Breast Neoplasms/surgery* ; Carcinoma in Situ ; Carcinoma, Ductal, Breast ; Carcinoma, Intraductal, Noninfiltrating/surgery* ; China ; Female ; Humans ; Mastectomy

PURPOSE: Absorbable retaining thread (ART) needle localization utilizes a guiding needle with a thread; this technique was invented to reduce patient discomfort and wire migration. We investigated the feasibility of ultrasound (US)-guided ART needle localization for nonpalpable breast lesions. METHODS: ART needle localization was performed for 26 nonpalpable breast lesions in 26 patients who were scheduled to undergo surgical excision the day after localization. Seventeen breast lesions were initially diagnosed as invasive ductal carcinoma, six as ductal carcinomas in situ, and one as fibrocystic change. The other two cases without an initial pathologic diagnosis had suspicious US features, and excision was planned concomitantly with contralateral breast cancer surgery. The primary outcome was the technical success rate of ART needle localization confirmed by US immediately after the procedure, and the secondary outcomes were the percentage of clear margins on pathology and the complication rate of ART needle localization. RESULTS: The technical success rate of ART needle localization was 96.2% (25 of 26 patients), and the ART was located 1 cm away from the mass in one patient (3.8%). The lesions were successfully removed with clear margins in all 26 patients. No significant complications related to ART needle localization were observed. CONCLUSION: ART needle localization can be an alternative to wire needle localization for nonpalpable breast lesions.
Breast Neoplasms ; Breast ; Carcinoma, Ductal ; Diagnosis ; Humans ; Needles ; Pathology ; Surgery, Computer-Assisted ; Ultrasonography

Humans ; Female ; Carcinoma, Intraductal, Noninfiltrating/surgery* ; Thoracic Wall/pathology* ; Adenocarcinoma, Papillary ; Breast Neoplasms/surgery* ; Carcinoma, Ductal, Breast/pathology*

Humans ; Female ; Mastectomy, Segmental ; Margins of Excision ; Reoperation ; Breast Neoplasms/surgery* ; Retrospective Studies ; Carcinoma, Ductal, Breast/surgery* ; Neoplasm Recurrence, Local

Breast Neoplasms ; pathology ; surgery ; Carcinoma, Ductal, Breast ; pathology ; surgery ; Carcinoma, Papillary ; pathology ; surgery ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Mastectomy, Segmental ; Neoplasm Invasiveness

OBJECTIVETo study the appropriate surgical treatment for breast ductal carcinoma in situ (DCIS).

METHODSTwenty-six such patients treated between 1992 and 2001 were retrospectively analyzed. Among them, 3 patients were treated by simple mastectomy, 23 patients by mastectomy and axillary lymph node dissection, 8 patients by chemotherapy and one patient by radiotherapy after operation. Median follow-up was 42 m (rang 12 - 112 m).

RESULTSExcept 3 of these 26 patients lost in follow-up and 1 patient died from diabetes mellitus, all the other 22 patients survived over 5 years. All lymph nodes dissected from 23 patients were negative. After surgery, 3 patients developed lymph edema of the arm.

CONCLUSIONDCIS, lacking the potential of metastasis, is not invasive. Conservative breast surgery without lymph node dissection is feasible for most DCIS patients.

Adult ; Aged ; Breast Neoplasms ; mortality ; pathology ; surgery ; Carcinoma in Situ ; mortality ; pathology ; surgery ; Carcinoma, Ductal, Breast ; mortality ; pathology ; surgery ; Female ; Humans ; Lymph Node Excision ; Mastectomy ; Middle Aged ; Retrospective Studies

Acute Disease ; Appendicitis ; etiology ; surgery ; Carcinoma, Ductal, Breast ; complications ; pathology ; surgery ; Colectomy ; Female ; Humans ; Middle Aged ; Neoplasm Metastasis ; Postoperative Period

OBJECTIVETo explore the clinical indications of MRI-guided puncture positioning or biopsy, and evaluate the clinical practical value.

