1.Central adenoid cystic carcinoma of the mandible: a case report.
You LI ; Chunjie LI ; Fanglong WU ; Tang LI ; Ning GAO ; Longjiang LI
West China Journal of Stomatology 2015;33(5):548-550
Central malignant salivary gland tumor of the mandible is rarely observed with adenoid cystic carcinoma, which only comprises a small proportion of cancer patients. In this study, a patient with central adenoid cystic carcinoma of the mandible is presented, and relevant literature is reviewed.
Carcinoma, Adenoid Cystic
;
diagnosis
;
Humans
;
Mandible
;
pathology
;
Salivary Gland Neoplasms
;
diagnosis
2.Adenomyoepithelioma of the breast: its diagnostic problems and histogenesis.
Jin Sub CHOI ; Jong Yup BAE ; Woo Hee JUNG
Yonsei Medical Journal 1996;37(4):284-289
We report three cases of adenomyoepithelioma of the breast that occurred in middle aged women. The tumor is characterized by a balanced proliferation of epithelial tubules and surrounding myoepithelial cells that are spindle shaped or have clear cytoplasms. The first case mimicked tubular adenoma in the initial biopsy. However, on excision it turned out to be an adenomyoepithelioma of the tubular. The other two cases were lobulated types and had fibroadenomatous areas. The morphologic appearance of this tumor varies, making it misleading to other benign or even malignant lesions. The tumor has a potential for local recurrence, therefore, wide excision is recommended for proper diagnosis and treatment.
Adult
;
Breast Neoplasms/metabolism/*pathology
;
Carcinoma, Adenoid Cystic/metabolism/*pathology
;
Case Report
;
Diagnosis, Differential
;
Female
;
Human
;
Immunohistochemistry
;
Middle Age
3.Magnetic resonance imaging for diagnosis of parotid malignant tumors and the pathological basis.
Li-xin DU ; Jian-peng YUAN ; Hong GUAN ; Wei-dong ZHANG ; Bi-ling LIANG
Journal of Southern Medical University 2010;30(5):1107-1110
OBJECTIVETo investigate magnetic resonance imaging (MRI) features of parotid malignant tumors and study their pathological basis.
METHODSForty-seven patients with parotid malignant tumors confirmed by surgery (41 patients) or biopsy (6 patients) were enrolled in this study. A comparative analysis was conducted of the pathological and MRI findings in 30 patients with the entire lesions available. Each of the MRI features was analyzed retrospectively and the typical MRI findings of common parotid malignant tumors were summarized.
RESULTSMRI allowed accurate diagnosis of parotid malignant tumors. Four patients with low-grade mucoepidermoid carcinoma showed well-defined tumor margin and were difficult to distinguish from benign tumors. Six patients with high-grade mucoepidermoid carcinoma had obscure margin of the tumor which easily underwent necrosis with liable lymph node involvement. The 8 cases of adenoid cystic carcinoma was characterized by extensive invasion surrounding the parotid gland. Most of 8 cases of malignant pleomorphic adenoma still showed high and heterogeneous signal on T2WI, with irregular shape and poorly defined margin. Nine cases of lymphoma all had secondary lesions characterized by extensive involvement and presence of multiple nodules. The 4 cases of acinic cell carcinoma showed either regular or irregular tumor morphology, presenting with high signal intensity on T1WI and T(2)WI.
CONCLUSIONMRI is an important modality for the diagnosis of parotid malignant tumors. Most of the common parotid malignant tumors have characteristic MRI and pathological features, which make possible their differential diagnosis.
Adolescent ; Adult ; Aged ; Carcinoma, Adenoid Cystic ; diagnosis ; pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Parotid Neoplasms ; diagnosis ; pathology ; Retrospective Studies ; Young Adult
4.A Hybrid Carcinoma of Epithelial-Myoepithelial Carcinoma and Adenoid Cystic Carcinoma in Maxillary Sinus.
Jeong Su WOO ; Soon Young KWON ; Kwang Yoon JUNG ; Insun KIM
Journal of Korean Medical Science 2004;19(3):462-465
Hybrid carcinoma of the salivary gland is a very rare entity that has been described only in the parotid and palate. The occurrence of a hybrid carcinoma of maxillary sinus has not been reported. The diagnosis of hybrid carcinoma is important particularly when the components of tumor have different biologic behaviors. Diagnosis and treatment require a high index of suspicion, especially when the tumor is an epithelial-myoepithelial carcinoma, pathological effort to look for a more aggressive accompanying tumor, and proper oncologic treatment. We describe a case of 26-yrold woman with a hybrid carcinoma composed of epithelial-myoepithelial carcinoma with an adenoid cystic carcinoma component (cribriform pattern) in the right maxillary sinus with a brief review of the relevant literature.
