/*diagnosis ; Protein Precursors/*blood ; Prothrombin ; Tumor Markers, Biological/*blood

Hepatocellular carcinoma can metastasize via the blood vessels or the lymphatics and may invade adjacent tissues directly. But skin metastases from primary hepatocellular carcinoma occur rarely, though hepatocellular carcinoma is a common malignancy in Korea. We report cases of cutaneous metastasis in patients with preexisting hepatocellular carcinoma. First patient was a 64-year-old male who had multiple indurated papules and nodules on the scalp. Nodules, which were composed of tumor cells and intervening capillaries, showed characteristic histopathologic features mimicking those of primary hepatocellular carcinoma. The other patient was a 55-year-old female presenting a solitary nodule on the vulva, which showed the histopathology similar to those of the first patient. We discussed these cases with a review of previous reports of skin metastasis from hepatocellular carcinoma.
Blood Vessels ; Capillaries ; Carcinoma, Hepatocellular* ; Female ; Humans ; Korea ; Male ; Middle Aged ; Neoplasm Metastasis* ; Scalp ; Skin ; Vulva

Vasculitis is a heterogeneous group of diseases that destroy blood vessel walls by inflammation. Approximately half of vasculitis cases are idiopathic, but sometimes associated with genetic factors, medicines, chronic infection, autoimmune diseases, and malignancies. Although the mechanism remains unclear, vasculitis secondary to malignancy, also known as paraneoplastic vasculitis, has been reported. It is generally associated with hematologic malignancies rather than solid malignancies and commonly presents as leukocytoclastic vasculitis or polyarteritis nodosa. We experienced a case of leukocytoclastic vasculitis in a patient with hepatocellular carcinoma and membranous obstruction of the inferior vena cava. Here, we report this case with a brief review of literature.
Autoimmune Diseases ; Blood Vessels ; Carcinoma, Hepatocellular* ; Hematologic Neoplasms ; Humans ; Inflammation ; Polyarteritis Nodosa ; Vasculitis* ; Vena Cava, Inferior*