No abstract available.
Carcinoembryonic Antigen* ; Citalopram*

No abstract available.
Carcinoembryonic Antigen* ; Citalopram*

No abstract available.
Carcinoembryonic Antigen ; Colorectal Neoplasms

No abstract available.
Carcinoembryonic Antigen ; Colorectal Neoplasms

Background: Human carcinoembryonic antigen (CEA) is widely used as tumor marker. Striking similarities have been reported between process of tumor genesis and atherosclerotic diseases. CEA has been reported as a useful biomarker for diagnosis of acute coronary syndrome whose main pathogenesis mechanism is rupture of atherosclerotic plaque. Although same pathogenic mechanism leads to ischemic stroke, the role of CEA in stroke has not been studied. This study was aimed at evaluating role of CEA as diagnostic marker for acute atherosclerotic ischemic stroke. Methods: Sixty male subjects between 40 to 60 years of age were divided into 2 groups with 30 subjects each: Group A (ischemic stroke) and Group B (age and sex matched healthy controls). Exclusion criteria for Group A included diabetes mellitus, heavy smoking, recent cerebrovascular or myocardial events. The blood sample was taken not later than 24 hours of onset of stroke in Group A. In Group B, the blood samples were drawn at the time of enrollment in the study. CEA levels were estimated using double sandwich ELISA method. Results: The mean (SE) serum CEA levels in healthy controls and ischemic stroke patients were 0.95(0.11) and 5.57 (0.20) ng/mL respectively (p<0.001). After adjusting for confounders such as total leucocytes count, waist hip ratio, hypertension and smoking mean (SE) were 1.38 (1.23) and 5.26 (0.85) ng/ml respectively (p<0.001). Conclusions: Patients with ischemic stroke have raised level of CEA. CEA is a promising novel biomarker for diagnosis of acute ischemic stroke.
Carcinoembryonic Antigen ; Stroke

No abstract available.
Breast* ; Carcinoembryonic Antigen* ; Humans ; Stomach*

No abstract available.
Carcinoembryonic Antigen* ; Colorectal Neoplasms* ; Humans

No abstract available.
Carcinoembryonic Antigen* ; Colon* ; Exons* ; Humans*

Carcinoembryonic Antigen ; analysis ; Humans ; Luminescence

PURPOSE: We have conducted this study to investigate the role of c-myc and AAT in gastric carcinoma progression and to see if clinical application of its expression in cancer tissue is of help for the diagnosis or in determining prognosis of gastric carcinoma. MATERIALS AND METHOD: The expression of c-Myc and AAT by immunohistochemical method applied to paraffin-embedded tissue sections of endoscopic biopsy materials of 71 cases of gastric carcinoma (24 early and 47 advanced) and immunoreactivities of antigens were correlated with histological differentiation of carcinoma, degree of tumor infiltration of mononuclear cells, serum levels of carcinoembryonic antigen (CEA) and presence of distant metastases. RESULTS: c-Myc in gastric carcinoma tissue was expressed in 24 cases (33.8%), and the rate of immunoreactivity of c-Myc was higher in the advanced carcinoma cases (38.2%) than early carcinoma cases (25.0%), but the difference was not stastistically significant. The elevated c-Myc expression correlated well with the elevation of serum CEA levels (P<0.05), with the presence of distant metastses (p<0.05), especially with peritoneal metastsis (p<0.05). AAT expression in gastric carcinoma was shown in 11 cases (14.1%), and the rate of immunoreactivity of AAT was significantly higher in advanced carcinoma cases (21.3%) than early carcinoma cases (4.2%) (p<0.05). The elevated expression of AAT correlated well with the elevation of serum CEA levels (p<0.05), and showed negative correlation with the degree of mononuclear cell infiltration in tumor area (p<0.05). The increased expression of c-Myc and AAT in gastric carcinoma correlated well (p=0.05, k= 0.31), which suggests the cooperative action of the two in gastric carcinoma progression. CONCLUSIONS: Our findings suggest that c-Myc expression may be a good marker of high grade malignancy in gastric carcinoma, and may be able to be used clinically in predicting distant metastases, especially for peritoneal dissemination. Our data also imply that c-myc, through its proliferative action, may play an important role in the progression of gastric carcinoma in cooperation with AAT which has immunosuppresive action.
Biopsy ; Carcinoembryonic Antigen ; Diagnosis ; Neoplasm Metastasis ; Prognosis