Adult
;
Carcinoma/*diagnosis/pathology
;
Carcinoma, Adenoid Cystic/*diagnosis/pathology
;
Female
;
Human
;
Immunohistochemistry
;
Maxillary Sinus Neoplasms/*diagnosis/pathology
;
Neoplasm Metastasis
;
Neoplasms, Glandular and Epithelial/*diagnosis/pathology
;
Neoplasms, Multiple Primary/*diagnosis/pathology
;
Prognosis
;
Recurrence
;
Treatment Outcome
5.Factors Affecting the Results of Fine Needle Aspiration Cytology in the Diagnosis of Breast Cancer.
Chung Hun HONG ; Jae Bok LEE ; Ae Ree KIM ; Eun Suk LEE ; Jeoung Won BAE ; Bum Hwan KOO
Journal of the Korean Surgical Society 2000;58(4):480-486
PURPOSE: High false negative results on fine needle aspiration cytology (FNAC) have been reported in the diagnosis of breast cancers, which are small sized, desmoplastic type, infiltrating lobular cancers, tubular cancers, and mucinous cancer. METHODS: From Jan. 1997 to Dec. 1998, we performed 622 FNACs at the Department of Surgery, Korea University Hospital. Among those aspirates, 246 cases were followed by subsequent pathological confirmation and were included in this study. Pathological reports for breast specimens were reviewed for the size, the location, the grade or the pathological subtype, and the presence of fibrosis in the breast lesions. The pathological characteristics were compared statistically with the results of the fine needle aspiration cytology. RESULTS: The likelihood ratios for malignant, suspicious, atypical, benign, and unsatisfactory cytological diagnoses were 98.7, 5.5, 1.1, 0.07, and 0.6, respectively. The absolute and the complete sensitivities for the malignant lesions were 64.5% and 90.3%, respectively. The rate of unsatisfactory diagnosis was 9.3%, and the false-negative rate was 4.3%. The concordance rates of FNAC results were 75% for tumors less than 1 cm in size, 60.7% for 1-2 cm, 76.5% for 2-5 cm, and 50% for greater than 5 cm (p=0.01). The location of the tumor also affected the FNAC result, and the highest concordant rate was found in tumors of the lower outer quadrant of the breast (73.3%, p=0.001). The Bloom-Richardson grade and histologic type of the breast cancer also affected the FNAC result. Low-grade tumors, medullary carcinomas, metaplastic carcinomas, lobular carcinomas, adenoid cystic carcinomas, and mucinous carcinomas usually showed discordant FNAC results. The presence or the absence of fibrotic pathology did not affect the FNAC result (p=0.39). CONCLUSION: The sensitivity of FNAC was 90.3% in the diagnosis of breast cancer and the false negative rate was 4.3%. The greatest concordance of FNAC diagnosis was found in the patients with tumor less than 5 cm in size and located in the axilla and locoregional recurrent area. The FNAC results for breast cancer were frequently incorrect for low-grade tumors and cancers of a rare pathological type.
Adenocarcinoma, Mucinous
;
Axilla
;
Biopsy, Fine-Needle*
;
Brain Stem Neoplasms
;
Breast Neoplasms*
;
Breast*
;
Carcinoma, Adenoid Cystic
;
Carcinoma, Lobular
;
Diagnosis*
;
Fibrosis
;
Humans
;
Korea
;
Mucins
;
Pathology
6.Histopathologic Factors affection the Results of Fine Needle Aspiration Cytology in the Diagnosis of Breast Cancer.
