No abstract available.
Carbon Disulfide* ; Carbon* ; Poisoning*

No abstract available.
Carbon Disulfide* ; Carbon* ; Humans ; Poisoning*

OBJECTIVES: To investigate the chronological subjective symptoms and related factors in ex-workers who were occupationally exposed to Carbon disulfide. METHODS: One hundred and seventy-seven subjects (147 males and 30 females) were randomly selected among ex-workers and interviewed by well trained doctors, who filled out a structured questionnaire developed by authors on the subjective symptoms. The questionnaire was composed of symptoms in the head and neck, and those of the neuro-psychological, respiratory, endocrine, musculoskeletal, and reproductive systems. Other factors such as general and occupational characteristics including work department, work duration, duration since cessation of exposure, and compensation for occupational disease were also investigated. RESULTS: The mean subject age was 55.4 years. The mean cumulative exposure index (CEI) was 38.96 +/- 31.18. CEI was significantly higher in the compensated group (47.61 +/- 32.51) than in the non-compensated group (26.81 +/- 24.75)(p=0.000). Symptom complaints were significantly higher in the compensated group in all organ systems, and their incidence increased gradually until 10 years after cessation of work, and then decreased. The mean duration for cessation of exposure at the time of compensation was 10.97 years. The significantly different factors between the compensated group and the non-compensated group were total cumulative exposure index and the time interval between the cessation of work and the time of compensation. CONCLUSION: Our findings suggest that total cumulative exposure index and the time interval between the cessation of work and the time of compensation may be important factors affecting the compensation for occupational disease. Therefore, further studies will be necessary.
Carbon Disulfide* ; Carbon* ; Compensation and Redress* ; Head ; Humans ; Incidence ; Male ; Neck ; Occupational Diseases ; Occupations* ; Poisoning* ; Questionnaires

OBJECTIVES: We surveyed the awareness and current status of using fumigant carbon disulfide for exterminate Curculio sikkimensis among chestnut farmers in Chungnam Province to suggest directions for health education and public relations. METHODS: We designed questionnaires to evaluate recognition of fumigant carbon disulfide. We conducted a questionnaire survey to assess recognition and recognition level of fumigant carbon disulfide by the study variables. RESULTS: The recognition status for fumigant carbon disulfide was 74.5%, but the recognition level was low (know well 27.5%). The path of recognition was 45.1% and 15.7% for neighbor and rural technology center, respectively. The recognition status for warning label of fumigant carbon disulfide was 52.9%. Recognition for warning label of fumigant carbon disulfide was tended to increase with high educational attainment, bigger owning land area. Recognition on the content of warning label were 29.4%, 27.5%, 21.6%, and 21.6% for inflammability, toxicity, hazard, and explosiveness, respectively. Using personal protection equipment was tended to increase with the high status of awareness on fumigant carbon disulfide. CONCLUSIONS: Health education programs for using fumigant carbon disulfide are needed for chestnut farmers. In addition, publicity information activities about prevention and protection of carbon disulfide poisoning are needed for high risk farmers.
Carbon Disulfide* ; Carbon* ; Chungcheongnam-do ; Farmers* ; Fumigation ; Health Education ; Humans ; Poisoning ; Public Relations ; Weevils*

Acute Disease ; Adult ; Brain Diseases ; chemically induced ; Carbon Disulfide ; poisoning ; Humans ; Male ; Occupational Diseases ; chemically induced

OBJECTIVES: A previous study conducted in 2000 measuring the heart rate variability (HRV) of carbon disulfide (CS2)-poisoned subjects suggested that their HRV was reduced after exposure cessation. However, the study was limited by the following procedural limitations: (1) only 71 CS2-poisoned subjects participated, (2) no females participated, and (3) the CS2-poisoned subjects were older than the controls. This study was therefore conducted to overcome these limitations of the earlier study. METHODS: The study subjects comprised 122 retired workers with CS2 poisoning and the same number of age- and sex-matched controls. Information on individual age, sex, height, weight, smoking history, alcohol drinking, regular exercise, medical and occupational history, chest x-ray, and ECG recording of the two groups was collected though a self-administered questionnaire and a medical examination. Standard Deviation of NN intervals (SDNN), Root-Mean-Square of Successive Differences (RMSSD), Total Power (TP), Low Frequency (LF), High Frequency (HF), and LF/HF ratio were measured as HRV indices for 5 minutes in the sitting position. RESULTS: Univariate analysis revealed that all HRV indices of CS2-poisoned subjects were lower than those of the controls. Multiple linear regression analysis showed that CS2 poisoning had negative association with all HRV indices and that its association with RMSSD was statistically significant (P<0.05). CONCLUSIONS: This study suggests that CS2-poisoned subjects continue to have reduced HRV, even though the exposure has ceased.
Alcohol Drinking ; Carbon Disulfide* ; Carbon* ; Electrocardiography ; Female ; Heart Rate* ; Heart* ; Humans ; Linear Models ; Poisoning ; Questionnaires ; Smoke ; Smoking ; Thorax