METHODSThe clinicopathological data of 30 patients who underwent MRI-guided puncture positioning or biopsy were retrospectively collected and analyzed, and the patients were followed up after operation.

RESULTSThe success rate of MRI-guided puncture was 100%. After biopsy or surgical resection, the pathological diagnoses were as follows: 6 cases (20.0%) of invasive carcinoma, 9 cases (30.0%) of ductal carcinoma in suit (DCIS), and 15 cases (50.0%) of benign lesions, and the false negative rate was 0.In the 30 patients, the lesions of 22 patients were not clear and difficult to analyze qualitatively by ultrasound or mammography imaging examination. After MRI-guided puncture positioning or biopsy, the pathological examination showed that 11 cases (50.0%) of them were malignant tumors. MRI examinations indicated as malignant in 21 cases, among them, seven cases were pathologically confirmed as benign pathology, with a false positive rate of 33.3%. MRI examination considered benign in 9 cases, in which one case was pathologically diagnosed as malignant, thus, the false negative rate was 11.1%.In the 30 patients, there were no hematoma, infection and other complications after the puncture. The median follow-up time was 7.5 months. One patient died due to breast cancer metastasis, one patient showed relapse by imaging examination and underwent surgery, one case was lost, and the remaining patients were normal in the regularly follow-up results.

CONCLUSIONSMRI-guided biopsy of breast microlesions is a safe, rapid and accurate diagnostic method. When the ultrasound and mammography can not find clear lesions or the lesions are difficult to analyze qualitatively, MRI-guided puncture positioning or biopsy can be applied to improve early diagnosis and treatment, and reduce false negative rate of breast cancer.

Biopsy ; methods ; Breast ; pathology ; Breast Neoplasms ; pathology ; surgery ; Carcinoma ; pathology ; surgery ; Carcinoma in Situ ; pathology ; surgery ; Carcinoma, Ductal, Breast ; pathology ; surgery ; Female ; Humans ; Magnetic Resonance Imaging, Interventional ; Mammography ; Punctures ; methods ; Retrospective Studies

Adenocarcinoma, Mucinous ; pathology ; Adult ; Breast Neoplasms ; metabolism ; pathology ; surgery ; Carcinoma ; pathology ; Carcinoma in Situ ; metabolism ; pathology ; surgery ; Carcinoma, Ductal, Breast ; metabolism ; pathology ; surgery ; Diagnosis, Differential ; Female ; Fibrocystic Breast Disease ; metabolism ; pathology ; surgery ; Humans ; Hyperplasia ; Lactalbumin ; metabolism ; S100 Proteins ; metabolism

OBJECTIVETo study the clinical features and histologic criteria of Paget's disease of breast, and evaluate the potential prognostic factors for better appropriate treatment strategies.

METHODSThirty-three patients treated for Paget's disease of breast were reviewed retrospectively.

RESULTSThe median age of diagnosis was 57 years. Twenty-nine patients were treated by modified radical mastectomy, 4 cases by mastectomy. Twenty-three (69.7%) patients had underlying carcinoma. Twenty-six (78.8%) patients did not have a palpable breast mass, 10 of them was simple Paget's disease, eight had ductal carcinoma in situ, eight had invasive ductal carcinoma. Seven patients had a palpable breast mass, and none of them was simple Paget's disease, except one of them had ductal carcinoma in situ, six had invasive ductal carcinoma.

CONCLUSIONSMost patients with Paget's disease had associated breast carcinoma. Paget's disease of the breast with a palpable breast mass is more likely to be accompanied by an invasive ductal carcinoma and had a poor prognosis. Patients with any nipple complaints deserve a serious investigation.

Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms ; diagnosis ; surgery ; Carcinoma, Ductal, Breast ; diagnosis ; surgery ; Diagnostic Errors ; Female ; Humans ; Middle Aged ; Paget's Disease, Mammary ; diagnosis ; surgery