Jaebok LEE ; Aeree KIM ; Eunsuk LEE ; Jeoungwon BAE ; Bumhwan KOO
Journal of Korean Breast Cancer Society 1999;2(1):77-85
The diagnostic accuracy of fine needle aspiration cytology (FNAC) had been reported about 88-99% in the preoperative diagnosis of breast cancer. High false negative results were reported in the diagnosis of breast cancers, which were small size desmoplastic type, infiltrating lobular cancer, tubular cancer and mucinous cancer. The purpose of this study is to define the possible histopathologic characteristics of breast cancer affecting the results of fine needle aspiration cytology. From Jan. 1997 to Dec. 1998, we performed 622 cases of FNAC at the department of surgery, Korea University Hospital. Among these aspirate, 246 cases were followed by subsequent pathological confirmation and were included in this study. The results of fine needle aspiration cytololgy were classified as benign, suspicious and malignant cells. Pathological reports for breast specimens were reviewed for the size, the location, grade or pathological subtypes and presence or fibrosis in the breast lesions. The pathological characteristics were compared statistically with the results of fine needle aspiration cytology. The likelihood ratios for malignant, suspicious, atypical, benign and unsatisfactory cytological diagnosis were 98.7, 5.5, 1.1 and 0.6, respectively. Absolute and complete sensitivities for the malignant lesions were 64.5% and 90.3%. The specificity was 71.9%. False negative and positive rates were 4.3% and 0.7%. The predictive value for malignant cytology in malignancy was 98.4%. The rate of unsatisfactory diagnosis was 9.3%. The range of tumor size is from 0.6 cm to 6.5 cm. The concordance rates of FNAC results wee 75% of less than 1 cm, 60.7% of 1-2 cm, 76.5% of 2-5 cm, and 50% of greater than 5cm of tumor, respectively (p=0.01). The location of tumor also affect the FNAC result and the highest concordant rate was found in the tumor of lower outer quadrant of breast (73.3%, p=0.001). The Bloom-Richardson grade histologic type of breast cancer also affect the FNAC result. Low grade tumor, medullary carcinoma, metaplastic, carcinoma, lobular carcinoma, adenoid cystic carcinoma and mucinous carcinoma usually showed discordant FNAC results. The presence or absence of fibrotic pathology did not affect the FNAC result (p=0.39) In conclusion, the sensitivity of FNAC was 90.3% in the diagnosis of breast cancer and the false negative rate was 4.3%. The great concordance of FNAC diagnosis was found in the patients with tumor of less than 5cm and located in the axilla and locoregional recurrent area. The FNAC results of breast cancer were frequently incorrect in the low grade tumor and cancer of rare pathological type such as lobular, medullary, mucinous and adenoid cystic carcinoma of breast.
Adenocarcinoma, Mucinous
;
Axilla
;
Biopsy, Fine-Needle*
;
Brain Stem Neoplasms
;
Breast Neoplasms*
;
Breast*
;
Carcinoma, Adenoid Cystic
;
Carcinoma, Lobular
;
Diagnosis*
;
Fibrosis
;
Humans
;
Korea
;
Mucins
;
Pathology
;
Sensitivity and Specificity
7.Computed tomography of lacrimal fossa tumors
Chan Sup PARK ; Young Goo KIM ; Kee Hyun CHANG
Journal of the Korean Radiological Society 1985;21(6):876-882
The lacrimal fossa can be invovled by a wide specturm of orbital pathology. The correct diagnosis is importantto avoid unnecessary procedure and to do appropriate management. 14 patients with mass lesions in the lacrimalfossa were evaluated with CT and clinical findings. The results were as follows: 1. Final diagnosis of 14 caseswith lacrimal fossa tumors was pleomorphic adenoma in 3 cases, adenoid cystic carcinoma in 1 case, pseudotumor incases, lymphoma in 2 cases, neurofibroma in 1 case, chloroma in 1 case and metastatic adenocarcinoma in 1 case. 2.The duration of symptoms of pleumorphic adenoma was more than 1 year and characteristic CT findings were globularmasses with pressure erosion of the adjacent bone. Patient wih adenoid cystic carcinoma had a short history ofsymptoms. CT showed a fusiform mass but intracranial extension with frank destruction of sphenoid bone. 3.Patients wtih pseudotumor and lymphoma had symptoms for less than 1 year. The CT findings were ill-definedinfiltrative patterns with scleral thickening and the differential diagnosis of them was difficult. 4. The marginsof neurofibroma and chloroma were well defined while that of the metastatic adenocarcinoma was ill-defined. 5. Thedegree and the extent of the contrast enhancement gave no benefit in the differential diagnosis of each diseaseentities and even of the benign and malignant lesions.
Adenocarcinoma
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Adenoma
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Adenoma, Pleomorphic
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Carcinoma, Adenoid Cystic
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Diagnosis
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Diagnosis, Differential
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Humans
;
Lymphoma
;
Neurofibroma
;
Orbit
;
Pathology
;
Sarcoma, Myeloid
;
Sphenoid Bone
;
Unnecessary Procedures
8.Diagnosis and treatment of rare malignant tumors in external auditory canal.
Fangyuan WANG ; Nan WU ; Zhaohui HOU ; Jun LIU ; Weidong SHEN ; Weiju HAN ; Shiming YANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(16):1438-1442
OBJECTIVE:
To analyze the diagnosis, therapy and prognosis of the rare cases of malignant tumors in external auditory canal.
METHOD:
Eight cases of rare malignant tumors in external auditory canal were collected except squamous cell carcinoma and adenoid cystic carcinoma. The clinical manifestation, staging, surgical method, secondary treatment and prognosis were analysed.