Adult ; Carbon Disulfide ; poisoning ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Multiphasic Screening ; Neural Conduction ; Occupational Diseases ; diagnosis ; physiopathology

OBJECTIVES: Mass poisoning by carbon disulfide (CS2) occurred in a viscose rayon factory in Korea. Up until 1998, 830 employees, including 38 who had died, were diagnosed with CS2 poisoning. Among the CS2 poisoned subjects, heart rate variability (HRV) was evaluated to investigate whether the toxic effect of CS2 persists after the exposure has ceased. The dose-response relationship between carbon disulfide exposure and HRV was also evaluated. METHODS: The case group was comprised of 71 retired male workers diagnosed as being CS2 poisoned. The control group was comprised of 127 males of same age-range who had no history of CS2 exposure and cardiovascular diseases. Information on individual age, height, weight, cigarette smoking, alcohol drinking, regular exercise, medical and occupational history, chest x-ray, and ECG recording of the two groups were collected through a self-administered questionnaire and with a medical examination. Time (maximum, average, minimum RR interval) and frequency domain measures (low frequency - LF, high frequency - HF, total power spectrum TPS, and LF/HF ratio) of the two groups were analyzed. CS2 exposure indices of the case group (duration of employment, exposure level per work department, cumulative exposure index and duration of retirement) were investigated. RESULTS: Using a univariate analysis, the frequency domain measures for the case group were significantly lower than those in the control group, except for HF. In the multivariate analysis, previous history of CS2 poisoning was inversely related to all frequency domain parameters and it significantly affected the LF (p<0.05) and the LF/HF ratio (p<0.05). There was no significant dose-response relationship between CS2 exposure indices and HRV parameters in the case group. CONCLUSION: This study suggests that further studies are necessary to evaluate the residual effects of CS2 poisoning even after the CS2 exposure has ceased.
Alcohol Drinking ; Carbon Disulfide* ; Carbon* ; Cardiovascular Diseases ; Electrocardiography ; Employment ; Heart Rate* ; Heart* ; Humans ; Korea ; Male ; Multivariate Analysis ; Poisoning* ; Questionnaires ; Smoking ; Thorax

OBJECTIVE: To evaluate the findings of brain MRI in patients with carbon disulfide poisoning. MATERIALS AND METHODS: Ninety-one patients who had suffered carbon disulfide poisoning [male:female=87:4; age, 32-74 (mean 53.3) years] were included in this study. To determine the extent of white matter hyperintensity (Grade 0-V) and lacunar infarction, T2-weighted MR imaging of the brain was performed. RESULTS: T2-weighted images depicted white matter hyperintensity in 70 patients (76.9%) and lacunar infarcts in 27 (29.7%). CONCLUSION: In these patients, the prevalent findings at T2-weighted MR imaging of the brain were white matter hyperintensity and lacunar infarcts. Disturbance of the cardiovascular system by carbon disulfide might account for these results.
Adult ; Aged ; Brain/*drug effects/*pathology ; Brain Infarction/*pathology ; Carbon Disulfide/*poisoning ; Female ; Human ; Magnetic Resonance Imaging ; Male ; Middle Age ; Retrospective Studies

OBJECTIVETo investigate whether the alterations of microtubule and microfilament expression are responsible for the neurotoxicity of carbon disulfide.

METHODSWistar rats were administered with carbon disulfide by gavage at a dosage of 300 or 500 mg/kg for continuous 12 weeks (five times per week). Spinal cords of carbon disulfide-intoxicated rats and their age-matched controls were Triton-extracted and ultracentrifuged to yield a pellet and a corresponding supernatant fraction. Then, the contents of alpha-tubulin, beta-tubulin, and beta-actin in both fractions were determined by immunoblotting. In the meantime, their mRNA levels in spinal cords were quantified using reverse transcriptase-polymerase chain reaction (RT-PCR).

RESULTSIn the supernatant fraction, the contents of beta-tubulin and beta-actin in both treated groups increased significantly (P < 0.01) the content of beta-tubulin increased by 141% and 158% respectively, and the content of beta-actin increased by 19% and 32% respectively. In the pellet fraction, the content of beta-tubulin in both groups increased by 107%(P < 0.01) and 118%(P < 0.01) respectively, and the others keep unaffected. In the meantime, the levels of of mRNA expression of beta-tubulin and beta-actin gene were elevated consistently in CS(2)-treated groups (P < 0.01) the levels of mRNA expression of beta-tubulin increased by 207% and 212% respectively, and the levels of mRNA expression of beta-actin increased by 94% and 91% respectively.

CONCLUSIONCarbon disulfide intoxication results in alternations of microtubule and microfilament expression, and the alternations might be related to its neurotoxicity.

Actins ; genetics ; metabolism ; Animals ; Carbon Disulfide ; poisoning ; Disease Models, Animal ; Male ; RNA, Messenger ; genetics ; Rats ; Rats, Wistar ; Spinal Cord ; drug effects ; metabolism ; Tubulin ; genetics ; metabolism