RESULT:
There were 5 cases of basal cell carcinoma and 2 cases of mucoepidermoid carcinoma and 1 case of myoepithelial carcinoma. Three cases of the 5 basal cell carcinoma in external auditory canal have been misdiagnosed for a long time. After admission, 4 of the 5 basal cell carcinoma were T1 stage and cured only by a complete resection of tumor. One case of T2 stage basal cell carcinoma was found recurrence 2 years later after the first excision of tumor, and was treated with radiotherapy. Tumor was controlled. Two cases of mucoepidermoid carcinoma had been misdiagnosed as a benign tumor and received a resection. One case was found metastasis to the parapharyngeal space and nasopharynx and was treated with concurrent chemotherapy. Tumor was also controlled after 5-years follow-up. Another case was found metastasis to parotid gland and received an expanding tumor resection. No recurrence was detected after a 1-year followed up. One case of T4 stage myoepithelial carcinoma in external auditory canal was a metastasis of parotid and received a partial temporal bone resection. No-recurrence was found 1 year later.
CONCLUSION
Because the tumors above have a very low incidence in external ear canal and the location of tumors are hidden, they are often misdiagnosed and delayed in treatment. Therefore, otologists should pay more attention to avoid the misdiagnosis. To the treatment, complete surgical resection of early-stage tumor is important and for late-stage tumor, a supplemented by chemoradiotherapy may be needed.
Carcinoma, Adenoid Cystic
;
diagnosis
;
surgery
;
Carcinoma, Basal Cell
;
diagnosis
;
surgery
;
Carcinoma, Squamous Cell
;
diagnosis
;
surgery
;
Ear Canal
;
pathology
;
Ear Neoplasms
;
diagnosis
;
surgery
;
Humans
;
Neoplasm Recurrence, Local
;
Neoplasm Staging
;
Parotid Gland
;
pathology
;
Prognosis
;
Retrospective Studies
;
Temporal Bone
;
surgery
9.Recurred Adenoid Cystic Carcinoma of Lacrimal Gland with Aggressive Local Invasion to the Maxillary Bone Marrow without Increased Uptake in PET-CT.
Moonjung CHOI ; Ja Seung KOO ; Jin Sook YOON
Korean Journal of Ophthalmology 2015;29(1):68-70
No abstract available.
Bone Marrow/*pathology/radiography/radionuclide imaging
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Carcinoma, Adenoid Cystic/*diagnosis
;
Eye Neoplasms/*diagnosis
;
Female
;
Humans
;
Lacrimal Apparatus/*pathology/radiography/radionuclide imaging
;
Lacrimal Apparatus Diseases/*diagnosis
;
Maxilla
;
Middle Aged
;
Neoplasm Invasiveness
;
Neoplasm Recurrence, Local
;
*Positron-Emission Tomography
;
*Tomography, X-Ray Computed
10.Nasopharyngeal adenoid cystic carcinoma: magnetic resonance imaging features in ten cases.
Xue-Wen LIU ; Chuan-Miao XIE ; Hui LI ; Rong ZHANG ; Zhi-Jun GENG ; Yun-Xian MO ; Jing ZHAO ; Mu-Yan CAI ; Yan-Chun LV ; Pei-Hong WU
Chinese Journal of Cancer 2012;31(1):19-28
Nasopharyngeal adenoid cystic carcinoma (NACC) is a rare malignancy with high local invasiveness. To date, there is no consensus on the imaging characteristics of NACC. To address this, we retrospectively reviewed 10 cases of NACC and summarized the magnetic resonance imaging (MRI) features. MR images of 10 patients with histologically validated NACC were reviewed by two experienced radiologists. The location, shape, margin, signal intensity, lesion texture, contrast enhancement patterns, local invasion, and cervical lymphadenopathy of all tumors were evaluated. Clinical and pathologic records were also reviewed. No patients were positive for antibodies against Epstein-Barr virus (EBV). The imaging patterns of primary tumors were classified into two types as determined by location, shape, and margin. Of all patients, 7 had tumors with a type 1 imaging pattern and 3 had tumors with a type 2 imaging pattern. The 4 tubular NACCs were all homogeneous tumors, whereas 3 (60%) of 5 cribriform NACCs and the sole solid NACC were heterogeneous tumors with separations or central necrosis on MR images. Five patients had perineural infiltration and intracranial involvement, and only 2 had cervical lymphadenopathy. Based on these results, we conclude that NACC is a local, aggressive neoplasm that is often negative for EBV infection and associated with a low incidence of cervical lymphadenopathy. Furthermore, MRI features of NACC vary in locations and histological subtypes.
Adult
;
Aged
;
Carcinoma, Adenoid Cystic
;
diagnosis
;
pathology
;
surgery
;
Female
;
Humans
;
Lymphatic Metastasis
;
Magnetic Resonance Imaging
;
methods
;
Male
;
Middle Aged
;
Nasopharyngeal Neoplasms
;
diagnosis
;
pathology
;
surgery
;
Neoplasm Invasiveness
;
Neoplasm Staging
;
Retrospective Studies